2. Gene
  3. AIMP2 - aminoacyl tRNA synthetase complex interacting multifunctional protein 2 Gene

AIMP2 - aminoacyl tRNA synthetase complex interacting multifunctional protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as P38; JTV1; HLD17; JTV-1

Gene ID: 7965 | Gene type: protein coding

About AIMP2

Cytogenetic location: 7p22.1 Genomic coordinates (GRCh38): 7:6,009,272-6,023,834 (from NCBI)

This gene has 4 transcripts (splice variants), 219 orthologues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 18.6), duodenum (RPKM 17.0) and 25 other tissues.

Summary

The protein encoded by this gene is part of the Aminoacyl-tRNA Synthetase complex, which contains nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. The encoded protein is one of the non-enzymatic factors and is required for assembly and stability of the complex. [provided by RefSeq, May 2016]

AIMP2 Products(8)

mRNA Protein Name
NM_001326606.2 NP_001313535.1 aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform b
NM_001326607.2 NP_001313536.1 aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform c
NM_001326609.2 NP_001313538.1 aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform d
NM_001326610.2 NP_001313539.1 aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform d
NM_001326611.3 NP_001313540.1 aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform d
NM_001362785.2 NP_001349714.1 aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform e
NM_001362787.2 NP_001349716.1 aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform f
NM_006303.4 NP_006294.2 aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform a

AIMP2 Protein Structure

GST_C_3

GST_C_3: Glutathione S-transferase, C-terminal domain (227 - 307)

  • 0
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  • 300
  • 320 a.a.
Protein Preferred Names Protein Names

aminoacyl tRNA synthase complex-interacting multifunctional protein 2

ARS-interacting multi-functional protein 2

AIMP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
AIMP2 Q13155 NECAB2 Homo sapiens Q7Z6G3-2
Validated Y2H
25416956
Intra
AIMP2 Q13155 NECAB2 Homo sapiens Q7Z6G3-2
Y2H Array
25416956
Intra
AIMP2 Q13155 ZGPAT Homo sapiens Q8N5A5-2
Y2H Prey Pooling
32296183
Intra
AIMP2 Q13155 ZGPAT Homo sapiens Q8N5A5-2
Validated Y2H
32296183
Intra
AIMP2 Q13155 ZGPAT Homo sapiens Q8N5A5-2
Y2H Array
25416956
Intra
AIMP2 Q13155 ZGPAT Homo sapiens Q8N5A5-2
Y2H Array
32296183
Intra
AIMP2 Q13155 AIMP1 Homo sapiens Q12904
Y2H Prey Pooling
25416956
Intra
AIMP2 Q13155 AIMP1 Homo sapiens Q12904
Validated Y2H
25416956
Intra
AIMP2 Q13155 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
AIMP2 Q13155 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
AIMP2 Q13155 KRT33B Homo sapiens Q14525
Validated Y2H
32296183
Intra
AIMP2 Q13155 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
32296183
Intra
AIMP2 Q13155 KRT33B Homo sapiens Q14525
Y2H Array
32296183
Intra
AIMP2 Q13155 BCAS2 Homo sapiens O75934
Y2H Array
31515488
Intra
AIMP2 Q13155 BCAS2 Homo sapiens O75934
Y2H Array
32296183
Intra
AIMP2 Q13155 BCAS2 Homo sapiens O75934
Y2H Array
25416956
Intra
AIMP2 Q13155 BCAS2 Homo sapiens O75934
Y2H Prey Pooling
32296183
Intra
AIMP2 Q13155 MIS18A Homo sapiens Q9NYP9
Y2H Array
25416956
Intra
AIMP2 Q13155 MIS18A Homo sapiens Q9NYP9
Validated Y2H
32296183
Intra
AIMP2 Q13155 MIS18A Homo sapiens Q9NYP9
Y2H Prey Pooling
25416956
Intra
AIMP2 Q13155 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
25416956
Intra
AIMP2 Q13155 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
AIMP2 Q13155 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
AIMP2 Q13155 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
25416956
Intra
AIMP2 Q13155 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
AIMP2 Q13155 SPATA18 Homo sapiens Q8TC71
Validated Y2H
32296183
Intra
AIMP2 Q13155 CBY2 Homo sapiens Q8NA61-2
Validated Y2H
32296183
Intra
AIMP2 Q13155 KRT36 Homo sapiens O76013-2
Y2H Array
32296183
Intra
AIMP2 Q13155 KRT36 Homo sapiens O76013-2
Y2H Prey Pooling
32296183
Intra
AIMP2 Q13155 LMO2 Homo sapiens P25791-3
Y2H Prey Pooling
32296183
Intra
AIMP2 Q13155 LMO2 Homo sapiens P25791-3
Y2H Array
32296183
Intra
AIMP2 Q13155 DRC12 Homo sapiens Q494R4-2
Y2H Array
32296183
Intra
AIMP2 Q13155 DRC12 Homo sapiens Q494R4-2
Y2H Prey Pooling
32296183
Intra
AIMP2 Q13155 DRC12 Homo sapiens Q494R4-2
Validated Y2H
32296183
Intra
AIMP2 Q13155 DISC1 Homo sapiens Q9NRI5-2
Validated Y2H
32296183
Intra
AIMP2 Q13155 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
Intra
AIMP2 Q13155 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
Intra
AIMP2 Q13155 TEX12 Homo sapiens Q9BXU0
Validated Y2H
32296183
Intra
AIMP2 Q13155 AIMP1 Homo sapiens Q12904-2
Y2H Prey Pooling
32296183
Intra
AIMP2 Q13155 AIMP1 Homo sapiens Q12904-2
Y2H Array
32296183
Intra
AIMP2 Q13155 PRKAA2 Homo sapiens P54646
Y2H Array
25416956
Intra
AIMP2 Q13155 PRKAA2 Homo sapiens P54646
Validated Y2H
25416956
Intra
AIMP2 Q13155 PRKAA2 Homo sapiens P54646
Y2H Prey Pooling
25416956
Intra
AIMP2 Q13155 SBK3 Homo sapiens P0C264
Y2H Prey Pooling
32296183
Intra
AIMP2 Q13155 SBK3 Homo sapiens P0C264
Y2H Array
32296183
Intra
AIMP2 Q13155 TCP11 Homo sapiens Q8WWU5-7
Y2H Array
32296183
Intra
AIMP2 Q13155 TCP11 Homo sapiens Q8WWU5-7
Y2H Prey Pooling
32296183
Intra
AIMP2 Q13155 TCP11 Homo sapiens Q8WWU5-7
Validated Y2H
32296183
Intra
AIMP2 Q13155 PCMT1 Homo sapiens P22061
Y2H Prey Pooling
25416956
Intra
AIMP2 Q13155 PCMT1 Homo sapiens P22061
Validated Y2H
25416956
Intra
AIMP2 Q13155 KARS1 Homo sapiens Q15046
Validated Y2H
25416956
Intra
AIMP2 Q13155 KARS1 Homo sapiens Q15046
Y2H Prey Pooling
32296183
Intra
AIMP2 Q13155 KARS1 Homo sapiens Q15046
BRET
29997244
Intra
AIMP2 Q13155 KARS1 Homo sapiens Q15046
Lumier
32814053
Intra
AIMP2 Q13155 KARS1 Homo sapiens Q15046
Validated Y2H
32296183
Intra
AIMP2 Q13155 KARS1 Homo sapiens Q15046
Y2H Array
32296183
Intra
AIMP2 Q13155 KARS1 Homo sapiens Q15046
Lumier
29997244
Intra
AIMP2 Q13155 KARS1 Homo sapiens Q15046
Y2H
21900206
Intra
AIMP2 Q13155 PFDN6 Homo sapiens O15212
Y2H Prey Pooling
32296183
Intra
AIMP2 Q13155 PFDN6 Homo sapiens O15212
Y2H Array
32296183
Intra
AIMP2 Q13155 DARS1 Homo sapiens P14868
Y2H Prey Pooling
25416956
Intra
AIMP2 Q13155 DARS1 Homo sapiens P14868
Y2H Array
25416956
Intra
AIMP2 Q13155 DARS1 Homo sapiens P14868
Y2H Array
32296183
Intra
AIMP2 Q13155 DARS1 Homo sapiens P14868
Y2H
21900206
Intra
AIMP2 Q13155 DARS1 Homo sapiens P14868
Y2H Prey Pooling
32296183
Intra
AIMP2 Q13155 TP53 Homo sapiens P04637
Pull Down
18695251
Intra
AIMP2 Q13155 RABEP1 Homo sapiens Q15276
Y2H Prey Pooling
32296183
Intra
AIMP2 Q13155 RABEP1 Homo sapiens Q15276
Validated Y2H
32296183
Intra
AIMP2 Q13155 RABEP1 Homo sapiens Q15276
Y2H Array
32296183
Intra
AIMP2 Q13155 FUBP1 Homo sapiens Q96AE4
Y2H
21988832
Intra
AIMP2 Q13155 FUBP1 Homo sapiens Q96AE4
IF
21285945
Intra
AIMP2 Q13155 LNX1 Homo sapiens Q8TBB1
Validated Y2H
25416956
Intra
AIMP2 Q13155 LNX1 Homo sapiens Q8TBB1
Y2H Pooling
16189514
Intra
AIMP2 Q13155 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
AIMP2 Q13155 LNX1 Homo sapiens Q8TBB1
Y2H Array
25416956
Intra
AIMP2 Q13155 LNX1 Homo sapiens Q8TBB1
Y2H Array
29892012
Intra
AIMP2 Q13155 GYS1 Homo sapiens P13807
Y2H Prey Pooling
25416956
Intra
AIMP2 Q13155 GYS1 Homo sapiens P13807
Validated Y2H
25416956
Intra
AIMP2 Q13155 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
25416956
Intra
AIMP2 Q13155 FHL3 Homo sapiens Q13643
Lumier
32814053
Intra
AIMP2 Q13155 FHL3 Homo sapiens Q13643
Validated Y2H
25416956
Intra
AIMP2 Q13155 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
32296183
Intra
AIMP2 Q13155 FHL3 Homo sapiens Q13643
Validated Y2H
32296183
Intra
AIMP2 Q13155 FHL3 Homo sapiens Q13643
Y2H Array
25416956
Intra
AIMP2 Q13155 FHL3 Homo sapiens Q13643
Y2H Array
32296183
Intra
AIMP2 Q13155 FHL3 Homo sapiens Q13643
Y2H
21516116
Intra
AIMP2 Q13155 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
AIMP2 Q13155 BRME1 Homo sapiens Q0VDD7
Y2H Prey Pooling
25416956
Intra
AIMP2 Q13155 BRME1 Homo sapiens Q0VDD7
Pull Down
16189514
Intra
AIMP2 Q13155 BRME1 Homo sapiens Q0VDD7
Y2H Pooling
19060904
Intra
AIMP2 Q13155 BRME1 Homo sapiens Q0VDD7
Y2H Array
19060904
Intra
AIMP2 Q13155 BRME1 Homo sapiens Q0VDD7
Y2H Pooling
16189514
Intra
AIMP2 Q13155 EXOC8 Homo sapiens Q8IYI6
Validated Y2H
32296183
Intra
AIMP2 Q13155 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
25416956
Intra
AIMP2 Q13155 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
25416956
Intra
AIMP2 Q13155 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
25416956
Intra
AIMP2 Q13155 CEP170P1 Homo sapiens Q96L14
Validated Y2H
25416956
Intra
AIMP2 Q13155 CEP170P1 Homo sapiens Q96L14
Y2H Pooling
16189514
Intra
AIMP2 Q13155 CEP170P1 Homo sapiens Q96L14
Y2H Array
25416956
Intra
AIMP2 Q13155 C1orf216 Homo sapiens Q8TAB5
Validated Y2H
32296183
Intra
AIMP2 Q13155 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Intra
AIMP2 Q13155 NDEL1 Homo sapiens Q9GZM8
Validated Y2H
25416956
Intra
AIMP2 Q13155 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
AIMP2 Q13155 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra
AIMP2 Q13155 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AIMP2 Proteins

Cat. No. Product Name Accession Purity
HY-P71538 AIMP2 Protein, Human (His) Q13155 (1M-320K) ≥95%

Related Diseases

Diseases Alias
Leukodystrophy, Hypomyelinating, 17

HLD17
Leukodystrophy, Hypomyelinating, 3

Hypomyelinating Leukodystrophy 3

HLD3

Pelizaeus-Merzbacher-Like Disease Due To Aimp1 Mutation

Leukodystrophy, Hypomyelinating 3

Perinatal Sudanophilic Leukodystrophy

Leukodystrophy, Hypomyelinating, Type 3

Pelizaeus-Merzbacher-Like Disease, Autosomal Recessive, 2
Leukodystrophy, Hypomyelinating, 7, With Or Without Oligodontia And/Or Hypogonadotropic Hypogonadism

HLD7

Leukoencephalopathy-Ataxia-Hypodontia-Hypomyelination Syndrome

Addh

Leukodystrophy, Hypomyelinating, With Hypodontia And Hypogonadotropic Hypogonadism

4h Syndrome

4h Leukodystrophy 1

Hypomyelinating Leukodystrophy 7 With Or Without Oligodontia And-Or Hypogonadotropic Hypogonadism

Hypomyelination-Cerebellar Atrophy-Hypoplasia Of The Corpus Callosum Syndrome

Leukodystrophy With Oligodontia

Tach Syndrome

Tremor-Ataxia-Central Hypomyelination Syndrome

Leukoencephalopathy, Hypomyelinating, With Ataxia And Delayed Dentition

Ataxia, Delayed Dentition, And Hypomyelination

Ataxia-Delayed Dentition-Hypomyelination Syndrome

Odontoleukodystrophy

Dentoleukoencephalopathy

Hypomyelinating Leukodystrophy-Ataxia-Hypodontia-Hypomyelination Syndrome

Ataxia-Delayed Dentition-Hypomyelination Syndrome

Ataxia Delayed Dentition And Hypomyelination

Leukodystrophy Hypomyelinating With Hypodontia And Hypogonadotropic Hypogonadism 4h Syndrome

Leukoencephalopathy Hypomyelinating With Ataxia And Delayed Dentition

Tach

Tremor-Ataxia With Central Hypomyelination

Attention Deficit Hyperactivity Disorder

Leukodystrophy, Dysmyelinating, With Oligodontia
Leukodystrophy

Leukodystrophies
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Hypomyelinating Leukodystrophy

Hld

Leukodystrophy, Hypomyelinating
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136431 BC-DXI-843 Inhibitor 99.76% Unkown
HY-150719 AIMP2-DX2-IN-1 Inhibitor ≥98.0% Unkown
HY-RS00498 AIMP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta AIMP2 VGNC VGNC:69650
Bos taurus AIMP2 VGNC VGNC:25766
Mus musculus AIMP2 MGD MGI:2385237
Rattus norvegicus AIMP2 RGD RGD:1560787
Felis catus AIMP2 VGNC VGNC:80550
Others AIMP2 NCBI