MrgprX2 antagonist-5

Name: MrgprX2 antagonist-5
Brand: MedChemExpress
SKU: HY-145195
Rating: 4.5 (1 reviews)

Cat. No.: HY-145195 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

MrgprX2 antagonist-5 is an MrgprX2 antagonist extracted from patent WO2020223255A1, example 16. MrgprX2 antagonist-5 can be used for the research of inflammatory disorders of the skin.

For research use only. We do not sell to patients.

MrgprX2 antagonist-5 Chemical Structure

CAS No. : 2527815-74-1

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 467	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 467	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 425	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 680	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1380	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2200	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

MrgprX2 antagonist-5 is an MrgprX2 antagonist extracted from patent WO2020223255A1, example 16. MrgprX2 antagonist-5 can be used for the research of inflammatory disorders of the skin^[1].

IC₅₀ & Target

MrgprX2^[1]

In Vitro

MRGPRX2, a member of the Mas-related gene family, was found to be expressed in sensory neurons, mast cells and, most recently, in keratinocytes. MRGPRX2 mRNA is present in adipose tissue, esophagus, urinary bladder, lungs with the highest levels found in skin. Activation of MRGPRX2 leads to mast cell degranulation with subsequent pseudo-allergic reactions^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

434.85

Formula

C₁₉H₁₃ClF₂N₄O₂S

CAS No.

2527815-74-1

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=S1(N=C(NCC2=NC=CC=C2F)NC3=C(C4=C(Cl)C=CC=C4)C=C(C=C31)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL (45.99 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2996 mL	11.4982 mL	22.9964 mL
5 mM	0.4599 mL	2.2996 mL	4.5993 mL
10 mM	0.2300 mL	1.1498 mL	2.2996 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (253 KB) HNMR (116 KB) CNMR (100 KB) LCMS (140 KB)

Handling Instructions (2659 KB)

References

[1]. BIGI S, et, al. 3-amino-4h-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives as inhibitors of mrgx2. WO2020223255A1.

[2]. Porebski G, et, al. Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions. Front Immunol. 2018 Dec 20;9:3027. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2996 mL	11.4982 mL	22.9964 mL	57.4911 mL
	5 mM	0.4599 mL	2.2996 mL	4.5993 mL	11.4982 mL
	10 mM	0.2300 mL	1.1498 mL	2.2996 mL	5.7491 mL
	15 mM	0.1533 mL	0.7665 mL	1.5331 mL	3.8327 mL
	20 mM	0.1150 mL	0.5749 mL	1.1498 mL	2.8746 mL
	25 mM	0.0920 mL	0.4599 mL	0.9199 mL	2.2996 mL
	30 mM	0.0767 mL	0.3833 mL	0.7665 mL	1.9164 mL
	40 mM	0.0575 mL	0.2875 mL	0.5749 mL	1.4373 mL