LUC7L - LUC7 like Gene

Homo sapiens

Also known as Luc7; SR+89; LUC7B1; hLuc7B1

Gene ID: 55692 | Gene type: protein coding

About LUC7L

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:188,990-229,449 (from NCBI)

This gene has 21 transcripts (splice variants), 203 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 18.6), spleen (RPKM 15.0) and 25 other tissues.

Summary

The LUC7L gene may represent a mammalian heterochromatic gene, encoding a putative RNA-binding protein similar to the yeast Luc7p subunit of the U1 snRNP splicing complex that is normally required for 5-prime splice site selection (Tufarelli et al., 2001 [PubMed 11170747]).[supplied by OMIM, Mar 2008]

LUC7L Products(4)

mRNA	Protein	Name
NM_001320226.2	NP_001307155.1	putative RNA-binding protein Luc7-like 1 isoform a
NM_001330420.2	NP_001317349.1	putative RNA-binding protein Luc7-like 1 isoform c
NM_018032.5	NP_060502.1	putative RNA-binding protein Luc7-like 1 isoform a
NM_201412.3	NP_958815.1	putative RNA-binding protein Luc7-like 1 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	22365833	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22365833	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LUC7L Protein Structure

LUC7

0
100
200
300
371 a.a.

Protein Preferred Names

Protein Names

putative RNA-binding protein Luc7-like 1

putative SR protein LUC7B1

LUC7L Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LUC7L	Q9NQ29	RNASEH1	Homo sapiens	O60930	Anti Tag CoIP	33961781
Intra	LUC7L	Q9NQ29	NFKBIL1	Homo sapiens	Q9UBC1	Anti Tag CoIP	33961781
Intra	LUC7L	Q9NQ29	SRPK2	Homo sapiens	P78362	Anti Tag CoIP	33961781
Intra	LUC7L	Q9NQ29	SRPK1	Homo sapiens	Q96SB4	Anti Tag CoIP	33961781
Intra	LUC7L	Q9NQ29	SRPK1	Homo sapiens	Q96SB4	Protein Kinase Assay	23602568
Intra	LUC7L	Q9NQ29	CLK2	Homo sapiens	P49760	Anti Tag CoIP	33961781
Intra	LUC7L	Q9NQ29	TNPO3	Homo sapiens	Q9Y5L0	Anti Tag CoIP	33961781
Intra	LUC7L	Q9NQ29	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	LUC7L	Q9NQ29	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	LUC7L	Q9NQ29	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Alpha-Thalassemia

Alpha Thalassemia	Alpha Thalassaemia
Alpha Plus Thalassemia	Thalassemia, Alpha-
Thalassemias, Alpha-	A-Thalassemia
Α-Thalassemia	A-THAL
Thalassemia	Alpha Thalassaemia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07888	LUC7L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07889	LUC7L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07890	LUC7L3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LUC7L	MGD	MGI:1914228
Canis familiaris	LUC7L	VGNC	VGNC:42863
Bos taurus	LUC7L	VGNC	VGNC:31079
Rattus norvegicus	LUC7L	RGD	RGD:1307542
Macaca mulatta	LUC7L	VGNC	VGNC:74461
Felis catus	LUC7L	VGNC	VGNC:80589

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