2. MAPK/ERK Pathway NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. JNK p38 MAPK Reactive Oxygen Species
  4. p-Cresyl sulfate

p-Cresyl sulfate  (Synonyms: p-Tolyl sulfate)

Cat. No.: HY-111431 Purity: 99.87%
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Handling Instructions Technical Support

p-Cresyl sulfate (p-Tolyl sulfate) is a uremic toxin, that can cause renal damage and dysfunction. p-Cresyl sulfate shows antiproliferation activity. p-Cresyl sulfate increases the protein expression of HIF-1α and VHL, decreases the protein expression of HIF-2α. p-Cresyl sulfate induces epithelial-mesenchymal transition (EMT). p-Cresyl sulfate activates the JNK and p38 MAPK signaling pathways.

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p-Cresyl sulfate Chemical Structure

p-Cresyl sulfate Chemical Structure

CAS No. : 3233-58-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
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10 mg In-stock
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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of p-Cresyl sulfate:

p-Cresyl sulfate Related Antibodies

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JNK1 JNK2 JNK3 JNK

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

p-Cresyl sulfate (p-Tolyl sulfate) is a uremic toxin, that can cause renal damage and dysfunction. p-Cresyl sulfate shows antiproliferation activity. p-Cresyl sulfate increases the protein expression of HIF-1α and VHL, decreases the protein expression of HIF-2α. p-Cresyl sulfate induces epithelial-mesenchymal transition (EMT). p-Cresyl sulfate activates the JNK and p38 MAPK signaling pathways[1][2][3].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

p-Cresyl sulfate (0-500 μM; 0-48 h) shows antiproliferation activity in a dose- and time-dependent manner[1].
p-Cresyl sulfate (100, 200 μM; 1, 3, 5 days) increases the protein expression of HIF-1α and VHL, decreases the protein expression of HIF-2α[1].
p-Cresyl sulfate (40 µg/mL) inhibits lipogenesis and increases lipolysis in adipocytes in 3T3-L1 cells[2].
p-Cresyl sulfate (0.125 mM, 24 h) induces osteoblast dysfunction through activating JNK and p38 MAPK pathways[3].
p-Cresyl sulfate (0-0.5 mM; 60 min) induces ROS production in primary osteoblastic cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

p-Cresyl sulfate Related Antibodies

Cell Proliferation Assay[1]

Cell Line: 786-O, A498 cells
Concentration: 20, 50, 100, 200, 500 μM
Incubation Time: 0-48 h
Result: Inhibited cell proliferation in a dose- and time-dependent manner.

Western Blot Analysis[1]

Cell Line: 786-O, A498 cells
Concentration: 100, 200 μM
Incubation Time: 1, 3, 5 days
Result: Increased the protein expression of HIF-1α and VHL, decreased the protein expression of HIF-2α.

Western Blot Analysis[3]

Cell Line: Primary osteoblastic cells
Concentration: 0.125 mM
Incubation Time: 24 h
Result: Induced rapid and sustained phosphorylation of JNK.
In Vivo

p-Cresyl sulfate (10 mg/kg; IP; twice daily for 4 weeks) exhibits hyperglycemia and hypercholesterolemia[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD1 Swiss mice[2]
Dosage: 10 mg/kg
Administration: IP; twice daily for 4 weeks
Result: Increased the fasting plasma glucose concentration, plasma cholesterol levels were increased by >50% compared with vehicle mice, Induced insulin resistance.
Molecular Weight

188.20

Formula

C7H8O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(OC1=CC=C(C)C=C1)(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1328.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 100 mg/mL (531.35 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3135 mL 26.5675 mL 53.1350 mL
5 mM 1.0627 mL 5.3135 mL 10.6270 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (11.05 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (11.05 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.87%

SDS (252 KB)

COA (249 KB) HNMR (232 KB) LCMS (86 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 5.3135 mL 26.5675 mL 53.1350 mL 132.8374 mL
5 mM 1.0627 mL 5.3135 mL 10.6270 mL 26.5675 mL
10 mM 0.5313 mL 2.6567 mL 5.3135 mL 13.2837 mL
15 mM 0.3542 mL 1.7712 mL 3.5423 mL 8.8558 mL
20 mM 0.2657 mL 1.3284 mL 2.6567 mL 6.6419 mL
25 mM 0.2125 mL 1.0627 mL 2.1254 mL 5.3135 mL
30 mM 0.1771 mL 0.8856 mL 1.7712 mL 4.4279 mL
40 mM 0.1328 mL 0.6642 mL 1.3284 mL 3.3209 mL
50 mM 0.1063 mL 0.5313 mL 1.0627 mL 2.6567 mL
60 mM 0.0886 mL 0.4428 mL 0.8856 mL 2.2140 mL
80 mM 0.0664 mL 0.3321 mL 0.6642 mL 1.6605 mL
100 mM 0.0531 mL 0.2657 mL 0.5313 mL 1.3284 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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p-Cresyl sulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p-Cresyl3233-58-7p-TolylJNKp38 MAPKReactive Oxygen Speciesc-Jun N-terminal kinaseepithelial-mesenchymal transition (EMT)786-OA498 cells3T3-L1 cellshyperglycemiahypercholesterolemiaInhibitorinhibitorinhibit

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