2. Metabolic Enzyme/Protease Others
  3. Endogenous Metabolite Drug Intermediate
  4. Phenylglyoxylic acid

Phenylglyoxylic acid  (Synonyms: Benzoylformic acid)

Cat. No.: HY-W010255 Purity: 99.66%
Data Sheet
SDS
COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human. Phenylglyoxylic acid can be used as drug intermediate for synthesis of antineoplastic compounds.

For research use only. We do not sell to patients.

Phenylglyoxylic acid Chemical Structure

Phenylglyoxylic acid Chemical Structure

CAS No. : 611-73-4

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Based on 1 publication(s) in Google Scholar

Other Forms of Phenylglyoxylic acid:

Phenylglyoxylic acid Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human. Phenylglyoxylic acid can be used as drug intermediate for synthesis of antineoplastic compounds[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

Phenylglyoxylic acid (50-200 mg/kg, po, 3 doses) exhibits anti-inflammatory activity in rats formalin-induced paw swelling model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Formalin-induced paw swelling in rats model[3]
Dosage: 50-200 mg/kg
Administration: po, 3 doses, 48 h, 24 h and 30 min before formalin administration
Result: Reduced the degree of hind paw swelling in rats.
Molecular Weight

150.13

Formula

C8H6O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O)C(C1=CC=CC=C1)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (333.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.6608 mL 33.3038 mL 66.6076 mL
5 mM 1.3322 mL 6.6608 mL 13.3215 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (16.65 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (16.65 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.66%

Data Sheet (292 KB) SDS (392 KB)

COA (248 KB) RP-HPLC (89 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.6608 mL 33.3038 mL 66.6076 mL 166.5190 mL
5 mM 1.3322 mL 6.6608 mL 13.3215 mL 33.3038 mL
10 mM 0.6661 mL 3.3304 mL 6.6608 mL 16.6519 mL
15 mM 0.4441 mL 2.2203 mL 4.4405 mL 11.1013 mL
20 mM 0.3330 mL 1.6652 mL 3.3304 mL 8.3260 mL
25 mM 0.2664 mL 1.3322 mL 2.6643 mL 6.6608 mL
30 mM 0.2220 mL 1.1101 mL 2.2203 mL 5.5506 mL
40 mM 0.1665 mL 0.8326 mL 1.6652 mL 4.1630 mL
50 mM 0.1332 mL 0.6661 mL 1.3322 mL 3.3304 mL
60 mM 0.1110 mL 0.5551 mL 1.1101 mL 2.7753 mL
80 mM 0.0833 mL 0.4163 mL 0.8326 mL 2.0815 mL
100 mM 0.0666 mL 0.3330 mL 0.6661 mL 1.6652 mL
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Phenylglyoxylic acid Related Classifications

Keywords:

Phenylglyoxylic acid611-73-4Benzoylformic acidEndogenous MetaboliteDrug IntermediateDrug Iintermediateorally activeInhibitorinhibitorinhibit

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