2. Gene
  3. BLK - BLK proto-oncogene, Src family tyrosine kinase Gene

BLK - BLK proto-oncogene, Src family tyrosine kinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MODY11

Gene ID: 640 | Gene type: protein coding

About BLK

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:11,494,387-11,564,599 (from NCBI)

This gene has 9 transcripts (splice variants), 196 orthologues, 32 paralogues and is associated with 3 phenotypes. Biased expression in lymph node (RPKM 18.9), spleen (RPKM 13.7) and 4 other tissues.

Summary

This gene encodes a nonreceptor tyrosine-kinase of the Src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates Insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]

BLK Products(2)

mRNA Protein Name
NM_001330465.2 NP_001317394.1 tyrosine-protein kinase Blk isoform 2
NM_001715.3 NP_001706.2 tyrosine-protein kinase Blk isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables non-membrane spanning protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
876631 GOA
enables non-membrane spanning protein tyrosine kinase activity IMP
IMP: Inferred from mutant phenotype
23555801 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16273093 GOA
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
30356214 GOA
Biological Process GO Annotation Evidence Reference Source
involved in B cell receptor signaling pathway IDA
IDA: Inferred from direct assay
876631 GOA
involved in B cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
23555801 GOA
involved in peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
30356214 GOA
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
19667185 GOA
involved in positive regulation of protein binding IMP
IMP: Inferred from mutant phenotype
23555801 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BLK Protein Structure

SH3_1

SH3_1: SH3 domain (64 - 110)

SH2

SH2: SH2 domain (124 - 205)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (241 - 489)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase Blk

B lymphoid tyrosine kinase

Recombinant BLK Proteins

Cat. No. Product Name Accession Purity
HY-P70040 BLK Protein, Human (His) P51451 (G2-P505) ≥95%
HY-P72853 BLK Protein, Human (sf9, GST) P51451 (M1-P505) ≥95%

Related Diseases

Diseases Alias
Maturity-Onset Diabetes Of The Young, Type 11

Maturity-Onset Diabetes Of The Young Type 11

MODY11

Maturity-Onset Diabetes Of The Young 11

Mody-11

Mody Type 11

Diabetes Of The Young, Maturity-Onset, Type 11
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
Maturity-Onset Diabetes Of The Young, Type 7

Maturity-Onset Diabetes Of The Young Type 7

MODY7

Maturity-Onset Diabetes Of The Young, Type Vii

Maturity-Onset Diabetes Of The Young 7

Mody-7

Mody Type 7

Diabetes Of The Young, Maturity-Onset, Type 7
Maturity-Onset Diabetes Of The Young, Type 9

Maturity-Onset Diabetes Of The Young Type 9

MODY9

Maturity-Onset Diabetes Of The Young, Type Ix

Maturity-Onset Diabetes Of The Young 9

Mody-9

Mody Type 9

Diabetes Of The Young, Maturity-Onset, Type 9
Maturity-Onset Diabetes Of The Young, Type 13

Maturity-Onset Diabetes Of The Young Type 13

MODY13

Mody Type 13

Mody, Type 13

Maturity-Onset Diabetes Of The Young 13

Diabetes Of The Young, Maturity-Onset, Type 13
Maturity-Onset Diabetes Of The Young, Type 8, With Exocrine Dysfunction

Maturity-Onset Diabetes Of The Young Type 8

MODY8

Dped

Maturity-Onset Diabetes Of The Young, Type Viii

Mody Type 8

Diabetes And Pancreatic Exocrine Dysfunction

Diabetes-Pancreatic Exocrine Dysfunction Syndrome

Diabetes And Pancreatic Exocrine

Maturity-Onset Diabetes Of The Young Type 8 With Exocrine Dysfunction

Maturity-Onset Diabetes Of The Young 8 With Exocrine Dysfunction

Diabetes And Pancreatic Exocrine Dysfunction Syndrome

Mody-8

Diabetes Of The Young, Maturity-Onset, Type 8
Maturity-Onset Diabetes Of The Young, Type 14

Maturity-Onset Diabetes Of The Young Type 14

MODY14

Maturity-Onset Diabetes Of The Young 14

Diabetes Of The Young, Maturity-Onset, Type 14
Kawasaki Disease

Mucocutaneous Lymph Node Syndrome

Acute Febrile Mucocutaneous Lymph Node Syndrome

Kawasaki Syndrome

Kd

Infantile Polyarteritis

Kawasaki Disease, Susceptibility To

Acute Febrile Mcls

Kawasaki'S Disease

Mlns

KWD
Maturity-Onset Diabetes Of The Young, Type 10

Maturity-Onset Diabetes Of The Young Type 10

MODY10

Maturity-Onset Diabetes Of The Young 10

Mody-10

Mody Type 10

Diabetes Of The Young, Maturity-Onset, Type 10
Keratolytic Winter Erythema

KWE

Oudtshoorn Skin Disease

Erythrokeratolysis Hiemalis Ichthyosis

Erythrokeratolysis Hiemalis

Oudtshoorn Skin

Oudtshoorn Disease
Maturity-Onset Diabetes Of The Young, Type 6

MODY6

Maturity-Onset Diabetes Of The Young Type 6

Maturity-Onset Diabetes Of The Young 6

Mody Type 6

Mody, Type 6

Mody-6

Diabetes Of The Young, Maturity-Onset, Type 6
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Heart Aneurysm

Cardiac Aneurysm
Coronary Aneurysm

Aneurysm Of Coronary Vessels

Aneurysmal Lesion Of Coronary Artery

Arteriovenous Aneurysm Of Coronary Vessels
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
Maturity-Onset Diabetes Of The Young, Type 4

Maturity-Onset Diabetes Of The Young Type 4

MODY4

Mody, Type Iv

Mody Type 4

Mody, Type 4

Maturity-Onset Diabetes Of The Young 4

Mody-4

Diabetes Of The Young, Maturity-Onset, Type 4

Maturity-Onset Diabetes Of The Young, Type Iv
Maturity-Onset Diabetes Of The Young, Type 1

Maturity-Onset Diabetes Of The Young Type 1

MODY1

Mild Juvenile Diabetes Mellitus

Mody, Type I

Diabetes Mellitus Type 2

Mody Type 1

Mody, Type 1

Maturity-Onset Diabetes Of The Young 1

Mody-1

Diabetes Of The Young, Maturity-Onset, Type 1
Maturity-Onset Diabetes Of The Young, Type 2

Maturity-Onset Diabetes Of The Young Type 2

MODY2

Mody Glucokinase-Related

Mody Type 2

Mody, Type 2

Mody, Glucokinase-Related

Mody, Type Ii

Maturity-Onset Diabetes Of The Young 2

Mody-2

Diabetes Of The Young, Maturity-Onset, Type 2

Diabetes Mellitus Autosomal Dominant Type Ii
Co-Trimoxazole Allergy

Bactrim Allergy

Cotrimoxazol Allergy

Tmp/Smx Allergy

Trimethoprim/Sulfamethoxazole Allergy
Maturity-Onset Diabetes Of The Young, Type 3

Maturity-Onset Diabetes Of The Young Type 3

MODY3

Mody, Type Iii

Mody Type 3

Mody, Type 3

Maturity-Onset Diabetes Of The Young 3

Mody-3

Diabetes Of The Young, Maturity-Onset, Type 3
Renal Cysts And Diabetes Syndrome

RCAD

Mody5

Congenital Anomalies Of The Kidney And Urinary Tract With Diabetes

Cakut With Diabetes

Maturity-Onset Diabetes Of The Young Type 5

Tubulointerstitial Kidney Disease, Autosomal Dominant, 3

Adtkd3

Atypical Familial Juvenile Hyperuricemic Nephropathy

Atypical Fjhn

Familial Hypoplastic Glomerulocystic Kidney

Maturity-Onset Diabetes Of The Young, Type 5

Hyperuricemic Nephropathy, Familial Juvenile, Atypical

Fjhn, Atypical

Glomerulocystic Kidney Disease, Hypoplastic Type

Glomerulocystic Kidney, Familial Hypoplastic

Hypoplastic Type Glomerulocystic Kidney Disease

Glomerulocystic Kidney Disease Hypoplastic Type

Renal-Diabetes Mody5 Syndrome
Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable
Lymph Node Disease

Abnormality Of The Lymph Nodes

Disorder Of Lymph Node
Permanent Neonatal Diabetes Mellitus

Pndm

Permanent Diabetes Mellitus Of Infancy

Pdmi

Neonatal Diabetes Mellitus, Permanent
Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome

Chromosome 11p11.2 Deletion Syndrome

Pss

11p11.2 Deletion

P11pds

Defect11 Syndrome

Deletion Of Chromosome 11p11.2

POSHS
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos
Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Anomaly

Coronary Artery Disease, Susceptibility To

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-120622 BMS-243117 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BLK RGD RGD:1308859
Macaca mulatta BLK VGNC VGNC:70253
Canis familiaris BLK VGNC VGNC:38464
Bos taurus BLK VGNC VGNC:26504
Mus musculus BLK MGD MGI:88169
Felis catus BLK VGNC VGNC:60121
Others BLK NCBI