Search Result
Results for "
Euphorbia
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-N5001
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Apoptosis
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Cancer
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Euphorbia factor L2, a lathyrane diterpenoid isolated from caper euphorbia seed (the seeds of Euphorbia lathyris L.), has been traditionally applied to treat cancer. Euphorbia factor L2 shows potent cytotoxicity and induces apoptosis via a mitochondrial pathway .
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- HY-N8121
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Others
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Others
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Euphorbia factor L7a, a diterpenoid compound, can be isolated from the seeds of Euphorbia lathyris .
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- HY-N8118
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Others
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Others
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Euphorbia factor L7b is an isolathyrolditerpene compound .
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- HY-N0562
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Euphorbia factor L3
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Others
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Cancer
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5,15-Diacetyl-3-benzoyllathyrol is one of the lathyrane diterpenoids, that has anti-cancer activity.
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- HY-N0868
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Euphorbia factor Pe1
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Others
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Others
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20-O-Acetylingenol-3-angelate is a natural compound.
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- HY-N8119
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Others
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Others
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Euphorbia factor L(8) is a diterpenoid from the seeds of Euphorbia lathyris .
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- HY-W123056
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Euphorbia CERIFERA (CANDELILLA) WAX
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Biochemical Assay Reagents
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Others
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Candelilla wax is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-N10875
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Others
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Others
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Euphebracteolatin B is a nature product that could be isolated from Euphorbia fischeriana .
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-
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- HY-N1645
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Kaurane-2β,16-diol
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Others
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Others
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2,16-Kauranediol, a diterpene compound, is a natural product that can be isolated from the aerial part of Euphorbia hirta .
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- HY-N12730
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Others
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Others
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Euphoscopin B (compound 5) is a cytotoxic macrocyclic diterpene isolated from Euphorbia helioscopia L .
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- HY-N12731
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Others
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Others
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Epieuphoscopin B (compound 3) is a cytotoxic macrocyclic diterpene isolated from Euphorbia helioscopia L .
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- HY-138142
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Others
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Metabolic Disease
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Euphol acetate is a triterpene that can be isolated from Euphorbia broteri. Euphol acetate is an inhibitor of hepatic transport proteins organic anion-transporting polypeptide 1/3 (OATP1B1/3) .
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- HY-N7464
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Others
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Others
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Jolkinolide E is a casbane diterpenoid from the roots of Euphorbia rapulum. Jolkinolide E shows weak selective activity against HepG2, MCF-7, and C6 cell lines .
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- HY-N10990
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Others
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Others
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Ingol 7,8,12-triacetate 3-(4-methoxyphenyl)acetate is a highly functionalized ingol diterpene that can be isolated from Euphorbia officinarum latex .
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- HY-N2556
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Others
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Inflammation/Immunology
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Tirucallol, a tetracyclic triterpene, is isolated from Euphorbia lacteal latex. Tirucallol has topical anti-inflammatory effect. Tirucallol can suppress ear edema in the mouse model and inhibit nitrite production in lipopolysaccharide-stimulated macrophages .
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- HY-137242
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HIV
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Infection
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Ingenol-3-palmitate, an ingenane diterpenoid, is a nature product that could be isolated from the roots of Euphorbia ebracteolata. Ingenol-3-palmitate is a potent HIV-1 (HIV) inhibitor with an IC50 value of 4.1 nM .
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- HY-N7332
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P-glycoprotein
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Cancer
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Pepluanin A is a natural compound isolated from Euphorbia peplus L. Pepluanin A shows a very high activity for a jatrophane diterpene, outperforming Cyclosporin A by a factor of at least 2 in the inhibition of Pgp-mediated Daunomycin (HY-13062A) transport [1]
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- HY-N0866
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Autophagy
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Inflammation/Immunology
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20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA) .
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- HY-N10839
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Others
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Cancer
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Yuexiandajisu E is a diterpenoid that can be found in Euphorbia ebracteolata .
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- HY-N1704
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Others
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Others
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24-Methylenecycloartanol acetate is a triterpene that can be found in Euphorbia segetalis .
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- HY-N7893
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Others
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Others
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Ebracteolata cpd B is a natural phenol compound found in Euphorbia ebracteolata .
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- HY-125114
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Others
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Others
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Jatrophane 4 is a secondary metabolite of Euphorbia peplus. Jatrophane 4 is a diterpene .
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- HY-N9207
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Others
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Others
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Germanicol acetate can be extracted from Euphorbia heterophylla L. and has phytotoxic activity .
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- HY-N2880
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Others
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Others
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Antiquorin is a Diterpenoids product that can be isolated from the roots of Euphorbia fischeriana. .
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- HY-N1310
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Others
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Others
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Simiarenone is a Triterpenoids product that can be isolated from the herbs of Euphorbia lathyris L. .
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- HY-N11060
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PBI 344
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Others
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Others
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(Rac)-Dehydrovomifoliol (PBI 344) is a bisnorsesquiterpene compound that can be found in Euphorbia peplus .
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- HY-N3401
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Others
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Cancer
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Lasiodiplodin is a potent anti-leukemic macrolide can be isolated from Euphorbia splendens .
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- HY-N7304
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Others
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Others
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Jatrophane I is a Diterpenoids product that can be isolated from the herbs of Euphorbia peplus .
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- HY-N7306
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Others
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Others
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Jatrophane VI is a Diterpenoids product that can be isolated from the herbs of Euphorbia peplus .
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- HY-133209
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Others
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Cancer
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Fischeria A is a norditerpene lactone of a new carbon skeleton, can be isolated from Euphorbia fischeriana .
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- HY-137037
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Others
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Cancer
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Ingenol 20-palmitate (compound 2) is a diterpene that can be found in Euphorbia lath yris .
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- HY-N11025
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Others
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Others
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Kansenone, a euphane-type triterpene, can be isolated from a 60% EtOH extract of Euphorbia kansui .
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- HY-N7823
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Others
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Others
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Phorbol 13-acetate is a Diterpenoids product that can be isolated from the roots of Euphorbia pekinensis Rupr. .
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- HY-N8959
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Others
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Others
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9-O-Ethyldeacetylorientalide is a Sesquiterpenoids product that can be isolated from the herbs of Euphorbia pekinensis .
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- HY-N0732
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Apoptosis
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Cancer
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Jolkinolide B, a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud, is known to induce apoptosis in cancer cells .
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- HY-N10075
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P-glycoprotein
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Others
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Euphohelioscopin A is a diterpenoid can be isolated from the Euphorbia helioscopia L. plant. Euphohelioscopin A weakly inhibits P-glycoprotein-mediated efflux of mitoxantrone .
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- HY-N2709
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6-epi-O-Demethylesquirolin D
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Others
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Others
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6-Epidemethylesquirolin D (6-epi-O-Demethylesquirolin D) is a Diterpenoids product that can be isolated from the herbs of Euphorbia ehracteolata .
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- HY-N8555
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Others
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Others
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ent-Kaurane-16β,19,20-triol is a Diterpenoids product that can be isolated from the herbs of Euphorbia ehracteolata .
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- HY-N1596
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Ent-3-oxokaurane-16α,17-diol
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Others
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Others
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Ent-16α,17-dihydroxykauran-3-one is a diterpenoid, which can be isolated from the roots of Euphorbia ebracteolata .
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- HY-N0425
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P-glycoprotein
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Cancer
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Epoxylathyrol, an epoxylathyrane derivative isolated from the Euphorbia boetica, is a P-glycoprotein (P-gp) inhibitor. Epoxylathyrol is a P-gp-mediated multidrug resistance (MDR) reverser .
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- HY-N2662
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5,7-Dihydroxy-6,8-dimethoxyflavon
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Others
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Others
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6-Methoxywogonin (5,7-Dihydroxy-6,8-dimethoxyflavon) is a Diterpenoids product that can be isolated from the roots of Euphorbia pekinensis Rupr. .
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- HY-N3813
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Others
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Others
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ent-16α,17-Dihydroxyatisan-3-one is a Diterpenoids product that can be isolated from the herbs of Euphorbia Antiquorum. .
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- HY-N12434
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EOF2
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Others
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Metabolic Disease
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Euphorblin R (EOF2) is a rhamnyl diterpenoid isolated from Euphorbia resinifera. Euphorblin R may promote lysosomal biogenesis and has the potential to be used in the study of lysosome-related diseases.
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- HY-125648
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alpha-Euphorbol
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Parasite
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Infection
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Euphorbadienol (alpha-Euphorbol), a triterpenic compound, isolated from the latex of Euphorbia resinifera. The derivatives of Euphorbadienol can be used as elicitors of disease resistance, and has antileishmanial and antitrypanosomal activity .
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- HY-N3970
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Others
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Neurological Disease
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Gopherenediol is a diterpenoid with putative antifeedant activity against Mammalian herbivores. Gopherenediol is the active compound in to form deterrent effect, protects gopherweed, Euphorbia lathyris (Euphorbiaceae) from feeding by Mammalian herbivores .
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- HY-N9189
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Others
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Others
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5,8,9,14-Tetraacetoxy-3-benzoyloxy-10,15-dihydroxypepluane is a Diterpenoids product that can be isolated from the herbs of Euphorbia peplus .
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- HY-N7267
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Others
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Endocrinology
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31-Norlanostenol is a triterpenic compound isolated from the latex of Euphorbia officinarum. 31-Norlanostenol can act as efficient insect growth regulator on S. frugiperda and Tenebrio molitor .
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- HY-N13116
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Parasite
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Others
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3-O-(2",3"-Dimethylbutanoyl)-13-O-decanoylingenol (compound 2) is a diterpenoid with antinematode activity, which can be isolated from Euphorbia kansui .
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- HY-N1897
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Others
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Others
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4-Hydroxy-11,12,13-trinor-5-eudesmen-7-one is a Sesquiterpenoids product that can be isolated from the roots of Euphorbia fischeriana. .
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- HY-N11027
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Others
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Others
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5-O-Benzoyl-20-deoxyingenol is a diterpene that can be isolated from the roots of Euphorbia kansui. 5-O-Benzoyl-20-deoxyingenol inhibits cell proliferation .
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- HY-N0732R
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Apoptosis
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Cancer
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Jolkinolide B (Standard) is the analytical standard of Jolkinolide B. This product is intended for research and analytical applications. Jolkinolide B, a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud, is known to induce apoptosis in cancer cells .
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- HY-N9280
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Others
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Others
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ent-11α-Hydroxyabieta-8(14),13(15)-dien-16,12α-olide (compound 12) is a natural bioactive diterpenoid found in the roots of Euphorbia fischeriana .
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- HY-N8560
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Others
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Others
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3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one is a Diterpenoids product that can be isolated from the roots of Euphorbia kansui. .
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- HY-W744699
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(+)-Larixol
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Src
ERK
Akt
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Inflammation/Immunology
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Larixol is an fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Larixol can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Larixol inhibits fMLP (0.1 μM)-induced superoxide anion production (IC50: 1.98 μM), cathepsin G release (IC50: 2.76 μM), and chemotaxis. Larixol improves neutrophil hyperactivation and reduces inflammation or tissue damage. A series of Larixol derivatives were found to have inhibitory effects on FSGS-related TRPC6 functional mutants .
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- HY-N10046
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ent-Kaurane-3-oxo-17β-ol
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Others
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Others
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ent-17-Hydroxykauran-3-one (ent-Kaurane-3-oxo-17β-ol; compound 7) is a kaurane-type diterpenoid that can be found in the roots of Euphorbia fischeriana .
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- HY-N3443
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Others
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Cancer
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Jolkinol A is a natural product that can be found in Euphorbia pubescens. Jolkinol A inhibits cell growth with GI50s of 95.3, 57.3, >100 µM for MCF-7, NCI-460, SF-268 cells, respectively .
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- HY-N1969
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3,8-Di-O-methylellagic acid
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Bacterial
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Infection
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3,3'-Di-O-methylellagic acid obtained from Euphorbia adenochlora selectively inhibits the formation of acid-fastness in mycobacteria without retardation of their growth. 3,3'-di-O-methylellagic acid as a hepatoprotective compound is apparently due to its antioxidative effect .
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- HY-B0719
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Ingenol 3-angelate; PEP005
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PKC
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Inflammation/Immunology
Cancer
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Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.
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- HY-119767
-
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VEGFR
Apoptosis
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Cancer
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Jolkinolide A is a diterpenoid, can be extracted from the roots of Euphorbia fischeriana Steud. Jolkinolide A exhibits anti-tumor activity, by affecting on angiogenesis of tumor tissues. Jolkinolide A significantly inhibits the Akt-STAT3-mTOR signaling pathway and reduces the expression of VEGF in A549 cells .
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- HY-N2333
-
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(+)-Resiniferatoxin
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TRP Channel
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Cardiovascular Disease
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Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period .
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- HY-N0313
-
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MAGL
Endogenous Metabolite
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Inflammation/Immunology
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Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain .
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- HY-N3824
-
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Others
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Others
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ent-Atisane-3β,16α,17-triol is a compound that can be isolated from the acetone extract of roots of Euphorbia sieboldiana. ent-Atisane-3β,16α,17-triol is a natural control product .
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- HY-N3811
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RSV
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Infection
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ent-11β-Hydroxyatis-16-ene-3,14-dione (compound 11) is a diterpenoid from the fresh roots of Euphorbia jolkinii. ent-11β-Hydroxyatis-16-ene-3,14-dione has anti-RSV activity .
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- HY-B0719R
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PKC
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Inflammation/Immunology
Cancer
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Ingenol Mebutate (Standard) is the analytical standard of Ingenol Mebutate. This product is intended for research and analytical applications. Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.
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- HY-N7168A
-
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Others
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Others
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3-O-(2'E ,4'Z-Decadienoyl)-20-O-acetylingenol (compound 6) is a diterpene that can be isolated from Euphorbia kansui. 3-O-(2'E ,4'Z-Decadienoyl)-20-O-acetylingenol shows cleavage inhibition activity of individual Xenopus cells at the blastular stage .
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- HY-N13083
-
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PCSK9
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Cardiovascular Disease
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PCSK9-IN-28 (Compound C11) is a PCSK9 inhibitor that can be isolated from Euphorbia esula. By binding to HNF1α, PCSK9-IN-28 inhibits PCSK9 transcription by binding to HNF1α and affecting its nuclear distribution, thereby enhancing LDLR and promoting LDL uptake. PCSK9-IN-28 exhibits significant lipid-lowering activity in the high-fat diet (HFD) mouse model and can be used in the study of hyperlipidemia .
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- HY-N13201
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Apoptosis
CDK
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Inflammation/Immunology
Cancer
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12-Deoxyphorbol 13-palmitate is a traditional Chinese medicine monomer with antitumor activity that can be isolated from the root of Euphorbia fischeriana. 12-Deoxyphorbol 13-palmitate induces gastric cancer cell cycle arrest and apoptosis by regulating key cell cycle regulators such as cyclin B、cyclin A and CDC2. In addition, 12-Deoxyphorbol 13-palmitate can significantly weaken APOL2–SERCA2–PERK–HES1 signaling and slow liver fibrosis by targeting APOL2 .
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| Cat. No. |
Product Name |
Type |
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- HY-W123056
-
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Euphorbia CERIFERA (CANDELILLA) WAX
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Biochemical Assay Reagents
|
|
Candelilla wax is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
- HY-N9280
-
-
- HY-N8560
-
-
- HY-W744699
-
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(+)-Larixol
|
Larix decidua Miller
Structural Classification
Natural Products
Pinaceae
Source classification
Plants
|
Src
ERK
Akt
|
|
Larixol is an fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Larixol can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Larixol inhibits fMLP (0.1 μM)-induced superoxide anion production (IC50: 1.98 μM), cathepsin G release (IC50: 2.76 μM), and chemotaxis. Larixol improves neutrophil hyperactivation and reduces inflammation or tissue damage. A series of Larixol derivatives were found to have inhibitory effects on FSGS-related TRPC6 functional mutants .
|
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- HY-N10046
-
-
- HY-N3443
-
-
- HY-N1969
-
-
- HY-B0719
-
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Ingenol 3-angelate; PEP005
|
Structural Classification
Classification of Application Fields
Terpenoids
Euphorbia peplus Linn.
Diterpenoids
Euphorbiaceae
Plants
Inflammation/Immunology
Disease Research Fields
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PKC
|
|
Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.
|
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- HY-119767
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-
- HY-N2333
-
-
- HY-N0313
-
-
- HY-N3824
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-
- HY-N3811
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-
- HY-B0719R
-
|
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Structural Classification
Terpenoids
Euphorbia peplus Linn.
Diterpenoids
Euphorbiaceae
Plants
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PKC
|
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Ingenol Mebutate (Standard) is the analytical standard of Ingenol Mebutate. This product is intended for research and analytical applications. Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.
|
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- HY-N7168A
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- HY-N13083
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- HY-N13201
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