2. Gene
  3. TSPAN4 - tetraspanin 4 Gene

TSPAN4 - tetraspanin 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NAG2; NAG-2; TM4SF7; TSPAN-4; TETRASPAN

Gene ID: 7106 | Gene type: protein coding

About TSPAN4

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:842,852-867,111 (from NCBI)

This gene has 20 transcripts (splice variants), 200 orthologues and 32 paralogues. Ubiquitous expression in fat (RPKM 26.0), spleen (RPKM 24.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

TSPAN4 Products(7)

mRNA Protein Name
NM_001025234.2 NP_001020405.1 tetraspanin-4 isoform a
NM_001025235.2 NP_001020406.1 tetraspanin-4 isoform a
NM_001025236.2 NP_001020407.1 tetraspanin-4 isoform a
NM_001025237.2 NP_001020408.1 tetraspanin-4 isoform a
NM_001025238.2 NP_001020409.1 tetraspanin-4 isoform a
NM_001025239.2 NP_001020410.1 tetraspanin-4 isoform b
NM_003271.5 NP_003262.1 tetraspanin-4 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables antigen binding IDA
IDA: Inferred from direct assay
9360996 GOA
enables integrin binding IPI
IPI: Inferred from physical interaction
9360996 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
9360996 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
9360996 GOA
located in vesicle IDA
IDA: Inferred from direct assay
9360996 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tetraspanin-4

novel antigen 2

Related Diseases

Diseases Alias
Bladder Exstrophy

Exstrophy Of The Bladder

Classic Exstrophy Of The Bladder
Paralytic Poliomyelitis

Poliomyelitis, Paralytic
Glioblastoma Proneural Subtype
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15170 TSPAN4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TSPAN4 VGNC VGNC:101421
Rattus norvegicus TSPAN4 RGD RGD:1305810
Felis catus TSPAN4 VGNC VGNC:66634
Canis familiaris TSPAN4 VGNC VGNC:56097
Bos taurus TSPAN4 VGNC VGNC:36439
Mus musculus TSPAN4 MGD MGI:1928097