p-Cresyl sulfate potassium (Synonyms: p-Tolyl sulfate potassium)

Name: p-Cresyl sulfate potassium
Brand: MedChemExpress
SKU: HY-111431A
Rating: 5.0 (4 reviews)

Cat. No.: HY-111431A Purity: 99.92%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

p-Cresyl sulfate potassium is a uremic toxin that binds to a prototype protein. p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways. p-Cresyl sulfate potassium has pro-inflammatory activity.

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p-Cresyl sulfate potassium Chemical Structure

CAS No. : 91978-69-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 66	In-stock	Estimated Time of Arrival: December 31
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10 mM * 1 mL in DMSO	USD 66	In-stock	Estimated Time of Arrival: December 31
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50 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of p-Cresyl sulfate potassium:

4 Publications Citing Use of MCE p-Cresyl sulfate potassium

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

In Vitro

p-Cresyl sulfate potassium (0.125 mM, 24 h) induces osteoblast dysfunction by activating JNK and p38 MAPK pathways^[1].
p-Cresyl sulfate potassium (40 μg/mL, 30 min) inhibits adipogenesis and increases lipolysis of adipocytes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Primary osteoblastic cells
Concentration:	0.05, 0.125, 0.25, 0.5 mM
Incubation Time:	24 h
Result:	Decreased cell viability in a dose-dependent manner.

Cell Proliferation Assay^[1]

Cell Line:	Primary osteoblastic cells
Concentration:	0.05, 0.125, 0.25, 0.5 mM
Incubation Time:	24 h
Result:	Increased DNA fragmentation and decreased cell proliferation.

Western Blot Analysis^[1]

Cell Line:	Primary osteoblastic cells
Concentration:	0.125 mM
Incubation Time:	24 h
Result:	Induced rapid and sustained phosphorylation of JNK.

In Vivo

p-Cresyl sulfate potassium (10 mg/kg intraperitoneal injection twice daily for 4 weeks) promotes insulin resistance associated with CKD in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CKD mice modrl^[2]
Dosage:	10 mg/kg
Administration:	i.p.
Result:	Increased fasting plasma glucose concentration and plasma cholesterol levels.

Molecular Weight

226.29

Formula

C₇H₇KO₄S

CAS No.

91978-69-7

Appearance

Solid

Color

White to off-white

SMILES

O=S(OC1=CC=C(C)C=C1)(O[K])=O

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (552.39 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 100 mg/mL (441.91 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4191 mL	22.0955 mL	44.1911 mL
5 mM	0.8838 mL	4.4191 mL	8.8382 mL
10 mM	0.4419 mL	2.2096 mL	4.4191 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (11.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (11.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (11.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (220.96 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (279 KB) SDS (394 KB)

COA (249 KB) HNMR (239 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Tanaka H, et al, Fukagawa M. p-Cresyl sulfate induces osteoblast dysfunction through activating JNK and p38 MAPK pathways. Bone. 2013 Oct;56(2):347-54. [Content Brief]

[2]. Koppe L, et al. p-Cresyl sulfate promotes insulin resistance associated with CKD. J Am Soc Nephrol. 2013 Jan;24(1):88-99. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	4.4191 mL	22.0955 mL	44.1911 mL	110.4777 mL
	5 mM	0.8838 mL	4.4191 mL	8.8382 mL	22.0955 mL
	10 mM	0.4419 mL	2.2096 mL	4.4191 mL	11.0478 mL
	15 mM	0.2946 mL	1.4730 mL	2.9461 mL	7.3652 mL
	20 mM	0.2210 mL	1.1048 mL	2.2096 mL	5.5239 mL
	25 mM	0.1768 mL	0.8838 mL	1.7676 mL	4.4191 mL
	30 mM	0.1473 mL	0.7365 mL	1.4730 mL	3.6826 mL
	40 mM	0.1105 mL	0.5524 mL	1.1048 mL	2.7619 mL
	50 mM	0.0884 mL	0.4419 mL	0.8838 mL	2.2096 mL
	60 mM	0.0737 mL	0.3683 mL	0.7365 mL	1.8413 mL
	80 mM	0.0552 mL	0.2762 mL	0.5524 mL	1.3810 mL
	100 mM	0.0442 mL	0.2210 mL	0.4419 mL	1.1048 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

p-Cresyl sulfate potassium Related Classifications

Metabolic Disease Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p-Cresyl sulfate91978-69-7p-Tolyl sulfateEndogenous MetaboliteJNKp38 MAPKc-Jun N-terminal kinasePrimary osteoblastic cellsCKDUremic toxinInhibitorinhibitorinhibit

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p-Cresyl sulfate potassium (Synonyms: p-Tolyl sulfate potassium)

Customer Review

Other Forms of p-Cresyl sulfate potassium:

p-Cresyl sulfate potassium Related Antibodies

4 Publications Citing Use of MCE p-Cresyl sulfate potassium

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All JNK Isoform Specific Products:

View All p38 MAPK Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

p-Cresyl sulfate potassium Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

p-Cresyl sulfate potassium Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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