TRIM37 - tripartite motif containing 37 Gene

Homo sapiens

Also known as MUL; POB1; TEF3

Gene ID: 4591 | Gene type: protein coding

About TRIM37

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,967,201-59,106,880 (from NCBI)

This gene has 14 transcripts (splice variants), 206 orthologues, 80 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 19.8), brain (RPKM 14.1) and 23 other tissues.

Summary

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. Mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. TRIM37 localizes in peroxisomal membranes, and has been implicated in human peroxisomal biogenesis disorders. [provided by RefSeq, Jul 2020]

TRIM37 Products(11)

mRNA	Protein	Name
NM_001005207.5	NP_001005207.1	E3 ubiquitin-protein ligase TRIM37 isoform a
NM_001320987.3	NP_001307916.1	E3 ubiquitin-protein ligase TRIM37 isoform b
NM_001320988.3	NP_001307917.1	E3 ubiquitin-protein ligase TRIM37 isoform c
NM_001320989.3	NP_001307918.1	E3 ubiquitin-protein ligase TRIM37 isoform c
NM_001320990.3	NP_001307919.1	E3 ubiquitin-protein ligase TRIM37 isoform d
NM_001353082.2	NP_001340011.1	E3 ubiquitin-protein ligase TRIM37 isoform e
NM_001353083.2	NP_001340012.1	E3 ubiquitin-protein ligase TRIM37 isoform f
NM_001353084.2	NP_001340013.1	E3 ubiquitin-protein ligase TRIM37 isoform g
NM_001353085.2	NP_001340014.1	E3 ubiquitin-protein ligase TRIM37 isoform h
NM_001353086.2	NP_001340015.1	E3 ubiquitin-protein ligase TRIM37 isoform i
NM_015294.6	NP_056109.1	E3 ubiquitin-protein ligase TRIM37 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone H2AK119 ubiquitin ligase activity	IDA IDA: Inferred from direct assay	25470042	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11279055	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11279055	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	23077300	GOA
enables tumor necrosis factor receptor binding	IPI IPI: Inferred from physical interaction	11279055	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	28724525	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	11279055	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	15885686	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in aggresome assembly	IDA IDA: Inferred from direct assay	15885686	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	11279055	GOA
involved in negative regulation of centriole replication	IMP IMP: Inferred from mutant phenotype	23769972	GOA
involved in negative regulation of gene expression, epigenetic	IDA IDA: Inferred from direct assay	25470042	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	25470042	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	23077300	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	23077300	GOA
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	15885686	GOA
acts upstream of protein import into peroxisome matrix	IDA IDA: Inferred from direct assay	28724525	GOA
involved in protein monoubiquitination	IDA IDA: Inferred from direct assay	28724525	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	28724525	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ESC/E(Z) complex	IDA IDA: Inferred from direct assay	25470042	GOA
located in aggresome	IDA IDA: Inferred from direct assay	15885686	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23769972	GOA
located in cytosol	IDA IDA: Inferred from direct assay	11279055	GOA
is active in peroxisomal membrane	IDA IDA: Inferred from direct assay	28724525	GOA
located in peroxisome	IDA IDA: Inferred from direct assay	11938494	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM37 Protein Structure

zf-B_box

MATH

0
200
400
600
800
964 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase TRIM37

RING-B-box-coiled-coil protein

TRIM37 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRIM37	O94972	a8k932_human	Homo sapiens	A8K932	Validated Y2H	25416956
Intra	TRIM37	O94972	a8k932_human	Homo sapiens	A8K932	Y2H Array	25416956
Intra	TRIM37	O94972	FAM107A	Homo sapiens	O95990-3	Y2H Prey Pooling	25416956
Intra	TRIM37	O94972	FAM107A	Homo sapiens	O95990-3	Validated Y2H	25416956
Intra	TRIM37	O94972	FAM107A	Homo sapiens	O95990-3	Y2H Array	25416956
Intra	TRIM37	O94972	CDC20B	Homo sapiens	Q86Y33	Validated Y2H	25416956
Intra	TRIM37	O94972	DZIP1L	Homo sapiens	Q8IYY4	Validated Y2H	32296183
Intra	TRIM37	O94972	PNKP	Homo sapiens	Q96T60	Y2H Pooling	16189514
Intra	TRIM37	O94972	PNKP	Homo sapiens	Q96T60	Validated Y2H	32296183
Intra	TRIM37	O94972	PNKP	Homo sapiens	Q96T60	BRET	38225382
Intra	TRIM37	O94972	TCEANC	Homo sapiens	Q8N8B7-2	Validated Y2H	32296183
Intra	TRIM37	O94972	CDC20B	Homo sapiens	Q86Y33-5	Validated Y2H	32296183
Intra	TRIM37	O94972	UBASH3A	Homo sapiens	P57075	Validated Y2H	25416956
Intra	TRIM37	O94972	UBASH3A	Homo sapiens	P57075	Y2H Array	25416956
Intra	TRIM37	O94972	UBASH3A	Homo sapiens	P57075	Y2H Prey Pooling	25416956
Intra	TRIM37	O94972	SSX2IP	Homo sapiens	Q9Y2D8	Validated Y2H	25416956
Intra	TRIM37	O94972	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Array	25416956
Intra	TRIM37	O94972	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Prey Pooling	25416956
Intra	TRIM37	O94972	ZMAT2	Homo sapiens	Q96NC0	Y2H Prey Pooling	25416956
Intra	TRIM37	O94972	MCRS1	Homo sapiens	Q96EZ8	Y2H Prey Pooling	25416956
Intra	TRIM37	O94972	MCRS1	Homo sapiens	Q96EZ8	Y2H Pooling	16189514
Intra	TRIM37	O94972	DDX6	Homo sapiens	P26196	Y2H Prey Pooling	25416956
Intra	TRIM37	O94972	DDX6	Homo sapiens	P26196	Y2H Array	25416956
Intra	TRIM37	O94972	BYSL	Homo sapiens	Q13895	Validated Y2H	25416956
Intra	TRIM37	O94972	BYSL	Homo sapiens	Q13895	Validated Y2H	32296183
Intra	TRIM37	O94972	COPB1	Homo sapiens	P53618	Validated Y2H	32296183
Intra	TRIM37	O94972	CDKL3	Homo sapiens	Q8IVW4	Validated Y2H	32296183
Intra	TRIM37	O94972	CWF19L2	Homo sapiens	Q2TBE0	Validated Y2H	32296183
Intra	TRIM37	O94972	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	32296183
Intra	TRIM37	O94972	FAM161A	Homo sapiens	Q3B820	Y2H Prey Pooling	25416956
Intra	TRIM37	O94972	FAM161A	Homo sapiens	Q3B820	Validated Y2H	25416956
Intra	TRIM37	O94972	ZNF417	Homo sapiens	Q8TAU3	Y2H Prey Pooling	25416956
Intra	TRIM37	O94972	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	25416956
Intra	TRIM37	O94972	ZNF417	Homo sapiens	Q8TAU3	Y2H Array	25416956
Intra	TRIM37	O94972	ZNF417	Homo sapiens	Q8TAU3	Y2H Pooling	16189514
Intra	TRIM37	O94972	RASD1	Homo sapiens	Q9Y272	Y2H Prey Pooling	25416956
Intra	TRIM37	O94972	RASD1	Homo sapiens	Q9Y272	Validated Y2H	25416956
Intra	TRIM37	O94972	RASD1	Homo sapiens	Q9Y272	Y2H Array	25416956
Intra	TRIM37	O94972	PRC1	Homo sapiens	O43663	Y2H Pooling	16189514
Intra	TRIM37	O94972	ELOA	Homo sapiens	Q14241	Validated Y2H	32296183
Intra	TRIM37	O94972	FAM50B	Homo sapiens	Q9Y247	Y2H Prey Pooling	25416956
Intra	TRIM37	O94972	AQP1	Homo sapiens	P29972	Validated Y2H	32296183
Intra	TRIM37	O94972	SYTL4	Homo sapiens	Q96C24	Validated Y2H	32296183
Intra	TRIM37	O94972	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mulibrey Nanism

MUL	Muscle-Liver-Brain-Eye Nanism
Pericardial Constriction And Growth Failure	Perheentupa Syndrome
Mulibrey Growth Disorder	Mulibrey Nanism Syndrome
Pericardial Constriction With Growth Failure	Nanism Mulibrey

Acid-Labile Subunit Deficiency

Short Stature Due To Primary Acid-Labile Subunit Deficiency	ACLSD
Acid-Labile Subunit, Deficiency Of	Decreased Levels Of Acid Labile Subunit
Growth Disorders

Peroxisomal Disease

Peroxisomal Disorder	Peroxisomal Disorders
Peroxisomal Defects

Constrictive Pericarditis

Pericarditis, Constrictive	Pericarditis Constrictive
Pericarditis Calculosa	Hutinel-Pick Syndrome
Chronic Tamponade	Chronic Pericardial Constriction
Pick Syndrome Of Heart	Pick Disease Of Heart
Concretio Cordis	Calcareous Pericarditis

Childhood Osteosarcoma

Pediatric Osteosarcoma

Three M Syndrome 1

3-M Syndrome	Yakut Short Stature Syndrome
3m Syndrome	Le Merrer Syndrome
Dolichospondylic Dysplasia	Gloomy Face Syndrome
Three M Syndrome	3M1
3m Syndrome 1	Miller-Mckusick-Malvaux Syndrome
3-Msbn	Three-M Slender-Boned Nanism
Miller-Mckusick-Malvaux-Syndrome	3-M Syndrome 1
3m Syndrome-1	3m Syndrome, Type 1
Dwarfism	Dwarfism Tall Vertebrae

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Peroxisomal Biogenesis Disorder

Zellweger Spectrum Disorders	Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum
Disorders Of Peroxisome Biogenesis	Zellweger Spectrum
Zellweger Syndrome Spectrum	Peroxisomal Biogenesis Disorders
Pbd, Zss	Pbd-Zsd
Pbd-Zss	Pbd-Zellweger Spectrum Disorder
Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum	Peroxisome Biogenesis Disorder
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorders
Zellweger Spectrum Disorder	Hyperpipecolic Acidaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15041	TRIM37 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRIM37	RGD	RGD:1308349
Bos taurus	TRIM37	VGNC	VGNC:36332
Mus musculus	TRIM37	MGD	MGI:2153072
Macaca mulatta	TRIM37	VGNC	VGNC:79966
Felis catus	TRIM37	VGNC	VGNC:68360
Canis familiaris	TRIM37	VGNC	VGNC:47818

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