CA1 - carbonic anhydrase 1 Gene

Homo sapiens

Also known as CAB; CA-I; Car1; HEL-S-11

Gene ID: 759 | Gene type: protein coding

About CA1

Cytogenetic location: 8q21.2 Genomic coordinates (GRCh38): 8:85,327,608-85,378,113 (from NCBI)

This gene has 25 transcripts (splice variants), 286 orthologues and 14 paralogues. Biased expression in bone marrow (RPKM 551.6) and colon (RPKM 322.2).

Summary

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]

CA1 Products(7)

mRNA	Protein	Name
NM_001128830.4	NP_001122302.1	carbonic anhydrase 1 isoform a
NM_001128829.4	NP_001122301.1	carbonic anhydrase 1 isoform a
NM_001738.5	NP_001729.1	carbonic anhydrase 1 isoform a
NM_001128831.4	NP_001122303.1	carbonic anhydrase 1 isoform a
NM_001164830.2	NP_001158302.1	carbonic anhydrase 1 isoform a
NM_001291968.2	NP_001278897.1	carbonic anhydrase 1 isoform c
NM_001291967.2	NP_001278896.1	carbonic anhydrase 1 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables arylesterase activity	IMP IMP: Inferred from mutant phenotype	7758465	GOA
enables carbonate dehydratase activity	IDA IDA: Inferred from direct assay	10550681	GOA
enables carbonate dehydratase activity	IMP IMP: Inferred from mutant phenotype	7758465	GOA
enables cyanamide hydratase activity	IDA IDA: Inferred from direct assay	10550681	GOA
enables hydro-lyase activity	IDA IDA: Inferred from direct assay	2114290	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CA1 Protein Structure

Carb_anhydrase

0
100
200
261 a.a.

Protein Preferred Names

Protein Names

carbonic anhydrase 1

carbonate dehydratase I	carbonic anhydrase B
carbonic anhydrase I	cyanamide hydratase CA1
epididymis secretory protein Li 11	epididymis secretory sperm binding protein

CA1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CA1	P00915	TFCP2	Homo sapiens	Q12800	Validated Y2H	25910212
Intra	CA1	P00915	TFCP2	Homo sapiens	Q12800	Y2H Bait-Prey Pool	25910212
Intra	CA1	P00915	TFCP2	Homo sapiens	Q12800	Y2H Array	25910212
Intra	CA1	P00915	TFCP2	Homo sapiens	Q12800	Validated Y2H	25416956
Intra	CA1	P00915	TFCP2	Homo sapiens	Q12800	Y2H Prey Pooling	25416956
Intra	CA1	P00915	TFCP2	Homo sapiens	Q12800	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7718	Carbonic Anhydrase 1 Protein, Human (His)	P00915 (A2-F261)	≥95%

Related Diseases

Diseases

Alias

Cataract 3, Multiple Types

Cataract 3 Multiple Types	CTRCT3
Cca2	Cataract, Congenital, Cerulean Type, 2
Cataract 3, Multiple Types, With Or Without Microcornea	Cataract 3 Multiple Types With Or Without Microcornea
Congenital Cerulean Type Cataract 2	Congenital Cataract Blue Dot Type 2
Congenital Cataract Cerulean Type 2	Cspc
Sutural Cataract With Punctate And Cerulean Opacities

Alzheimer Disease 11

Ad11	Alzheimer'S Disease 11
Alzheimer Disease, Familial, 11	Alzheimer Disease-11
Alzheimer'S Disease 11, Late Onset

Intracranial Hypertension, Idiopathic

Pseudotumor Cerebri	Benign Intracranial Hypertension
Idiopathic Intracranial Hypertension	Iih
Benign Intracran. Hypt.

Osteopetrosis, Autosomal Recessive 3

Osteopetrosis With Renal Tubular Acidosis	Marble Brain Disease
OPTB3	Guibaud-Vainsel Syndrome
Carbonic Anhydrase Ii Deficiency	Osteopetrosis, Autosomal Recessive 3, With Renal Tubular Acidosis
Autosomal Recessive Osteopetrosis 3	Carbonic Anhydrase 2 Deficiency
Autosomal Recessive Osteopetrosis 3 With Renal Tubular Acidosis	Osteopetrosis Autosomal Recessive 3
Autosomal Recessive Osteopetrosis Type 3	Guibaud Vainsel Syndrome
Mixed Rta	Mixed Renal Tubular Acidosis
Renal Tubular Acidosis Type 3	Carbonic Anhydrase Ii Deficiency Syndrome
Carbonic Anhydrase Ii Variant	Osteopetrosis, Autosomal Recessive, Type 3
Carbonic Anhydrase 2

Swine Influenza

Influenza Due To Influenza A Virus Subtype H1n1

Transient Global Amnesia

Amnesia, Transient Global

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0764	Bucladesine sodium		99.48%	Yes
HY-10932	Aniracetam	Modulator	99.89%	Unkown
HY-B1424	Benzthiazide	Inhibitor	99.70%	Unkown
HY-12882	Ifenprodil		/	Unkown
HY-116790	(-)-Penbutolol	Antagonist	/	Unkown

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-I1070	D-Isoleucine		≥98.0%	Unkown
HY-P3914	Cecropin A (1-7)-Melittin A (2-9)	Inhibitor	98.99%	Unkown
HY-100606	l-Pindolol		99.89%	Unkown
HY-N5130	Effusol	Inhibitor	99.83%	Unkown
HY-103502	CGP7930	Modulator	≥99.0%	Unkown
HY-106784A	(E)-Ajoene		/	Unkown
HY-16147	Combretastatin A1 phosphate		98.00%	Unkown
HY-P1387	β-Amyloid (1-40) (rat)	Inducer	95.13%	Unkown
HY-100843	L-AP6		/	Unkown
HY-116431	I-BOP	Agonist	/	Unkown
HY-117578	KB 5666		/	Unkown
HY-136980	Aspartylglutamate		/	Unkown
HY-139145	Etbicyphat	Antagonist	≥98.0%	Unkown
HY-139145S	Etbicyphat-13C3		/	Unkown
HY-P4397	(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin		/	Unkown
HY-RS01762	CA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-116143	MAGL-IN-12	Inhibitor	/	Unkown
HY-14477	UPF-1035	Inhibitor	/	Unkown
HY-159870	E12CA1A3		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CA1	VGNC	VGNC:38604
Felis catus	CA1	VGNC	VGNC:60239
Rattus norvegicus	CA1	RGD	RGD:1309780
Macaca mulatta	CA1	VGNC	VGNC:83986
Mus musculus	CA1	MGD	MGI:88268
Macaca fascicularis	CA1	NCBI	NCBI:102126955
Susscrofa domestica	CA1	NCBI
Others	CA1	NCBI

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