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Results for "

CHOP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (1) Apoptosis (14) Autophagy (3) Bacterial (1) Bcl-2 Family (4) Biochemical Assay Reagents (3) CDK (1) DAPK (1) Deubiquitinase (1) Endogenous Metabolite (18) Eukaryotic Initiation Factor (eIF) (2) FOXO (1) HSP (29) IRE1 (1) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (15) JNK (1) Microtubule/Tubulin (1) NF-κB (1) Nuclear Hormone Receptor 4A/NR4A (1) Parasite (1) PERK (3) Proteasome (1) Reactive Oxygen Species (3) TNF Receptor (1) TRP Channel (1)
By Research Areas:	Cancer (36) Cardiovascular Disease (18) Infection (2) Inflammation/Immunology (3) Metabolic Disease (28) Neurological Disease (19)

By Targets:

AMPK (1)

Anaplastic lymphoma kinase (ALK) (1)

Antibiotic (1)

Apoptosis (14)

Autophagy (3)

Bacterial (1)

Bcl-2 Family (4)

Biochemical Assay Reagents (3)

CDK (1)

DAPK (1)

Deubiquitinase (1)

Endogenous Metabolite (18)

Eukaryotic Initiation Factor (eIF) (2)

FOXO (1)

HSP (29)

IRE1 (1)

Isocitrate Dehydrogenase (IDH) (1)

Isotope-Labeled Compounds (15)

JNK (1)

Microtubule/Tubulin (1)

NF-κB (1)

Nuclear Hormone Receptor 4A/NR4A (1)

Parasite (1)

PERK (3)

Proteasome (1)

Reactive Oxygen Species (3)

TNF Receptor (1)

TRP Channel (1)

By Research Areas:

Cancer (36)

Cardiovascular Disease (18)

Infection (2)

Inflammation/Immunology (3)

Metabolic Disease (28)

Neurological Disease (19)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0830B

Palmitic acid sodium Maximum Cited Publications 51 Publications Verification	Biochemical Assay Reagents HSP Endogenous Metabolite	Cancer
Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid sodium is used to establish a cell steatosis model .

HY-147831

EIF2α activator 1	Eukaryotic Initiation Factor (eIF)	Cancer
EIF2α activator 1 (Compound 40) is an activator of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. EIF2α activator 1 increases the expression level of eIF2α downstream proteins, ATF and CHOP. EIF2α activator 1 exhibits antiproliferative activity againist K562 and PBMC cells with IC₅₀s of 4.00 and 19.3 μM, respectively .

HY-W134007S1

Hexadecanoate-13C16 potassium 3 Publications Verification	Isotope-Labeled Compounds HSP	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Hexadecanoate- ¹³C₁₆ (potassium) is the ¹³C-labeled Hexadecanoate sodium. Hexadecanoate potassium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-100548

GSK621 4 Publications Verification	AMPK Autophagy Apoptosis	Cancer
GSK621 is a specific AMPK activator, with IC₅₀ values of 13-30 μM for AML cells. GSK621 induces autophagy and apoptosis. GSK621 induces eiF2α phosphorylation-a hallmark of UPR activation .

HY-168843

PSP205	Apoptosis Autophagy	Cancer
PSP205 is a potent anticancer agent. PSP205 shows cytotoxicity. PSP205 induces apoptosis. PSP205 induces ER-stress-mediated autophagy. PSP205 increases the protein expression of LC3BII and increases the CHOP and spliced XBP1 at the mRNA and protein levels .

HY-145504

12-Dipalmitoyl-3-Linoelaidoyl-rac-glycerol 1,2-Palmitin-3-Linoelaidin	Biochemical Assay Reagents	Metabolic Disease
12-Dipalmitoyl-3-Linoelaidoyl-rac-glycerol is a triacylglycerol containing palmitic acid (HY-N0830) at the sn-1 and sn-2 positions and linoelaidic acid (HY-W071746) at the sn-3 position. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Linolelaidic acid, an omega-6 trans fatty acid, acts as a source of energy. Linolelaidic acid is an essential nutrient, adding in enteral, parenteral, and infant formulas. Linolelaidic acid can be used for heart diseases research .

HY-149918

Antiproliferative agent-23	Microtubule/Tubulin Apoptosis	Cancer
Antiproliferative agent-23 is a microtubule-destabilizing agent (MDA) and efficiently disturbes the tubulin-microtubule system. Antiproliferative agent-23 induces apoptosis via a mitochondrion-dependent pathway by downregulating the Bcl-2 protein, upregulating Bax and Cyt c proteins, and activating the caspase cascade. Antiproliferative agent-23 initiates reactive oxygen species (ROS)-mediated endoplasmic reticulum stress in A549/CDDP cells (cisplatin resistant cancer cell line) via the PERK/ATF4/CHOP signaling pathway. Antiproliferative agent-23 has anti-tumor activity .

HY-145540

1,2-Dipalmitoyl-3-Octanoyl-rac-glycerol 1,2-Palmitin-3-caprylin	Biochemical Assay Reagents	Metabolic Disease
1,2-Dipalmitoyl-3-Octanoyl-rac-glycerol is a triacylglycerol containing palmitic acid (HY-N0830) at the sn-1 and sn-2 positions and octanoic acid (HY-41417) at the sn-3 position. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Octanoic acid is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes. Octanoic acid is also a tremor-suppressing agent .

HY-167868

DWP-05195	TRP Channel Apoptosis	Neurological Disease Cancer
DWP-05195 is a TRPV1 antagonist that can inhibit the pain signal transduction. DWP-05195 induces ER stress-dependent apoptosis through the ROS-p38-CHOP pathway in human ovarian cancer cells .

HY-13559

Atiprimod Azaspirane	Apoptosis	Cancer
Atiprimod (Azaspirane) is an orally bioavailable small molecule with antitumor, anti-inflammatory, and anti-angiogenic activities. Atiprimod blocks the signaling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) by inhibiting the phosphorylation of signal transducer and activator of transcription 3 (STAT3). Atiprimod also downregulates the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, inducing cell cycle arrest, and inducing apoptosis. Atiprimod triggers persistent ER stress-mediated apoptosis in breast cancer cells by activating the PERK/eIF2α/ATF4/CHOP axis and inhibiting the nuclear translocation of STAT3/NF-κB transcription factors .

HY-121200

Azadirone	TNF Receptor Bcl-2 Family Parasite	Infection Cancer
Azadirone sensitized cancer cells to TNF-related apoptosis-inducing ligand (TRAIL) through ROS-ERK-CHOP-mediated up-regulation of DR5 and DR4 expression, down-regulation of cell survival proteins, and up-regulation of proapoptotic proteins (Bid). Azadirone has antiplasmodial activity .

HY-101991

ML291	PERK Eukaryotic Initiation Factor (eIF) Apoptosis	Cancer
ML291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide. ML291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML291 can activate the *PERK/eIF2a/CHOP* (apoptotic) arm of the UPR and reduce leukemic cell burden .

HY-N0830

Palmitic acid Maximum Cited Publications 51 Publications Verification	HSP Endogenous Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model .

HY-N0830S18

Palmitic acid-d1	Isotope-Labeled Compounds HSP Endogenous Metabolite	Metabolic Disease
Palmitic acid-d is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S4

Palmitic acid-d2	HSP	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid-d₂ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S7

Palmitic acid-d4	HSP	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid-d₄ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830A

Palmitic acid calcium	HSP Endogenous Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease
Palmitic acid calcium is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid calcium is used to establish a cell steatosis model .

HY-N0830S2

Palmitic acid-d31	HSP Endogenous Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid-d₃₁ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S21

Palmitic acid-d5	Isotope-Labeled Compounds HSP Endogenous Metabolite	Metabolic Disease
Palmitic acid-d₅ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830BS1

Palmitic acid-13C16 sodium 3 Publications Verification	Isotope-Labeled Compounds HSP	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid- ¹³C₁₆ sodium is the ¹³C-labeled Palmitic acid sodium. Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .

HY-N0830S14

Palmitic acid-d17	Isotope-Labeled Compounds HSP Endogenous Metabolite	Inflammation/Immunology
Palmitic acid-d₁₇ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830BS

Palmitic acid-13C sodium	Isotope-Labeled Compounds HSP	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid- ¹³C (sodium) is the ¹³C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S20

Palmitic acid-d9	Isotope-Labeled Compounds HSP Endogenous Metabolite	Metabolic Disease
Palmitic acid-d₉ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S5

Palmitic acid-d3	HSP Endogenous Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid-d₃ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0878

Bufotalin 4 Publications Verification	Apoptosis Reactive Oxygen Species	Cancer
Bufotalin is a steroid lactone isolated from Venenum Bufonis with potently antitumor activities. Bufotalin induces cancer cell apoptosis and also induces endoplasmic reticulum (ER) stress activation .

HY-N0830S12

Palmitic acid-d4-1	HSP Endogenous Metabolite	Cancer
Palmitic acid-d₄-1 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2][3].

HY-N0830S11

Palmitic acid-d2-1	HSP	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid-d₂-1 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S17

Palmitic acid-d2-4	Isotope-Labeled Compounds HSP Endogenous Metabolite	Metabolic Disease
Palmitic acid-d₂-4 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S15

Palmitic acid-d2-2	Isotope-Labeled Compounds HSP Endogenous Metabolite	Cancer
Palmitic acid-d₂-2 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S6

Palmitic acid-13C16 3 Publications Verification	HSP Endogenous Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid- ¹³C₁₆ is the ¹³C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S13

Palmitic acid-d4-2	Isotope-Labeled Compounds HSP Endogenous Metabolite	Metabolic Disease
Palmitic acid-d₄-2 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S19

Palmitic acid-d2-5	Isotope-Labeled Compounds HSP Endogenous Metabolite	Metabolic Disease
Palmitic acid-d₂-5 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S16

Palmitic acid-d2-3	Isotope-Labeled Compounds HSP Endogenous Metabolite	Cancer
Palmitic acid-d₂-3 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830R

Palmitic acid (Standard) Maximum Cited Publications 51 Publications Verification	HSP Endogenous Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid (Standard) is the analytical standard of Palmitic acid. This product is intended for research and analytical applications. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .

HY-N0830S10

Palmitic acid-13C2	HSP	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid- ¹³C₂ is the ¹³C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S9

Palmitic acid-13C	Isotope-Labeled Compounds HSP	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid- ¹³C is the ¹³C-labeled Palmitic acid (HY-N0830). Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells .

HY-N0830S8

Palmitic acid-9,10-d2	Isotope-Labeled Compounds HSP	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid-9,10-d₂ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S3

Palmitic acid-1-13C	HSP	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid-1- ¹³C is the ¹³C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S1

Palmitic acid-15,15,16,16,16-d5	HSP Endogenous Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid-15,15,16,16,16-d₅ is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-N0830S

Palmitic acid-1,2,3,4-13C4	Isotope-Labeled Compounds HSP	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Palmitic acid-1,2,3,4- ¹³C₄ is the ¹³C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2].

HY-P10714

Ub4ix	Proteasome Apoptosis Deubiquitinase	Cancer
Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC₅₀ value of 1.6 μM .

HY-153347

JY-2 1 Publications Verification	FOXO	Metabolic Disease
JY-2 is a moderately selective and orally active Forkhead transcription factor forkhead box O1 (FoxO1) inhibitor that inhibits FoxO1 transcriptional activity with an IC₅₀ of 22 μM. JY-2 shows moderate inhibition against FoxO3a and FoxO4. JY-2 shows anti-diabetic activity .

HY-123024

Cefatrizine BL-S-640; SK&F 60771	Apoptosis Bacterial Antibiotic	Infection Cancer
Cefatrizine (BL-S-640) is an orally active and broad-spectrum cephalosporin antibiotic. Cefatrizine is also a eEF2K inhibitor, with anti-proliferative activity in human breast cancer cells, which could induce ER stress, leading to cell death. Cefatrizine can be used in studies of cancer and bacterial infection .

HY-121337

Flurochloridone R-40244	Apoptosis Bcl-2 Family	Others
Flurochloridone (R-40244) is a selective preemergence and persistent herbicide. Flurochloridone induces endoplasmic reticulum (ER) stress and activated unfolded protein response (UPR) signaling pathways. Flurochloridone impairs cell viability and induces cytotoxicity and apoptosis mediated by ER stress via activating *eIF2α-ATF4/ATF6-CHOP-Bim/Bax* signaling pathways in TM4 cells .

HY-124646

KIRA-7	IRE1	Inflammation/Immunology
KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC₅₀ of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect .

HY-121337R

Flurochloridone (Standard)	Apoptosis Bcl-2 Family	Others
Flurochloridone (Standard) is the analytical standard of Flurochloridone. This product is intended for research and analytical applications. Flurochloridone (R-40244) is a selective preemergence and persistent herbicide. Flurochloridone induces endoplasmic reticulum (ER) stress and activated unfolded protein response (UPR) signaling pathways. Flurochloridone impairs cell viability and induces cytotoxicity and apoptosis mediated by ER stress via activating eIF2α-ATF4/ATF6-CHOP-Bim/Bax signaling pathways in TM4 cells .

HY-111237

Butyrolactone I Olomoucin	CDK NF-κB PERK Bcl-2 Family Reactive Oxygen Species Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
Butyrolactone I is an orally active and ATP-competitive inhibitor of CDK1. Butyrolactone I inhibits NF-κB, cdc2 kinase, Bax, ROS production, modulates the *PERK/CHOP. Butyrolactone I mitigates heat-stress-induced Apoptosis*. Butyrolactone I shows anti-inflammatory and intestinal protective activity. Butyrolactone I has antitumor effects against non-small cell lung, small cell lung, prostate cancer and leukemia. Butyrolactone I can be used in NASH research .

HY-135887

ZX-29	Anaplastic lymphoma kinase (ALK) Apoptosis Autophagy	Cancer
ZX-29 is a potent and selective ALK inhibitor with an IC₅₀ of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect .

HY-162886

BSO-07	JNK Reactive Oxygen Species	Cancer
BSO-07 is a ROS/JNK activator with significant anticancer effects, having an IC₅₀ value of 24.81 μM against human breast cancer (BC) cells. BSO-07 induces apoptosis (Apoptosis) and paraptosis by activating JNK and increasing ROS levels, including enhancing the expression of apoptosis-associated proteins such as PARP, Bax, phosphorylated p53, ATF4, and CHOP, while decreasing the levels of anti-apoptotic proteins like Bcl-2, Bcl-xL, and Survivin. BSO-07 holds promise for research in the field of breast cancer .

HY-112056

DIM-C-pPhCO2Me 1 Publications Verification	Nuclear Hormone Receptor 4A/NR4A Apoptosis DAPK Isocitrate Dehydrogenase (IDH) PERK	Cancer
DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhCO2Me induces Apoptosis. DIM-C-pPhCO2Me decreases PAX3-FOXO1A, N-Myc, Rassf4, MyoD1, Grem1, and DAPK1 proteins. DIM-C-pPhCO2Me decreases expression of TXNDC5 and IDH1, induces markers of ER stress (CHOP, ATF4 and p-PERK). DIM-C-pPhCO2Me inhibits renal cell carcinoma, breast cancer. DIM-C-pPhCO2Me can also be used in rhabdomyosarcoma research .

Cat. No.	Product Name	Type