BNIP3L - BCL2 interacting protein 3 like Gene

Homo sapiens

Also known as NIX; BNIP3a

Gene ID: 665 | Gene type: protein coding

About BNIP3L

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:26,383,054-26,413,127 (from NCBI)

This gene has 7 transcripts (splice variants), 312 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 69.4), ovary (RPKM 49.9) and 24 other tissues.

Summary

This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 Family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]

BNIP3L Products(2)

mRNA	Protein	Name
NM_001330491.2	NP_001317420.1	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2
NM_004331.3	NP_004322.1	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	10381623	GOA
enables lamin binding	IDA IDA: Inferred from direct assay	10381623	GOA
enables lamin binding	IPI IPI: Inferred from physical interaction	10381623	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9973195	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	10381623	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to hypoxia	IGI IGI: Inferred from genetic interaction	19273585	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	9973195	GOA
involved in mitochondrial protein catabolic process	IMP IMP: Inferred from mutant phenotype	21264228	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	10381623	GOA
acts upstream of or within negative regulation of programmed cell death	IGI IGI: Inferred from genetic interaction	19273585	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	9973195	GOA
acts upstream of or within positive regulation of macroautophagy	IGI IGI: Inferred from genetic interaction	19273585	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	10381623	GOA
located in mitochondrial outer membrane	IMP IMP: Inferred from mutant phenotype	21264228	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	9973195	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	10381623	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BNIP3L Protein Structure

BNIP3

0
100
200
219 a.a.

Protein Preferred Names

Protein Names

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A

BNIP3L Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BNIP3L	O60238	LDLRAD1	Homo sapiens	Q5T700	Y2H Array	31515488
Intra	BNIP3L	O60238	LDLRAD1	Homo sapiens	Q5T700	Y2H Prey Pooling	25416956
Intra	BNIP3L	O60238	LDLRAD1	Homo sapiens	Q5T700	Validated Y2H	25416956
Intra	BNIP3L	O60238	TMPRSS4	Homo sapiens	Q9NRS4	Validated Y2H	32296183
Intra	BNIP3L	O60238	CLEC7A	Homo sapiens	Q9BXN2-6	Y2H Array	32296183
Intra	BNIP3L	O60238	CLEC7A	Homo sapiens	Q9BXN2-6	Y2H Prey Pooling	32296183
Intra	BNIP3L	O60238	CLEC7A	Homo sapiens	Q9BXN2-6	Validated Y2H	32296183
Intra	BNIP3L	O60238	TNMD	Homo sapiens	Q9H2S6-2	Validated Y2H	32296183
Intra	BNIP3L	O60238	NR4A1	Homo sapiens	P22736-1	Pull Down	24316735
Intra	BNIP3L	O60238	NR4A1	Homo sapiens	P22736-1	Anti Tag CoIP	24316735
Cross	BNIP3L	O60238	ORF10	SARS-CoV-2	A0A663DJA2	Anti Tag CoIP	34845370
Cross	BNIP3L	O60238	ORF10	SARS-CoV-2	A0A663DJA2	Confocal	34845370
Intra	BNIP3L	O60238	CLEC7A	Homo sapiens	Q9BXN2	Y2H Array	25416956
Intra	BNIP3L	O60238	CLEC7A	Homo sapiens	Q9BXN2	Y2H	21516116
Intra	BNIP3L	O60238	CLEC7A	Homo sapiens	Q9BXN2	Y2H Prey Pooling	25416956
Intra	BNIP3L	O60238	ATP13A2	Homo sapiens	Q9NQ11	Anti Tag CoIP	22645275
Intra	BNIP3L	O60238	BAD	Homo sapiens	Q92934	Pull Down	9973195
Intra	BNIP3L	O60238	GABARAPL2	Homo sapiens	P60520	Validated Y2H	32296183
Intra	BNIP3L	O60238	TMEM11	Homo sapiens	P17152	Validated Y2H	32296183
Intra	BNIP3L	O60238	TMEM11	Homo sapiens	P17152	Y2H Array	25416956
Intra	BNIP3L	O60238	TMEM11	Homo sapiens	P17152	Y2H Pooling	16189514
Intra	BNIP3L	O60238	TMEM11	Homo sapiens	P17152	Validated Y2H	27107012
Intra	BNIP3L	O60238	TMEM11	Homo sapiens	P17152	Y2H Prey Pooling	25416956
Intra	BNIP3L	O60238	FATE1	Homo sapiens	Q969F0	Validated Y2H	25416956
Intra	BNIP3L	O60238	FATE1	Homo sapiens	Q969F0	Y2H Array	25416956
Intra	BNIP3L	O60238	GABARAPL1	Homo sapiens	Q9H0R8	Validated Y2H	32296183
Intra	BNIP3L	O60238	BNIP3	Homo sapiens	Q12983	BFG-2H	27107012
Intra	BNIP3L	O60238	BNIP3	Homo sapiens	Q12983	Y2H Array	19060904
Intra	BNIP3L	O60238	BNIP3	Homo sapiens	Q12983	TAP	24981860
Intra	BNIP3L	O60238	BNIP3	Homo sapiens	Q12983	Validated Y2H	32296183
Intra	BNIP3L	O60238	BNIP3	Homo sapiens	Q12983	Y2H	10381623
Intra	BNIP3L	O60238	BNIP3	Homo sapiens	Q12983	Beta Galactosidase	10381623
Intra	BNIP3L	O60238	BNIP3	Homo sapiens	Q12983	Y2H Pooling	19060904
Intra	BNIP3L	O60238	BNIP3	Homo sapiens	Q12983	Y2H Array	32296183
Intra	BNIP3L	O60238	BNIP3	Homo sapiens	Q12983	Y2H Prey Pooling	25416956
Intra	BNIP3L	O60238	BNIP3	Homo sapiens	Q12983	Y2H Prey Pooling	32296183
Intra	BNIP3L	O60238	BNIP3	Homo sapiens	Q12983	Anti Tag CoIP	10381623
Intra	BNIP3L	O60238	MALL	Homo sapiens	Q13021	Validated Y2H	32296183
Intra	BNIP3L	O60238	BCL2	Homo sapiens	P10415	Pull Down	9973195
Intra	BNIP3L	O60238	BNIP3L	Homo sapiens	O60238	Y2H	10381623
Intra	BNIP3L	O60238	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183
Intra	BNIP3L	O60238	SMCO4	Homo sapiens	Q9NRQ5	Y2H Array	25416956
Intra	BNIP3L	O60238	SMCO4	Homo sapiens	Q9NRQ5	Y2H	21516116
Intra	BNIP3L	O60238	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	25416956
Cross	BNIP3L	O60238	E1B	Human adenovirus C	P03247	Y2H	10381623
Cross	BNIP3L	O60238	E1B	Human adenovirus C	P03247	Pull Down	9973195

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BNIP3L Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75471	BNIP3L Protein, Human	NP_004322.1 (S2-K187)	≥95%

BNIP3L Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80571	BNIP3L Antibody	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Pediculus Humanus Capitis Infestation

Pediculosis Capitis	Pediculus Capitis Infestation
Head Louse Infestation	Pediculus Capitis
Head-Louse Infestation	Head Lice
Infestation By Pediculus Capitis

Lice Infestation

Pediculosis	Louse Infestation
Mixed Pediculosis	Lice Infestations
Infestation By Pediculus	Mixed Pediculosis Infestation
Pediculosis + Lice	Pediculosis And Phthirus Infection
Pediculosis And Phthirus Infections	Pediculosis And Phthirus Infestation
Infestation By Anoplura	Pediculus Infestation
Lice Nos

Asbestos-Related Lung Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01565	BNIP3L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BNIP3L	MGD	MGI:1332659
Rattus norvegicus	BNIP3L	RGD	RGD:621354
Bos taurus	BNIP3L	VGNC	VGNC:26534
Macaca mulatta	BNIP3L	VGNC	VGNC:70274
Felis catus	BNIP3L	VGNC	VGNC:78457
Others	BNIP3L	NCBI

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