2. Gene
  3. TLR8 - toll like receptor 8 Gene

TLR8 - toll like receptor 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CD288; IMD98; hTLR8

Gene ID: 51311 | Gene type: protein coding

About TLR8

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:12,906,620-12,923,169 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues, 22 paralogues and is associated with 1 phenotype. Biased expression in appendix (RPKM 10.8), spleen (RPKM 6.1) and 9 other tissues.

Summary

The protein encoded by this gene is a member of the Toll-like Receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

TLR8 Products(2)

mRNA Protein Name
NM_138636.5 NP_619542.1 toll-like receptor 8 isoform 2 precursor
NM_016610.4 NP_057694.2 toll-like receptor 8 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
16123302 GOA
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
16111635 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
23520111 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22164301 GOA
enables single-stranded RNA binding IDA
IDA: Inferred from direct assay
14976262 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
19593445 GOA
involved in defense response to virus IDA
IDA: Inferred from direct assay
33718825 GOA
involved in defense response to virus IEP
IEP: Inferred from expression pattern
32634389 GOA
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
16188996 GOA
involved in negative regulation of interleukin-12 production IDA
IDA: Inferred from direct assay
24942581 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
12032557 GOA
involved in positive regulation of innate immune response IDA
IDA: Inferred from direct assay
16123302 GOA
involved in positive regulation of interferon-alpha production IDA
IDA: Inferred from direct assay
16286015 GOA
involved in positive regulation of interferon-beta production IDA
IDA: Inferred from direct assay
16286015 GOA
involved in positive regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
24942581 GOA
involved in positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
24942581 GOA
involved in positive regulation of interleukin-8 production IMP
IMP: Inferred from mutant phenotype
16188996 GOA
involved in positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
16286015 GOA
involved in response to virus IDA
IDA: Inferred from direct assay
12032557 GOA
involved in toll-like receptor 8 signaling pathway IDA
IDA: Inferred from direct assay
12032557 GOA
Cellular Component GO Annotation Evidence Reference Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
24942581 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLR8 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (66 - 97)

LRR_8

LRR_8: Leucine rich repeat (222 - 256)

LRR_8

LRR_8: Leucine rich repeat (278 - 323)

LRR_6

LRR_6: Leucine Rich repeat (584 - 596)

LRR_8

LRR_8: Leucine rich repeat (640 - 700)

LRR_8

LRR_8: Leucine rich repeat (712 - 773)

TIR

TIR: TIR domain (882 - 1020)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1041 a.a.
Protein Preferred Names Protein Names

toll-like receptor 8

Recombinant TLR8 Proteins

Cat. No. Product Name Accession Purity
HY-P72270 Toll-like receptor 8/TLR8 Protein, Human (P.pastoris, His) Q9NR97 (E27-T827) ≥95%

Related Diseases

Diseases Alias
Anemia, Autoimmune Hemolytic

Autoimmune Hemolytic Anemia

Idiopathic Autoimmune Hemolytic Anemia

Immuno-Hemolytic Anemia

Anemia, Hemolytic, Autoimmune

Autoimmune Haemolytic Anaemia

Autoimmune Hemolytic Anaemia

Acquired Autoimmune Hemolytic Anemia

Anemia Hemolytic Autoimmune

Familial Auto-Immune Hemolytic Anemia

Aha

Aiha
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Agammaglobulinemia

Hypogammaglobulinemia

Ighm

Mu Heavy Chain Deficiency

Mu-Heavy Chain Disease

Mu-Hcd

Mu-Chain Disease
Anogenital Venereal Wart

Genital Warts

Condylomata Acuminata

Anogenital Warts

Condyloma Acuminatum

Anogenital Human Papilloma Virus Infectious Disease

Genital Wart Virus Infectious Disease

Venereal Wart

Venereal Warts

Verrucae Anogenitales

Verrucae Genitales
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Immunodeficiency 98 With Autoinflammation, X-Linked

Infltr8

IMD98

Inflammation, Neutropenia, Bone Marrow Failure, And Lymphoproliferation Caused By Tlr8
Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site
Superficial Basal Cell Carcinoma

Multifocal Superficial Basal Cell Carcinoma

Multicentric Basal Cell Carcinoma

Superficial Multicentric Basal-Cell Carcinoma
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Encephalopathy With Basal Ganglia Calcification

Aicardi-Goutières Syndrome

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1
Spherocytosis, Type 5

Hereditary Spherocytosis Type 5

SPH5

Hs5

Spherocytosis, Hereditary, 5

Hereditary Spherocytosis 5

Spherocytosis 5

Spherocytosis, Hereditary, Type 5
X-Linked Immunodeficiency 74

Immunodeficiency 74, Covid-19-Related, X-Linked

Imd74

Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection

Tlr7 Deficiency

X-Linked Immunodeficiency 74,Covid-19-Related
Viral Infectious Disease

Arbovirus Infections

Viral Disease

Virus Infection

Virus Diseases

Viral Infection

Viral Infections

Virus Infections
Actinic Keratosis

Solar Keratosis

Actinic Keratosis

Senile Hyperkeratosis

Sk - Solar Keratosis

Keratosis, Actinic

Seborrheic Keratosis

Ak - [Actinic Keratosis]

Sk - [Solar Keratosis]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-13740 Resiquimod Agonist 99.95% Phase 2
HY-134581 Enpatoran Inhibitor 99.77% Phase 2
HY-13773 Motolimod Agonist 98.12% Phase 2
HY-109137 Selgantolimod Agonist 98.23% Phase 2
HY-134581A Enpatoran hydrochloride Inhibitor 99.33% Phase 2
HY-13740G Resiquimod (GMP) Agonist / Phase 2
HY-109104 Telratolimod Agonist 98.98% Phase 1
Pre-clinical Phase
Bioactive Molecules (36)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-128799 CL097 Agonist 99.89% Unkown
HY-117066 CL075 Agonist 99.25% Unkown
HY-103697A Gardiquimod diTFA Agonist ≥99.0% Unkown
HY-139323 TLR7/8-IN-1 Inhibitor 99.92% Unkown
HY-103697 Gardiquimod Agonist 99.91% Unkown
HY-103698 TLR7/8 agonist 1 Agonist 97.33% Unkown
HY-112050 CU-CPT-8m Antagonist 99.98% Unkown
HY-130797 TLR7/8 agonist 3 Agonist 99.96% Unkown
HY-112667 CU-CPT-9a Antagonist 99.36% Unkown
HY-101929 CU-CPT17e Agonist 99.00% Unkown
HY-131945 CU-115 Antagonist 99.55% Unkown
HY-139017 TLR7/8 agonist 4 Agonist 99.04% Unkown
HY-112051 CU-CPT9b Antagonist 99.03% Unkown
HY-10018 Toll-like receptor modulator Modulator 99.36% Unkown
HY-160229 ssRNA40 sodium Activator 93.25% Unkown
HY-13740S Resiquimod-d5 Agonist 99.84% Unkown
HY-128799A CL097 hydrochloride Agonist 99.51% Unkown
HY-145960 MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Agonist 99.39% Unkown
HY-159102 PVP-037.2 Agonist / Unkown
HY-158694A TLR7 agonist 20 hydrochloride Agonist 99.86% Unkown
HY-138139A AXC-715 hydrochloride Agonist / Unkown
HY-153543 TLR7/8 agonist 8 Agonist / Unkown
HY-141454A TLR8 agonist 2 hydrochloride Agonist / Unkown
HY-139017A TLR7/8 agonist 4 TFA Agonist / Unkown
HY-141454 TLR8 agonist 2 Agonist / Unkown
HY-121496 3M-011 Agonist / Unkown
HY-161629 TLR8 agonist 7 Agonist / Unkown
HY-169057 BI1543673 Inhibitor / Unkown
HY-161630 TLR8 agonist 8 Agonist / Unkown
HY-160228A ORN 02 sodium Activator / Unkown
HY-160228 ORN 02 Activator / Unkown
HY-162845 TLR7/8 agonist 11 Agonist / Unkown
HY-163670 TLR7 agonist 21 Inhibitor / Unkown
HY-161631 TLR8 agonist 9 Agonist / Unkown
HY-158694 TLR7 agonist 20 Agonist / Unkown
HY-153544 TLR7/8 agonist 9 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TLR8 RGD RGD:1590327
Macaca mulatta TLR8 VGNC VGNC:78391
Canis familiaris TLR8 VGNC VGNC:55002
Mus musculus TLR8 MGD MGI:2176887
Felis catus TLR8 VGNC VGNC:66221
Others TLR8 NCBI