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Results for "

C. Elegans

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) AMPK (1) Apoptosis (1) ATP Synthase (1) Autophagy (4) Bacterial (4) Cholinesterase (ChE) (1) Cytochrome P450 (1) Dopamine Receptor (1) Endogenous Metabolite (5) Fungal (1) GABA Receptor (1) HDAC (1) Histamine Receptor (1) Histone Acetyltransferase (1) JNK (2) Keap1-Nrf2 (1) Mitochondrial Metabolism (3) Monoamine Oxidase (1) mTOR (1) NF-κB (2) Parasite (4) STAT (2) α-synuclein (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (3) Infection (9) Inflammation/Immunology (8) Metabolic Disease (5) Neurological Disease (4)

By Targets:

5-HT Receptor (1)

AMPK (1)

Apoptosis (1)

ATP Synthase (1)

Autophagy (4)

Bacterial (4)

Cholinesterase (ChE) (1)

Cytochrome P450 (1)

Dopamine Receptor (1)

Endogenous Metabolite (5)

Fungal (1)

GABA Receptor (1)

HDAC (1)

Histamine Receptor (1)

Histone Acetyltransferase (1)

JNK (2)

Keap1-Nrf2 (1)

Mitochondrial Metabolism (3)

Monoamine Oxidase (1)

mTOR (1)

NF-κB (2)

Parasite (4)

STAT (2)

α-synuclein (1)

By Research Areas:

Cancer (5)

Cardiovascular Disease (3)

Infection (9)

Inflammation/Immunology (8)

Metabolic Disease (5)

Neurological Disease (4)

Inhibitors & Agonists

Natural
Products

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145376

Cholera autoinducer 1 CAI-1	Others	Others
Cholera autoinducer 1 is Vibrio cholerae autoinducer (S)-3-hydroxytridecan-4-one. Cholera autoinducer 1 influences chemotaxis in C. elegans .

HY-141894

5-Ph-IAA-AM	Histone Acetyltransferase	Metabolic Disease
5-Ph-IAA-AM is an eggshell-permeable 5-Ph-IAA (HY-134653) analog which contains an acetoxymethyl (AM) group. 5-Ph-IAA-AM affords an enhanced protein degradation in laid embryos. 5-Ph-IAA-AM can be used to disclosure the roles of proteins in C. elegans, in particular those that are involved in embryogenesis and development, through temporally controlled protein degradation .

HY-P2779

Microsomal aminopeptidase, Microorganism	Endogenous Metabolite	Metabolic Disease
Microsomal aminopeptidase, Microorganism is first reported from C. elegans. The Microsomal aminopeptidase, Microorganism is beneficial for the development of molecular vaccines against parasitic nematodes .

HY-120620

BMS-195270	Others	Others
BMS-195270 is a small molecule that inhibits Carbachol (HY-B1208)-evoked tonicity of isolated rat bladder strips. BMS-195270 inhibits calcium flux .

HY-163804

Cyprocide-B	Cytochrome P450 Parasite	Others
Cyprocide-B is activated by Cytochrome P450 and converted to electrophilic metabolites that selectively kill nematodes C. elegans. Cyprocide-B is promising for research of selective nematicide .

HY-158423

NPD8790	Mitochondrial Metabolism Parasite	Infection
NPD8790 is a species selective mitochondrial respiratory complex I inhibitor with an IC₅₀ of 2.4 µM for C. elegans complex I. NPD8790 is more selective for nematode species mitochondria than human, bovine, and mouse mitochondria. NPD8790 is an anthelmintic that kills adult soil-transmitted helminths .

HY-169156

HDAC6-IN-49	HDAC Monoamine Oxidase Cholinesterase (ChE) Histamine Receptor 5-HT Receptor	Neurological Disease
HDAC6-IN-49 (Compound 3) is an inhibitor for HDAC with IC₅₀ of 0.012 and 0.735 μM for HDAC6 and HDAC1. HDAC6-IN-49 also exhibits inhibitory activities against MAO-B, cholinesterase (ChE), histamine receptor (H3R) and serotonin 6 receptor (5-HT6R). HDAC6-IN-49 exhibits neuroprotective efficacy on SH-SY5Y cell. HDAC6-IN-49 improves cognitive function and locomotor ability in Drosophila Parkinson's disease models and in C. elegans Alzheimer's disease models .

HY-N12887

Mycothiazole	Mitochondrial Metabolism	Others Cancer
Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC₅₀ is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans .

HY-125134

Alloaromadendrene	Parasite	Inflammation/Immunology
Alloaromadendrene, an antioxidant, can be isolated from the leaves of mixed-type C. osmophloeum. Alloaromadendrene protects C. elegans against oxidative stress induced by walnut quinone and prolongs the life of C. elegans .

HY-147644

α-Synuclein inhibitor 3	Others	Neurological Disease
α-Synuclein inhibitor 3 (Compound 7g) is a α-synuclein (α -Syn) aggregation inhibitor. α-Synuclein inhibitor 3 can be used for Parkinson’s disease research .

HY-N12486

Isofalcarintriol	Keap1-Nrf2 ATP Synthase	Metabolic Disease
Isofalcarintriol is a NRF2 activator and selective inhibitor of the mitochondrial ATP synthase. Isofalcarintriol can be used for aging study .

HY-N12722

Ophiocordylongiiside A	Others	Others
Ophiocordylongiiside A is a compound found in Polyphilus sieberi. Ophiocordylongiiside A shows activity against the free-living nematode Caenorhabditis elegans .

HY-N2149

Tomatidine 5 Publications Verification	NF-κB JNK Autophagy Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling . Tomatidine activates autophagy either in mammal cells or C elegans .

HY-N2149A

Tomatidine hydrochloride 5 Publications Verification	NF-κB JNK Autophagy Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling . Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans .

HY-162297

4-(Sulfooxy)benzoic acid	Others	Others
4-(Sulfooxy)benzoic acid is a sulfated phenolic acid found in C. elegans. 4-(Sulfooxy)benzoic acid is a metabolite of ethyl para-hydroxybenzoate and several flavonoids .

HY-125731

Glycodeoxycholic Acid	Endogenous Metabolite STAT Autophagy	Inflammation/Immunology Cancer
Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .

HY-W035409

RPW-24 1 Publications Verification	Bacterial	Infection
RPW-24 protects C. elegans from bacterial infection by stimulating the host immune response of the nematode. RPW-24 has antibacterial activity .

HY-121152

Chiisanoside	α-synuclein Apoptosis GABA Receptor Dopamine Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Chiisanoside exhibits neuroprotective, anticancer, antidepressant, anti-inflammatory, anti-obesity and anti-platelet activities. Chiisanoside inhibits tumor growth in H22 xenograft mouse model, through immunoregulation, induction of apoptosis and inhibition of angiogenesis. Chiisanoside attenuates Parkinson’s disease through regulation of Parkin/ZNF746/PGC-1α axis, and promotion of mitochondrial biogenesis .

HY-123265

Luteoreticulin Griseulin	Bacterial	Infection
Luteoreticulin is a nitro-containing bacterial metabolite originally isolated from S. luteoreticuli. It has mosquitocidal activity against A. aegypti when used at a concentration of 6.25 mg/L and nematocidal activity against C. elegans.

HY-161163

IND 1316	AMPK	Neurological Disease
IND 1316 is an orally active, blood-brain barrier permeable AMPK activator with neuroprotective effects in animal models of Huntington's disease. IND 1316 can be used for research on neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease .

HY-125731R

Glycodeoxycholic Acid (Standard)	Endogenous Metabolite STAT Autophagy	Inflammation/Immunology Cancer
Glycodeoxycholic Acid (Standard) is the analytical standard of Glycodeoxycholic Acid. This product is intended for research and analytical applications. Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .

HY-N12526

Isolappaol A	Others	Others
Isolappaol A is a natural product that can be isolated from the Arctium lappa. Isolappaol A upregulates the expression of jnk-1, which may promote longevity and stress resistance of C. elegans through the JNK-1-DAF-16 cascade .

HY-116498

Penigequinolone A	Others	Infection
Penigequinolone A is an alkaloid isolated from Penicillium. It is lethal to P. penetrans (LD50=100 mg/L) but has no effect on C. elegans at concentrations up to 1000 mg/L.1 Penigequinolone A also accelerates the root growth of rice seedlings in a dose-dependent manner.

HY-133859

M084	Mitochondrial Metabolism	Metabolic Disease
M084 is a benzimidazole derivative. M084 inhibits the mitochondrial respiration, activate mitochondrial unfolded protein response and AMPK, recruites SIR-2.1 and SKN-1, and finally through the transcription factor DAF-16, delays the aging process of C. elegans .

HY-123693

ML358	Others	Inflammation/Immunology
ML358 is a first in class, potent, and selective inhibitor of the SKN-1 pathway (IC₅₀=0.24 μM). ML358 sensitizes the model nematode C. elegans to oxidants and anthelmintic. ML358 potentially used as adjuvants to increase the efficacy and useful life of current anthelmintics .

HY-130431

Vinclozolin M2	Parasite	Infection
Vinclozolin M2 is an active metabolite of vinclozolin. It is formed from vinclozolin by successive esterase activity and decarboxylation of vinclozolin in C. elegans and by decarboxylation in human liver microsomes. Vinclozolin M2 is an antagonist of the mineralocorticoid receptor (IC₅₀=1,400 nM) and androgen receptor (IC₅₀=0.17 nM) in reporter assays using MCF-7 cells.

HY-161404

Antibacterial agent 202	Bacterial	Infection
Antibacterial agent 202 (compound 45c) is a low cytotoxicity bacterial inhibitor with good activity against Gram-negative bacteria, including Escherichia coli, Klebsiella pneumonia, especially Pseudomonas aeruginosa, (MIC (minimum inhibitory concentration)=7.8-31.25 μM). Antibacterial agent 202 can exert antibacterial activity by destroying the integrity of cell membranes and can be used in the research of bacterial infections .

HY-163473

IITR08367	Bacterial	Infection
IITR08367 is a potent effector pump Acinetobacter baumannii Fosfomycin Efflux pump (AbaF) inhibitor for enhancing the antimicrobial activity of Fosfomycin (HY-B1075A) against *Acinetobacter baumannii*. IITR08367 acts by interfering with Fosfomycin/H ⁺ reverse transporter activity. .

HY-W592871

10-Hydroxy-2-decenoic acid 10-HDA	mTOR	Cardiovascular Disease Inflammation/Immunology Cancer
10-Hydroxy-2-decenoic acid (10-HDA) is the major lipid component of royal jelly produced by honeybees. 10-Hydroxy-2-decenoic acid has several health-beneficial effects in mammals, such as antitumor activity, anti-inflammatory activity, and antiangiogenic activity. 10-Hydroxy-2-decenoic acid also extends the lifespan of C. elegans .

HY-168077

Antibiofilm agent-12	Fungal	Infection
Antibiofilm agent-12 (Compound C13) is an antifungal agent that belongs to the class of carbazate derivatives. Antibiofilm agent-12 exhibits significant antifungal activity against Candida auris, with a MIC₉₀ of 237.9 μM. By inhibiting the drug efflux pump activity of Candida auris and promoting ergosterol depletion, Antibiofilm agent-12 hinders biofilm formation and reduces the metabolic flexibility of Candida auris. Additionally, Antibiofilm agent-12 demonstrates antifungal activity in a Candida auris-infected C. elegans model .

HY-W643167

1,2,3-Tritridecanoylglycerol Glycerol Tritridecanoyl; 13:0 TAG; 13:0/13:0/13:0-TG	Others	Infection
1,2,3-Tritridecanoyl glycerol is a synthetic triacylglycerol that contains tridecanoic acid in the sn-1, sn-2, and sn-3 positions. It has been used as a standard for the relative quantification of triacylglycerols in C. elegans fat stores. It has also been used as an internal standard for the quantification of triacylglycerols in the serum and liver of adult rat offspring receiving dietary conjugated linoleic acids during and after gestation.

Tomatidine 5 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Anti-aging Source classification Pyridine Alkaloids Solanum lycopersicum L. Plants Alkaloids Solanaceae Inflammation/Immunology Disease Research Fields Steroids	NF-κB JNK Autophagy Endogenous Metabolite
Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling . Tomatidine activates autophagy either in mammal cells or C elegans .

Tomatidine hydrochloride 5 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Solanum lycopersicum L. Solanaceae Plants Disease Research Fields Steroids	NF-κB JNK Autophagy Endogenous Metabolite
Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling . Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans .

Glycodeoxycholic Acid	Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite STAT Autophagy
Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .

Mycothiazole	Structural Classification Natural Products Marine natural products Source classification Sponge	Mitochondrial Metabolism
Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC₅₀ is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans .

Alloaromadendrene	Structural Classification Natural Products Cinnamomum osmophloeum Kanehira Source classification Plants Lauraceae	Parasite
Alloaromadendrene, an antioxidant, can be isolated from the leaves of mixed-type C. osmophloeum. Alloaromadendrene protects C. elegans against oxidative stress induced by walnut quinone and prolongs the life of C. elegans .

Isofalcarintriol	Structural Classification Natural Products Source classification Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Plants Umbelliferae	Keap1-Nrf2 ATP Synthase
Isofalcarintriol is a NRF2 activator and selective inhibitor of the mitochondrial ATP synthase. Isofalcarintriol can be used for aging study .

Ophiocordylongiiside A	Structural Classification Natural Products Source classification Endogenous metabolite	Others
Ophiocordylongiiside A is a compound found in Polyphilus sieberi. Ophiocordylongiiside A shows activity against the free-living nematode Caenorhabditis elegans .

Chiisanoside	Eleutherococcus henryi var. faberi (Harms) S. Y. Hu Triterpenes Structural Classification Terpenoids Source classification Plants Araliaceae	α-synuclein Apoptosis GABA Receptor Dopamine Receptor
Chiisanoside exhibits neuroprotective, anticancer, antidepressant, anti-inflammatory, anti-obesity and anti-platelet activities. Chiisanoside inhibits tumor growth in H22 xenograft mouse model, through immunoregulation, induction of apoptosis and inhibition of angiogenesis. Chiisanoside attenuates Parkinson’s disease through regulation of Parkin/ZNF746/PGC-1α axis, and promotion of mitochondrial biogenesis .

Luteoreticulin Griseulin	Microorganisms Source classification	Bacterial
Luteoreticulin is a nitro-containing bacterial metabolite originally isolated from S. luteoreticuli. It has mosquitocidal activity against A. aegypti when used at a concentration of 6.25 mg/L and nematocidal activity against C. elegans.

Glycodeoxycholic Acid (Standard)	Structural Classification Microorganisms Source classification Endogenous metabolite Steroids	Endogenous Metabolite STAT Autophagy
Glycodeoxycholic Acid (Standard) is the analytical standard of Glycodeoxycholic Acid. This product is intended for research and analytical applications. Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .

Isolappaol A	Structural Classification Source classification Lignans Phenols Polyphenols Phenylpropanoids Plants Compositae Caesalpinia magnifoliolata Metc.	Others
Isolappaol A is a natural product that can be isolated from the Arctium lappa. Isolappaol A upregulates the expression of jnk-1, which may promote longevity and stress resistance of C. elegans through the JNK-1-DAF-16 cascade .

Penigequinolone A	Microorganisms Source classification	Others
Penigequinolone A is an alkaloid isolated from Penicillium. It is lethal to P. penetrans (LD50=100 mg/L) but has no effect on C. elegans at concentrations up to 1000 mg/L.1 Penigequinolone A also accelerates the root growth of rice seedlings in a dose-dependent manner.

10-Hydroxy-2-decenoic acid 10-HDA	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	mTOR
10-Hydroxy-2-decenoic acid (10-HDA) is the major lipid component of royal jelly produced by honeybees. 10-Hydroxy-2-decenoic acid has several health-beneficial effects in mammals, such as antitumor activity, anti-inflammatory activity, and antiangiogenic activity. 10-Hydroxy-2-decenoic acid also extends the lifespan of C. elegans .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82610

	ULK3 Antibody (YA2355) Serine/threonine-protein kinase ULK3; Ulk3; unc 51 like kinase 3 (C. Elegans); Unc-51-like kinase 3	WB	Human
	ULK3 Antibody (YA2355) is a biotin-conjugated non-conjugated IgG antibody, targeting ULK3, with a predicted molecular weight of 53 kDa (observed band size: 53 kDa). ULK3 Antibody (YA2355) can be used for WB experiment in human background.

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