VP3.15 dihydrobromide

Name: VP3.15 dihydrobromide
Brand: MedChemExpress
SKU: HY-128879A
Rating: 5.0 (2 reviews)

Cat. No.: HY-128879A Purity: 98.01%: Data Sheet
SDS

COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC₅₀s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 dihydrobromide has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS).

For research use only. We do not sell to patients.

VP3.15 dihydrobromide Chemical Structure

CAS No. : 1281681-33-1

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 93	In-stock	Estimated Time of Arrival: April 11
Solution
10 mM * 1 mL in DMSO	USD 98	In-stock	Estimated Time of Arrival: April 11
Solid
5 mg	USD 84	In-stock	Estimated Time of Arrival: April 11
10 mg	USD 137	In-stock	Estimated Time of Arrival: April 11
25 mg	USD 294	In-stock	Estimated Time of Arrival: April 11
50 mg	USD 515	In-stock	Estimated Time of Arrival: April 11
100 mg	USD 893	In-stock	Estimated Time of Arrival: April 11
200 mg		Get quote
500 mg		Get quote

Get it by tomorrow April 11 for select sizes. Order within 7 hrs 29 mins.

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of VP3.15 dihydrobromide:

VP3.15 Get quote

2 Publications Citing Use of MCE VP3.15 dihydrobromide

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms

PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

View All GSK-3 Isoform Specific Products:

View All Isoforms

GSK-3 GSK-3α GSK-3β

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 1.59 μM (PDE7), 0.88 μM (GSK-3)^[1]

Molecular Weight

528.30

Formula

C₂₀H₂₄Br₂N₄OS

CAS No.

1281681-33-1

Appearance

Solid

Color

Light yellow to yellow

SMILES

[H]Br.[H]Br.N1(CC/N=C2N=C(C3=CC=CC=C3)N(C4=CC=CC=C4)S/2)CCOCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (118.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8929 mL	9.4643 mL	18.9286 mL
5 mM	0.3786 mL	1.8929 mL	3.7857 mL
10 mM	0.1893 mL	0.9464 mL	1.8929 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.94 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.94 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (3.94 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Purity & Documentation

Purity: 98.01%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (249 KB)

Handling Instructions (2659 KB)

References

[1]. Medina-Rodríguez EM, et al. Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis. Sci Rep. 2017 Mar 3;7:43545. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8929 mL	9.4643 mL	18.9286 mL	47.3216 mL
	5 mM	0.3786 mL	1.8929 mL	3.7857 mL	9.4643 mL
	10 mM	0.1893 mL	0.9464 mL	1.8929 mL	4.7322 mL
	15 mM	0.1262 mL	0.6310 mL	1.2619 mL	3.1548 mL
	20 mM	0.0946 mL	0.4732 mL	0.9464 mL	2.3661 mL
	25 mM	0.0757 mL	0.3786 mL	0.7571 mL	1.8929 mL
	30 mM	0.0631 mL	0.3155 mL	0.6310 mL	1.5774 mL
	40 mM	0.0473 mL	0.2366 mL	0.4732 mL	1.1830 mL
	50 mM	0.0379 mL	0.1893 mL	0.3786 mL	0.9464 mL
	60 mM	0.0315 mL	0.1577 mL	0.3155 mL	0.7887 mL
	80 mM	0.0237 mL	0.1183 mL	0.2366 mL	0.5915 mL
	100 mM	0.0189 mL	0.0946 mL	0.1893 mL	0.4732 mL