2. Gene
  3. PPIL1 - peptidylprolyl isomerase like 1 Gene

PPIL1 - peptidylprolyl isomerase like 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CYPL1; PCH14; hCyPX; PPIase; CGI-124

Gene ID: 51645 | Gene type: protein coding

About PPIL1

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:36,854,829-36,874,803 (from NCBI)

This gene has 2 transcripts (splice variants), 215 orthologues, 22 paralogues and is associated with 2 phenotypes. Ubiquitous expression in adrenal (RPKM 23.5), thyroid (RPKM 20.4) and 25 other tissues.

Summary

This gene is a member of the Cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and Infection of HIV-1 virions. Based on similarity to Other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [provided by RefSeq, Jul 2008]

PPIL1 Products(1)

mRNA Protein Name
NM_016059.5 NP_057143.1 peptidyl-prolyl cis-trans isomerase-like 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables disordered domain specific binding IPI
IPI: Inferred from physical interaction
20007319 GOA
enables peptidyl-prolyl cis-trans isomerase activity IDA
IDA: Inferred from direct assay
16595688 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16595688 GOA
Biological Process GO Annotation Evidence Reference Source
involved in embryonic brain development IMP
IMP: Inferred from mutant phenotype
33220177 GOA
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
involved in mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
33220177 GOA
involved in protein peptidyl-prolyl isomerization IDA
IDA: Inferred from direct assay
16595688 GOA
Cellular Component GO Annotation Evidence Reference Source
part of U2-type catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28076346 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPIL1 Protein Structure

Pro_isomerase

Pro_isomerase: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (15 - 162)

  • 0
  • 100
  • 166 a.a.
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase-like 1

cyclophilin like 1

PPIL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PPIL1 Q9Y3C6 RIMBP3 Homo sapiens Q9UFD9
Y2H Array
25416956
Intra
PPIL1 Q9Y3C6 KPRP Homo sapiens Q5T749
Y2H Prey Pooling
32296183
Intra
PPIL1 Q9Y3C6 KPRP Homo sapiens Q5T749
Y2H Array
32296183
Intra
PPIL1 Q9Y3C6 PRR35 Homo sapiens P0CG20
Y2H Prey Pooling
32296183
Intra
PPIL1 Q9Y3C6 PRR35 Homo sapiens P0CG20
Y2H Array
32296183
Intra
PPIL1 Q9Y3C6 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
PPIL1 Q9Y3C6 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
PPIL1 Q9Y3C6 SPDYE4 Homo sapiens A6NLX3
Y2H Array
32296183
Intra
PPIL1 Q9Y3C6 SPDYE4 Homo sapiens A6NLX3
Y2H Prey Pooling
32296183
Intra
PPIL1 Q9Y3C6 LHX2 Homo sapiens P50458
Y2H Prey Pooling
32296183
Intra
PPIL1 Q9Y3C6 LHX2 Homo sapiens P50458
Y2H Array
32296183
Intra
PPIL1 Q9Y3C6 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra
PPIL1 Q9Y3C6 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra
PPIL1 Q9Y3C6 N4BP2L2 Homo sapiens Q92802
Y2H Array
32296183
Intra
PPIL1 Q9Y3C6 N4BP2L2 Homo sapiens Q92802
Y2H Prey Pooling
32296183
Intra
PPIL1 Q9Y3C6 COL17A1 Homo sapiens Q9UMD9
Y2H Array
32296183
Intra
PPIL1 Q9Y3C6 COL17A1 Homo sapiens Q9UMD9
Y2H Prey Pooling
32296183
Intra
PPIL1 Q9Y3C6 CPSF6 Homo sapiens Q16630
Y2H Prey Pooling
25416956
Intra
PPIL1 Q9Y3C6 CPSF6 Homo sapiens Q16630
Validated Y2H
25416956
Intra
PPIL1 Q9Y3C6 SNW1 Homo sapiens Q13573
Pull Down
20368803
Intra
PPIL1 Q9Y3C6 SNW1 Homo sapiens Q13573
Pull Down
16595688
Intra
PPIL1 Q9Y3C6 SNW1 Homo sapiens Q13573
Y2H Prey Pooling
25416956
Intra
PPIL1 Q9Y3C6 SNW1 Homo sapiens Q13573
Validated Y2H
25416956
Intra
PPIL1 Q9Y3C6 SNW1 Homo sapiens Q13573
Y2H Prey Pooling
32296183
Intra
PPIL1 Q9Y3C6 SNW1 Homo sapiens Q13573
Y2H Array
25416956
Intra
PPIL1 Q9Y3C6 SNW1 Homo sapiens Q13573
Anti Tag CoIP
33961781
Intra
PPIL1 Q9Y3C6 SNW1 Homo sapiens Q13573
Y2H Array
32296183
Intra
PPIL1 Q9Y3C6 SNW1 Homo sapiens Q13573
Anti Tag CoIP
28514442
Intra
PPIL1 Q9Y3C6 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
PPIL1 Q9Y3C6 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
PPIL1 Q9Y3C6 WDR83 Homo sapiens Q9BRX9
Y2H
22365833
Intra
PPIL1 Q9Y3C6 WDR83 Homo sapiens Q9BRX9
Anti Tag CoIP
33961781
Intra
PPIL1 Q9Y3C6 WDR83 Homo sapiens Q9BRX9
Anti Tag CoIP
22365833
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPIL1 Proteins

Cat. No. Product Name Accession Purity
HY-P71226 PPIL1 Protein, Human (His) Q9Y3C6 (M1-G166) ≥95%

Related Diseases

Diseases Alias
Pontocerebellar Hypoplasia, Type 14

PCH14

Pontocerebellar Hypoplasia Type 14

Pontocerebellar Hypoplasia 14

Doid:0112325
Pontocerebellar Hypoplasia

Pch

Congenital Pontocerebellar Hypoplasia

Opch

Hypoplasia, Pontocerebellar

Pontoneocerebellar Hypoplasia

Nonsyndromic Pontocerebellar Hypoplasia
Spastic Quadriplegia

Spastic Quadriplegic Cerebral Palsy

Quadriplegic Infantile Cerebral Palsy

Tetraplegic Infantile Cerebral Palsy

Cerebral Palsy Spastic Quadriplegic

Quadriplegic Cerebral Palsy

Spastic Quadriplegia Cerebral Palsy

Spastic Tetraplegia Cerebral Palsy

Cerebral Palsy, Quadriplegic, Infantile

Cerebral Palsy With Spastic Tetraplegia

Congenital Spastic Quadriplegia

Spastic Tetraplegic Cerebral Palsy

Congenital Quadriplegia Nos

Tetraplegic Cerebral Palsy
Quadriplegia

Tetraplegia

Tetraplegias
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10954 PPIL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PPIL1 VGNC VGNC:102486
Rattus norvegicus PPIL1 RGD RGD:1309119
Bos taurus PPIL1 VGNC VGNC:33201
Mus musculus PPIL1 MGD MGI:1916066
Macaca mulatta PPIL1 VGNC VGNC:104420
Canis familiaris PPIL1 VGNC VGNC:44855
Others PPIL1 NCBI