2. GPCR/G Protein
  3. Mas-related G-protein-coupled Receptor (MRGPR)
  4. MrgprX2 antagonist-5

MrgprX2 antagonist-5 is an MrgprX2 antagonist extracted from patent WO2020223255A1, example 16. MrgprX2 antagonist-5 can be used for the research of inflammatory disorders of the skin.

For research use only. We do not sell to patients.

MrgprX2 antagonist-5 Chemical Structure

MrgprX2 antagonist-5 Chemical Structure

CAS No. : 2527815-74-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 467 In-stock
Solution
10 mM * 1 mL in DMSO USD 467 In-stock
Solid
5 mg USD 425 In-stock
10 mg USD 680 In-stock
25 mg USD 1380 In-stock
50 mg USD 2200 In-stock
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Based on 1 publication(s) in Google Scholar

MrgprX2 antagonist-5 Related Antibodies

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Description

MrgprX2 antagonist-5 is an MrgprX2 antagonist extracted from patent WO2020223255A1, example 16. MrgprX2 antagonist-5 can be used for the research of inflammatory disorders of the skin[1].

IC50 & Target

MrgprX2[1]
In Vitro

MRGPRX2, a member of the Mas-related gene family, was found to be expressed in sensory neurons, mast cells and, most recently, in keratinocytes. MRGPRX2 mRNA is present in adipose tissue, esophagus, urinary bladder, lungs with the highest levels found in skin. Activation of MRGPRX2 leads to mast cell degranulation with subsequent pseudo-allergic reactions[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MrgprX2 antagonist-5 Related Antibodies
Molecular Weight

434.85

Formula

C19H13ClF2N4O2S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=S1(N=C(NCC2=NC=CC=C2F)NC3=C(C4=C(Cl)C=CC=C4)C=C(C=C31)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (45.99 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2996 mL 11.4982 mL 22.9964 mL
5 mM 0.4599 mL 2.2996 mL 4.5993 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2996 mL 11.4982 mL 22.9964 mL 57.4911 mL
5 mM 0.4599 mL 2.2996 mL 4.5993 mL 11.4982 mL
10 mM 0.2300 mL 1.1498 mL 2.2996 mL 5.7491 mL
15 mM 0.1533 mL 0.7665 mL 1.5331 mL 3.8327 mL
20 mM 0.1150 mL 0.5749 mL 1.1498 mL 2.8746 mL
25 mM 0.0920 mL 0.4599 mL 0.9199 mL 2.2996 mL
30 mM 0.0767 mL 0.3833 mL 0.7665 mL 1.9164 mL
40 mM 0.0575 mL 0.2875 mL 0.5749 mL 1.4373 mL
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MrgprX2 antagonist-5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MrgprX2 antagonist-52527815-74-1Mas-related G-protein-coupled Receptor (MRGPR)MrgprX2skinanaphylaxisallergyhypersensitivityInhibitorinhibitorinhibit

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