LAMTOR1 - late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Gene

Homo sapiens

Also known as p18; PDRO; C11orf59; p27RF-Rho; Ragulator1

Gene ID: 55004 | Gene type: protein coding

About LAMTOR1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,097,292-72,103,297 (from NCBI)

This gene has 8 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in thyroid (RPKM 58.6), adrenal (RPKM 40.5) and 25 other tissues.

Summary

Enables GTPase binding activity. Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including Cholesterol homeostasis; positive regulation of TOR signaling; and regulation of Cholesterol transport. Located in lysosome. Part of Ragulator complex. [provided by Alliance of Genome Resources, Apr 2022]

LAMTOR1 Products(1)

mRNA	Protein	Name
NM_017907.3	NP_060377.1	ragulator complex protein LAMTOR1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase binding	IPI IPI: Inferred from physical interaction	22424946	GOA
contributes to guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	22980980	GOA
contributes to molecular adaptor activity	IDA IDA: Inferred from direct assay	22980980	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20381137	GOA
enables protein-membrane adaptor activity	IDA IDA: Inferred from direct assay	28935770	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	22980980	GOA
involved in cellular response to amino acid stimulus	IMP IMP: Inferred from mutant phenotype	20381137	GOA
involved in cellular response to nutrient levels	IDA IDA: Inferred from direct assay	28935770	GOA
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	20544018	GOA
involved in positive regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	20381137	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	28935770	GOA
involved in positive regulation of protein localization to lysosome	IDA IDA: Inferred from direct assay	28935770	GOA
involved in protein localization	IMP IMP: Inferred from mutant phenotype	20381137	GOA
involved in protein localization to membrane	IDA IDA: Inferred from direct assay	28935770	GOA
involved in regulation of cell growth	IMP IMP: Inferred from mutant phenotype	20381137	GOA
involved in regulation of cholesterol efflux	IMP IMP: Inferred from mutant phenotype	20544018	GOA
involved in regulation of cholesterol import	IMP IMP: Inferred from mutant phenotype	20544018	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of FNIP-folliculin RagC/D GAP	IDA IDA: Inferred from direct assay	36103527	GOA
part of Ragulator complex	IDA IDA: Inferred from direct assay	20381137	GOA
part of Ragulator complex	IPI IPI: Inferred from physical interaction	28935770	GOA
is active in lysosomal membrane	IDA IDA: Inferred from direct assay	29158492	GOA
located in lysosome	IDA IDA: Inferred from direct assay	20544018	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LAMTOR1 Protein Structure

LAMTOR

0
100
161 a.a.

Protein Preferred Names

Protein Names

ragulator complex protein LAMTOR1

RhoA activator C11orf59

LAMTOR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LAMTOR1	Q6IAA8	LAMTOR3	Homo sapiens	Q9UHA4	X-Ray Diffraction	29123114
Intra	LAMTOR1	Q6IAA8	LAMTOR3	Homo sapiens	Q9UHA4	Anti Bait CoIP	22980980
Intra	LAMTOR1	Q6IAA8	LAMTOR3	Homo sapiens	Q9UHA4	Anti Tag CoIP	25561175
Intra	LAMTOR1	Q6IAA8	LAMTOR3	Homo sapiens	Q9UHA4	Lumier	37398436
Intra	LAMTOR1	Q6IAA8	LAMTOR3	Homo sapiens	Q9UHA4	Anti Tag CoIP	22980980
Intra	LAMTOR1	Q6IAA8	LAMTOR3	Homo sapiens	Q9UHA4	BRET	37398436
Intra	LAMTOR1	Q6IAA8	LAMTOR3	Homo sapiens	Q9UHA4	Anti Tag CoIP	33961781
Intra	LAMTOR1	Q6IAA8	LAMTOR3	Homo sapiens	Q9UHA4	Light Scattering	29123114
Intra	LAMTOR1	Q6IAA8	CTAG1A	Homo sapiens	P78358	Y2H Prey Pooling	32296183
Intra	LAMTOR1	Q6IAA8	CTAG1A	Homo sapiens	P78358	Y2H Array	32296183
Intra	LAMTOR1	Q6IAA8	CHAT	Homo sapiens	P28329-3	Validated Y2H	32814053
Intra	LAMTOR1	Q6IAA8	CHAT	Homo sapiens	P28329-3	Y2H Array	32814053
Intra	LAMTOR1	Q6IAA8	CHAT	Homo sapiens	P28329-3	Y2H Pooling	32814053
Intra	LAMTOR1	Q6IAA8	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	LAMTOR1	Q6IAA8	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	LAMTOR1	Q6IAA8	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	LAMTOR1	Q6IAA8	LAMTOR2	Homo sapiens	Q9Y2Q5	Light Scattering	29123114
Intra	LAMTOR1	Q6IAA8	LAMTOR2	Homo sapiens	Q9Y2Q5	Anti Bait CoIP	22980980
Intra	LAMTOR1	Q6IAA8	LAMTOR2	Homo sapiens	Q9Y2Q5	Anti Tag CoIP	25561175
Intra	LAMTOR1	Q6IAA8	LAMTOR2	Homo sapiens	Q9Y2Q5	Anti Tag CoIP	22980980
Intra	LAMTOR1	Q6IAA8	LAMTOR2	Homo sapiens	Q9Y2Q5	BRET	37398436
Intra	LAMTOR1	Q6IAA8	LAMTOR2	Homo sapiens	Q9Y2Q5	Anti Tag CoIP	33961781
Intra	LAMTOR1	Q6IAA8	LAMTOR2	Homo sapiens	Q9Y2Q5	X-Ray Diffraction	29123114
Intra	LAMTOR1	Q6IAA8	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	LAMTOR1	Q6IAA8	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	LAMTOR1	Q6IAA8	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	LAMTOR1	Q6IAA8	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	LAMTOR1	Q6IAA8	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	LAMTOR1	Q6IAA8	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	LAMTOR1	Q6IAA8	VIM	Homo sapiens	P08670	Validated Y2H	32814053
Intra	LAMTOR1	Q6IAA8	VIM	Homo sapiens	P08670	Y2H Pooling	32814053
Intra	LAMTOR1	Q6IAA8	VIM	Homo sapiens	P08670	Y2H Array	32814053
Intra	LAMTOR1	Q6IAA8	LAMTOR4	Homo sapiens	Q0VGL1	Anti Tag CoIP	25561175
Intra	LAMTOR1	Q6IAA8	LAMTOR4	Homo sapiens	Q0VGL1	X-Ray Diffraction	29123114
Intra	LAMTOR1	Q6IAA8	LAMTOR4	Homo sapiens	Q0VGL1	Anti Bait CoIP	22980980
Intra	LAMTOR1	Q6IAA8	LAMTOR4	Homo sapiens	Q0VGL1	Lumier	37398436
Intra	LAMTOR1	Q6IAA8	LAMTOR4	Homo sapiens	Q0VGL1	Light Scattering	29123114
Intra	LAMTOR1	Q6IAA8	LAMTOR4	Homo sapiens	Q0VGL1	Anti Tag CoIP	22980980
Intra	LAMTOR1	Q6IAA8	LAMTOR4	Homo sapiens	Q0VGL1	Anti Tag CoIP	33961781
Intra	LAMTOR1	Q6IAA8	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	LAMTOR1	Q6IAA8	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	LAMTOR1	Q6IAA8	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	LAMTOR1	Q6IAA8	RRAGA	Homo sapiens	Q7L523	Anti Tag CoIP	22980980
Intra	LAMTOR1	Q6IAA8	RRAGA	Homo sapiens	Q7L523	Anti Bait CoIP	25567906
Intra	LAMTOR1	Q6IAA8	RRAGA	Homo sapiens	Q7L523	Anti Bait CoIP	25561175
Intra	LAMTOR1	Q6IAA8	RRAGA	Homo sapiens	Q7L523	Anti Bait CoIP	22980980
Intra	LAMTOR1	Q6IAA8	RRAGA	Homo sapiens	Q7L523	Anti Tag CoIP	33961781
Intra	LAMTOR1	Q6IAA8	RRAGA	Homo sapiens	Q7L523	Anti Tag CoIP	25561175
Intra	LAMTOR1	Q6IAA8	RRAGC	Homo sapiens	Q9HB90	Anti Tag CoIP	22980980
Intra	LAMTOR1	Q6IAA8	RRAGC	Homo sapiens	Q9HB90	Anti Tag CoIP	33961781
Intra	LAMTOR1	Q6IAA8	RRAGC	Homo sapiens	Q9HB90	Anti Tag CoIP	25561175
Intra	LAMTOR1	Q6IAA8	RRAGC	Homo sapiens	Q9HB90	BiLC	37398436
Intra	LAMTOR1	Q6IAA8	RRAGC	Homo sapiens	Q9HB90	Anti Bait CoIP	22980980
Intra	LAMTOR1	Q6IAA8	RRAGC	Homo sapiens	Q9HB90	IF	20381137
Intra	LAMTOR1	Q6IAA8	SLC38A9	Homo sapiens	Q8NBW4	Anti Tag CoIP	25561175
Intra	LAMTOR1	Q6IAA8	SLC38A9	Homo sapiens	Q8NBW4	Anti Bait CoIP	25567906
Intra	LAMTOR1	Q6IAA8	SLC38A9	Homo sapiens	Q8NBW4	Anti Tag CoIP	25567906
Intra	LAMTOR1	Q6IAA8	SLC38A9	Homo sapiens	Q8NBW4	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LAMTOR1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71583	LAMTOR1 Protein, Human (His)	Q6IAA8 (2G-161P)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07513	LAMTOR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LAMTOR1	RGD	RGD:735078
Bos taurus	LAMTOR1	VGNC	VGNC:30779
Felis catus	LAMTOR1	VGNC	VGNC:82041
Canis familiaris	LAMTOR1	VGNC	VGNC:42577
Macaca mulatta	LAMTOR1	VGNC	VGNC:74129
Mus musculus	LAMTOR1	MGD	MGI:1913758
Others	LAMTOR1	NCBI

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