PDE4D - phosphodiesterase 4D Gene

Homo sapiens

Also known as DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2

Gene ID: 5144 | Gene type: protein coding

About PDE4D

Cytogenetic location: 5q11.2-q12.1 Genomic coordinates (GRCh38): 5:58,969,038-60,522,128 (from NCBI)

This gene has 28 transcripts (splice variants), 243 orthologues, 20 paralogues and is associated with 5 phenotypes. Broad expression in bone marrow (RPKM 7.8), lung (RPKM 3.1) and 20 other tissues.

Summary

This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]

PDE4D Products(18)

mRNA	Protein	Name
NM_001104631.2	NP_001098101.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D4
NM_001165899.2	NP_001159371.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D7
NM_001197218.2	NP_001184147.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D5
NM_001197219.2	NP_001184148.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D8
NM_001197220.2	NP_001184149.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D9
NM_001197221.2	NP_001184150.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D2
NM_001197222.2	NP_001184151.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D1
NM_001197223.2	NP_001184152.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D6
NM_001349241.2	NP_001336170.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 10
NM_001349242.2	NP_001336171.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 11
NM_001349243.2	NP_001336172.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 12
NM_001364599.1	NP_001351528.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D7
NM_001364600.2	NP_001351529.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 14
NM_001364601.1	NP_001351530.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 15
NM_001364602.2	NP_001351531.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 16
NM_001364603.1	NP_001351532.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D2
NM_001364604.1	NP_001351533.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 12
NM_006203.5	NP_006194.2	cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3',5'-cyclic-AMP phosphodiesterase activity	IDA IDA: Inferred from direct assay	9371713	GOA
enables 3',5'-cyclic-AMP phosphodiesterase activity	IGI IGI: Inferred from genetic interaction	8413254	GOA
enables ATPase binding	IPI IPI: Inferred from physical interaction	21903937	GOA
enables cAMP binding	IDA IDA: Inferred from direct assay	9371713	GOA
enables heterocyclic compound binding	IPI IPI: Inferred from physical interaction	9371713	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17620599	GOA
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	15182229	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	16213210	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17404263	GOA
involved in cellular response to cAMP	IDA IDA: Inferred from direct assay	12121997	GOA
involved in cellular response to epinephrine stimulus	IDA IDA: Inferred from direct assay	12121997	GOA
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	20819076	GOA
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19252089	GOA
involved in positive regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	17404263	GOA
involved in positive regulation of interleukin-5 production	IMP IMP: Inferred from mutant phenotype	17404263	GOA
involved in positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	17404263	GOA
involved in regulation of cell communication by electrical coupling involved in cardiac conduction	IMP IMP: Inferred from mutant phenotype	16213210	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of calcium channel complex	IDA IDA: Inferred from direct assay	16213210	GOA
located in cytosol	IDA IDA: Inferred from direct assay	9371713	GOA
NOT located in membrane	IDA IDA: Inferred from direct assay	9371713	GOA
located in membrane	IDA IDA: Inferred from direct assay	9371713	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE4D Protein Structure

PDEase_I

0
200
400
600
809 a.a.

Protein Preferred Names

Protein Names

cAMP-specific 3',5'-cyclic phosphodiesterase 4D

cAMP-specific phosphodiesterase PDE4D6

Related Diseases

Diseases

Alias

Acrodysostosis 2 With Or Without Hormone Resistance

ACRDYS2	Acrodysostosis 2, With Or Without Hormone Resistance
Acrodysostosis, With/Without Hormone Resistance, Type 2	Acrodysostosis

Acrodysostosis With Multiple Hormone Resistance

Acrodysostosis

Acrodysplasia	Arkless-Graham Syndrome
Maroteaux-Malamut Syndrome	Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome
Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome

Chromosome 5q12 Deletion Syndrome

Pde4d Haploinsufficiency Syndrome

Pseudohypoparathyroidism

Familial Pseudohypoparathyroidism	Parathyroid Hormone Resistant Hypoparathyroidism
Php - [Pseudohypoparathyroidism]	Constitutional Chronic Hypocalcaemia

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Ocular Hypotension

Hypotony Of Eye

Spinal Stenosis

Lumbar Spinal Stenosis	Cervical Spinal Stenosis
Spinal Stenosis Of Lumbar Region	Spinal Stenosis In Cervical Region
Spinal Canal Stenosis

Brachydactyly

Hypertension And Brachydactyly Syndrome

Brachydactyly With Hypertension	Bilginturan Syndrome
HTNB	Brachydactyly-Arterial Hypertension Syndrome
Brachydactyly, Type E, With Short Stature And Hypertension	Bilginturan Brachydactyly
Brachydactyly Type E With Short Stature And Hypertension	Type E Brachydactyly With Short Stature And Hypertension
Brachydactyly Type E, With Short Stature And Hypertension	Hypertension With Brachydactyly

Hypothyroidism, Congenital, Nongoitrous, 1

Tsh Resistance	CHNG1
Hypothyroidism Due To Tsh Receptor Mutations	Thyrotropin Resistance
Thyroid-Stimulating Hormone	Rtsh
Hypothyroidism Due To Unresponsiveness To Thyrotropin	Congenital Nongoitrous Hypothyroidism 1
Thyroid-Stimulating Hormone, Resistance To	Hypothyroidism, Nonautoimmune
Hypothyroidism, Congenital, Due To Tsh Resistance	Hypothyroidism, Congenital, Non-Goitrous, 1
Congenital Hypothyroidism Due To Tsh Resistance	Non-Autoimmune Hypothyroidism
Thyroid-Stimulating Hormone Resistance	Hypothyroidism, Congenital, Nongoitrous, Type 1
Hypothyroidism, Congenital, Nongoitrous, 3	Thyroid Hormone Resistance Syndrome

Pseudohypoparathyroidism, Type Ia

Albright'S Hereditary Osteodystrophy	Albright Hereditary Osteodystrophy
Pseudohypoparathyroidism Type 1a	PHP1A
Albright Hereditary Osteodystrophy With Multiple Hormone Resistance	Pseudohypoparathyroidism Ia
AHO	Pseudohypoparathyroidism With Albright Hereditary Osteodystrophy
Pseudo-Pseudohypoparathyroidism	Pseudohypoparathyroidism Type I A
Php Ia	Pseudopseudohypoparathyroidism
Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance	Pphp
Pseudopseudo-Hypoparathyroidism	Aho-Php Syndrome Ia
Albright Hereditary Osteodystrophy-Php Syndrome Ia	Pseudohypoparathyroidism 1a
Pseudohypoparathyroidism

Impotence

Erectile Dysfunction	Sexual Impotence
Erectile Dysfunction Adverse Event

Pseudopseudohypoparathyroidism

PPHP	Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance
Normocalcemic Pseudohypoparathyroidism	Aho-Pphp Syndrome
Albright Hereditary Osteodystrophy-Pphp Syndrome	Pseudohypoparathyroidism

Chondrodysplasia, Blomstrand Type

Chondrodysplasia Blomstrand Type	BOCD
Blomstrand Lethal Chondrodysplasia	Blomstrand Lethal Osteochondrodysplasia
Blomstrand'S Lethal Chondrodysplasia	Blc
Blomstrand Chondrodysplasia	Blomstrand Osteochondrodysplasia

Osseous Heteroplasia, Progressive

Progressive Osseous Heteroplasia	POH
Osteoma Cutis	Familial Ectopic Ossification
Ectopic Ossification Familial Type	Ectopic Ossification
Heterotopic Ossification	Ectopic Ossification, Familial
Cutaneous Ossification	Myositis Ossificans Progressiva
Osteodermia	Osteosis Cutis
Ossification Heterotopic	Heteroplasia, Osseous, Progressive
Fibrodysplasia Ossificans Progressiva

Chromosome 2q37 Deletion Syndrome

Albright Hereditary Osteodystrophy-Like Syndrome	2q37 Microdeletion Syndrome
Brachydactyly-Intellectual Disability Syndrome	Deletion 2q37
2q37 Deletion Syndrome	Brachydactyly-Mental Retardation Syndrome
Bdmr	Albright Hereditary Osteodystrophy Type 3
Del(2)(Q37)	Monosomy 2q37qter
Albright'S Hereditary Osteodystrophy-Like Syndrome	Monosomy 2q37
Chromosome Deletion Syndrome 2q37

Pulmonary Disease, Chronic Obstructive

Chronic Obstructive Pulmonary Disease	COPD
Pulmonary Disease, Chronic Obstructive, Severe Early-Onset	Chronic Obstructive Lung Disease
Chronic Obstructive Airway Disease	Pulmonary Disease, Chronic Obstructive, Susceptibility To
Cold	Severe Early-Onset Chronic Obstructive Pulmonary Disease
Pulmonary Disease Chronic Obstructive	Pulmonary Disease, Obstructive, Chronic, Susceptibility To
Chronic Obstructive Pulmonary Disease Of Horses	Common Cold
Upper Respiratory Infections	Copd - [Chronic Obstructive Pulmonary Disease]
Coad - [Chronic Obstructive Airways Disease]	Cold - [Chronic Obstructive Lung Disease]
Chronic Airway Disease Nos	Chronic Airways Limitation, Unspecified
Chronic Obstructed Airway, Unspecified	Chronic Obstructive Airway Disease, Unspecified
Chronic Obstructive Airway, Unspecified	Obstructive Lung Disease Nos
Chronic Obstructive Lung Disease Nos	Chronic Obstructive Lung Nos
Obstructive Pulmonary Disease Nos	Exacerbation Copd Nos
Acute Exacerbation Copd

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Pseudohypoparathyroidism, Type Ib

Pseudohypoparathyroidism Type 1b	PHP1B
Pseudohypoparathyroidism Ib	Pseudohypoparathyroidism Type Ib
Php Ib	Pseudohypoparathyroidism 1b

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Cerebral Palsy

Infantile Cerebral Palsy	Mixed Cerebral Palsy
Palsy Cerebral	Palsy, Cerebral
Cerebral Palsy, Mixed

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-117571	Zatolmilast	Inhibitor	98.98%	Phase 3
HY-16900	Rolipram	Inhibitor	99.58%	Phase 2
HY-117960	Orismilast	Inhibitor	99.37%	Phase 2
HY-15178	Oglemilast	Inhibitor	98.00%	Phase 2
HY-106003	GSK356278	Inhibitor	99.82%	Phase 1

Pre-clinical Phase

Bioactive Molecules (29)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-128358	MR-L2	Activator	99.23%	Unkown
HY-122942	Moracin M		98.90%	Unkown
HY-15444	D159687	Inhibitor	98.34%	Unkown
HY-115687	PDE4B-IN-2	Inhibitor	99.21%	Unkown
HY-16900A	(R)-(-)-Rolipram	Inhibitor	99.89%	Unkown
HY-119190	PF-06445974	Inhibitor	98.23%	Unkown
HY-103050	ML-030	Inhibitor	99.50%	Unkown
HY-131707	LEO 39652	Inhibitor	99.51%	Unkown
HY-100246	CI-1044	Inhibitor	98.02%	Unkown
HY-117977	FCPR03	Inhibitor	99.82%	Unkown
HY-RS10225	PDE4D Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-131340	LASSBio-1632	Inhibitor	/	Unkown
HY-112704	PDE5-IN-2	Inhibitor	/	Unkown
HY-130262	PDE1-IN-3	Inhibitor	/	Unkown
HY-115913	PDE4-IN-6	Inhibitor	/	Unkown
HY-121037	Eggmanone	Inhibitor	/	Unkown
HY-147846	AChE/PDE4-IN-1	Inhibitor	/	Unkown
HY-154957	mTOR inhibitor-11	Inhibitor	/	Unkown
HY-159654	PDE4-IN-19	Inhibitor	/	Unkown
HY-161772	(S)-Gebr32a	Inhibitor	/	Unkown
HY-161936	Z21115	Inhibitor	/	Unkown
HY-162582	Z19153	Inhibitor	/	Unkown
HY-162583	PDE4-IN-17	Inhibitor	/	Unkown
HY-163604	PDE4B/D-IN-1	Inhibitor	/	Unkown
HY-163605	PDE4B/D-IN-2	Inhibitor	/	Unkown
HY-163606	PDE4B/D-IN-3	Inhibitor	/	Unkown
HY-168558	PDE4B/D-IN-4	Inhibitor	/	Unkown
HY-N3180	Norbraylin	Inhibitor	/	Unkown
HY-119799	UK-500001	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PDE4D	VGNC	VGNC:32677
Felis catus	PDE4D	VGNC	VGNC:68759
Macaca mulatta	PDE4D	VGNC	VGNC:75917
Canis familiaris	PDE4D	VGNC	VGNC:44355
Rattus norvegicus	PDE4D	RGD	RGD:3281
Mus musculus	PDE4D	MGD	MGI:99555
Others	PDE4D	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.