2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. GW405833 hydrochloride

GW405833 hydrochloride  (Synonyms: L768242 hydrochloride)

Cat. No.: HY-110036A Purity: 99.59%
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GW-405833 (L768242) hydrochloride is a potent, selective cannabinoid receptor 2 (CB2) agonist with an EC50 of 50.7 nM. GW-405833 hydrochloride also behaves as a noncompetitive CB1 antagonist. GW-405833 hydrochloride suppresses inflammatory and neuropathic pain.

For research use only. We do not sell to patients.

GW405833 hydrochloride Chemical Structure

GW405833 hydrochloride Chemical Structure

CAS No. : 1202865-22-2

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10 mg USD 150 In-stock
25 mg USD 270 In-stock
50 mg USD 420 In-stock
100 mg USD 670 In-stock
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Based on 1 publication(s) in Google Scholar

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GW405833 hydrochloride Related Antibodies

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Description

GW-405833 (L768242) hydrochloride is a potent, selective cannabinoid receptor 2 (CB2) agonist with an EC50 of 50.7 nM. GW-405833 hydrochloride also behaves as a noncompetitive CB1 antagonist. GW-405833 hydrochloride suppresses inflammatory and neuropathic pain[1][2][3][4].

Molecular Weight

483.82

Formula

C23H25Cl3N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(C(Cl)=CC=C1)Cl)N2C3=C(C=C(OC)C=C3)C(CCN4CCOCC4)=C2C.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (258.36 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0669 mL 10.3344 mL 20.6688 mL
5 mM 0.4134 mL 2.0669 mL 4.1338 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0669 mL 10.3344 mL 20.6688 mL 51.6721 mL
5 mM 0.4134 mL 2.0669 mL 4.1338 mL 10.3344 mL
10 mM 0.2067 mL 1.0334 mL 2.0669 mL 5.1672 mL
15 mM 0.1378 mL 0.6890 mL 1.3779 mL 3.4448 mL
20 mM 0.1033 mL 0.5167 mL 1.0334 mL 2.5836 mL
25 mM 0.0827 mL 0.4134 mL 0.8268 mL 2.0669 mL
30 mM 0.0689 mL 0.3445 mL 0.6890 mL 1.7224 mL
40 mM 0.0517 mL 0.2584 mL 0.5167 mL 1.2918 mL
50 mM 0.0413 mL 0.2067 mL 0.4134 mL 1.0334 mL
60 mM 0.0344 mL 0.1722 mL 0.3445 mL 0.8612 mL
80 mM 0.0258 mL 0.1292 mL 0.2584 mL 0.6459 mL
100 mM 0.0207 mL 0.1033 mL 0.2067 mL 0.5167 mL
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GW405833 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GW4058331202865-22-2L768242GW 405833GW-405833L 768242L-768242Cannabinoid ReceptorCB2 receptor agonistInhibitorinhibitorinhibit

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