MOB1A - MOB kinase activator 1A Gene

Homo sapiens

Also known as MOB1; MATS1; Mob4B; C2orf6; MOBK1B; MABKL1B; MOBKL1B

Gene ID: 55233 | Gene type: protein coding

About MOB1A

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:74,152,528-74,178,879 (from NCBI)

This gene has 6 transcripts (splice variants), 122 orthologues and 6 paralogues. Ubiquitous expression in lymph node (RPKM 51.6), appendix (RPKM 43.0) and 24 other tissues.

Summary

The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing Apoptosis. Loss of the encoded protein results in cell proliferation and Cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

MOB1A Products(4)

mRNA	Protein	Name
NM_001317110.2	NP_001304039.1	MOB kinase activator 1A isoform 2
NM_001317111.2	NP_001304040.1	MOB kinase activator 1A isoform 3
NM_001317112.2	NP_001304041.1	MOB kinase activator 1A isoform 4
NM_018221.5	NP_060691.2	MOB kinase activator 1A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15197186	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	18328708	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in hippo signaling	IDA IDA: Inferred from direct assay	18328708	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	18328708	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOB1A Protein Structure

Mob1_phocein

0
100
200
216 a.a.

Protein Preferred Names

Protein Names

MOB kinase activator 1A

MOB1 Mps One Binder homolog A

Recombinant MOB1A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70917	MOB1A Protein, Human (His)	Q9H8S9-1 (S2-R216)	≥95%

Related Diseases

Diseases

Alias

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

Neurofibromatosis, Type Ii

Neurofibromatosis 2	Neurofibromatosis, Type 2
NF2	Neurofibromatosis Type Ii
Bilateral Acoustic Neurofibromatosis	Banf
Acn	Central Neurofibromatosis
Neurofibromatosis, Central Type	Acoustic Schwannomas, Bilateral
Acoustic Neurinoma, Bilateral	Bilateral Acoustic Neurinoma
Bilateral Acoustic Schwannomas	Familial Acoustic Neuromas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08573	MOB1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MOB1A	RGD	RGD:1307014
Felis catus	MOB1A	VGNC	VGNC:63543
Bos taurus	MOB1A	VGNC	VGNC:31541
Mus musculus	MOB1A	MGD	MGI:2442631
Canis familiaris	MOB1A	VGNC	VGNC:43299
Others	MOB1A	NCBI

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