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Results for "

5-LOX Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Lipoxygenase (46) LOX-1 (3) Apoptosis (4) Autophagy (2) Bacterial (2) Beta-secretase (1) Carbonic Anhydrase (1) Caspase (2) Cholinesterase (ChE) (2) COX (21) Epoxide Hydrolase (3) Ferroptosis (2) FLAP (4) Leukotriene Receptor (7) Monoamine Oxidase (4) NF-κB (2) NO Synthase (1) Notch (2) PGE synthase (3) Phospholipase (1) Reactive Oxygen Species (2)
By Research Areas:	Cancer (17) Cardiovascular Disease (2) Inflammation/Immunology (41) Metabolic Disease (3) Neurological Disease (11)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: LOX-1 Lipoxygenase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138939

5-LOX-IN-2	Lipoxygenase	Cancer
5-LOX-IN-2, an inhibitor of 5-lipoxygenase (5-LOX) with an IC₅₀ of 0.33 μM, inhibits 5-LOX in a dose-dependent manner . 5-LOX-IN-2, reduces the cell viability of renal cancer cells and induces apoptosis, can be used for cancer research .

HY-117048

PF-4191834 PF-04191834	Lipoxygenase	Inflammation/Immunology
PF-4191834 (PF-04191834) is an orally active, noniron chelating, and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) (IC₅₀=229 nM), displays ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX, shows no activity toward the cyclooxygenase enzymes, and is effective in inflammation and pain .

HY-148134

5-LOX-IN-1	Lipoxygenase	Inflammation/Immunology
5-LOX-IN-1 (compound 2b) is an inhibitor of human 5-Lipoxygenase *(5-LOX)* with an IC₅₀ value of 2.3 μM. 5-LOX-IN-1 can be used for the research of inflammation .

HY-113807

ZLJ-6	COX Lipoxygenase	Inflammation/Immunology
ZLJ-6 is a dual COX and *5-LOX* inhibitor with oral activity. The IC₅₀ values for COX-1, COX-2 and 5-LOX were 0.73, 0.31 and 0.99 μM, respectively. ZLJ-6 has anti-inflammatory and analgesic activity .

HY-W009671

3-Chloroiminodibenzyl	Lipoxygenase	Cancer
3-Chloroiminodibenzyl (compound 8) is a dual inhibitor of sHE and *5-LOX. 3-Chloroiminodibenzyl inhibits* sHE and 5-LOX with IC₅₀ of 140 μM and 6.5 μM, respectively .

HY-170957

5-LOX/NO-IN-1	Lipoxygenase NO Synthase	Inflammation/Immunology
5-LOX/NO-IN-1 (Compound 7e) is a 5-LOX and NO release inhibitor. 5-LOX/NO-IN-1 shows an IC₅₀ of 2.833 μM for 5-LOX. 5-LOX/NO-IN-1 has anti-inflammatory effects .

HY-155407

ALR-6	FLAP	Inflammation/Immunology
ALR-6 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-6 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM and has no significant effect on direct inhibition of 5-LOX .

HY-149476

5-LOX-IN-5	Lipoxygenase	Neurological Disease
5-LOX-IN-5 (Compound 29) is a 5-LOX inhibitor (IC₅₀: 56 nM). 5-LOX-IN-5 can be used for research of neurodegenerative diseases .

HY-155408

ALR-27	FLAP	Inflammation/Immunology
ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes .

HY-N9115

Plathymenin	Lipoxygenase	Inflammation/Immunology
Plathymenin is a flavonoid that can be isolated from Nepalese propolis. Plathymenin is a potent inhibitor of *5-LOX* .

HY-133215

Zileuton sulfoxide	Lipoxygenase	Inflammation/Immunology
Zileuton sulfoxide is a sulfoxide derivative of Zileuton (HY-14164), a potent and selective inhibitor of lipoxygenase *5-LOX* with anti-asthmatic properties .

HY-173056

Ruthenoleuton	Lipoxygenase	Inflammation/Immunology
Ruthenoleuton is a 5-lipoxygenase (5-LOX) inhibitor with an IC₅₀ of 3.49 μM and a K_i of 0.80 μM. Ruthenoleuton has antioxidant activity and can be used in the research of inflammatory diseases .

HY-158204

CNB-001	Lipoxygenase	Neurological Disease
CNB-001 is a potent 5-lipoxygenase (5-LOX) inhibitor, decreases 5-LOX expression, and increases proteasome activity. CNB-001 also increases eIF2α phosphorylation and HSP90 and ATF4 levels in Alzheimer's disease transgenic mice, and limits the accumulation of soluble Aβ and ubiquitinated aggregated proteins. CNB-001 maintains the expression of synapse-associated proteins and improves memory. CNB-001 can be used for the research of Alzheimer's disease .

HY-N0198

Nordihydroguaiaretic acid 4 Publications Verification NDGA	Lipoxygenase Autophagy Ferroptosis	Neurological Disease Cancer
Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC₅₀=8 μM) and tyrosine kinase inhibitor.

HY-116763

COX-2/5-LOX-IN-4	COX LOX-1
COX-2/5-LOX-IN-4 (Compound 1) is a dual inhibitor that acts on both COX-2 and *5-LOX, with IC₅₀* values of 0.05 μM for COX-2 and 0.003 μM for *5-LOX. By inhibiting* the arachidonic acid metabolism pathway, COX-2/5-LOX-IN-4 reduces the production of prostaglandins and leukotrienes, alleviating inflammatory responses. In a rat ear edema model, intravenous administration (0.01 and 0.1 mg/kg) reduced edema by 41% and 44%, respectively, demonstrating significant anti-inflammatory effects. COX-2/5-LOX-IN-4 shows promise for studying the mechanisms of inflammatory diseases .

HY-155409

ALR-38	Lipoxygenase	Inflammation/Immunology
ALR-38 is a 5-lipoxygenase (5-LOX) inhibitor (IC₅₀: 1.1 μM) with anti-inflammatory activity. ALR-38 effectively reduces ROS levels in neutrophils .

HY-163736

mPGES-1/5-LOX-IN-1	Lipoxygenase PGE synthase	Inflammation/Immunology
mPGES-1/5-LOX-IN-1 (compound 3j) is a potent and orally active mPGES-1 and *5-LOX* dual inhibitor with IC₅₀ values of 0.92, 1.89 µM, respectively. mPGES-1/5-LOX-IN-1 shows anti-inflammatory impact .

HY-146675

COX/5-LOX-IN-1	COX	Inflammation/Immunology
COX/5-LOX-IN-1 (compound 6b) is a potent and dual inhibitor of *COX/5-LOX* with IC₅₀s of 1.07, 0.55, and 0.28 μM for COX-1, COX-2, and 5-LOX enzyme, respectively. COX/5-LOX-IN-1 has the potential for the research of inflammation diseases .

HY-147951

COX-2/5-LOX-IN-3	COX Lipoxygenase	Inflammation/Immunology
COX-2/5-LOX-IN-3 (compound 5b) is a potent and dual *COX-2/5-LOX* inhibitor with IC₅₀ values of 45.73, 5.45 and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. COX-2/5-LOX-IN-3 has the potential for the research of inflammation diseases .

HY-118268

RG 6866	Lipoxygenase	Cardiovascular Disease
RG 6866 is a 5-lipoxygenase (5-LOX) inhibitor with the potential to inhibit coronary artery constriction and negative cardiac inotropic effects in cardiac inflammatory states. When the heart is stimulated by antigens, RG 6866 can block the antigen-induced reduction in coronary flow in the heart.

HY-N0232

Psoralidin 4 Publications Verification	COX Lipoxygenase Notch Reactive Oxygen Species Bacterial	Cancer
Psoralidin is a dual inhibitor of COX-2 and *5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties . Psoralidin significantly downregulates NOTCH1* signaling. Psoralidin also greatly induces ROS generation .

HY-114796

tHGA	Lipoxygenase	Inflammation/Immunology
tHGA is a compound with anti-inflammatory activity and has the activity to inhibit soybean 15-LOX. tHGA showed significant inhibitory effects in experiments on human leukocytes, with an IC₅₀ value of 0.42 μM, which is close to the effect of commonly used standard NDGA. tHGA concentration-dependently inhibits the synthesis of 5-LOX products, especially the cysteine leukotriene LTC(4), with an IC₅₀ value of 1.80 μM. and showed no cytotoxicity. The anti-inflammatory effects of tHGA do not appear to be through redox or metal chelation mechanisms, as the compound was negative in these bioactivity tests. tHGA works through a dual LOX/COX inhibition mechanism and has higher selectivity for 5-LOX and COX-2, with an IC₅₀ value of 0.40 μM .

HY-10439

HPGDS inhibitor 1	PGE synthase	Inflammation/Immunology
HPGDS inhibitor 1 is a potent, selective and orally active Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC₅₀s of 0.6 nM and 32 nM in enzyme and cellular assays, respectively. HPGDS inhibitor 1 does not inhibit human L-PGDS, mPGES, COX-1, COX-2, or 5-LOX .

HY-121585

CAY10698	Lipoxygenase	Inflammation/Immunology
CAY10698 (compound 1) is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC₅₀ of 5.1 μM. CAY10698 is inactive against 5-LOX, 15-LOX-1, 15-LOX-2 and COX-1/2 .

HY-106835

Flobufen VUFB 16066	COX Lipoxygenase	Inflammation/Immunology
Flobufen (VUFB 16066) is a non-steroidal anti-inflammatory agent and cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibitor agent. Flobufen inhibits alloantigen-driven cellular immune responses and stimulates phagocytosis of peritoneal cells. Flobufen can improve immunopathological disorders and has an inhibitory effect on rheumatoid arthritis .

HY-N0198R

Nordihydroguaiaretic acid (Standard)	Lipoxygenase Autophagy Ferroptosis	Neurological Disease Cancer
Nordihydroguaiaretic acid (Standard) is the analytical standard of Nordihydroguaiaretic acid. This product is intended for research and analytical applications. Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC₅₀=8 μM) and tyrosine kinase inhibitor.

HY-162523

hMAO-B-IN-8	Monoamine Oxidase Cholinesterase (ChE) COX Lipoxygenase	Neurological Disease
hMAO-B-IN-8 (Compound 23) is a hMAO-B, eeAChE, COX-2 and *5-LOX* inhibitor, with IC₅₀ values of 0.037 μM, 0.071 μM, 14.3 μM and 0.59 μM, respectively. hMAO-B-IN-8 can be used for the research of Alzheimer's disease .

HY-105024

FPL 62064	Lipoxygenase COX	Inflammation/Immunology
FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC₅₀ values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity .

HY-156329

sEH/FLAP-IN-1	Epoxide Hydrolase FLAP	Inflammation/Immunology
sEH/FLAP-IN-1 (Compound 46A) is a sEH/FLAP inhibitor. sEH/FLAP-IN-1 inhibits 5-LOX product formation in SACM-stimulated PBMCs (EC₅₀: 11 nM). sEH/FLAP-IN-1 inhibit sEH (EC₅₀: 18 nM) and thromboxane production. sEH/FLAP-IN-1 can be used for research of inflammatory diseases .

HY-B1452

Licofelone 1 Publications Verification ML-3000	COX Lipoxygenase Apoptosis	Inflammation/Immunology Cancer
Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC₅₀=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins .

HY-A0060

Malotilate NKK 105	Lipoxygenase	Cancer
Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC₅₀=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes .

HY-146295

COX-2/5-LOX-IN-2	COX	Inflammation/Immunology
COX-2/5-LOX-IN-2 (5b) is a potent and dual inhibitor of *COX-2/5-LOX*. COX-2/5-LOX-IN-2 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-2 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-2 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC₅₀s of 5.40, 0.01 and 1.78 μM, respectively .

HY-146294

COX-2/5-LOX-IN-1	COX	Inflammation/Immunology
COX-2/5-LOX-IN-1 (compound 3a) is a potent and dual inhibitor of *COX-2/5-LOX*. COX-2/5-LOX-IN-1 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-1 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-1 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC₅₀s of 12.13, 0.4 and 4.96 μM, respectively .

HY-118848

A63162	Lipoxygenase Leukotriene Receptor	Inflammation/Immunology
A63162 is a specific 5-lipoxygenase (5-LOX) inhibitor. A63162 inhibits mitogen (PHA)-induced horse mononuclear cell (BMC) proliferation and inhibits Calcimycin (HY-N6687)-induced leukotriene LTB4 synthesis at the same concentration. A63162 can be used in the study of chronic obstructive pulmonary disease, arthritis and inflammatory bowel disease .

HY-N0232R

Psoralidin (Standard)	COX Lipoxygenase Notch Reactive Oxygen Species Bacterial	Cancer
Psoralidin (Standard) is the analytical standard of Psoralidin. This product is intended for research and analytical applications. Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties . Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation .

HY-128171

Diflapolin 1 Publications Verification	FLAP Epoxide Hydrolase	Inflammation/Immunology
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC₅₀s?of? 30 and 170?nM, respectively, and suppressed the activity of isolated sEH (IC₅₀=20?nM) .

HY-N0551

Wedelolactone Maximum Cited Publications 18 Publications Verification	Caspase Lipoxygenase Apoptosis	Inflammation/Immunology Cancer
Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC₅₀ of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-114873

LY256548 LY25684	Phospholipase COX Lipoxygenase Leukotriene Receptor	Inflammation/Immunology
LY256548 (LY25648) is an orally available anti-ischemic and anti-inflammatory compound with central nervous system activity. LY256548 is an inhibitor of phospholipase A2, 5-lipoxygenase (5-LOX), and COX, and inhibits A23187 (HY-N6687)-stimulated leukotriene B4 production. LY256548 inhibits bone damage and paw swelling in the rat Freund's complete adjuvant-induced arthritis (FCA) model .

HY-B1452S1

Licofelone-d6 ML-3000-d₆	Apoptosis Lipoxygenase COX	Cancer
Licofelone-d₆ is the deuterium labeled Licofelone[1]. Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins[2][3][4].

HY-149270

COX-2-IN-31	COX	Inflammation/Immunology
COX-2-IN-31 (compound 7b) is an orally active and dual inhibitor of COX-2 (IC₅₀=60 nM) and *5-LOX* (IC₅₀=1.9 μM). COX-2-IN-31 also inhibits transmembrane hCA IX(K_i=48.9 nM) and hCA XII(K_i=5.8 nM) activity. COX-2-IN-31 exhibits anti-inflammatory and analgesic activity .

HY-111140

YS121	PGE synthase Lipoxygenase	Inflammation/Immunology
YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC₅₀=3.4 μM) and 5-lipoxygenase (5-LOX; IC₅₀=6.5 μM). YS121 dose- dependently reduces PGE2 production with EC₅₀=12 μM in IL-1β-stimulated A549 cells .

HY-N0551R

Wedelolactone (Standard)	Caspase Lipoxygenase Apoptosis	Inflammation/Immunology Cancer
Wedelolactone (Standard) is the analytical standard of Wedelolactone. This product is intended for research and analytical applications. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC50 of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-N2056

11-Keto-beta-boswellic acid 11-Keto-β-boswellic acid	Lipoxygenase Leukotriene Receptor NF-κB	Metabolic Disease Cancer
11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production .

HY-N1942

5-O-Demethylnobiletin 1 Publications Verification 5-Demethylnobiletin	Lipoxygenase Leukotriene Receptor	Neurological Disease Inflammation/Immunology Cancer
5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC₅₀=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB₄) formation in rat neutrophils and elastase release in human neutrophils with an IC₅₀ of 0.35 μM .

HY-125975

1-Naphthyl 3,5-dinitrobenzoate	Lipoxygenase	Inflammation/Immunology
1-Naphthyl 3,5-dinitrobenzoate is a potent 5-lipoxygenase inhibitor with IC₅₀ values of 1.04 µM and 3.6 µM for 5-LOX and mPGES-1, respectively. 1-Naphthyl 3,5-dinitrobenzoate has strong inhibition activity in the human whole blood (HWB) assay with an IC₅₀ value of 8.6 μM. 1-Naphthyl 3,5-dinitrobenzoate can be used in research of inflammation .

HY-111310

ML351 1 Publications Verification	Lipoxygenase	Neurological Disease Metabolic Disease
ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC₅₀ of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2 . ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D .

HY-149269

COX-2-IN-30	COX Carbonic Anhydrase LOX-1	Inflammation/Immunology
COX-2-IN-30 is a benzenesulfonamide derivative, as well as an orally active and dual inhibitor of COX (IC₅₀=49 nM for COX-2, 10.4 μM for COX-1) and *5-LOX* (IC₅₀=2.4 μM). COX-2-IN-30 also inhibits transmembrane hCA IX and hCA XII isoform with nanomolar calss K_i values. COX-2-IN-30 exhibits analgesic, anti-inflammatory, and ulcerogenic activities, and does not show acute gastric effect .

HY-170938

AChE-IN-82	Cholinesterase (ChE) Monoamine Oxidase Beta-secretase COX LOX-1	Neurological Disease
AChE-IN-82 (compound 49) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-82 inhibits eeAChE, eqBChE, hMAO-A, hMAO-B, and BACE-1 with IC₅₀s of 0.072, 9.81, 14.52, 0.024, 2.42 μM, respectively. AChE-IN-82 inhibits COX-1, COX-2 and *5-LOX* with IC₅₀s of 60.41, 0.187, 0.18 μM, respectively. AChE-IN-82 shows an excellent neuroprotective effect by significantly reducing oxidative stress induced by H₂ O₂ .

HY-N2056R

11-Keto-beta-boswellic acid (Standard)	Lipoxygenase Leukotriene Receptor NF-κB	Metabolic Disease Cancer
11-Keto-beta-boswellic acid (Standard) is the analytical standard of 11-?Keto-?beta-?boswellic acid. This product is intended for research and analytical applications. 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production .

HY-N1942R

5-O-Demethylnobiletin (Standard)	Lipoxygenase Leukotriene Receptor	Neurological Disease Inflammation/Immunology Cancer
5-O-Demethylnobiletin (Standard) is the analytical standard of 5-O-Demethylnobiletin. This product is intended for research and analytical applications. 5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC₅₀=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC₅₀ of 0.35 μM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0198

Nordihydroguaiaretic acid 4 Publications Verification NDGA	Structural Classification Neurological Disease Classification of Application Fields Anti-aging Source classification Lignans Plants other families Phenols Polyphenols Phenylpropanoids Disease Research Fields Cancer	Lipoxygenase Autophagy Ferroptosis
Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC₅₀=8 μM) and tyrosine kinase inhibitor.

HY-N0232

Psoralidin 4 Publications Verification	Structural Classification Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Cancer	COX Lipoxygenase Notch Reactive Oxygen Species Bacterial
Psoralidin is a dual inhibitor of COX-2 and *5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties . Psoralidin significantly downregulates NOTCH1* signaling. Psoralidin also greatly induces ROS generation .

HY-N0551

Wedelolactone Maximum Cited Publications 18 Publications Verification	Structural Classification Classification of Application Fields Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae Inflammation/Immunology Disease Research Fields	Caspase Lipoxygenase Apoptosis
Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC₅₀ of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-N2056

11-Keto-beta-boswellic acid 11-Keto-β-boswellic acid	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Boswellia serrata Plants Burseraceae Disease Research Fields Cancer	Lipoxygenase Leukotriene Receptor NF-κB
11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production .

HY-N1942

5-O-Demethylnobiletin 1 Publications Verification 5-Demethylnobiletin	Structural Classification Flavonoids Neurological Disease Classification of Application Fields Flavones Rutaceae Plants Citrus Disease Research Fields Cancer	Lipoxygenase Leukotriene Receptor
5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC₅₀=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB₄) formation in rat neutrophils and elastase release in human neutrophils with an IC₅₀ of 0.35 μM .

HY-N9115

Plathymenin	Saussurea costus (Falc.) Lipsch. Structural Classification Flavonoids Flavones Leguminosae Source classification Plants	Lipoxygenase
Plathymenin is a flavonoid that can be isolated from Nepalese propolis. Plathymenin is a potent inhibitor of *5-LOX* .

HY-N0198R

Nordihydroguaiaretic acid (Standard)	Structural Classification other families Source classification Lignans Phenols Polyphenols Phenylpropanoids Plants	Lipoxygenase Autophagy Ferroptosis
Nordihydroguaiaretic acid (Standard) is the analytical standard of Nordihydroguaiaretic acid. This product is intended for research and analytical applications. Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC₅₀=8 μM) and tyrosine kinase inhibitor.

HY-N0232R

Psoralidin (Standard)	Structural Classification Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants	COX Lipoxygenase Notch Reactive Oxygen Species Bacterial
Psoralidin (Standard) is the analytical standard of Psoralidin. This product is intended for research and analytical applications. Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties . Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation .

HY-N0551R

Wedelolactone (Standard)	Structural Classification Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae	Caspase Lipoxygenase Apoptosis
Wedelolactone (Standard) is the analytical standard of Wedelolactone. This product is intended for research and analytical applications. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC50 of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-N2056R

11-Keto-beta-boswellic acid (Standard)	Triterpenes Structural Classification Terpenoids Source classification Boswellia serrata Plants Burseraceae	Lipoxygenase Leukotriene Receptor NF-κB
11-Keto-beta-boswellic acid (Standard) is the analytical standard of 11-?Keto-?beta-?boswellic acid. This product is intended for research and analytical applications. 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production .

HY-N1942R

5-O-Demethylnobiletin (Standard)	Structural Classification Flavonoids Flavones Rutaceae Plants Citrus	Lipoxygenase Leukotriene Receptor
5-O-Demethylnobiletin (Standard) is the analytical standard of 5-O-Demethylnobiletin. This product is intended for research and analytical applications. 5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC₅₀=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC₅₀ of 0.35 μM .

HY-N0493

Pectolinarigenin 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Campylotropis hirtella (Franch.) Schindl. Source classification Phenols Polyphenols Plants Compositae Inflammation/Immunology Disease Research Fields	COX Lipoxygenase
Pectolinarigenin is a dual inhibitor of *COX-2/5-LOX*. Anti-inflammatory activity . Pectolinarigenin has potent inhibitory activities on melanogenesis .

HY-N8480

Atractylochromene	Structural Classification Natural Products Source classification Plants Compositae Erythrina sigmoidea Hua	Lipoxygenase COX
Atractylochromene is a potent dual inhibitor of *5-LOX/COX-1* with IC₅₀s of 0.6 and 3.3 μM, respectively .

HY-N0493R

Pectolinarigenin (Standard)	Structural Classification Flavonoids Flavones Campylotropis hirtella (Franch.) Schindl. Source classification Phenols Polyphenols Plants Compositae	COX Lipoxygenase
Pectolinarigenin (Standard) is the analytical standard of Pectolinarigenin. This product is intended for research and analytical applications. Pectolinarigenin is a dual inhibitor of COX-2/5-LOX. Anti-inflammatory activity . Pectolinarigenin has potent inhibitory activities on melanogenesis .

Cat. No.	Product Name	Chemical Structure

HY-B1452S1

Licofelone-d6
Licofelone-d₆ is the deuterium labeled Licofelone[1]. Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins[2][3][4].

Cat. No.	Product Name		Classification

HY-159169

5-LOX/sEH-IN-1		Azide
5-LOX/sEH-IN-1 (Compound 8o) is a dual *5-LOX/sEH-IN-1* inhibitor with cardioprotective effects, exhibiting IC₅₀ values of 3.05 μM and 2.20 nM respectively, and 5-LOX/sEH-IN-1 can also inhibit the activity of COX-2 (IC₅₀=10.50 μM). 5-LOX/sEH-IN-1 has analgesic and anti-inflammatory effects, while reducing ulcer pathogenicity, and can be used to develop anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects .

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5-LOX Inhibitor

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