Tlr8 - toll-like receptor 8 Gene

Rattus norvegicus

Gene ID: 684440 | Gene type: protein coding

About Tlr8

Primary_assembly X: 27,091,778-27,116,549 forward strand.mRatBN7.2:CM026994.1

This gene has 1 transcript (splice variant), 199 orthologues, 26 paralogues and is associated with 10 phenotypes. Biased expression in Spleen (RPKM 165.1), Lung (RPKM 67.6) and 7 other tissues.

Summary

Predicted to enable identical protein binding activity; nucleic acid binding activity; and pattern recognition receptor activity. Predicted to be involved in several processes, including cellular response to mechanical stimulus; negative regulation of interleukin-12 production; and positive regulation of cytokine production. Predicted to act upstream of or within regulation of protein phosphorylation. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human TLR8 (toll like receptor 8). [provided by Alliance of Genome Resources, Apr 2022]

Tlr8 Products(1)

mRNA	Protein	Name
NM_001101009.1	NP_001094479.1	toll-like receptor 8 precursor

Tlr8 Protein Structure

PRK15370

LRR_RI

PLN00113

LRR_RI

PRK15370

LRR_RI

PCC

TIR

0
200
400
600
800
1029 a.a.

Protein Preferred Names

Protein Names

toll-like receptor 8

Related Agents

Clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13740	Resiquimod	Agonist	99.95%	Phase 2
HY-134581	Enpatoran	Inhibitor	99.77%	Phase 2
HY-13773	Motolimod	Agonist	98.12%	Phase 2
HY-109137	Selgantolimod	Agonist	98.23%	Phase 2
HY-134581A	Enpatoran hydrochloride	Inhibitor	99.33%	Phase 2
HY-13740G	Resiquimod (GMP)	Agonist	/	Phase 2
HY-109104	Telratolimod	Agonist	98.98%	Phase 1

Pre-clinical Phase

Bioactive Molecules (36)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-128799	CL097	Agonist	99.89%	Unkown
HY-117066	CL075	Agonist	99.25%	Unkown
HY-103697A	Gardiquimod diTFA	Agonist	≥99.0%	Unkown
HY-139323	TLR7/8-IN-1	Inhibitor	99.92%	Unkown
HY-103697	Gardiquimod	Agonist	99.91%	Unkown
HY-103698	TLR7/8 agonist 1	Agonist	97.33%	Unkown
HY-112050	CU-CPT-8m	Antagonist	99.98%	Unkown
HY-130797	TLR7/8 agonist 3	Agonist	99.96%	Unkown
HY-112667	CU-CPT-9a	Antagonist	99.36%	Unkown
HY-101929	CU-CPT17e	Agonist	99.00%	Unkown
HY-131945	CU-115	Antagonist	99.55%	Unkown
HY-139017	TLR7/8 agonist 4	Agonist	99.04%	Unkown
HY-112051	CU-CPT9b	Antagonist	99.03%	Unkown
HY-10018	Toll-like receptor modulator	Modulator	99.36%	Unkown
HY-160229	ssRNA40 sodium	Activator	93.25%	Unkown
HY-13740S	Resiquimod-d5	Agonist	99.84%	Unkown
HY-128799A	CL097 hydrochloride	Agonist	99.51%	Unkown
HY-145960	MC-Val-Cit-PAB-Amide-TLR7 agonist 4	Agonist	99.39%	Unkown
HY-159102	PVP-037.2	Agonist	/	Unkown
HY-158694A	TLR7 agonist 20 hydrochloride	Agonist	99.86%	Unkown
HY-138139A	AXC-715 hydrochloride	Agonist	99.46%	Unkown
HY-153543	TLR7/8 agonist 8	Agonist	/	Unkown
HY-141454A	TLR8 agonist 2 hydrochloride	Agonist	/	Unkown
HY-139017A	TLR7/8 agonist 4 TFA	Agonist	/	Unkown
HY-141454	TLR8 agonist 2	Agonist	/	Unkown
HY-121496	3M-011	Agonist	/	Unkown
HY-161629	TLR8 agonist 7	Agonist	/	Unkown
HY-169057	BI1543673	Inhibitor	/	Unkown
HY-161630	TLR8 agonist 8	Agonist	/	Unkown
HY-160228A	ORN 02 sodium	Activator	/	Unkown
HY-160228	ORN 02	Activator	/	Unkown
HY-162845	TLR7/8 agonist 11	Agonist	/	Unkown
HY-163670	TLR7 agonist 21	Inhibitor	/	Unkown
HY-161631	TLR8 agonist 9	Agonist	/	Unkown
HY-158694	TLR7 agonist 20	Agonist	/	Unkown
HY-153544	TLR7/8 agonist 9	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tlr8	NCBI	NCBI:51311

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