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2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) 5-HT Receptor (2) Adrenergic Receptor (1) Antibiotic (1) Apoptosis (5) Autophagy (5) Cannabinoid Receptor (1) CFTR (1) CGRP Receptor (1) COX (2) Cytochrome P450 (1) Dengue virus (1) DNA/RNA Synthesis (2) Endogenous Metabolite (2) Enterovirus (1) Eukaryotic Initiation Factor (eIF) (1) Flavivirus (1) Galectin (1) Glucocorticoid Receptor (1) Glucokinase (1) HBV (1) Histamine Receptor (2) HIV (2) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (3) Ligands for E3 Ligase (2) mAChR (1) Molecular Glues (2) Monoamine Oxidase (1) Monoamine Transporter (1) Myosin (1) Nucleoside Antimetabolite/Analog (1) Opioid Receptor (3) P2X Receptor (1) Parasite (2) PDK-1 (1) Phosphodiesterase (PDE) (2) Platelet-activating Factor Receptor (PAFR) (1) PPAR (1) Proteasome (1) Reactive Oxygen Species (1) Reverse Transcriptase (1) SARS-CoV (2) Sodium Channel (1) TNF Receptor (1) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (10) Cardiovascular Disease (2) Endocrinology (2) Infection (6) Inflammation/Immunology (12) Metabolic Disease (11) Neurological Disease (15)

By Targets:

11β-HSD (1)

5-HT Receptor (2)

Adrenergic Receptor (1)

Antibiotic (1)

Apoptosis (5)

Autophagy (5)

Cannabinoid Receptor (1)

CFTR (1)

CGRP Receptor (1)

COX (2)

Cytochrome P450 (1)

Dengue virus (1)

DNA/RNA Synthesis (2)

Endogenous Metabolite (2)

Enterovirus (1)

Eukaryotic Initiation Factor (eIF) (1)

Flavivirus (1)

Galectin (1)

Glucocorticoid Receptor (1)

Glucokinase (1)

HBV (1)

Histamine Receptor (2)

HIV (2)

Isocitrate Dehydrogenase (IDH) (1)

Isotope-Labeled Compounds (3)

Ligands for E3 Ligase (2)

mAChR (1)

Molecular Glues (2)

Monoamine Oxidase (1)

Monoamine Transporter (1)

Myosin (1)

Nucleoside Antimetabolite/Analog (1)

Opioid Receptor (3)

P2X Receptor (1)

Parasite (2)

PDK-1 (1)

Phosphodiesterase (PDE) (2)

Platelet-activating Factor Receptor (PAFR) (1)

PPAR (1)

Proteasome (1)

Reactive Oxygen Species (1)

Reverse Transcriptase (1)

SARS-CoV (2)

Sodium Channel (1)

TNF Receptor (1)

Toll-like Receptor (TLR) (2)

By Research Areas:

Cancer (10)

Cardiovascular Disease (2)

Endocrinology (2)

Infection (6)

Inflammation/Immunology (12)

Metabolic Disease (11)

Neurological Disease (15)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-I0636

(R)-Apremilast (R)-CC-10004	Others	Inflammation/Immunology
(R)-Apremilast ((R)-CC-10004) is a enantiomer of Apremilast .

HY-109022A

(3R,5R,6S)-Atogepant (3R,5R,6S)-MK-8031; (3R,5R,6S)-AGN-241689	CGRP Receptor	Neurological Disease
(3R,5R,6S)-Atogepant ((3R,5R,6S)-MK-8031) is the enantiomer of Atogepant (HY-109022). Atogepant is a calcitonin gene-related peptide receptor (CGRP) antagonist. Atogepant can be used for researching migraine.

HY-128888A

(S,S)-GSK321	Isocitrate Dehydrogenase (IDH)	Cancer
(S,S)-GSK321 is a (S,S)-enantiomer of GSK321 .

HY-121161B

(2S,3R)-Brassinazole	Others	Metabolic Disease
(2S,3R)-Brassinazole, the enantiomer of Brassinazole (BRZ). Brassinazole inhibits brassinosteroid (BR) biosynthesis, via acting on the oxidative processes from 6-oxo-campestanol to teasterone. (2S,3R)-Brassinazole might be the most active form of Brz .

HY-121161C

(2R,3S)-Brassinazole	Others	Metabolic Disease
Brassinazole (0.5, 1, 5 μM) causes markedly deformed seedlings, whose morphology is similar to that of BR-deficient mutants. Brassinazole causes cress dwarfism, altering leaf morphology such as the typical downward curl and dark green appearance of Arabidopsis BR-deficient mutants. However, administration of 10 nM BR reversed dwarfism .

HY-155079A

(R)-DZD1516	Others	Others
(R)-DZD1516 is the R enantiomer of DZD1516 (HY-155079). DZD1516 is a potent and selective HER2 inhibitor .

HY-116974

ent-Thiamphenicol ent-Thiophenicol; ent-Dextrosulphenidol	Antibiotic	Others
ent-Thiamphenicol (ent-Dextrosulphenidol) is a enantiomer of Thiamphenicol (HY-B0479). Thiamphenicol, a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria) .

HY-18621B

(S)-OTS514	Others	Others
(S)-OTS514 is the S enantiomer of OTS514 (HY-18621). OTS514 is a highly potent TOPK inhibitor with an IC₅₀ of 2.6 nM. OTS514 strongly suppresses the growth of TOPK-positive cancer cells . OTS514 induces cell cycle arrest and apoptosis .

HY-124300A

(S)-JNJ-54166060	P2X Receptor	Neurological Disease
(S)-JNJ-54166060 is an enantiomer of JNJ 54166060. JNJ 54166060 is a potent P2X7 antagonist .

HY-141551B

(R)-GNE-274	Others	Others
(R)-GNE-274 is a enantiomer of GNE-274. GNE-274 is a non-degrader that is structurally related to GDC-0927 (estrogen receptor degrader) .

HY-W420033

(S)-(+)-Etomoxir	Others	Others
(S)-(+)-Etomoxir is the S enantiomer of Etomoxir (HY-50202). Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig .

HY-157294A

(R)-GSK866	Glucocorticoid Receptor	Cancer
(R)-GSK866 is the (R)-enantiomer of GSK866 (HY-157294). GSK866 is a selective agonist for glucocorticoid receptor with an IC₅₀ of 4.6 nM .

HY-147041A

(2S)-Selvigaltin (2S)-GB1211	Galectin	Cancer
(2S)-Selvigaltin is the S-enantiomer of Selvigaltin (HY-147041). Selvigaltin is an orally active galectin-3 (Gal-3) inhibitor .

HY-N0424

Cyclogalegenin Cyclogalegigenin	Others	Others
Cyclogalegenin (Cyclogalegigenin) is a isoprenoid that can be isolated from Astragalus galegiformis. Cyclogalegenin is the enantiomer of Cycloastragenol .

HY-12085S2

(Rac)-Apremilast-d5 (Rac)-CC-10004 d₅	Apoptosis Phosphodiesterase (PDE) TNF Receptor Isotope-Labeled Compounds	Inflammation/Immunology
(Rac)-Apremilast-d₅ is a deuterium labeled (R)-Apremilast. (R)-Apremilast ((R)-CC-10004) is a enantiomer of Apremilast[1].

HY-B1370A

(S)-Hydroxychloroquine (S)-HCQ	Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy	Infection
(S)-Hydroxychloroquine ((S)-HCQ) is the enantiomer of Hydroxychloroquine . Hydroxychloroquine, a synthetic antimalarial agent, inhibits Toll-like receptor 7/9 (TLR7/9) signaling, and shows efficiently inhibits SARS-CoV-2 infection in vitro .

HY-B1370B

(R)-Hydroxychloroquine (R)-HCQ	Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy	Infection
(R)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine . Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro .

HY-W012874

D-Threonine H-D-Thr-OH	Endogenous Metabolite	Metabolic Disease
D-Threonine (H-D-Thr-OH) is an enantiomer of L-threonine. D-Threonine is a metabolite of Saccharomyces cerevisiae.

HY-A0295

(R)-Propranolol hydrochloride	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Endocrinology
(R)-Propranolol hydrochloride is a less active enantiomer of the β-adrenoceptor antagonist propranolol (HY-B0573). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β₁AR and β₂AR with K_i values of 1.8 nM and 0.8 nM, respectively .

HY-N2267

(+)-Schisandrin B	Reactive Oxygen Species	Inflammation/Immunology
(+)-Schisandrin B is an enantiomer of Schisandrin B. Schisandrin B is an active dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis, has antioxidant effect on rodent liver and heart .

HY-22385B

(S)-Salsolidine	Monoamine Oxidase Endogenous Metabolite	Neurological Disease
(S)-Salsolidine is a weak monoamine oxidase (MAO) inhibitor (K_i=63 μM). The R enantiomer of Salsolidine is more potent than the S form (K_i=26 μM) .

HY-N11965

4'-Methoxyisoagarotetrol	Phosphodiesterase (PDE)	Inflammation/Immunology
4'-Methoxyisoagarotetrol is chromone derivative and shows moderate PDE?3A inhibitory activity (IC₅₀=54 μM) .

HY-W010042S3

L-Glucose-13C6 L-(-)-Glucose-¹³C₆	Isotope-Labeled Compounds	Metabolic Disease
L-Glucose- ¹³C₆ (L-(-)-Glucose- ¹³C₆) is C13-labeled L-Glucose. L-Glucose is an enantiomer of D-glucose. L-Glucose enhances food intake .

HY-107657

(+)-Blebbistatin 1 Publications Verification	Myosin	Others
(+)-Blebbistatin is the inactive enantiomer of (–)-Blebbistatin. (–)-Blebbistatin is a selective inhibitor of myosin II ATPase .

HY-15997A

(+)-U-50488 hydrochloride (+)-Trans-(1R,2R)-U-50488 hydrochloride	Opioid Receptor	Neurological Disease
(+)-U-50488 (hydrochloride) (+)-Trans-(1R,2R)-U-50488 hydrochloride) is a less active κ opioid receptor (KOR) agonist than the enantiomer of (-)-Trans-(1S,2S)-U-50488 (HY-15997) .

HY-119813

(S,S)-Sinogliatin (S,S)-HMS-5552; (S,S)-RO-5305552	Glucokinase	Metabolic Disease
(S,S)-Sinogliatin ((S,S)-HMS-5552) is the (S,S) -enantiomer of Sinogliatin. Sinogliatin is a glucokinase activator that can be used to study type 2 diabetes .

HY-135396

(1S,2S)-Bortezomib	Proteasome Apoptosis	Cancer
(1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a cell-permeable, reversible, and selective proteasome inhibitor, and potently inhibits 20S proteasome (K_i of 0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is an anti-cancer agent and the first therapeutic proteasome inhibitor to be used in humans .

HY-13856

(R)-PS210	PDK-1	Cancer
(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC₅₀ value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of PDK1. PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment .

HY-108908A

Modipafant UK-80067	Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
Modipafant (UK-80067), the (+)-enantiomer of UK-74505, is a potent, orally active, and selective platelet-activating factor (PAF) antagonist. Modipafant exhibits approximately double the intrinsic potency of UK-74505 .

HY-101930B

(R)-BMS-816336	11β-HSD	Metabolic Disease
(R)-BMS-816336 (Compound 6n-1) is a potent and orally active inhibitor of human, mouse and cynomolgus monkey 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC₅₀s of 14.5 nM, 50.3 nM and 16 nM, respectively .

HY-136453A

CR-1-30-B	Others	Cancer
CR-1-30-B is an inactive enantiomer of CR-1-31-B. CR-1-30-B, as a control, is inactive against eIF4A and has no apparent effect on the induction of MUC1-C translation .

HY-106993B

Cipralisant (enantiomer) GT-2331 (enantiomer)	Histamine Receptor	Neurological Disease
Cipralisant (GT-2331) enantiomer is the enantiomer of Cipralisant (HY-106993), Cipralisant is an orally active, potent, selective, and high affinity histamine H₃ receptor antagonist (rat K_i=0.47 nM) . Cipralisant (enantiomer) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-126082

(+)-Carbovir triphosphate	HIV Reverse Transcriptase	Infection
(+)-Carbovir triphosphate is an enantiomer of Carbovir triphosphate (HY-131607). (+)-Carbovir triphosphate is an inhibitor and substrate of HIV reverse transcriptase .

HY-160932

RS-15385-198	Others	Endocrinology
RS-15385-198 is the enantiomer of Delequamine (RS-15385-197) (HY-106874). RS-15385-198 exhibits a pK_i of 6.32 for α₂-adrenoceptors in the rat cortex. RS-15385-198 is an antagonist for UK-14304 (HY-B0659) in the rat vas deferens and in the guinea-pig ileum .

HY-101125B

D-Moses D-45	Others	Cancer
D-Moses (D-45) is an enantiomer of L-Moses (HY-101125). L-Moses (L-45) is a potent and selective p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor. D-Moses shows no observable binding for PCAF Brd. D-Moses can be used as an inactive control compound to L-Moses .

HY-14658B

(R)-Thalidomide (R)-(+)-Thalidomide	Molecular Glues Ligands for E3 Ligase Autophagy Apoptosis	Metabolic Disease
(R)-Thalidomide ((R)-(+)-Thalidomide) is the R-enantiomer of Thalidomide. (R)-Thalidomide has psychomotor stabilizing properties .

HY-B0352BS

(R)-Mirtazapine-d3 (R)-Org3770 d₃; (R)-6-Azamianserin d₃	Isotope-Labeled Compounds 5-HT Receptor	Neurological Disease
(R)-Mirtazapine-d₃ is a deuterium labeled (R)-Mirtazapine. (R)-Mirtazapine is a R(−)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a 5-HT3 receptor antagonist. (R)-Mirtazapine is mainly metabolized by CYP3A4[1].

HY-43913

(R)-eIF4A3-IN-2	Eukaryotic Initiation Factor (eIF)	Others
(R)-eIF4A3-IN-2 is a less active enantiomer of eIF4A3-IN-2. eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC₅₀ of 110 nM .

HY-147180

Dansyl-DL-valine cyclohexylammonium	Others	Others
Dansyl-DL-valine cyclohexylammonium is a salt form of Dansyl-DL-valine. Dansyl-DL-valine cyclohexylammonium can be used as analyte in chromatographic separation and separation column for the separation of enantiomers and diastereomers for dansyl amino acids, aromatic carboxylic acids, and isoxazolines .

HY-148151

(-)-5′-Noraristeromycin	HBV	Cancer
(-)-5′-Noraristeromycin is an antiviral agent. (-)-5′-Noraristeromycin also is an enantiomer of 5'-noraristeromycin and can inhibit intracellular HBV replication and virion production. (-)-5′-Noraristeromycin can be used for the research of cancer .

HY-W751734

HU 433	Cannabinoid Receptor	Others Neurological Disease Inflammation/Immunology
HU 433 is a synthetic cannabinoid CB2 receptor agonist and is the enantiomer of HU 308 (HY-161510). HU 433 exerts its anti-inflammatory and neuroprotective effects by binding to CB2 receptors. HU 433 can be used in the study of neuroinflammation and retinal diseases .

HY-B0590D

(-)-Tetrabenazine (-)-TBZ; (3S,11bS)-TBZ; (3S,11bS)-Tetrabenazine	Monoamine Transporter	Neurological Disease
(-)-Tetrabenazine ((-)-TBZ; compound 13) is an enantiomer of Tetrabenazine (HY-B0590). (+)-Tetrabenazine proves 3-fold more active than (-)-Tetrabenazine in inhibiting vesicular monoamine transporter 2 (VMAT2) .

HY-139386

15β-Travoprost 15(S)-Flu-Ipr	Others	Others
15β-Travoprost (15(S)-Flu-Ipr) is an enantiomer of Travoprost (HY-B0584). Travoprost, an isopropyl ester proagent, is a high affinity, selective FP prostaglandin full receptor agonist .

HY-15997B

(±)-U-50488 hydrochloride (±)-Trans-(1R,2R)-U-50488 hydrochloride	Opioid Receptor	Neurological Disease
(±)-U-50488 ((±)-Trans-(1R,2R)-U-50488) hydrochloride is a selective κ opioid receptor (KOR) agonist .

HY-15997C

(±)-U-50488 hydrate hydrochloride (±)-Trans-(1R,2R)-U-50488 hydrate hydrochloride	Opioid Receptor	Neurological Disease
(±)-U-50488 ((±)-Trans-(1R,2R)-U-50488) hydrate hydrochloride is a selective κ opioid receptor (KOR) agonist .

HY-B0352AS

(S)-Mirtazapine-d3 (S)-Org3770 d₃; (S)-6-Azamianserin d₃	5-HT Receptor	Neurological Disease
(S)-Mirtazapine-d₃ is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception.(S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2[1].

HY-100540B

Golgicide A-2 GCA-2	Flavivirus Dengue virus Enterovirus	Infection
Golgicide A-2 (GCA-2), a Golgicide A (GCA) derivative, is the most active enantiomer of GCA. Golgicide A-2 displays high selectivity and efficiency in killing An. stephensi larvae and can be used for the research of dengue virus related diseases .

HY-107647

(S)-(+)-Dimethindene maleate	mAChR Histamine Receptor	Inflammation/Immunology
(S)-(+)-Dimethindene maleate, an enantiomer, is a potent M₂-selective muscarinic receptor antagonist (pA₂ = 7.86/7.74; pK_i = 7.78). (S)-(+)-Dimethindene maleate shows lower affinities for the muscarinic M₁ (pA₂ = 6.83/6.36; pK_i = 7.08), the M₃ (pA₂ = 6.92/6.96; pK_i = 6.70) and the M₄ receptors (pK_i = 7.00), respectively. (S)-(+)-Dimethindene maleate also is a histamine H₁ receptor antagonist (pA₂ = 7.48) .

HY-N12360A

2,3-Dehydrosilybin B	Others	Others
2,3-Dehydrosilybin B is an enantiomer formed by the oxidation of the natural flavonolignans silybin A .

HY-14658A

(S)-Thalidomide (S)-(-)-Thalidomide	Molecular Glues Ligands for E3 Ligase Autophagy Apoptosis	Metabolic Disease Inflammation/Immunology
(S)-Thalidomide ((S)-(-)-Thalidomide) is the S-enantiomer of Thalidomide. (S)-Thalidomide has immunomodulatory, anti-inflammatory, antiangiogenic and pro-apoptotic effects . (S)-Thalidomide induces teratogenic effects by binding to cereblon (CRBN) .

Cat. No.	Product Name	Category	Target	Chemical Structure