2. Gene
  3. MOB1A - MOB kinase activator 1A Gene

MOB1A - MOB kinase activator 1A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MOB1; MATS1; Mob4B; C2orf6; MOBK1B; MABKL1B; MOBKL1B

Gene ID: 55233 | Gene type: protein coding

About MOB1A

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:74,152,528-74,178,879 (from NCBI)

This gene has 6 transcripts (splice variants), 122 orthologues and 6 paralogues. Ubiquitous expression in lymph node (RPKM 51.6), appendix (RPKM 43.0) and 24 other tissues.

Summary

The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing Apoptosis. Loss of the encoded protein results in cell proliferation and Cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

MOB1A Products(4)

mRNA Protein Name
NM_001317110.2 NP_001304039.1 MOB kinase activator 1A isoform 2
NM_001317111.2 NP_001304040.1 MOB kinase activator 1A isoform 3
NM_001317112.2 NP_001304041.1 MOB kinase activator 1A isoform 4
NM_018221.5 NP_060691.2 MOB kinase activator 1A isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15197186 GOA
enables protein serine/threonine kinase activator activity IDA
IDA: Inferred from direct assay
18328708 GOA
Biological Process GO Annotation Evidence Reference Source
involved in hippo signaling IDA
IDA: Inferred from direct assay
18328708 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
18328708 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOB1A Protein Structure

Mob1_phocein

Mob1_phocein: Mob1/phocein family (30 - 205)

  • 0
  • 100
  • 200
  • 216 a.a.
Protein Preferred Names Protein Names

MOB kinase activator 1A

MOB1 Mps One Binder homolog A

MOB1A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MOB1A Q9H8S9 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra
MOB1A Q9H8S9 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra
MOB1A Q9H8S9 TMEM190 Homo sapiens Q8WZ59
Y2H Prey Pooling
32296183
Intra
MOB1A Q9H8S9 TMEM190 Homo sapiens Q8WZ59
Y2H Array
32296183
Intra
MOB1A Q9H8S9 IKZF4 Homo sapiens Q9H2S9
Y2H Prey Pooling
32296183
Intra
MOB1A Q9H8S9 IKZF4 Homo sapiens Q9H2S9
Y2H Array
32296183
Intra
MOB1A Q9H8S9 KANK2 Homo sapiens Q63ZY3
Validated Y2H
25416956
Intra
MOB1A Q9H8S9 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
32296183
Intra
MOB1A Q9H8S9 KANK2 Homo sapiens Q63ZY3
Y2H Array
32296183
Intra
MOB1A Q9H8S9 PCYT1A Homo sapiens P49585
Y2H Prey Pooling
32296183
Intra
MOB1A Q9H8S9 PCYT1A Homo sapiens P49585
Y2H Array
32296183
Intra
MOB1A Q9H8S9 LZTFL1 Homo sapiens Q9NQ48
Validated Y2H
32296183
Intra
MOB1A Q9H8S9 LZTFL1 Homo sapiens Q9NQ48
Y2H Array
32296183
Intra
MOB1A Q9H8S9 LZTFL1 Homo sapiens Q9NQ48
Y2H Prey Pooling
32296183
Intra
MOB1A Q9H8S9 LATS2 Homo sapiens Q9NRM7
BioID
24255178
Intra
MOB1A Q9H8S9 LATS2 Homo sapiens Q9NRM7
Pull Down
19739119
Intra
MOB1A Q9H8S9 LATS2 Homo sapiens Q9NRM7
Anti Tag CoIP
24255178
Intra
MOB1A Q9H8S9 STK4 Homo sapiens Q13043
Anti Tag CoIP
24255178
Intra
MOB1A Q9H8S9 STK4 Homo sapiens Q13043
BioID
24255178
Intra
MOB1A Q9H8S9 STK4 Homo sapiens Q13043
Y2H
23386615
Cross
MOB1A Q9H8S9 q5zu83_legph Legionella pneumophila subsp. pneumophila Q5ZU83
Enzymatic Study
30212651
Intra
MOB1A Q9H8S9 LATS1 Homo sapiens O95835
BioID
24255178
Intra
MOB1A Q9H8S9 LATS1 Homo sapiens O95835
Anti Tag CoIP
24255178
Intra
MOB1A Q9H8S9 WASHC3 Homo sapiens Q9Y3C0
Validated Y2H
32296183
Intra
MOB1A Q9H8S9 WASHC3 Homo sapiens Q9Y3C0
Y2H Prey Pooling
32296183
Intra
MOB1A Q9H8S9 WASHC3 Homo sapiens Q9Y3C0
Y2H Array
32296183
Intra
MOB1A Q9H8S9 CMTM3 Homo sapiens Q96MX0
Validated Y2H
25416956
Intra
MOB1A Q9H8S9 SEPTIN3 Homo sapiens Q9UH03
Validated Y2H
32296183
Intra
MOB1A Q9H8S9 SEPTIN3 Homo sapiens Q9UH03
Y2H Array
32296183
Intra
MOB1A Q9H8S9 SEPTIN3 Homo sapiens Q9UH03
Y2H Prey Pooling
32296183
Intra
MOB1A Q9H8S9 KXD1 Homo sapiens Q9BQD3
Y2H Array
32296183
Intra
MOB1A Q9H8S9 KXD1 Homo sapiens Q9BQD3
Y2H Prey Pooling
32296183
Intra
MOB1A Q9H8S9 TRIM32 Homo sapiens Q13049
Y2H Array
32296183
Intra
MOB1A Q9H8S9 TRIM32 Homo sapiens Q13049
Y2H Prey Pooling
32296183
Intra
MOB1A Q9H8S9 TDO2 Homo sapiens P48775
Validated Y2H
25416956
Intra
MOB1A Q9H8S9 TDO2 Homo sapiens P48775
Y2H Array
25416956
Intra
MOB1A Q9H8S9 TDO2 Homo sapiens P48775
Y2H Array
32296183
Intra
MOB1A Q9H8S9 TDO2 Homo sapiens P48775
Y2H Prey Pooling
25416956
Intra
MOB1A Q9H8S9 TDO2 Homo sapiens P48775
Y2H Prey Pooling
32296183
Intra
MOB1A Q9H8S9 FAM118A Homo sapiens Q9NWS6
Validated Y2H
25416956
Intra
MOB1A Q9H8S9 FAM118A Homo sapiens Q9NWS6
Y2H Array
25416956
Intra
MOB1A Q9H8S9 FAM118A Homo sapiens Q9NWS6
Y2H Prey Pooling
25416956
Intra
MOB1A Q9H8S9 GMEB2 Homo sapiens Q9UKD1
Validated Y2H
32296183
Intra
MOB1A Q9H8S9 GMEB2 Homo sapiens Q9UKD1
Y2H Array
32296183
Intra
MOB1A Q9H8S9 GMEB2 Homo sapiens Q9UKD1
Y2H Prey Pooling
32296183
Intra
MOB1A Q9H8S9 STK38L Homo sapiens Q9Y2H1
BioID
24255178
Intra
MOB1A Q9H8S9 STK38L Homo sapiens Q9Y2H1
Pull Down
15197186
Intra
MOB1A Q9H8S9 STK3 Homo sapiens Q13188
Anti Tag CoIP
24255178
Intra
MOB1A Q9H8S9 STK3 Homo sapiens Q13188
BioID
24255178
Cross
MOB1A Q9H8S9 Q9WMX2-PRO_0000037551 Hepatitis C virus Q9WMX2-PRO_0000037551
Pull Down
18985028
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MOB1A Proteins

Cat. No. Product Name Accession Purity
HY-P70917 MOB1A Protein, Human (His) Q9H8S9-1 (S2-R216) ≥95%

Related Diseases

Diseases Alias
Sveinsson Chorioretinal Atrophy

SCRA

Atrophia Areata

Helicoid Peripapillary Chorioretinal Degeneration

Hpcd

Aa

Peripapillary Chorioretinal Degeneration, Icelandic Type

Helicoidal Peripapillary Chorioretinal Degeneration

Atrophy, Chorioretinal, Sveinsson
Neurofibromatosis, Type Ii

Neurofibromatosis 2

Neurofibromatosis, Type 2

NF2

Neurofibromatosis Type Ii

Bilateral Acoustic Neurofibromatosis

Banf

Acn

Central Neurofibromatosis

Neurofibromatosis, Central Type

Acoustic Schwannomas, Bilateral

Acoustic Neurinoma, Bilateral

Bilateral Acoustic Neurinoma

Bilateral Acoustic Schwannomas

Familial Acoustic Neuromas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08573 MOB1A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MOB1A RGD RGD:1307014
Felis catus MOB1A VGNC VGNC:63543
Bos taurus MOB1A VGNC VGNC:31541
Mus musculus MOB1A MGD MGI:2442631
Canis familiaris MOB1A VGNC VGNC:43299
Others MOB1A NCBI