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  4. Hispolon

Hispolon, a polyphenol, can be isolated from Phellinus linteus. Hispolon possesses anticancer, antidiabetic, antioxidant, antiviral, hepatoprotective, anti-diabetic, and anti-inflammatory activities.

For research use only. We do not sell to patients.

Hispolon Chemical Structure

Hispolon Chemical Structure

CAS No. : 173933-40-9

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100 mg USD 980 In-stock
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Based on 1 publication(s) in Google Scholar

Hispolon Related Antibodies

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Description

Hispolon, a polyphenol, can be isolated from Phellinus linteus. Hispolon possesses anticancer, antidiabetic, antioxidant, antiviral, hepatoprotective, anti-diabetic, and anti-inflammatory activities[1].

In Vitro

Hispolon (25 and 50 μM, 24-72 h) inhibits cell viability of U87MG cells[2].
Hispolon (25 and 50 μM, 24, 48 h) induces G2/M cell cycle arrest and apoptosis in U87MG cells[2].
Hispolon (25 and 50 μM, 2-8 h) decreases the expression of G1–S transition-related protein cyclin D4 but increases the expression of CDK inhibitor p21[2].
Hispolon (25 and 50 μM, 24 h) inhibits the migration of U87MG cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hispolon Related Antibodies

Cell Viability Assay[2]

Cell Line: U87MG cells
Concentration: 25 and 50 μM
Incubation Time: 24, 48, 72 h
Result: Inhibited cell viability in a dose and time dependent way.

Western Blot Analysis[2]

Cell Line: U87MG cells
Concentration: 25 and 50 μM
Incubation Time: 2, 4, 8 h
Result: Decreased cyclin D4 level, and increased p21 level.
In Vivo

Hispolon (2.5-10 mg/kg, i.p.) attenuates LPS-induced acute lung injury in mice[3].
Hispolon (5 and 10 mg/kg, s.c.) reduces tumor growth in DBTRG xenograft mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced acute lung injury mice[3]
Dosage: 2.5, 5 and 10 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Alleviated the pathological effects in the LPS-challenged mouse.
Reduced the W/D ratio in the lung and MPO activity.
Decreased pro-Inflammatory cytokine production.
Animal Model: DBTRG xenograft mice[4]
Dosage: 5 and 10 mg/kg
Administration: Subcutaneous injection (s.c.)
Result: Reduced tumor volume (RTV).
Inhibited GBM cell proliferation in vivo upon HE and ki-67 staining.
Molecular Weight

220.22

Formula

C12H12O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(/C=C(O)/C=C/C1=CC(O)=C(C=C1)O)=O
Structure Classification
Initial Source

Phellinus linteus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (567.61 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5409 mL 22.7046 mL 45.4091 mL
5 mM 0.9082 mL 4.5409 mL 9.0818 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.5409 mL 22.7046 mL 45.4091 mL 113.5228 mL
5 mM 0.9082 mL 4.5409 mL 9.0818 mL 22.7046 mL
10 mM 0.4541 mL 2.2705 mL 4.5409 mL 11.3523 mL
15 mM 0.3027 mL 1.5136 mL 3.0273 mL 7.5682 mL
20 mM 0.2270 mL 1.1352 mL 2.2705 mL 5.6761 mL
25 mM 0.1816 mL 0.9082 mL 1.8164 mL 4.5409 mL
30 mM 0.1514 mL 0.7568 mL 1.5136 mL 3.7841 mL
40 mM 0.1135 mL 0.5676 mL 1.1352 mL 2.8381 mL
50 mM 0.0908 mL 0.4541 mL 0.9082 mL 2.2705 mL
60 mM 0.0757 mL 0.3784 mL 0.7568 mL 1.8920 mL
80 mM 0.0568 mL 0.2838 mL 0.5676 mL 1.4190 mL
100 mM 0.0454 mL 0.2270 mL 0.4541 mL 1.1352 mL
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Hispolon Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hispolon173933-40-9AntibioticAnticancerantioxidantanti-inflammatoryU87MGLPSlung injuryInhibitorinhibitorinhibit

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