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Results for "

Arginase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Arginase (22) Apoptosis (3) Bacterial (1) Biochemical Assay Reagents (1) Endogenous Metabolite (4) NO Synthase (2) Parasite (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (2) Endocrinology (1) Infection (2) Inflammation/Immunology (4) Metabolic Disease (9)

Inhibitors & Agonists

Screening Libraries

Natural
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Recombinant Proteins

Antibodies

Targets Recommended: Arginase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15775

Arginase inhibitor 1 4 Publications Verification	Arginase	Cancer
Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC₅₀s of 223 and 509 nM, respectively.

HY-P3190

Arginase, Microorganism L-Arginine amidinase	Endogenous Metabolite	Metabolic Disease
Arginase, Microorganism (L-Arginine amidinase) is an enzyme of the urea cycle. Arginase catalyzes the hydrolysis of L-arginine to L-ornithine and urea .

HY-112885C

nor-NOHA dihydrochloride 2 Publications Verification Nω-Hydroxy-nor-L-arginine dihydrochloride	Apoptosis Arginase	Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA dihydrochloride is a selective and reversible *arginase* inhibitor. nor-NOHA dihydrochloride induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA dihydrochloride has anti-leukemic activity. nor-NOHA dihydrochloride can used in study endothelial dysfunction, immunosuppression and metabolism .

HY-112885B

nor-NOHA monoacetate 2 Publications Verification Nω-Hydroxy-nor-L-arginine monoacetate	Arginase	Metabolic Disease
nor-NOHA monoacetate is a selective and reversible *arginase* inhibitor. nor-NOHA monoacetate induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA monoacetate has anti-leukemic activity. nor-NOHA monoacetate can used in study of endothelial dysfunction, immunosuppression and metabolism .

HY-129476

L-Canaline	Parasite Endogenous Metabolite	Infection Cancer
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite *Plasmodium falciparum* with an IC₅₀ of 297 nM. L-Canaline has anticancer and antiproliferative effects .

HY-W062216

2-Aminoimidazole	Bacterial Arginase	Infection
2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of *human arginase* I with a K_i** of 3.6 mM .

HY-101979A

Numidargistat dihydrochloride Maximum Cited Publications 6 Publications Verification CB-1158 dihydrochloride; INCB01158 dihydrochloride	Arginase	Cancer
Numidargistat (CB-1158) dihydrochloride is a potent and orally active inhibitor of *arginase, with IC₅₀s of 86 nM and 296 nM for recombinant human arginase* 1 and recombinant human arginase 2**, respectively. Immuno-oncology agent .

HY-161061

Arginase inhibitor 7	Arginase	Cancer
Arginase inhibitor 7 (compound A17) is an arginase (ARG1) inhibitor, with an IC₅₀ of 0.16 μM. Arginase inhibitor 7 has high oral bioavailability .

HY-118371

Arginase inhibitor 2	Arginase	Cancer
Arginase inhibitor 2 is an *Arginase* inhibitor (Page 130 in reference patent). Arginase inhibitor 2 synergizes with adoptively transferred antigen- specific T cells to inhibit tumor growth .

HY-158735

Thioarginine hydrobromide	Biochemical Assay Reagents	Others
Thioarginine hydrobromide is a colorimetric substrate for arginase that can be used in the spectrophotometric assay of arginase .

HY-101979

Numidargistat Maximum Cited Publications 6 Publications Verification CB-1158; INCB01158	Arginase	Cancer
Numidargistat (CB-1158) is a potent and orally active inhibitor of *arginase, with IC₅₀s of 86 nM and 296 nM for recombinant human arginase* 1 and recombinant human arginase 2**, respectively. Immuno-oncology agent .

HY-N2237

Piceatannol 3'-O-glucoside Quzhaqigan	NO Synthase Arginase	Cardiovascular Disease
Piceatannol 3'-O-glucoside, an active component of Rhubarb, activates endothelial nitric oxide (NO) synthase through inhibition of arginase activity with IC₅₀s of 11.22 μM and 11.06 μM against arginase I and arginase II, respectively.

HY-155108B

OATD-02 hydrochloride 1 Publications Verification	Arginase	Cancer
OATD-02 hydrochloride is the hydrochloride salt form of OATD-02 (HY-155108). OATD-02 hydrochloride an orally active, competitive, reversible, noncovalent dual inhibitor of *Arginase1* and *Arginase2. OATD-02 hydrochloride is a slow offset inhibitor, blocking intracellular arginases* with IC₅₀s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 hydrochloride bolishes tumor immunosuppression induced by both arginases. OATD-02 hydrochloride can be used for melanoma study .

HY-N2237R

Piceatannol 3'-O-glucoside (Standard)	NO Synthase Arginase	Cardiovascular Disease
Piceatannol 3'-O-glucoside (Standard) is the analytical standard of Piceatannol 3'-O-glucoside. This product is intended for research and analytical applications. Piceatannol 3'-O-glucoside, an active component of Rhubarb, activates endothelial nitric oxide (NO) synthase through inhibition of arginase activity with IC₅₀s of 11.22 μM and 11.06 μM against arginase I and arginase II, respectively.

HY-155108

OATD-02	Arginase	Cancer
OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of *Arginase1* and 2. OATD-02 is a slow offset inhibitor, blocking intracellular arginases with IC₅₀s of 20 nM (hARG1), 39 nM (hARG2), 39 nM (mARG1), and 28 nM (rARG1), respectively. OATD-02 abolishes tumor immunosuppression induced by both arginases. OATD-02 can be used for melanoma study .

HY-W010510

DL-Norvaline 2-Aminopentanoic acid	Endogenous Metabolite Arginase	Metabolic Disease
DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase.

HY-112868B

ABH hydrochloride	Arginase	Inflammation/Immunology
ABH (hydrochloride) is a potent *arginase* inhibitor. ABH (hydrochloride) can be used for researching anti-inflammation .

HY-145331

ARG1-IN-1	Arginase	Cancer
ARG1-IN-1 (example 1) is a human arginase 1 inhibitor with an IC₅₀ of 29 nM .

HY-145331A

ARG1-IN-1 hydrochloride	Arginase	Cancer
ARG1-IN-1 (example 1) hydrochloride is a human arginase 1 inhibitor with an IC₅₀ of 29 nM .

HY-126332

NED-3238	Arginase	Metabolic Disease
NED-3238 is a highly potent arginase I and II inhibitor with IC₅₀ values of 1.3 nM and 8.1 nM, respectively .

HY-19548A

BEC hydrochloride 1 Publications Verification	Arginase	Metabolic Disease
BEC hydrochloride is a slow-binding and competitive Arginase II inhibitor with K_i of 0.31 μM and 30 nM at pH 7.5 and pH 9.5, respectively .

HY-W698343

NG-Hydroxy-L-arginine acetate NOHA acetate	Others	Others
NG-Hydroxy-L-arginine acetate (NOHA acetate) serves as a physiological inhibitor of arginase, playing a crucial role in the conversion of arginine to nitric oxide and citrulline by nitric oxide synthase.

HY-W010510R

DL-Norvaline (Standard)	Endogenous Metabolite Arginase	Metabolic Disease
DL-Norvaline (Standard) is the analytical standard of DL-Norvaline. This product is intended for research and analytical applications. DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase.

HY-122057

Bisdionin F	Others	Others
Bisdionin F is a compound with the ability to restore the antibacterial function of macrophages, which can block the arginase activity induced by Candida albicans and restore the nitric oxide production and antibacterial function of macrophages.

HY-19548

BEC	Arginase	Endocrinology
BEC, an arginine analogue, is a slow-binding competitive inhibitor of the binuclear manganese metalloenzyme arginase. BEC enhances substrate flux to NO synthase, thereby enhancing NO-dependent smooth muscle relaxation in the corpus cavernosum, and enhances penile erection .

HY-112885A

nor-NOHA acetate Nω-Hydroxy-nor-L-arginine acetate	Arginase Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) is a specific and reversible *arginase* inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. Anti-leukemic activity, effective in endothelial dysfunction, immunosuppression and metabolism .

HY-112885

nor-NOHA Nω-Hydroxy-nor-L-arginine	Apoptosis Arginase	Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA is a selective and reversible arginase inhibitor. nor-NOHA induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA has anti-leukemic activity. nor-NOHA can used in study of endothelial dysfunction, immunosuppression and metabolism .

Cat. No.	Product Name

HY-L189

Amino Acid Metabolism Compound Library	237 compounds
Amino acids, as one of the most fundamental organic compounds in living organisms, serve not only as the basic building blocks of proteins but also but also undertake the functions of energy supply, neurotransmitter synthesis, and maintenance of internal environment stability.Amino acid metabolic enzymes are a class of enzymes involved in the metabolic processes of amino acids, catalyzing their synthesis, breakdown, transformation, and interactions with other metabolic pathways. Abnormalities in amino acid metabolic enzymes can lead to various metabolic diseases, such as phenylketonuria and hyperammonemia, etc. Therefore, actively exploring and regulating the processes of amino acid metabolism is crucial for the development of drugs related to these diseases. MCE designs a unique collection of 237 small molecules target amino acid metabolizing enzymes, which is an important tool for studying studying amino acid metabolism processes or metabolism-related drug development.

Amino Acid Metabolism Compound Library

237 compounds

Amino acids, as one of the most fundamental organic compounds in living organisms, serve not only as the basic building blocks of proteins but also but also undertake the functions of energy supply, neurotransmitter synthesis, and maintenance of internal environment stability.Amino acid metabolic enzymes are a class of enzymes involved in the metabolic processes of amino acids, catalyzing their synthesis, breakdown, transformation, and interactions with other metabolic pathways. Abnormalities in amino acid metabolic enzymes can lead to various metabolic diseases, such as phenylketonuria and hyperammonemia, etc. Therefore, actively exploring and regulating the processes of amino acid metabolism is crucial for the development of drugs related to these diseases.

MCE designs a unique collection of 237 small molecules target amino acid metabolizing enzymes, which is an important tool for studying studying amino acid metabolism processes or metabolism-related drug development.

L-Canaline	Infection Structural Classification other families Classification of Application Fields Source classification Amino acids Plants Endogenous metabolite Disease Research Fields	Parasite Endogenous Metabolite
L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite *Plasmodium falciparum* with an IC₅₀ of 297 nM. L-Canaline has anticancer and antiproliferative effects .

2-Aminoimidazole	Infection Structural Classification Natural Products Animals Classification of Application Fields Source classification Disease Research Fields	Bacterial Arginase
2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of *human arginase* I with a K_i** of 3.6 mM .

Piceatannol 3'-O-glucoside Quzhaqigan	Cardiovascular Disease Structural Classification Stilbenes Classification of Application Fields Polygonaceae Source classification Rheum officinale Baill. Phenols Polyphenols Plants Disease Research Fields	NO Synthase Arginase
Piceatannol 3'-O-glucoside, an active component of Rhubarb, activates endothelial nitric oxide (NO) synthase through inhibition of arginase activity with IC₅₀s of 11.22 μM and 11.06 μM against arginase I and arginase II, respectively.

DL-Norvaline 2-Aminopentanoic acid	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Arginase
DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase.

Piceatannol 3'-O-glucoside (Standard)	Structural Classification Stilbenes Polygonaceae Source classification Rheum officinale Baill. Phenols Polyphenols Plants	NO Synthase Arginase
Piceatannol 3'-O-glucoside (Standard) is the analytical standard of Piceatannol 3'-O-glucoside. This product is intended for research and analytical applications. Piceatannol 3'-O-glucoside, an active component of Rhubarb, activates endothelial nitric oxide (NO) synthase through inhibition of arginase activity with IC₅₀s of 11.22 μM and 11.06 μM against arginase I and arginase II, respectively.

DL-Norvaline (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite Arginase
DL-Norvaline (Standard) is the analytical standard of DL-Norvaline. This product is intended for research and analytical applications. DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase.

Species:	Human (4) Mouse (2)
Tag:	SUMO (1) His (6)
Source:	HEK293 (1) P. pastoris (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P72090

	Arginase-2/ARG2 Protein, Mouse (His-SUMO) Arg2Arginase-2; mitochondrial; EC 3.5.3.1; Arginase II; Kidney-type Arginase; Non-hepatic Arginase; Type II Arginase	Mouse	E. coli
	Arginase-2 (ARG2) is a multifunctional regulator central to the regulation of arginine metabolism and nitric oxide synthesis outside the urea cycle. In addition to its hepatic effects, ARG2 affects innate and adaptive immune responses, negatively affecting the survival of activated CD4(+) and CD8(+) T cells. Arginase-2/ARG2 Protein, Mouse (His-SUMO) is the recombinant mouse-derived Arginase-2/ARG2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of Arginase-2/ARG2 Protein, Mouse (His-SUMO) is 332 a.a., with molecular weight of ~52.4 kDa.

HY-P71833

	Arginase-1/ARG1 Protein, Mouse (P.pastoris, His) 1 Publications Verification Arg1Arginase-1; EC 3.5.3.1; Liver-type Arginase; Type I Arginase	Mouse	P. pastoris
	Arginase-1 (ARG1) plays a key role in the urea cycle, converting L-arginine into urea and L-ornithine. This cycle maintains L-arginine homeostasis, which is critical for nitric oxide synthase to compete for arginine. Arginase-1/ARG1 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Arginase-1/ARG1 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Arginase-1/ARG1 Protein, Mouse (P.pastoris, His) is 323 a.a., with molecular weight of ~36.8 kDa.

HY-P7603

	Arginase-2/ARG2 Protein, Human (His) rHuArginase-2, His; ARG2; Arginase-2	Human	E. coli
	Arginase-2/ARG2 Protein, Human (His) expresses in E. coli with a His tag at the N-terminus. Arginase-2 (Arg2) acts as a fasting-induced hepatocyte factor that protects against hepatic and peripheral fat accumulation, hepatic inflammatory responses, and insulin and glucose intolerance in obese murine models.

HY-P7541

	Arginase-1/ARG1 Protein, Human (C-His) rHuArginase-1, His; ARG1; Arginase-1	Human	E. coli
	Arginase-1 Protein, Human (C-His) expresses in E. coli with a His tag at the C-terminus. Arginase-1 Protein inhibits the growth of the arginine-depleting enzyme arginine deiminase (ADI)-resistant Hep3B tumor cells in mice.

HY-P7541A

	Arginase-1/ARG1 Protein, Human (N-His) rHuArginase-1, His; ARG1; Arginase-1	Human	E. coli
	Arginase-1 (ARG1) protein, crucial in the urea cycle, converts L-arginine to urea and L-ornithine. ARG1 also regulates L-arginine levels outside the liver, impacting immune responses. ARG1's release by granulocytes suppresses T cell and NK cell functions. In ILC2s, ARG1 promotes lung inflammation. However, ARG1's role in human monocytic/macrophage/dendritic cells is unclear. Arginase-1/ARG1 Protein, Human (N-His) is the recombinant human-derived Arginase-1/ARG1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Arginase-1/ARG1 Protein, Human (N-His) is 322 a.a., with molecular weight of ~40 kDa.

HY-P7602

	Arginase-1/ARG1 Protein, Human (HEK293, His) rHuArginase-1, His; ARG1; Arginase-1	Human	HEK293
	Arginase-1 Protein, Human (HEK293, His) expresses in HEK293 cells with a His tag at the C-terminus. Arginase-1 Protein inhibits the growth of the arginine-depleting enzyme arginine deiminase (ADI)-resistant Hep3B tumor cells in mice.

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HY-P80019

	Arginase-1 Antibody	WB, IHC-P	Human
	Arginase-1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 35 kDa, targeting to Arginase-1. It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P83148

	Arginase 2 Antibody (YA2893) ARG2; Arginase-2; Type II Arginase	WB, ICC/IF, FC	Human
	Arginase 2 Antibody (YA2893) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2893), targeting Arginase 2, with a predicted molecular weight of 39 kDa (observed band size: 39 kDa). Arginase 2 Antibody (YA2893) can be used for WB, ICC/IF, FC experiment in human background.

HY-P80745

	*Liver Arginase* Antibody** Liver-type Arginase; Type I Arginase	WB, IHC-P	Mouse, Rat
	Liver Arginase Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 35 kDa, targeting to Liver Arginase. It can be used for WB,IHC-P assays with tag free, in the background of Mouse, Rat.

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