Search Result
Results for "
Cu2
" in MedChemExpress (MCE) Product Catalog:
4
Biochemical Assay Reagents
2
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-156780
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Cuproptosis
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Cancer
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NSC 689534 can form copper chelate with Cu 2+. NSC 689534/Cu 2+ complex is a potent oxidative stress inducer, and has antitumor activity .
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- HY-144324
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Cholinesterase (ChE)
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Neurological Disease
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AChE-IN-6 (Compound 12a) is an optimal multifunctional ligand with significant inhibition of AChE (EeAChE, IC50 = 0.20 μM; HuAChE, IC50 = 37.02 nM) and anti-Aβ activity (IC50 = 1.92 μM for self-induced Aβ1-42 aggregation; IC50 = 1.80 μM for disaggregation of Aβ1-42 fibrils; IC50 = 2.18 μM for Cu2+-induced Aβ1-42 aggregation; IC50 = 1.17 μM for disaggregation of Cu2+-induced Aβ1-42 fibrils). AChE-IN-6 has the potential for the research of Alzheimer's disease .
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- HY-W747575
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Endogenous Metabolite
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Metabolic Disease
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(±)13-HODE cholesteryl ester is originally extracted from atherosclerotic lesions1 and shown to be produced by Cu2+-catalyzed oxidation of LDL. Later studies determined that 15-LO from rabbit reticulocytes and human monocytes were able to metabolize cholesteryl linoleate, a major component of LDL, to 13-HODE cholesteryl ester.
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- HY-123016A
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Endogenous Metabolite
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Metabolic Disease
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(±)9-HODE cholesteryl ester is originally extracted from atherosclerotic lesions1 and shown to be produced by Cu2+-catalyzed oxidation of LDL.2 Later studies determined that 15-LO from rabbit reticulocytes and human monocytes were able to metabolize cholesteryl linoleate, a major component of LDL, to 9-HODE cholesteryl ester.
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- HY-B1637R
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Sodium diethyldithiocarbamate (Standard)
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HIV
Biochemical Assay Reagents
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Infection
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Ditiocarb sodium (Standard) is the analytical standard of Ditiocarb sodium. This product is intended for research and analytical applications. Ditiocarb sodium (Sodium diethyldithiocarbamate) is a copper reagent. The reaction with Cu2+ solution resulted in the formation of a complex, which increased the copper displacement precipitation rate. Ditiocarb sodium can reduce HIV infection and can be used in adjuvant immune research of high-risk breast cancer [2] .
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- HY-111297
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Biochemical Assay Reagents
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Cancer
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BMVC4 is a G-quadruplex (G4) stabilizer of the human telomeric sequence d[AG3(T2AG3)3]. Screening by circular dichroism (CD) spectroscopy revealed that BMVC4 is more suitable as the core molecule of G4 stabilizers than BMVC. The results showed that BMVC4-12C and BMVC4-8C3O are better candidates for G4 stabilizers and are worthy of further study. A simple and rapid screening method based on Cu2+-induced G4 unfolding can be used to find better G4 stabilizers for potential anticancer applications. CD results showed that the trivalent cations of 9-substituted BMVC derivatives are more suitable as G4 stabilizers than the divalent cations of BMVC. In addition, by monitoring the disappearance of the 291 nm CD band of human telomeres after Cu2+ addition, it was found that the core molecule of G4 stabilizer BMVC4 has better stability.
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- HY-N7135R
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Tyrosinase
Fungal
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Metabolic Disease
Inflammation/Immunology
Cancer
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Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC50 value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma [2] .
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- HY-W749394
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Isotope-Labeled Compounds
Drug Intermediate
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Others
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4-Methyl-5-thiazoleethanol- 13C3 is the 13C-labeled 4-Methyl-5-thiazoleethanol (HY-W015695). 4-Methyl-5-thiazoleethanol is a natural sulfur-containing flavor compound with the aroma of beef and nuts. In addition, the composite material prepared by modifying graphene oxide with 4-Methyl-5-thiazoleethanol through a one-step esterification reaction can selectively adsorb copper ions (Cu2+) in aqueous solutions [2].
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- HY-144392
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Cholinesterase (ChE)
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Neurological Disease
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AChE/BuChE-IN-1 (Compound 1), a chrysin derivative, is a selective butyrylcholinesterase (BuChE) inhibitor with an IC50 of 0.48 μM. AChE/BuChE-IN-1 inhibits acetylcholinesterase (AChE) with an IC50 of 7.16 μM. AChE/BuChE-IN-1 shows strong scavenging ·OH activities with a IC50 of 0.1674 μM. AChE/BuChE-IN-1 inhibits reactive oxygen species (ROS), Aβ1-42 aggregation (self-, Cu2+-induced, AChE-induced). AChE/BuChE-IN-1 has high BBB permeability and bioavailability and low cell toxicity. AChE/BuChE-IN-1 has the potential for Alzheimer' disease (AD) research .
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- HY-158117
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Apoptosis
Autophagy
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Cancer
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[Cu2Cl2(4'-(4-Methoxy-1-naphthyl)-terpy)2](PF6)2 (Compound 3) is a copper complex, which inhibits cell viability of HCT116, HCT116DoxR, A2780 and fibroblasts, with IC50s of 0.13, 0.15, 0.66 and 6.24 μM, respectively. [Cu2Cl2(4'-(4-Methoxy-1-naphthyl)-terpy)2](PF6)2 induces apoptosis and autophagy, and arrests cell cycle at G0/G1 phase in HCT116DoxR. [Cu2Cl2(4'-(4-Methoxy-1-naphthyl)-terpy)2](PF6)2 exhibits antimetastatic efficacy .
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- HY-D1601
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Fluorescent Dye
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Others
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N-Aminofluorescein is a fluorescein hydrazide with spiro form, a highly selective and sensitive fluorescence probe for Cu 2+. N-Aminofluorescein has no selective fluorescence response to other common metal ions, can be used for direct detection of Cu 2+ in biological systems with λex/em=495/516 nm [2]. N-Aminofluorescein can be used to measure the concentration of copper ions in cells .
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- HY-P11057
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Fluorescent Dye
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Others
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FGGH is a water-soluble peptide-based probe. FGGH performs the sequential detection of Cu 2+ and S 2- by fluorescence and colorimetry with high sensitivity (LOD: 1.42 and 22.2 nM for Cu 2+ and S 2-, respectively), and images both two ions in living cells and zebrafish models with low cytotoxicity. FGGH can be used for in vivo imaging and environmental pollution monitoring research .
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- HY-D1550
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Fluorescent Dye
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Others
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10-(4-(Bis(2-acetoxyethyl)amino)phenyl)-BODIPY 505/515 is a fluorescent dye for Cu 2+ ion .
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- HY-W414321
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D-Isoglucosamine hydrochloride
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Endogenous Metabolite
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Others
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Fructosamine (D-Isoglucosamine) hydrochloride is a metabolic intermediate and component of cell membranes and cartilage. Fructosamine hydrochloride induces site-specific breaks in DNA chains, especially in the presence of Cu 2+ .
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- HY-N7697E
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Others
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Others
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Chitotriose trihydrochloride is an orally active chitooligosaccharide with antioxidant activities. Chitotriose trihydrochloride inhibits hydroxylation of benzoate to salicylate by H2O2 in the presence of Cu 2+ (IC50 value of 80 μM) .
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- HY-147104
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Fluorescent Dye
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Others
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Fmoc-Lys(5-FITC)-OH is a marker for polypeptides or proteins. FITC is a fluorescence probe for the labeling of amines. FITC is a pH- and Cu 2+-sensitive fluorescence dye [2] .
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- HY-16074
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ATN-224
4 Publications Verification
Bis(choline)tetrathiomolybdate
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SOD
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Cancer
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ATN-224 is an orally active Cu 2+/Zn 2+-superoxide dismutase 1 (SOD1) inhibitor. ATN-224 inhibits SOD1 activity in endothelial cells, an effect that is dose dependent with an IC50 of 17.5 nM.
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- HY-D1549
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Fluorescent Dye
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Others
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o-Pah is a BODIPY derivative with an -NH2 and -OH substituted meso-Ph group. o-Pah exhibits metal-induced J-aggregation in the presence of Cu 2+ and a specific fluorescence enhancement for Hg 2+ (Ex/Em=483/(495-600) nM) .
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- HY-159943
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Cholinesterase (ChE)
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Neurological Disease
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ROS151 is an AChE inhibitor, with IC50s of 14 nM (hAChE), 1.68 μM (eqBChE), 8.17 μM (hFAAH) respectively. ROS151 is also a chelator of Fe 3+ and Cu 2+. ROS151 can be used for research of Alzheimer's disease .
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- HY-W009722
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Ditiocarb sodium trihydrate
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HIV
Biochemical Assay Reagents
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Infection
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Sodium diethylcarbamodithioate (Ditiocarb sodium) trihydrate is a copper reagent. The reaction with Cu 2+ solution resulted in the formation of a complex, which increased the copper displacement precipitation rate. Sodium diethylcarbamodithioate trihydrate can reduce HIV infection and can be used in adjuvant immune research of high-risk breast cancer [2] .
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- HY-152506
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Amyloid-β
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Neurological Disease
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Antioxidant agent-8 is an orally active inhibitor of Aβ1-42 deposition. Antioxidant agent-8 inhibits fibril aggregation (IC50=11.15 µM) and promotes fibril disaggregation (IC50=6.87 µM). Antioxidant agent-8 also inhibits Cu 2+-induced Aβ1-42 fibril aggregation (IC50=3.69 µM) and promotes Cu 2+-induced Aβ1-42 fibril disaggregation (IC50=3.35 µM). Antioxidant agent-8 has antioxidant activity, anti-inflammatory activity, biosafety, blood-brain barrier permeability and neuroprotective effect .
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- HY-162812
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Apoptosis
Cholinesterase (ChE)
Tau Protein
Ferroptosis
Histamine Receptor
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Neurological Disease
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H3R antagonist 4 (compound 11L) was a dual inhibitor of cholinesterase and histamine receptor (H3R), with corresponding IC50 of 7.04 μM (eeAChE), 9.73 μM (hAChE)(reversible) and 1.09 nM (H3R) , respectively. H3R antagonist 4 inhibited the aggregation of Aβ1-42 induced by itself and Cu 2+ (95.48% and 88.63%) , and degraded the Aβ1-42 fibrils induced by itself and Cu 2+ (80.16% and 89.30%) . H3R antagonist 4 chelate biometals such as Cu 2+, Zn 2+, Al 3+, and Fe 2+. H3R antagonist 4 significantly reduced tau protein hyperphosphorylation induced by Aβ1-42 and inhibited RSL-3-induced apoptosis and ferroptosis in PC12 cells. H3R antagonist 4 had the best blood-brain barrier permeability and intestinal absorption in hCMEC/D3 and hPepT1-MDCK cells.H3R antagonist 4 ameliorates learning and memory impairment in a mouse model of Alzheimer's disease induced by scopolamine (HY-N0296) .
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- HY-P1146
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Semax
1 Publications Verification
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Amyloid-β
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Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
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Semax is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu 2+. Semax is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax has immunomodulatory, nootropic and neuroprotective activities. Semax can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia [2] .
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- HY-P1146A
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Amyloid-β
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Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
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Semax acetate is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu 2+. Semax acetate is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax acetate has immunomodulatory, nootropic and neuroprotective activities. Semax acetate can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia [2] .
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- HY-W015695
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Drug Intermediate
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Others
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4-Methyl-5-thiazoleethanol is a natural sulfur-containing flavor compound with the aroma of beef and nuts. In addition, the composite material prepared by modifying graphene oxide with 4-Methyl-5-thiazoleethanol through a one-step esterification reaction can selectively adsorb copper ions (Cu 2+) in aqueous solutions [2].
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- HY-W009722A
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Ditiocarb sodium trihydrate, ACS, 99.0%
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HIV
Biochemical Assay Reagents
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Infection
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Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% (Ditiocarb sodium trihydrate, ACS, 99.0%) is a copper reagent. The reaction with Cu 2+ solution resulted in the formation of a complex, which increased the copper displacement precipitation rate. Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% can reduce HIV infection and can be used in adjuvant immune research of high-risk breast cancer [2] .
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- HY-143413
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Amyloid-β
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Neurological Disease
Inflammation/Immunology
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BuChE-IN-2 is an excellent butyrylcholinesterase (BuChE) inhibitor (IC50s of 1.28 μM and 0.67 μM for BuChE and NO). BuChE-IN-2 can inhibit the aggregation of Aβ, ROS formation and chelate Cu 2+, exhibiting proper blood-brain barrier (BBB) penetration. BuChE-IN-2 has potential to research Alzheimer’s disease .
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- HY-170650
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Phospholipase
Cholinesterase (ChE)
Bacterial
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Infection
Inflammation/Immunology
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SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase enzyme (SMase) inhibitor (IC50 value for B. cereus SMase is 6.43 µM). SMase-IN-1 also inhibits eqBuChE (59.50% inhibition rate at 50 µM concentration). SMase-IN-1 forms a complex with Cu 2+ in biometal interactions. SMase-IN-1 reduces B. cereus-induced hemolysis on sheep erythrocytes .
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- HY-W011060
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4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane
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Biochemical Assay Reagents
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Others
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Cryptand 2.2.2 is a metal ion chelating agent that can selectively form complexes with metal ions. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn 2+, Co 2+, Ni 2+, Cu 2+). Cryptand 2.2.2 can be used in the preparation of nanoparticles, transition metal compounds, and so on .
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- HY-N15706
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LDLR
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Cardiovascular Disease
Metabolic Disease
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Luteolin-7-O-β-D-glucuronide methyl ester is a flavonoid with antioxidative activity. Luteolin-7-O-β-D-glucuronide methyl ester exhibits potent antioxidative activity with an IC50 of 3.05 μg/mL in the NBT superoxide scavenging assay. Luteolin-7-O-β-D-glucuronide methyl ester inhibits LDL oxidation induced by Cu 2+ with the IC50 value is 71.13 μg/mL [2].
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- HY-168501
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Reactive Oxygen Species (ROS)
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Inflammation/Immunology
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Neuroprotective Agent 6 (Compound Y12) is a neuroprotective agent with antioxidant activity and capabilities in DPPH, ABTS radical scavenging. Neuroprotective Agent 6 demonstrates superior neuroprotective effects in both cellular models induced by oxygen-glucose deprivation/reoxygenation (OGD/R) and animal models induced by transient middle cerebral artery occlusion (tMCAO). Additionally, Neuroprotective Agent 6 exhibits significant metal chelating activity towards Cu 2+ .
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- HY-123645
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Fluorescent Dye
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Others
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Rhodamine B hydrazide is a fluorescent derivative based on rhodamine B, containing the spirocyclic structure of Rhodamine B (HY-Y0016), which can be used to detect copper ions (Cu 2+), mercury ions, peroxynitrite, hydroxyl radicals and nitric oxide (NO) [2] .
Excitation/emission wavelength:
Conventional detection: 510/578 nm.
Sulfite detection: 554 nm absorption, 574 nm emission (due to the formation of Rhodamine B fluorescent product).
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- HY-156376
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Cuproptosis
Apoptosis
Topoisomerase
Reactive Oxygen Species (ROS)
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Inflammation/Immunology
Cancer
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Cu(II)-Elesclomol is a complex formed by Elesclomol (HY-12040) and Cu 2+ (copper ions). Cu(II)-Elesclomol is also a weak inhibitor of DNA topoisomerase I. Cu(II)-Elesclomol exerts anticancer effects by inducing oxidative stress and DNA damage through copper chelation. Cu(II)-Elesclomol can inhibit tumor cell proliferation and induce cell cycle arrest and apoptosis. Cu(II)-Elesclomol can be used in the study of cancer [2].
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- HY-N7135
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Tyrosinase
Fungal
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Metabolic Disease
Inflammation/Immunology
Cancer
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Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC50 value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU 2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma [2] .
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- HY-B0240
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Disulfiram
Maximum Cited Publications
111 Publications Verification
Tetraethylthiuram disulfide; TETD
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Aldehyde Dehydrogenase (ALDH)
Interleukin Related
Pyroptosis
Apoptosis
Cuproptosis
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Metabolic Disease
Cancer
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Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier, with Cu 2+ increases intracellular ROS levels and induces cuproptosis [2] .
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- HY-B0240R
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Tetraethylthiuram disulfide (Standard); TETD (Standard)
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Reference Standards
Aldehyde Dehydrogenase (ALDH)
Interleukin Related
Pyroptosis
Apoptosis
Cuproptosis
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Metabolic Disease
Cancer
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Disulfiram (Standard) is the analytical standard of Disulfiram. This product is intended for research and analytical applications. Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram + Cu 2+ increases intracellular ROS levels triggering apoptosis of ovarian cancer stem cells [1-6].
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- HY-158030
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HDAC
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Neurological Disease
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HDAC6-IN-37 (compound W5) is an inhibitor of HDAC6 and has neuroprotective effects. HDAC6-IN-37 can restore the morphology of hippocampal neurons, reduce the expression of Aβ, Tau, and p-Tau proteins in the hippocampus of AD rats, and inhibit the formation of senile plaques and neurofibrillary tangles. Thus, HDAC6-IN-37 improves the Aβ/Cu 2+-induced AD model in rats, regulates oxidative stress status, and balances neurotransmitter disorders in brain tissue .
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- HY-170583
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Cholinesterase (ChE)
Amyloid-β
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Neurological Disease
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hAChE-IN-10 (Compound ET11) is the inhibitor for human acetylcholinesterase (AChE) with an IC50 of 6.34 nM. hAChE-IN-10 scavenges free radicals, and exhibits antioxidant activity. hAChE-IN-10 exhibits metal chelating activity, inhibits Cu 2+-induced Aβ1-42 aggregation, reduces the formation of amyloid plaques, and exhibits neuroprotective activity. hAChE-IN-10 ameliorates the Scopolamine (HY-N0296)-induced cognitive impairment in mouse models .
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- HY-149418
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HDAC
Cholinesterase (ChE)
Tau Protein
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Neurological Disease
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BChE/HDAC6-IN-2 (compound 29a) is a dual inhibitor of BChE and HDAC6 with IC50s of 1.8 nM and 71.0 nM, respectively. BChE/HDAC6-IN-2 has prominently neuroprotective effects and reactive oxygen species (ROS) scavenging activity. BChE/HDAC6-IN-2 is also an effective chelator of metal ion (Fe 2+ and Cu 2+). BChE/HDAC6-IN-2 inhibits phosphorylation of tau, and exhibits moderate immunomodulatory effect.
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- HY-W011060R
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4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane (Standard)
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Biochemical Assay Reagents
Reference Standards
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Others
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Cryptand 2.2.2 (Standard) is the analytical standard of Cryptand 2.2.2 (HY-W011060). This product is intended for research and analytical applications. Cryptand 2.2.2 is a metal ion chelating agent that can selectively form complexes with metal ions. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn 2+, Co 2+, Ni 2+, Cu 2+). Cryptand 2.2.2 can be used in the preparation of nanoparticles, transition metal compounds, and so on .
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- HY-144790
-
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Amyloid-β
Cholinesterase (ChE)
Monoamine Oxidase
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Neurological Disease
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AChE-IN-12 is a potent and blood-brain barrier (BBB) penetrant acetylcholinesterase (AChE) with IC50s of 0.41 μM and 1.88 μM for rat AChE and electric eel AChE. AChE-IN-12 is also a good antioxidant (ORAC = 3.3 eq), selective metal chelator and huMAO-B inhibitor (IC50 = 8.8 μM). AChE-IN-12 has remarkable inhibition of self- and Cu 2+-induced Aβ1-42 aggregation, as well as exhibits a good neuroprotective effect. AChE-IN-12 can be used for researching Alzheimer’s disease .
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- HY-W012572A
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Mitochondrial Metabolism
Bacterial
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Infection
Metabolic Disease
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D-Histidine hydrochloride hydrate is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine hydrochloride hydrate works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine hydrochloride hydrate downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine hydrochloride hydrate is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu 2+) [2] .
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- HY-W012572
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Mitochondrial Metabolism
Bacterial
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Infection
Metabolic Disease
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D-Histidine is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu 2+) [2] .
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- HY-B1306
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p-Aminohippuric acid
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Others
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Neurological Disease
Metabolic Disease
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4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu 2+, Fe 3+, Hg 2+) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD) [2] .
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- HY-W012572R
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Reference Standards
Mitochondrial Metabolism
Bacterial
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Infection
Metabolic Disease
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D-Histidine (Standard) is the analytical standard of D-Histidine (HY-W012572). This product is intended for research and analytical applications. D-Histidine is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu 2+) [2] .
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- HY-B1306R
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p-Aminohippuric acid (Standard)
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Reference Standards
Biochemical Assay Reagents
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Neurological Disease
Metabolic Disease
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4-Aminohippuric acid (p-Aminohippuric acid) (Standard) is the analytical standard of 4-Aminohippuric acid (HY-B1306). This product is intended for research and analytical applications. 4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu 2+, Fe 3+, Hg 2+) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD) [2] .
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- HY-B1306S
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p-Aminohippuric acid-d4
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Biochemical Assay Reagents
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Neurological Disease
Metabolic Disease
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4-Aminohippuric acid-d4 (p-Aminohippuric acid-d4) is the deuterium labeled 4-Aminohippuric acid (HY-B1306). 4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu 2+, Fe 3+, Hg 2+) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD) [2] .
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Cat. No. |
Product Name |
Type |
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- HY-D1601
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Fluorescent Dyes/Probes
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N-Aminofluorescein is a fluorescein hydrazide with spiro form, a highly selective and sensitive fluorescence probe for Cu 2+. N-Aminofluorescein has no selective fluorescence response to other common metal ions, can be used for direct detection of Cu 2+ in biological systems with λex/em=495/516 nm [2]. N-Aminofluorescein can be used to measure the concentration of copper ions in cells .
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- HY-D1550
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Fluorescent Dyes/Probes
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10-(4-(Bis(2-acetoxyethyl)amino)phenyl)-BODIPY 505/515 is a fluorescent dye for Cu 2+ ion .
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- HY-123645
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Fluorescent Dyes/Probes
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Rhodamine B hydrazide is a fluorescent derivative based on rhodamine B, containing the spirocyclic structure of Rhodamine B (HY-Y0016), which can be used to detect copper ions (Cu 2+), mercury ions, peroxynitrite, hydroxyl radicals and nitric oxide (NO) [2] .
Excitation/emission wavelength:
Conventional detection: 510/578 nm.
Sulfite detection: 554 nm absorption, 574 nm emission (due to the formation of Rhodamine B fluorescent product).
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- HY-D1549
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Dyes
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o-Pah is a BODIPY derivative with an -NH2 and -OH substituted meso-Ph group. o-Pah exhibits metal-induced J-aggregation in the presence of Cu 2+ and a specific fluorescence enhancement for Hg 2+ (Ex/Em=483/(495-600) nM) .
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Cat. No. |
Product Name |
Type |
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- HY-W009722
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Ditiocarb sodium trihydrate
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Chelators
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Sodium diethylcarbamodithioate (Ditiocarb sodium) trihydrate is a copper reagent. The reaction with Cu 2+ solution resulted in the formation of a complex, which increased the copper displacement precipitation rate. Sodium diethylcarbamodithioate trihydrate can reduce HIV infection and can be used in adjuvant immune research of high-risk breast cancer [2] .
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- HY-W011060
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4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane
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Biochemical Assay Reagents
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Cryptand 2.2.2 is a metal ion chelating agent that can selectively form complexes with metal ions. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn 2+, Co 2+, Ni 2+, Cu 2+). Cryptand 2.2.2 can be used in the preparation of nanoparticles, transition metal compounds, and so on .
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- HY-W009722A
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Ditiocarb sodium trihydrate, ACS, 99.0%
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Chelators
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Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% (Ditiocarb sodium trihydrate, ACS, 99.0%) is a copper reagent. The reaction with Cu 2+ solution resulted in the formation of a complex, which increased the copper displacement precipitation rate. Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% can reduce HIV infection and can be used in adjuvant immune research of high-risk breast cancer [2] .
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- HY-W011060R
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4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane (Standard)
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Biochemical Assay Reagents
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Cryptand 2.2.2 (Standard) is the analytical standard of Cryptand 2.2.2 (HY-W011060). This product is intended for research and analytical applications. Cryptand 2.2.2 is a metal ion chelating agent that can selectively form complexes with metal ions. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn 2+, Co 2+, Ni 2+, Cu 2+). Cryptand 2.2.2 can be used in the preparation of nanoparticles, transition metal compounds, and so on .
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P1146
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Semax
1 Publications Verification
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Amyloid-β
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Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
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Semax is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu 2+. Semax is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax has immunomodulatory, nootropic and neuroprotective activities. Semax can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia [2] .
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- HY-P1146A
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Amyloid-β
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Cardiovascular Disease
Neurological Disease
Inflammation/Immunology
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Semax acetate is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu 2+. Semax acetate is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax acetate has immunomodulatory, nootropic and neuroprotective activities. Semax acetate can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia [2] .
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- HY-P4283
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Peptides
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Others
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Glycylhistidylglycine is composed of two glycines and one histidine, which can detect and remove the concentration of Cu2+ ions in wastewater by forming a tripeptide complex with copper and nickel ions.
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- HY-P11057
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Fluorescent Dye
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Others
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FGGH is a water-soluble peptide-based probe. FGGH performs the sequential detection of Cu 2+ and S 2- by fluorescence and colorimetry with high sensitivity (LOD: 1.42 and 22.2 nM for Cu 2+ and S 2-, respectively), and images both two ions in living cells and zebrafish models with low cytotoxicity. FGGH can be used for in vivo imaging and environmental pollution monitoring research .
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- HY-P5079
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Peptides
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Others
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LGLLLRHLRHHSNLLANI (B18) is an 18 amino acid peptide. LGLLLRHLRHHSNLLANI derives from the membrane-associated protein binding. LGLLLRHLRHHSNLLANI shows a high affinity for Cu 2+ ions .
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- HY-W012572A
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Mitochondrial Metabolism
Bacterial
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Infection
Metabolic Disease
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D-Histidine hydrochloride hydrate is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine hydrochloride hydrate works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine hydrochloride hydrate downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine hydrochloride hydrate is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu 2+) [2] .
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- HY-K0255
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MCE IMAC Agarose (NTA) 6FF allows flexible chelation with metal ions such as Zn2+, Ni2+, or Cu2+, and is suitable for the purification of His-tagged recombinant proteins expressed in bacterial, mammalian, insect, and baculovirus systems.
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- HY-K0256
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MCE Chelating Agarose (IDA) 6FF allows flexible chelation with metal ions such as Zn2+, Ni2+, or Cu2+, and is suitable for the purification of His-tagged recombinant proteins expressed in bacterial, mammalian, insect, and baculovirus systems.
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
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- HY-W015695
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-
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- HY-N7135
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- HY-W012572
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Microorganisms
Source classification
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Mitochondrial Metabolism
Bacterial
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D-Histidine is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu 2+) [2] .
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-
- HY-B1306
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p-Aminohippuric acid
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Structural Classification
Classification of Application Fields
Ketones, Aldehydes, Acids
Source classification
Other Diseases
Endogenous metabolite
Disease Research Fields
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Others
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4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu 2+, Fe 3+, Hg 2+) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD) [2] .
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- HY-B1306R
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p-Aminohippuric acid (Standard)
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Structural Classification
Ketones, Aldehydes, Acids
Source classification
Endogenous metabolite
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Reference Standards
Biochemical Assay Reagents
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4-Aminohippuric acid (p-Aminohippuric acid) (Standard) is the analytical standard of 4-Aminohippuric acid (HY-B1306). This product is intended for research and analytical applications. 4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu 2+, Fe 3+, Hg 2+) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD) [2] .
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- HY-N7135R
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Olax imbricata
Structural Classification
Ketones, Aldehydes, Acids
Olacaceae
Source classification
Plants
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Tyrosinase
Fungal
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Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC50 value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma [2] .
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-
- HY-N7697E
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-
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- HY-N15706
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-
- HY-W012572R
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Microorganisms
Source classification
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Reference Standards
Mitochondrial Metabolism
Bacterial
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D-Histidine (Standard) is the analytical standard of D-Histidine (HY-W012572). This product is intended for research and analytical applications. D-Histidine is an anti-biofilm agent that targets bacterial quorum sensing systems (such as RhlI/RhlR pathway) and has antibacterial activity. D-Histidine works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility. D-Histidine downregulates quorum sensing-related gene expression, reduces the synthesis of virulence factors (such as alginate and proteases), and interferes with bacterial membrane stability, inhibiting biofilm formation, promoting the disintegration of mature biofilms, and enhancing antibiotic sensitivity. D-Histidine is also an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, which promotes the condensation of amino acids to form dipeptides (such as dialanine and dilysine) by forming a complex with copper ions (Cu 2+) [2] .
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Cat. No. |
Product Name |
Chemical Structure |
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- HY-B1306S
-
|
4-Aminohippuric acid-d4 (p-Aminohippuric acid-d4) is the deuterium labeled 4-Aminohippuric acid (HY-B1306). 4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu 2+, Fe 3+, Hg 2+) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD) [2] .
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-
- HY-W749394
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4-Methyl-5-thiazoleethanol- 13C3 is the 13C-labeled 4-Methyl-5-thiazoleethanol (HY-W015695). 4-Methyl-5-thiazoleethanol is a natural sulfur-containing flavor compound with the aroma of beef and nuts. In addition, the composite material prepared by modifying graphene oxide with 4-Methyl-5-thiazoleethanol through a one-step esterification reaction can selectively adsorb copper ions (Cu2+) in aqueous solutions [2].
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