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Alpha-Ketoglutaric acid

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By Targets:	Biochemical Assay Reagents (1) Endogenous Metabolite (7) GABA Receptor (1) Isotope-Labeled Compounds (2) Tyrosinase (8)
By Research Areas:	Endocrinology (1) Metabolic Disease (2) Neurological Disease (1)

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Biochemical Assay Reagents

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Isotope-Labeled Compounds

Targets Recommended: 5 alpha Reductase IFNAR α-synuclein PGC-1α Amino acid Transporter Amino Acid Derivatives Hydroxycarboxylic Acid Receptor (HCAR) Free Fatty Acid Receptor Fatty Acid Synthase (FASN) Apical Sodium-Dependent Bile Acid Transporter G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W013636

2-Ketoglutaric acid 3 Publications Verification Alpha-Ketoglutaric acid	Tyrosinase Endogenous Metabolite	Others
2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

HY-W013636C

2-Ketoglutaric acid potassium 3 Publications Verification Alpha-Ketoglutaric acid potassium	Tyrosinase	Metabolic Disease
2-Ketoglutaric acid potassium (Alpha-Ketoglutaric acid potassium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid potassium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid potassium is a reversible inhibitor of tyrosinase with an IC₅₀ value of 15 mM .

HY-W013636A

2-Ketoglutaric acid Sodium 3 Publications Verification Alpha-Ketoglutaric acid Sodium	Tyrosinase Endogenous Metabolite	Metabolic Disease
2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

HY-W013636S1

2-Ketoglutaric acid-d4 Alpha-Ketoglutaric acid-d₄	Tyrosinase Endogenous Metabolite	Others
2-Ketoglutaric acid-d₄ is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

HY-E70003

Glutamate dehydrogenase	Biochemical Assay Reagents	Endocrinology
Glutamate dehydrogenase is an enzyme in both prokaryotes and eukaryotic mitochondria. Glutamate dehydrogenase can be used for the enzymatic determination of ammonia, alpha-ketoglutaric acid, L-glutamate and urease .

HY-W013636R

2-Ketoglutaric acid (standard) 3 Publications Verification	Tyrosinase Endogenous Metabolite	Others
2-Ketoglutaric acid (Standard) is the analytical standard of 2-Ketoglutaric acid. This product is intended for research and analytical applications. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

HY-W013636S

2-Ketoglutaric acid-13C5	Tyrosinase Endogenous Metabolite	Others
2-Ketoglutaric acid- ¹³C₅ is the ¹³C labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

HY-W013636S2

2-Ketoglutaric acid-d6	Tyrosinase Endogenous Metabolite	Others
2-Ketoglutaric acid-d₆ is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

HY-W013636S3

2-Ketoglutaric acid-13C Alpha-Ketoglutaric acid-¹³C	Isotope-Labeled Compounds	Others
2-Ketoglutaric acid- ¹³C (Alpha-Ketoglutaric acid- ¹³C) is a ¹³C labeled 2-Ketoglutaric acid (HY-W013636) . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

HY-W013636S4

2-Ketoglutaric acid-13C2 Alpha-Ketoglutaric acid-¹³C₂	Isotope-Labeled Compounds Tyrosinase Endogenous Metabolite	Others
2-Ketoglutaric acid-13C2 is a deuterated labeled 2-Ketoglutaric acid . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

HY-15377

DL-Gabaculine hydrochloride	GABA Receptor	Neurological Disease
DL-Gabaculine hydrochloride is a neurotoxin that irreversibly inhibits bacterial pyridoxal phosphate linked *γ-aminobutyric acid-α-ketoglutaric* acid transaminase with a K_i** of 2.86 μM .

Cat. No.	Product Name	Type

HY-W013636C

2-Ketoglutaric acid potassium 3 Publications Verification Alpha-Ketoglutaric acid potassium	Biochemical Assay Reagents
2-Ketoglutaric acid potassium (Alpha-Ketoglutaric acid potassium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid potassium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid potassium is a reversible inhibitor of tyrosinase with an IC₅₀ value of 15 mM .

HY-E70003

Glutamate dehydrogenase	Biochemical Assay Reagents
Glutamate dehydrogenase is an enzyme in both prokaryotes and eukaryotic mitochondria. Glutamate dehydrogenase can be used for the enzymatic determination of ammonia, alpha-ketoglutaric acid, L-glutamate and urease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W013636

2-Ketoglutaric acid 3 Publications Verification Alpha-Ketoglutaric acid	Structural Classification Classification of Application Fields Anti-aging Source classification Endocrine diseases Endogenous metabolite Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Other Diseases Nervous System Disorder Disease Research Fields	Tyrosinase Endogenous Metabolite
2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

HY-W013636A

2-Ketoglutaric acid Sodium 3 Publications Verification Alpha-Ketoglutaric acid Sodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Tyrosinase Endogenous Metabolite
2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

HY-W013636R

2-Ketoglutaric acid (standard) 3 Publications Verification	Structural Classification Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Tyrosinase Endogenous Metabolite
2-Ketoglutaric acid (Standard) is the analytical standard of 2-Ketoglutaric acid. This product is intended for research and analytical applications. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

Tag:	His (1) Tag Free (1) Strep (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701905

	gucD Protein, Bacillus subtilis gucD; Alpha-Ketoglutaric semialdehyde dehydrogenase; AlphaKGSA dehydrogenase; 2; 5-dioxovalerate dehydrogenase	Others	E. coli
	The gucD protein is an important enzyme that catalyzes the irreversible ammonia removal of L-kynurenine to generate kynurenic acid (KA). This process is part of the tryptophan catabolic pathway and produces KA, known for its broad-spectrum antagonistic activity at excitatory amino acid receptors. gucD Protein, Bacillus subtilis is the recombinant gucD protein, expressed by E. coli , with tag free. The total length of gucD Protein, Bacillus subtilis is 487 a.a., .

HY-P701906

	gucD Protein, Bacillus subtilis (His, Strep) gucD; Alpha-Ketoglutaric semialdehyde dehydrogenase; AlphaKGSA dehydrogenase; 2; 5-dioxovalerate dehydrogenase	Others	E. coli
	The gucD protein is an important enzyme that catalyzes the irreversible ammonia removal of L-kynurenine to generate kynurenic acid (KA). This process is part of the tryptophan catabolic pathway and produces KA, known for its broad-spectrum antagonistic activity at excitatory amino acid receptors. gucD Protein, Bacillus subtilis (His, Strep) is the recombinant gucD protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of gucD Protein, Bacillus subtilis (His, Strep) is 487 a.a., .

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Cat. No.	Product Name	Chemical Structure

HY-W013636S1

2-Ketoglutaric acid-d4
2-Ketoglutaric acid-d₄ is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

HY-W013636S

2-Ketoglutaric acid-13C5
2-Ketoglutaric acid- ¹³C₅ is the ¹³C labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

HY-W013636S2

2-Ketoglutaric acid-d6
2-Ketoglutaric acid-d₆ is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

HY-W013636S3

2-Ketoglutaric acid-13C
2-Ketoglutaric acid- ¹³C (Alpha-Ketoglutaric acid- ¹³C) is a ¹³C labeled 2-Ketoglutaric acid (HY-W013636) . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

2-Ketoglutaric acid-13C

2-Ketoglutaric acid- ¹³C (Alpha-Ketoglutaric acid- ¹³C) is a ¹³C labeled 2-Ketoglutaric acid (HY-W013636) . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

HY-W013636S4

2-Ketoglutaric acid-13C2
2-Ketoglutaric acid-13C2 is a deuterated labeled 2-Ketoglutaric acid . 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM) .

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