2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Pipecuronium bromide

Pipecuronium bromide is a potent long-acting nondepolarizing steroidal neuromuscular blocking agent (NMBA), and a bisquaternary ammonium compound. Pipecuronium bromide is a powerful competitive nAChR antagonist with a Kd of 3.06 μM.

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Pipecuronium bromide Chemical Structure

Pipecuronium bromide Chemical Structure

CAS No. : 52212-02-9

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Based on 1 publication(s) in Google Scholar

Pipecuronium bromide Related Antibodies

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  • Purity & Documentation

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Description

Pipecuronium bromide is a potent long-acting nondepolarizing steroidal neuromuscular blocking agent (NMBA), and a bisquaternary ammonium compound. Pipecuronium bromide is a powerful competitive nAChR antagonist with a Kd of 3.06 μM[1][2][3][4][5].

IC50 & Target

nAChR[4][5]
In Vitro

Sugammadex has a high affinity for Pipecuronium bromide. As Pipecuronium bromide is about 6 to 7 times more potent than Rocuronium, fewer molecules are required to achieve a comparative blockade than in the case of Rocuronium[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pipecuronium bromide Related Antibodies
In Vivo

The average ED95 is 0.045mg/kg (0.035-0.059 mg/kg) of Pipecuronium bromide, the onset of action varies between 2 and 6.3 minutes, depending on the dose and the background anesthesia. Pipecuronium bromide does not liberate histamine, it has no cardiovascular side effects even in doses of 3× ED95, and anaphylaxis does not appear to be a problem[2].
Carboxymethylated γ-cyclodextrin shows efficient and complete reversal of the Pipecuronium bromide induced neuromuscular block in an ex vivo rat diaphragm experiment[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

762.70

Formula

C35H62Br2N4O4
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

C[C@@]1([C@H]2OC(C)=O)[C@](C[C@@H]2N3CC[N+](C)(C)CC3)([H])[C@@](CC[C@]4([H])[C@@]5(C[C@H](N6CC[N+](C)(C)CC6)[C@@H](OC(C)=O)C4)C)([H])[C@]5([H])CC1.[Br-].[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (196.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (131.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3111 mL 6.5557 mL 13.1113 mL
5 mM 0.2622 mL 1.3111 mL 2.6223 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.71%

COA (252 KB) HNMR (311 KB) LCMS (102 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.3111 mL 6.5557 mL 13.1113 mL 32.7783 mL
5 mM 0.2622 mL 1.3111 mL 2.6223 mL 6.5557 mL
10 mM 0.1311 mL 0.6556 mL 1.3111 mL 3.2778 mL
15 mM 0.0874 mL 0.4370 mL 0.8741 mL 2.1852 mL
20 mM 0.0656 mL 0.3278 mL 0.6556 mL 1.6389 mL
25 mM 0.0524 mL 0.2622 mL 0.5245 mL 1.3111 mL
30 mM 0.0437 mL 0.2185 mL 0.4370 mL 1.0926 mL
40 mM 0.0328 mL 0.1639 mL 0.3278 mL 0.8195 mL
50 mM 0.0262 mL 0.1311 mL 0.2622 mL 0.6556 mL
60 mM 0.0219 mL 0.1093 mL 0.2185 mL 0.5463 mL
80 mM 0.0164 mL 0.0819 mL 0.1639 mL 0.4097 mL
100 mM 0.0131 mL 0.0656 mL 0.1311 mL 0.3278 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Pipecuronium bromide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pipecuronium52212-02-9nAChRNicotinic acetylcholine receptorsLong-actingsteroidalneuromuscularblockingagentsafetynondepolarizingInhibitorinhibitorinhibit

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