Hdac4 - histone deacetylase 4 Gene

Rattus norvegicus

Gene ID: 363287 | Gene type: protein coding

About Hdac4

Primary_assembly 9: 92,507,611-92,750,164 reverse strand.mRatBN7.2:CM026982.1

This gene has 2 transcripts (splice variants), 263 orthologues, 12 paralogues and is associated with 40 phenotypes. Biased expression in Adrenal (RPKM 6.6), Thymus (RPKM 53.6) and 9 other tissues.

Summary

Enables promoter-specific chromatin binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to parathyroid hormone stimulus; and positive regulation of lamellipodium assembly. Located in cytosol; nucleus; and sarcomere. Part of protein-containing complex. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in ataxia telangiectasia; chromosome 2q37 deletion syndrome; eating disorder; and retinal degeneration. Orthologous to human HDAC4 (histone deacetylase 4). [provided by Alliance of Genome Resources, Apr 2022]

Hdac4 Products(1)

mRNA	Protein	Name
NM_053449.1	NP_445901.1	histone deacetylase 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	21586557	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	21464227	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19261284	RGD
involved in cellular response to parathyroid hormone stimulus	IEP IEP: Inferred from expression pattern	20097749	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	22389387	RGD
involved in positive regulation of lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	24166750	RGD
involved in positive regulation of male mating behavior	IMP IMP: Inferred from mutant phenotype	21586557	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	23925573	RGD
involved in positive regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	24166750	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	24166750	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	24166750	RGD
involved in response to alcohol	IEP IEP: Inferred from expression pattern	26509893	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	16767219	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in A band	IDA IDA: Inferred from direct assay	18250163	RGD
located in Z disc	IDA IDA: Inferred from direct assay	18250163	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	22360269	RGD
located in sarcomere	IDA IDA: Inferred from direct assay	18250163	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hdac4 Protein Structure

ClassIIa_HDAC4_Gln-rich-N

HDAC4

0
200
400
600
800
1000
1096 a.a.

Protein Preferred Names

Protein Names

histone deacetylase 4

HD4

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15149	Romidepsin	Inhibitor	99.98%	Unkown
HY-13322	Pracinostat	Inhibitor	99.82%	Yes
HY-14842	Givinostat	Inhibitor	98.16%	Yes

Clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10528	Tasquinimod	Modulator	99.94%	Phase 3
HY-14842B	Givinostat hydrochloride monohydrate	Inhibitor	≥98.0%	Phase 3
HY-14842A	Givinostat hydrochloride	Inhibitor	98.06%	Phase 3
HY-16026	Ricolinostat	Inhibitor	99.83%	Phase 2
HY-15433	Quisinostat	Inhibitor	98.34%	Phase 2
HY-13522	Fimepinostat	Inhibitor	99.95%	Phase 2
HY-15433A	Quisinostat dihydrochloride	Inhibitor	99.05%	Phase 2
HY-10223	CUDC-101	Inhibitor	99.05%	Phase 1

Pre-clinical Phase

Bioactive Molecules (42)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18361	TMP195	Inhibitor	99.57%	Unkown
HY-18998	LMK-235	Inhibitor	99.61%	Unkown
HY-13428	Tubacin	Inhibitor	99.54%	Unkown
HY-18360	TMP269	Inhibitor	98.05%	Unkown
HY-16699	Nexturastat A	Inhibitor	98.28%	Unkown
HY-115475	SW-100	Inhibitor	99.93%	Unkown
HY-119939	CHDI-390576	Inhibitor	98.07%	Unkown
HY-123295	HDAC3-IN-T247	Inhibitor	98.94%	Unkown
HY-19350	BML-210	Inhibitor	98.06%	Unkown
HY-12954	PTACH	Inhibitor	99.65%	Unkown
HY-149285	NT160	Inhibitor	99.58%	Unkown
HY-146153	HDAC-IN-40	Inhibitor	98.71%	Unkown
HY-117554	BRD9757	Inhibitor	99.75%	Unkown
HY-146678	HDAC6-IN-5	Inhibitor	/	Unkown
HY-146679	HDAC6-IN-6	Inhibitor	/	Unkown
HY-150109	Purinostat mesylate	Inhibitor	99.45%	Unkown
HY-163143	HDAC8-IN-6	Inhibitor	/	Unkown
HY-149208	HDAC-IN-53	Inhibitor	/	Unkown
HY-151263	G4/HDAC-IN-1	Inhibitor	/	Unkown
HY-170379	HDAC-IN-84	Inhibitor	/	Unkown
HY-149372	HDAC6-IN-17	Inhibitor	/	Unkown
HY-150595	HDAC6-IN-10	Inhibitor	/	Unkown
HY-151897	HDAC-IN-49	Inhibitor	/	Unkown
HY-152225	MC2625	Inhibitor	/	Unkown
HY-169400	HDACs/EZH2-IN-1	Inhibitor	/	Unkown
HY-147934	HDAC8-IN-3	Inhibitor	/	Unkown
HY-143233	PIM-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-146684	HDAC-IN-36	Inhibitor	/	Unkown
HY-124946	C1A	Inhibitor	/	Unkown
HY-163803	CM-444	Inhibitor	/	Unkown
HY-157740	XSJ-10	Inhibitor	/	Unkown
HY-15144B	(S)-Trichostatin A	Inhibitor	/	Unkown
HY-150503	KH-259	Inhibitor	/	Unkown
HY-152226	MC2590	Inhibitor	/	Unkown
HY-161778	ZG-126	Inhibitor	/	Unkown
HY-146159	PI3K/HDAC-IN-2	Inhibitor	/	Unkown
HY-151896	HDAC6-IN-14	Inhibitor	/	Unkown
HY-149721	HDAC4-IN-1	Inhibitor	/	Unkown
HY-162630	HDAC6-IN-44	Inhibitor	/	Unkown
HY-148624	CHDI-00484077	Inhibitor	/	Unkown
HY-135714	Bavarostat	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hdac4	NCBI	NCBI:9759

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