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ATP analogue

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By Targets:	ATP Synthase (2) Akt (1) Apoptosis (1) Autophagy (1) Biochemical Assay Reagents (3) CFTR (1) DNA/RNA Synthesis (1) Endogenous Metabolite (2) Fungal (1) Guanylate Cyclase (1) HSP (2) mTOR (1) P2X Receptor (1) P2Y Receptor (1) PINK1/Parkin (2) Potassium Channel (2)
By Research Areas:	Cancer (7) Cardiovascular Disease (3) Infection (1) Metabolic Disease (6) Neurological Disease (5)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Targets Recommended: ATP Synthase ATP Citrate Lyase ATP-binding Cassette (ABC) transporter P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136647

8-Bromoadenosine 5'-triphosphate tetrasodium 8-Br-ATP tetrasodium	Others	Others
8-Bromoadenosine 5'-triphosphate tetrasodium (8-Br-ATP tetrasodium) is an ATP analogue. ATP is a central component of energy storage and metabolism in vivo .

HY-134398A

Kinetin triphosphate tetrasodium 6-Fu-ATP tetrasodium; KTP tetrasodium	PINK1/Parkin	Neurological Disease Cancer
Kinetin triphosphate(6-Fu-ATP) tetrasodium is an ATP analogue that regulates or enhances kinase function with higher catalytic efficiency than its endogenous substrate, ATP. Kinetin triphosphate tetrasodium can be used in Parkinson's disease research .

HY-D0183

ATP-polyamine-biotin 1 Publications Verification	Biochemical Assay Reagents	Others
ATP-polyamine-biotin, the first cell-permeable ATP analogue, is an efficient kinase cosubstrate. ATP-polyamine-biotin promotes biotin labeling of kinase substrates in live cells .

HY-134266

8-Bromo-AMP 1 Publications Verification 8-Bromoadenosine 5'-monophosphate; 8-Bromoadenylic acid	Endogenous Metabolite	Cardiovascular Disease
8-Bromo-AMP (8-Bromoadenosine 5'-monophosphate) is a membrane permeable cAMP analogue. 8-Bromo-AMP can improve the ability of the heart to recover from ischemia and reperfusion by increasing the levels of ATP, ADP, and total adenine nucleotides .

HY-128933

AMP-PNP tetralithium 1 Publications Verification Adenylyl-imidodiphosphate tetralithium	Potassium Channel	Metabolic Disease
AMP-PNP tetralithium (Adenylyl-imidodiphosphate tetralithium) is a non-hydrolysable analogue of ATP and inhibits K_ATP channels .

HY-130777

AMP-PNP Adenylyl imidodiphosphate	Biochemical Assay Reagents	Others
AMP-PNP (Adenylyl imidodiphosphate) is a non-hydrolysable ATP analogue .

HY-134398

Kinetin triphosphate 6-Fu-ATP; KTP	PINK1/Parkin	Neurological Disease Cancer
Kinetin triphosphate(6-Fu-ATP; KTP) is an ATP analogue that regulates or enhances kinase function with higher catalytic efficiency than its endogenous substrate, ATP. Kinetin triphosphate can be used in Parkinson's disease research .

HY-155754

3′-Acetate-ATP	ATP Synthase	Others
3’-Acetate-ATP, an ATP analogue, is ATP acetylation product with an maxima uv absorption at 259 nm in water at neutral pH. 3’-Acetate-ATP exerts a blocking effect on nucleic acid polymerization .

HY-134361

ATP-γ-S tetrasodium	P2Y Receptor	Neurological Disease Metabolic Disease
ATP-γ-S tetrasodium, an ATP analogue, is a P2Y11 receptor agonist. ATP-γ-S tetrasodium is active in ATP hydrolysis. ATP-γ-S tetrasodium is also an antioxidant and neuroprotectant .

HY-134262

8-Bromo-ATP 8-Bromoadenosine 5'-triphosphate; 8-Br-ATP	P2X Receptor	Cancer
8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate), an ATP analogue, is a purinergic P2X receptor agonist. 8-Bromo-ATP shows cytotoxic to multiple myeloma cells with an IC₅₀ of 23.1 μM .

HY-131800

3'-Deoxy-3'-amino-ATP	Others	Metabolic Disease
3'-Deoxy-3'-amino-ATP, an ATP analogue, is a potent and competitive inhibitor of ATP, with a K_i of 2.3 μM. 3'-Deoxy-3'-amino-ATP can be used to synthesis of 3′-Amino-3′-deoxy transfer RNA by incorporation into the 3' terminus of tRNA-C-C .

HY-134385

6-PhEt-dATP	CFTR	Others
6-PhEt-dATP is an ATP analog that specifically enhances the function of certain CFTR mutants and is useful for studying cystic fibrosis .

HY-161681

Formycin triphosphate	Guanylate Cyclase	Metabolic Disease
Formycin triphosphate is a fluorescent analogue of ATP which on binding to enzyme active sites exhibits enhanced fluorescence. Formycin triphosphate is an ATP-competitive chicken liver pyruvate carboxylase inhibitor. Formycin triphosphate potentiates atrial natriuretic factor (ANF)-stimulated guanylate cyclase activity with an EC₅₀ at about 90 μM and inhibits ATP-stimulated guanylate cyclase activity with an IC₅₀ at about 100 μM .

HY-106723

AMP-PCP	HSP	Cancer
AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a K_d value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90 .

HY-106723A

AMP-PCP disodium	HSP	Cancer
AMP-PCP disodium is an ATP analogue and can bind to Hsp90 N-terminal domain with a K_d value of 3.8 μM. AMP-PCP disodium binding favors the formation of the active homodimer of Hsp90 .

HY-134391

6-Phe-ADP	Biochemical Assay Reagents	Others
6-Phe-ADP is an ATP analog used as a precursor to prepare the corresponding radiolabeled triphosphate for chemical genetics approaches to study substrate specificity and catalytic efficiency of protein kinases .

HY-B0445A

NAD sodium Maximum Cited Publications 25 Publications Verification β-DPN sodium; β-NAD sodium; β-Nicotinamide Adenine Dinucleotide sodium	Endogenous Metabolite	Metabolic Disease
NAD (β-Nicotinamide Adenine Dinucleotide) sodium is an analogue of NAD. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions which oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria that indirectly generates ATP .

HY-130354

Dibutyryl-cGMP sodium 2 Publications Verification Bt2cGMP sodium	Potassium Channel	Cardiovascular Disease
Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analogue. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits the release of [ ³H]-arachidonic acid from γ thrombin-stimulated human platelets. Dibutyryl-cGMP sodium induces peripheral antinociception via activation of ATP-sensitive K ⁺ channels .

HY-125927

8-Aminoadenosine 1 Publications Verification 8-NH2-Ado	DNA/RNA Synthesis Akt mTOR Autophagy Apoptosis	Cancer
8-Aminoadenosine (8-NH2-Ado), a RNA-directed nucleoside analogue, reduces cellular ATP levels and inhibits mRNA synthesis. 8-Aminoadenosine blocks Akt/mTOR signaling and induces autophagy and apoptosis in a p53-independent manner. 8-Aminoadenosine has antitumor activity .

HY-139382

2-(Isopentylamino)naphthalene-1,4-dione	Others	Neurological Disease
2-(Isopentylamino)naphthalene-1,4-dione (compound 3d), a Vitamin K (HY-B2172) analogue, shows protection in Pentylenetetrazole (PTZ)-induced seizure model. 2-(Isopentylamino)naphthalene-1,4-dione significantly increases ATP levels in zebrafish as well as HT-22 cells. 2-(Isopentylamino)naphthalene-1,4-dione shows excellent permeability into the brain .

HY-151555

Antifungal agent 44	Fungal	Infection
Antifungal agent 44 (compound 2A-5) is an antifungal agent, and shows excellent fungicidal activity superior to Kresoxim-methyl (HY-125776). Antifungal agent 44 shows fungicidal activity against Phytophthora capsici most remarkably, with an EC₅₀ value of about 5 μM .

HY-W017540

Cyclocreatine 1 Publications Verification	ATP Synthase	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Cyclocreatine, a creatine analogue, acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine can be phosphorylated and dephosphorylated by creatine kinases. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion in dogs and rats. Cyclocreatine decreases plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology. Cyclocreatine is proming for research of ischemic heart disease, cardiovascular diseases, Alzheimer’s disease and other neurodegenerative diseases associated with microglial dysfunction, prostate cancer .

Cat. No.	Product Name	Type

HY-D0183

ATP-polyamine-biotin 1 Publications Verification	Enzyme Substrates
ATP-polyamine-biotin, the first cell-permeable ATP analogue, is an efficient kinase cosubstrate. ATP-polyamine-biotin promotes biotin labeling of kinase substrates in live cells .

HY-B0445A

NAD sodium Maximum Cited Publications 25 Publications Verification β-DPN sodium; β-NAD sodium; β-Nicotinamide Adenine Dinucleotide sodium	Enzyme Substrates
NAD (β-Nicotinamide Adenine Dinucleotide) sodium is an analogue of NAD. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions which oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria that indirectly generates ATP .

HY-130777

AMP-PNP Adenylyl imidodiphosphate	Gene Sequencing and Synthesis
AMP-PNP (Adenylyl imidodiphosphate) is a non-hydrolysable ATP analogue .

8-Aminoadenosine 1 Publications Verification 8-NH2-Ado	Structural Classification Natural Products Source classification Endogenous metabolite	DNA/RNA Synthesis Akt mTOR Autophagy Apoptosis
8-Aminoadenosine (8-NH2-Ado), a RNA-directed nucleoside analogue, reduces cellular ATP levels and inhibits mRNA synthesis. 8-Aminoadenosine blocks Akt/mTOR signaling and induces autophagy and apoptosis in a p53-independent manner. 8-Aminoadenosine has antitumor activity .

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ATP analogue

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Natural
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