Arc - activity-regulated cytoskeleton-associated protein Gene

Rattus norvegicus

Also known as rg3.1

Gene ID: 54323 | Gene type: protein coding

About Arc

Summary

Enables mRNA binding activity. Involved in several processes, including learning or memory; positive regulation of AMPA Receptor activity; and regulation of synaptic plasticity. Located in actin Cytoskeleton and extracellular vesicle. Is active in glutamatergic synapse; postsynaptic density membrane; and postsynaptic endosome. Biomarker of middle cerebral artery infarction and visual epilepsy. Orthologous to human ARC (activity regulated Cytoskeleton associated protein). [provided by Alliance of Genome Resources, Apr 2022]

Arc Products(1)

mRNA	Protein	Name
NM_019361.2	NP_062234.2	activity-regulated cytoskeleton-associated protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA binding	IDA IDA: Inferred from direct assay	29328916	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	22036569	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in learning	IEP IEP: Inferred from expression pattern	20111591	RGD
involved in long-term memory	IMP IMP: Inferred from mutant phenotype	10818134	RGD
involved in mRNA transport	IDA IDA: Inferred from direct assay	29328916	RGD
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	17898216	RGD
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	17898216	RGD
involved in positive regulation of AMPA receptor activity	IMP IMP: Inferred from mutant phenotype	17088211	RGD
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	29328916	RGD
involved in regulation of dendritic spine morphogenesis	IGI IGI: Inferred from genetic interaction	15537891	RGD
involved in regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	10818134	RGD
involved in regulation of neuronal synaptic plasticity	IEP IEP: Inferred from expression pattern	7857651	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	21590283	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	18322102	RGD
involved in response to morphine	IEP IEP: Inferred from expression pattern	21549764	RGD
involved in vesicle-mediated intercellular transport	IDA IDA: Inferred from direct assay	29328916	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	7857651	RGD
located in extracellular vesicle	IDA IDA: Inferred from direct assay	29328916	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17088211	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17088211	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	17088211	RGD
is active in postsynaptic density membrane	IMP IMP: Inferred from mutant phenotype	17088211	RGD
is active in postsynaptic endosome	IDA IDA: Inferred from direct assay	17088211	RGD
is active in postsynaptic endosome	IMP IMP: Inferred from mutant phenotype	17088211	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

activity-regulated cytoskeleton-associated protein

ARC/ARG3.1	activity regulated cytoskeletal-associated protein
activity-regulated gene 3.1 protein	arg3.1

Arc Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Arc	Q63053	P49768-PRO_0000025591	Homo sapiens	P49768-PRO_0000025591	Anti Tag CoIP	22036569
Intra	Arc	Q63053	Camk2b	Rattus norvegicus	P08413	Y2H	22579289
Intra	Arc	Q63053	Camk2b	Rattus norvegicus	P08413	Confocal	22579289
Intra	Arc	Q63053	Camk2b	Rattus norvegicus	P08413	Anti Bait CoIP	22579289

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10064	Ticagrelor	Antagonist	99.98%	Yes
HY-147080	Avacincaptad pegol sodium	Inhibitor	98.53%	Unkown
HY-B0678	Metaxalone		99.77%	Unkown
HY-19638	Cangrelor	Antagonist	/	Unkown
HY-B0678R	Metaxalone (Standard)		/	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-147079	Egaptivon pegol	Inhibitor	92.75%	Phase 2
HY-153480	ARC19499	Inhibitor	93.65%	Phase 1
HY-19845	Ordopidine	Antagonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (32)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13248	AR-C155858	Inhibitor	99.62%	Unkown
HY-110126	AR-C118925XX	Antagonist	≥99.0%	Unkown
HY-12709A	ARC 239 dihydrochloride	Antagonist	99.57%	Unkown
HY-126112	Mephenoxalone		98.57%	Unkown
HY-N2673	5-Heptadecylresorcinol	Activator	99.83%	Unkown
HY-12122A	AR-C102222 hydrochloride	Inhibitor	99.83%	Unkown
HY-153480A	ARC19499 sodium	Inhibitor	93.65%	Unkown
HY-78542	Deshydroxyethoxy ticagrelor	Inhibitor	/	Unkown
HY-153785	NH2-C6-ARC186 sodium	Inhibitor	92.50%	Unkown
HY-153098	ARC186	Inhibitor	94.13%	Unkown
HY-153098A	ARC186 sodium	Inhibitor	94.13%	Unkown
HY-119996A	AR-C141990 hydrochloride	Inhibitor	≥98.0%	Unkown
HY-12709	ARC 239		99.71%	Unkown
HY-77734	AR-C133913XX		99.76%	Unkown
HY-108633	BYK 49187	Inhibitor	/	Unkown
HY-108665	AR-C66096 tetrasodium	Antagonist	/	Unkown
HY-119996	AR-C141990	Inhibitor	/	Unkown
HY-122048	AR-C67085	Antagonist	/	Unkown
HY-124270	Sibenadet hydrochloride	Agonist	/	Unkown
HY-146769	Antimalarial agent 11	Inhibitor	/	Unkown
HY-147079A	Egaptivon pegol sodium	Inhibitor	92.75%	Unkown
HY-153492A	Olpasiran sodium	Inhibitor	/	Unkown
HY-153610	ARC7		99.57%	Unkown
HY-153611	ARC12		≥99.0%	Unkown
HY-78542S	Deshydroxyethoxy Ticagrelor-d7		/	Unkown
HY-B0678S	Metaxalone-d3		≥98.0%	Unkown
HY-B0678S1	Metaxalone-d6		/	Unkown
HY-RS00890	ARC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-114602	AR-C117977	Inhibitor	/	Unkown
HY-118942	Topovale	Inhibitor	/	Unkown
HY-12122	AR-C102222	Inhibitor	/	Unkown
HY-148826	Rovunaptabin	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arc	NCBI	NCBI:23237
Macaca fascicularis	Arc	NCBI	NCBI:102130416
Canis lupus familiaris	Arc	NCBI
Mus musculus	Arc	NCBI	NCBI:11838
Macaca mulatta	Arc	NCBI	NCBI:702690

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