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Antitubercular

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By Targets:	Antibiotic (8) Autophagy (4) Bacterial (81) DNA/RNA Synthesis (2) Endogenous Metabolite (1) Fungal (8) Isotope-Labeled Compounds (2) MDM-2/p53 (1) p38 MAPK (1) Parasite (4)
By Research Areas:	Cancer (7) Infection (78) Inflammation/Immunology (5) Metabolic Disease (1) Neurological Disease (1)

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Natural
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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-151960

Antitubercular agent-36	Bacterial	Infection
Antitubercular agent-36 (compound 53) is an antitubercular agent. Antitubercular agent-36 inhibits the growth of Mtb_H37Rv with a MIC₉₀ value of 1.25 μg/mL. Antitubercular agent-36 can be used for the research of tuberculosis .

HY-163437

Antitubercular agent-45	Bacterial Fungal	Infection
Antitubercular agent-45 (Compound 5g) is an antifungal and antitubercular agent. Antitubercular agent-45 inhibits S. aureus, MRSA, B. subtilis, E. coli, C. albicans with MIC values of 6.4, 10.8, 6.1, 8.4 , 8.1 μM respectively .

HY-144722

Antitubercular agent-12	Bacterial	Infection
Antitubercular agent-12 (Compound 2c) is an antitubercular agent (MIC = 1.439 μg/mL). Antitubercular agent-12 shows greatly lower cytotoxicity (CC50: 57.34 μg/mL) .

HY-151958

Antitubercular agent-35	Bacterial	Infection
Antitubercular agent-35 (compound 42l) is an antitubercular agent. Antitubercular agent-35 inhibits the growth of Mtb_H37Rv and *M. Marinum* with MIC₉₀ values of 1.25 and 2 μg/mL, respectively. Antitubercular agent-35 shows the ability of escaping metabolic degradation by human liver microsomes. Antitubercular agent-35 can be used for the research of tuberculosis .

HY-146107

Antitubercular agent-23	Bacterial Fungal	Infection
Antitubercular agent-23 (Compound 3a) is a potent anticandidiasis and antitubercular agent with MIC values of 1.1 µg/ml and 1 µg/ml against Candida albicans MTCC 3017 and M. tuberculosis (H37Rv), respectively .

HY-146106

Antitubercular agent-22	Bacterial Fungal	Infection
Antitubercular agent-22 (Compound 2) is a potent anticandidiasis and antitubercular agent with MIC values of 2.34 µg/ml and 2 µg/ml against Candida albicans MTCC 3017 and M. tuberculosis (H37Rv), respectively .

HY-151339

Antitubercular agent-31	Bacterial	Infection
Antitubercular agent-31 (Compound 2) is an antitubercular agent with an MIC of 0.03 μM against M. tuberculosis H37Rv. Antitubercular agent-31 also inhibits DprE1 with an IC₅₀ of 1.1 μM .

HY-151957

Antitubercular agent 34	Bacterial	Infection
Antitubercular agent 34 (compound 42g) is an antitubercular agent. Antitubercular agent 34 inhibits the growth of Mtb_H37Rv with a MIC₉₀ value of 1.25 μg/mL with the ability of escaping metabolic degradation by human liver microsomes. Antitubercular agent 34 can be used for the research of tuberculosis .

HY-155190

Antitubercular agent-39	Bacterial	Infection
Antitubercular agent-39 (Compound P1) is a potent antitubercular agent. Antitubercular agent-39 is active against drug-resistant strains and drug-susceptible clinical isolates. Antitubercular agent-39 inhibits Mtb strain H37Rv with a MIC less than 1 μM .

HY-144723

Antitubercular agent-13	Bacterial	Infection
Antitubercular agent-13 (Compound 3d) is an antitubercular agent with MIC values of 0.007 µg/mL and 1.851 µg/mL against MTB H37Rv and MDR-MTB 16833, respectively. Antitubercular agent-13 shows metabolic instability .

HY-146051

Antitubercular agent-18	Bacterial	Infection
Antitubercular agent-18 (Compound 9a) is an antitubercular agent with MIC values of 2, 2, 2 and 128 µg/ml against M. tuberculosis H37Rv, Spec. 192, Spec 210 and Spec. 800, respectively. Antitubercular agent-18 shows highly selective antimycobacterial effects .

HY-146050

Antitubercular agent-17	Bacterial	Infection
Antitubercular agent-17 (Compound 8a) is an antitubercular agent with MIC values of 2, 2, 2 and 128 µg/ml against M. tuberculosis H37Rv, Spec. 192, Spec 210 and Spec. 800, respectively. Antitubercular agent-17 shows highly selective antimycobacterial effects .

HY-163069

Antitubercular agent-43	Bacterial	Infection
Antitubercular agent-43 (compound A11) is an orally active and potent antitubercular agent. Antitubercular agent-43 shows highly metabolic stability against human and mouse cytochrome P450 enzymes. Antitubercular agent-43 exhibits bactericidal efficacy in acute TB infection mouse model .

HY-163033

Antitubercular agent-42	Bacterial	Infection
Antitubercular agent-42(19) is a selective fatty acyl-AMP ligase (FAAL) inhibitor (MIC₉₀ = 1.4 µg/mL for M. tuberculosis H37Rv). Antitubercular agent-42 shows antitubercular activity .

HY-151340

Antitubercular agent-32	Bacterial	Infection
Antitubercular agent-32 is a derivate of Benzothiazinone (HY-13579A), inhibits M. tuberculosis, and shows improved metabolic stability and enhanced water solubility. Antitubercular agent-32 exerts antitubercular effect by targeting decaprenylphosphoryl-β-D-ribose 2’-oxidase (DprE1, IC₅₀=3.9 μM) .

HY-148111

Antitubercular agent-33	Bacterial	Infection
Antitubercular agent-33 is a 2-aminothiazole derivative, shows potent antintubercular activity against Mycobacterium tuberculosis (Mtb) .

HY-162684

Antitubercular agent-46	Bacterial	Infection Inflammation/Immunology
Antitubercular agent-46 (4B) is an anti-tubercular agent, with a MIC of 7.81 μg/ mL. Antitubercular agent-46 (4B) possesses antioxidant activity .

HY-132928

Antitubercular agent-10	Bacterial	Infection
Antitubercular agent-10 shows potent antitubercular activity with a MIC value of 30 nM.

HY-144721

Antitubercular agent-11	Bacterial	Infection
Antitubercular agent-11 (Compound 1e) is an antitubercular agent. Antitubercular agent-11 with a bulkier electron-donating group (Bu-t) demonstrated the best MIC value of 0.060 μg/mL .

HY-149857

Antitubercular agent-37	Bacterial	Infection
Antitubercular agent-37 is an antibacterial agent. Antitubercular agent-37 has antimycobacterial activity with an MIC values of 0.16 μg/mL. Antitubercular agent-37 can be used for the research of tuberculosis .

HY-146496

Antitubercular agent-20	Bacterial	Infection
Antitubercular agent-20 (Compound 2d) is an orally active antitubercular agent. Antitubercular agent-20 shows excellent activity against MTB H37Rv and MDR-MTB strains (MIC: ＜0.016 µg/ml). Antitubercular agent-20 has low cytotoxicity and good tolerance in BALB/c mice .

HY-147505

Antitubercular agent-21	Bacterial Fungal	Infection
Antitubercular agent-21 (Compound 15) is an antitubercular agent with an MIC of o.4 µg/mL against M. tuberculosis H₃₇R_v. Antitubercular agent-21 exhibits lower activity against other microorganism such as bacteria gram-positive, gram-negative or fungi. Antitubercular agent-21 shows low cytotoxicity .

HY-132910

Antitubercular agent-9	Bacterial	Infection
Antitubercular agent-9 shows effective antitubercular activity with a MIC value of 1.03-2.32 μM.

HY-156022

Antitubercular agent-41	Bacterial	Neurological Disease
Antitubercular agent-41 (Compound 106) is an antitubercular agent that can be used in the study of Mycobacterium tuberculosis infection .

HY-146495

Antitubercular agent-19	Bacterial	Infection
Antitubercular agent-19 (Compound 1c) is an antitubercular agent. Antitubercular agent-19 shows excellent activity against MTB H37Rv and MDR-MTB strains (MIC: ＜0.016 µg/ml). Antitubercular agent-19 shows low cytotoxicity and relatively high acute lethal toxicity in BALB/c mice .

HY-146555

Antitubercular agent-14	Bacterial	Infection
Antitubercular agent-14 (Compound 1) is an antitubercular agent with an MIC of 0.3 µg/mL against M. tuberculosis .

HY-146120

Antitubercular agent-25	Bacterial	Infection
Antitubercular agent-25 (Compound 28) is an anti-tubercular agent with an extracellular IC₅₀ of 0.42 μM and an intracellular IC₅₀ of 0.20 μM against M. tuberculosis H37Rv. Antitubercular agent-25 exhibits good metabolic stability .

HY-147884

Antitubercular agent-28	Bacterial	Infection
Antitubercular agent-28 (compound 2) is a potent *antitubercular* agent with an IC₅₀ value of 1.5 µM, an MIC value of 4.5 µM, an IC₉₀ value of 2.5 µM. Antitubercular agent-28 shows antimycobacterial activity for resistant isolates of Mycobacterium tuberculosis H37Rv. Antitubercular agent-28 shows effective intracellular antimycobacterial activity and low cytotoxicity .

HY-147883

Antitubercular agent-27	Bacterial	Infection
Antitubercular agent-27 (compound 1) is a potent *antitubercular* agent with an IC₅₀ value of 3.2 µM, an MIC value of 7.8 µM, an IC₉₀ value of 7.0 µM. Antitubercular agent-27 shows antimycobacterial activity for resistant isolates of Mycobacterium tuberculosis H37Rv. Antitubercular agent-27 shows effective intracellular antimycobacterial activity and low cytotoxicity .

HY-156021

Antitubercular agent-40	Bacterial	Infection
Antitubercular agent-40 (compound 93) is a thieno[2,3-b]quinoline-2-carboxamide compound with potential antitubercular activity .

HY-146121

Antitubercular agent-26	Bacterial	Infection
Antitubercular agent-26 (Compound 32) is an orally active anti-tubercular agent with an extracellular IC₅₀ of 0.50 μM and an intracellular IC₅₀ of 0.51 μM against M. tuberculosis H37Rv. Antitubercular agent-26 shows good metabolic stability, low risk of cardiotoxicity and no genotoxicity .

HY-155067

Antitubercular agent-38	Bacterial	Infection
Antitubercular agent-38 is an orally active Benzothiazinones (BTZs) derivate, with potent antituberculosis activity. Antitubercular agent-38 exhibits low cardiac toxicity, low cell cytotoxicity .

HY-162094

Antitubercular agent-44	Bacterial	Infection
Antitubercular agent-44 (compound 21b) has anti-tuberculosis (H37Rv MIC = 0.06 μM). Antitubercular agent-44 has oral activity .

HY-146119

Antitubercular agent-24	Bacterial	Infection
Antitubercular agent-24 (Compound 1) is an anti-tubercular agent with an extracellular IC₅₀ of 0.83 μM and an intracellular IC₅₀ of 0.17 μM against M. tuberculosis H37Rv .

HY-151236

Antitubercular agent-30	Bacterial	Infection
Antitubercular agent-30 is an antibacterial agent against Mycobacterium tuberculosis (MIC=50 μg/mL). Antitubercular agent-30 has little cytotoxic effect on murine macrophage cells (LD₈₅=~100 μg/mL) .

HY-146556

Antitubercular agent-15	Bacterial	Infection
Antitubercular agent-15 (Compound 5n) is an antitubercular agent with MIC₉₀ values of 0.73, 7.69, 9.38, 18.80, 7.53 and 7.31 μg/mL against M. tuberculosis H37Rv, CF16, CF61, CF76, CF152 and CF161, respectively. Antitubercular agent-15 shows low cytotoxicity against macrophages and pulmonary fibroblasts .

HY-146557

Antitubercular agent-16	Bacterial	Infection
Antitubercular agent-16 (Compound 5q) is an antitubercular agent with MIC₉₀ values of 0.40, 20.11, 23.51, 19.62, 10.93 and 13.62 μg/mL against M. tuberculosis H37Rv, CF16, CF61, CF76, CF152 and CF161, respectively. Antitubercular agent-16 shows low cytotoxicity against macrophages and pulmonary fibroblasts .

HY-168123

Antitubercular agent-47	Bacterial	Cancer
Antitubercular agent-47 (compund 5C) shows potent activity against tuberculosis and was effective against DS/MDR/XDR clinical isolates .

HY-150554

Antitubercular agent-29	Bacterial	Infection
Antitubercular agent-29 (compound 6xa) is a potent agent resistant (DR) Mycobacterium tuberculosis (Mtb) inhibitor with MIC of 0.03 μg/mL against agent-susceptible (DS)-Mtb strains, MIC of 0.03-0.06 μg/mL against DR-Mtb strains, and favourable selectivity (SI>40) against Vero cells .

HY-N12276

(±)-Emodin bianthrone	Parasite Bacterial Fungal	Infection
(±)-Emodin bianthrone (compound 10), a natural product, exhibits antimalarial, antitubercular and ntifungal activities .

HY-156361

Tuberculosis inhibitor 11	Bacterial	Infection
Tuberculosis inhibitor 11 (Compound 14) can sensitize the antimycobacterial activity of the antitubercular agent .

HY-155332

AB131	Bacterial	Infection
AB131 is a MSMEG 6649 and Rv2172c inhibitor (K_d: 0.16 and 0.02 μM respectively). AB131 can sensitize the antimycobacterial activity of the antitubercular agent .

HY-160922

BAY 249716	MDM-2/p53 Bacterial	Infection Cancer
BAY 249716 stabilizes all three p53 protein variants. BAY 249716 also has antitubercular activity (IC₉₀: <0.10 μg/mL for Tuberculosis) .

HY-N9596

Stigmasta-4,22-dien-3-one	Bacterial	Infection Cancer
Stigmasta-4,22-dien-3-one is an *antitubercular* agent. Stigmasta-4,22-dien-3-one shows cytotoxicity against human HT1080 tumoral cell line with an IC₅₀ of 0.3 mM .

HY-19750

TBA-7371 1 Publications Verification	Bacterial	Infection
TBA-7371 is a potent, noncovalent DprE1 inhibitor. TBA-7371 has potent antitubercular activity .

HY-124301

Penicolinate A	Bacterial	Infection
Penicolinate A is a picolinic acid derivative. Penicolinate A is isolated from endophytic Penicillium sp. BCC16054. Penicolinate A exhibits antimalarial and antitubercular activities .

HY-N3661

(24S)-Cycloartane-3β,24,25-triol	Bacterial	Infection
(24S)-Cycloartane-3β,24,25-triol, a cycloartane, has antitubercular activity against Mycobacterium tuberculosis H37Rv (MIC: 32 μg/mL). (24S)-Cycloartane-3β,24,25-triol can be isolated from the flowers of Chrysanthemum morifolium .

HY-B1526

Thiacetazone Thioacetazone; Amithiozone	Bacterial Antibiotic	Infection
Thiacetazone (Thioacetazone) is a thiourea-containing antitubercular agent and is an orally active antibiotic. Thiacetazone has antibacterial action, which inhibits growth of *Mycobacterium tuberculosis H37Rv* with a MIC value of 0.1 μg/mL .

HY-B0271

Pyrazinamide 2 Publications Verification Pyrazinecarboxamide; Pyrazinoic acid amide	Bacterial Autophagy Antibiotic	Infection
Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

HY-B0271R

Pyrazinamide (Standard)	Bacterial Autophagy Antibiotic	Infection
Pyrazinamide (Standard) is the analytical standard of Pyrazinamide. This product is intended for research and analytical applications. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0271

Pyrazinamide 2 Publications Verification Pyrazinecarboxamide; Pyrazinoic acid amide	Microorganisms Source classification	Bacterial Autophagy Antibiotic
Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

HY-W005327

1-Hydroxy-2-butanone	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Bacterial Endogenous Metabolite
1-Hydroxy-2-butanone is a natural compound isolated from Bomboo Juice with antitubercular activity .

HY-N0804

Narirutin 2 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavonones Source classification Rutaceae Phenols Polyphenols Plants Citrus Inflammation/Immunology Disease Research Fields	Bacterial
Narirutin, one of the active constituents isolated from citrus fruits, has antioxidant and anti-inflammatory activities. Narirutin is a shikimate kinase inhibitor with anti-tubercular potency .

HY-N12276

(±)-Emodin bianthrone	Structural Classification Microorganisms Source classification Phenols Polyphenols	Parasite Bacterial Fungal
(±)-Emodin bianthrone (compound 10), a natural product, exhibits antimalarial, antitubercular and ntifungal activities .

HY-N9596

Stigmasta-4,22-dien-3-one	Leguminosae Source classification Plants Steroids Erythrina variegata Linn.	Bacterial
Stigmasta-4,22-dien-3-one is an *antitubercular* agent. Stigmasta-4,22-dien-3-one shows cytotoxicity against human HT1080 tumoral cell line with an IC₅₀ of 0.3 mM .

HY-124301

Penicolinate A	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Pyridine Alkaloids Disease Research Fields	Bacterial
Penicolinate A is a picolinic acid derivative. Penicolinate A is isolated from endophytic Penicillium sp. BCC16054. Penicolinate A exhibits antimalarial and antitubercular activities .

HY-N3661

(24S)-Cycloartane-3β,24,25-triol	Triterpenes Structural Classification Terpenoids Source classification Dendranthema morifolium (Ramat.) Tzvel. Plants Compositae	Bacterial
(24S)-Cycloartane-3β,24,25-triol, a cycloartane, has antitubercular activity against Mycobacterium tuberculosis H37Rv (MIC: 32 μg/mL). (24S)-Cycloartane-3β,24,25-triol can be isolated from the flowers of Chrysanthemum morifolium .

HY-B0271R

Pyrazinamide (Standard)	Microorganisms Source classification	Bacterial Autophagy Antibiotic
Pyrazinamide (Standard) is the analytical standard of Pyrazinamide. This product is intended for research and analytical applications. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

HY-126640

Phomoxanthone A	Quinones Structural Classification Microorganisms Anthraquinones Source classification	Parasite
Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC₅₀ is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC₅₀ is 0.99, 0.51 and 1.4 µg/mL, respectively .

HY-N10992

Pomolic acid 3-acetate	Triterpenes Structural Classification Terpenoids Source classification Rosaceae Plants Acaena pinnatifida Ruiz & Pav.	Bacterial
Pomolic acid 3-acetate is an *antitubercular* agent with a MIC of 32 μM against Mycobacterium tuberculosis H₃₇Rv .

HY-N8388

Collinin	Structural Classification Zanthoxylum schinifolium Sieb. et Zucc. Source classification Rutaceae Coumarins Phenylpropanoids Plants	Bacterial
Collinin is a anti-tubercular agent, it can be isolated from leaves of Z. schinifolium. Collinin has an excellent anti-tuberculosis effect against multidrug-resistant (MDR), extensively drug-resistant (XDR) strains .

HY-N0804R

Narirutin (Standard)	Structural Classification Flavonoids Flavonones Source classification Rutaceae Phenols Polyphenols Plants Citrus	Bacterial
Narirutin (Standard) is the analytical standard of Narirutin. This product is intended for research and analytical applications. Narirutin, one of the active constituents isolated from citrus fruits, has antioxidant and anti-inflammatory activities. Narirutin is a shikimate kinase inhibitor with anti-tubercular potency .

HY-N2208

4-Hydroxylonchocarpin 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Metabolic Disease Plants Infection Chalcones Flavonoids Leguminosae Phenols Polyphenols Psoralea corylifolia L. Inflammation/Immunology Disease Research Fields	p38 MAPK
4-Hydroxylonchocarpin is a chalcone compound from an extract of Psoralea corylifolia. 4-Hydroxylonchocarpin increases phosphorylation of p38 MAPK, JNK and ERK. 4-Hydroxylonchocarpin has diverse pharmacological activities, including antibacterial, antifungal, anticancer, antireverse transcriptase, antitubercular, antimalarial, anti-inflammatory and antioxidant activities .

HY-N11650

(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Bacterial
(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid (compound 15) is an antitubercular agent with MIC value of 12.5 μg/mL for Mycobacterium tuberculosis H37Ra. (22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid shows cytotoxicity with IC₅₀ value of 32 μM for Vero cells .

Cat. No.	Product Name	Chemical Structure

HY-B0271S

Pyrazinamide-d3
Pyrazinamide-d3 is deuterium labeled Pyrazinamide. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis[1][2].

HY-B0271S1

Pyrazinamide-13C,15N
Pyrazinamide- ¹³C, ¹⁵N is ¹⁵N and ¹³C labeled Pyrazinamide (HY-B0271). Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

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Antitubercular

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