Search Result
Results for "
Garcinia acid
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-16007
-
|
Garcinia acid
|
ATP Citrate Lyase
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Metabolic Disease
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(-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. (-)-Hydroxycitric acid is a potent and competitive and orally active inhibitor of ATP citrate lyase. (-)-Hydroxycitric acid suppresses the fatty acid synthesis, lipogenesis, food intake, and induced weight loss .
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-
-
- HY-N7347
-
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Garcinia lactone
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ATP Citrate Lyase
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Metabolic Disease
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(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .
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-
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- HY-N5115
-
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Others
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Others
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Neosmitilbin is isolated from Garcinia mangostana.
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-
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- HY-N3347
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Maclurin
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Others
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Others
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Macurin is a xanthone that can be isolated from Garcinia lancilimba .
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-
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- HY-N4094
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-
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- HY-N14035
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ATP Citrate Lyase
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Cardiovascular Disease
Metabolic Disease
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Garcinia cambogia extract contains several active compounds, including hydroxycitric acid (HCA) (an ECC inhibitor), xanthones, benzophenones, hydroxycitric acid (an ATP-citrate lyase inhibitor). Garcinia cambogia extract lowers the body weight gain, visceral fat accumulation, blood and hepatic lipid concentrations, and plasma insulin and leptin levels in a high-fat diet (HFD)-induced obesity mouse model. Garcinia cambogia extract is promising for research of fatty liver, dyslipidemia, hyperinsulinemia and hyperleptinemia rendered by HFD .
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-
-
- HY-N9045
-
|
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Others
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Others
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7-Prenyljacareubin is a natural xanthone found in Garcinia gardneriana .
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-
-
- HY-N8878
-
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Others
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Others
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Latisxanthone C (compound 15) is a pyranoxanthonethat can be found in Garcinia species .
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-
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- HY-N3465
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Others
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Others
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Isonormangostin is a Xanthones product that can be isolated from the fruits of Garcinia mangostana .
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-
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- HY-N3637
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-
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- HY-124537
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Others
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Others
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(+)-Volkensiflavone is a biflavonoid, that can be isolated from the fruits of Garcinia livingstonei (Clusiaceae) .
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-
-
- HY-N10398
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Others
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Others
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Garcinielliptone HD is a compound isolated from the heartwood of Garcinia subelliptica Merr. .
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-
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- HY-N6247
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Others
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Others
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Fuscaxanthone C is an xanthone isolated from the stem bark of Garcinia fusca .
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-
-
- HY-N3189
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Others
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Others
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Nigrolineaxanthone V is a Xanthones product that can be isolated from the fruits of Garcinia mangostana L. .
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-
-
- HY-N9152
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Others
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Others
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Parvifolixanthone B is a Xanthones product that can be isolated from the twigs of Garcinia parvifolia. .
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-
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- HY-N1437
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Others
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Metabolic Disease
|
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Hydroxycitric acid is a natural antiobesity agent, that can be isolated from the fruits of Garcinia gummi-gutta (L.) Roxb .
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-
-
- HY-N1197
-
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1,4,5-Trihydroxyxanthone
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Others
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Others
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Subelliptenone G is a simple oxygenated xanthone that can be isolated from the root bark of Garcinia subelliptica .
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-
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- HY-N8557
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Others
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Others
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1,5-Dihydroxyxanthone (Compound 5) is a xanthone that can be isolated from the root of Garcinia cowa .
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-
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- HY-N8891
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Others
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Others
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1,2,5-Trihydroxyxanthone is a Xanthones product that can be isolated from the barks of Garcinia tetralata. .
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-
-
- HY-N9219
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Others
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Others
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2,5-Dihydroxyxanthone is a Xanthones product that can be isolated from the stem barks of Garcinia tetrandra .
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-
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- HY-N6248
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Bacterial
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Infection
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Cowaxanthone B is a xanthone isolated from the fruits of Garcinia cowa. Cowaxanthone B has weak antibacterial activity .
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-
-
- HY-N10673
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Others
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Cancer
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10α-Hydroxyepigambogic acid can be extracted from Garcinia hanburyi. 10α-Hydroxyepigambogic acid can be used in the research of tumors .
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-
-
- HY-N1868
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Others
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Others
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3-Prenyl-2,4,6-trihydroxybenzophenone is a Xanthones product that can be isolated from the herbs of Garcinia cowa .
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-
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- HY-N4094R
-
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Others
|
Inflammation/Immunology
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Morellic acid (Standard) is the analytical standard of Morellic acid. This product is intended for research and analytical applications. Morellic acid is isolated from Garcinia Morella with an antiangiogenic activity .
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-
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- HY-N3324
-
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(+)-Mangostanol
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Phosphodiesterase (PDE)
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Others
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Mangostanol ((+)-Mangostanol) is a polyoxygenated xanthone mangostanol, which can be isolated from the shell of Garcinia mangostana, and has inhibitory effect on cAMP phosphodiesterase (PDE) .
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- HY-N3482
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Others
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Neurological Disease
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Isogarciniaxanthone E (compound 1) is a natural product that can be found in Garcinia xanthochymus. Isogarciniaxanthone E enhances nerve growth factor-mediated neurite outgrowth .
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- HY-N9454
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Others
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Cancer
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Garcinoic acid is the vitamin E analogue extracted from Garcinia Kola seeds. Garcinoic acid shows a marked antiproliferative effect on glioma C6 cancer cells .
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- HY-N1647
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Others
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Others
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2',3',6-Trihydroxy-2,4-dimethoxybenzophenone (compound 1) is a benzophenone derivative, that can be isolated from the herbs of Garcinia xanthochymus .
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-
-
- HY-N1000
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Others
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Others
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1,7-Dihydroxy-3-methoxy-2-prenylxanthone is a Xanthones product that can be isolated from the fruits of Garcinia mangostana .
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-
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- HY-N4292
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Others
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Others
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3,8-Dihydroxy-2,4,6-trimethoxyxanthone is a trimethoxyxanthone, a natural product, can be isolated from the stems of Garcinia multiflora .
|
-
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- HY-N8857
-
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Reactive Oxygen Species
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Others
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Parvifolixanthone A is a xanthone compound that can be isolated from Garcinia parvifolia. Parvifolixanthone A exhibits antioxidant activity with IC50 of submicromolar level (0.18–0.38 μM) .
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-
-
- HY-N2702
-
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Others
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Others
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6-Benzoyl-5,7-dihydroxy-2,2-dimethylchromane is a Xanthones product that can be isolated from the herbs of Garcinia cowa .
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-
-
- HY-N8455
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Assiguxanthone A
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Parasite
|
Infection
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Isocudraniaxanthone A is a xanthone that can be isolated from Garcinia vieillardii. Isocudraniaxanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC50 of 2.3 μg/mL .
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-
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- HY-N0991
-
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Others
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Others
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1,5,8-Trihydroxy-3-methoxy-2-prenylxanthone is a natural product that can be isolated from the herbs of Garcinia mangostana .
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-
-
- HY-N8338
-
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Parasite
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Infection
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Pancixanthone A is a xanthone that can be isolated from Garcinia vieillardii. Pancixanthone A has antimalarial activity against chloroquino-resistant strains of Plasmodium falciparum with an IC50 of 1.6 μg/mL .
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-
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- HY-N2768
-
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Others
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Others
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8-Benzoyl-5,7-dihydroxy-2,2-dimethylchromane is a Xanthones product that can be isolated from the herbs of Garcinia cowa .
|
-
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- HY-N2058
-
|
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Bacterial
Apoptosis
|
Infection
Cancer
|
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Neogambogic acid, an active ingredient in garcinia, induces apoptosis and has anticancer effect. Neogambogic acid has significant inhibitory activity toward methicillin-resistant Staphylococcus aureus (MRSA) .
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-
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- HY-N9261
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Others
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Others
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3-(3-Hydroxy-3-methylbutanyl)-2,4,6-trihydroxybenzophenone is a Xanthones product that can be isolated from the herbs of Garcinia cowa. .
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-
-
- HY-N8876
-
|
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Others
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Cancer
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Paucinervin A (Compound 1) is a type of bittern.
Paucinervin A inhibits the growth of HeLa cells (IC50=29.5
μM). Paucinervin A is isolated from the natural Garcinia
paucinervis .
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-
-
- HY-N10676
-
|
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Others
|
Cancer
|
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8,8a-Dihydro-8-hydroxygambogic acid is a natural product, that can be isolated from the resin of Garcinia hanburyi. 8,8a-Dihydro-8-hydroxygambogic acid shows anticancer activity .
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-
-
- HY-N9113
-
|
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Others
|
Cardiovascular Disease
|
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1,3,5,6-Tetrahydroxyxanthone is a natural xanthone that can be isolated from Garcinia achachairu Rusby (Clusiaceae) branches. 1,3,5,6-Tetrahydroxyxanthone induces diuresis and saluresis in normotensive and hypertensive rats .
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- HY-N15370
-
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Bacterial
|
Infection
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Morellin is a caged-tetraprenylated xanthone compound found in the fruits of Garcinia hanburyi, exhibiting antibacterial activity with a minimum inhibitory concentration (MIC) of 200 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA), and can be utilized in anti-infective research .
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-
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- HY-N3974
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(+)-Griffipavixanthone
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Apoptosis
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Cancer
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Griffipavixanthone can be extracted from Garcinia schomburgkiana. Griffipavixanthone induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. Griffipavixanthone is an anti-cancer agent. Griffipavixanthone is a weak sucrase inhibitor (IC50: 4.58 mM) .
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- HY-N12436
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Aurora Kinase
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Cancer
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11α-O-Tigloyl-12β-O-acetyltenacigenin B is an ester derivative of Tenacigenin B (HY-N1168), which is isolated from Garcinia cambogia (MTC). Tenacigenin B modulates the antitumor effects of Aurora-A in lymphoma.
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- HY-N2795
-
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Xanthone I
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Parasite
Bacterial
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Infection
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9-Hydroxycalabaxanthone (Xanthone I) is a known xanthone isolated from Garcinia mangostana Linn. 9-Hydroxycalabaxanthone has quorum-sensing inhibitory, anti-microbial, and anti-malarial activities (IC50=1.2-1.5 μM) .
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- HY-N8475
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PKC
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Cancer
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6-Deoxyisojacareubin is a PKC inhibitor that inhibits the proliferation of QGY-7703 cells in a concentration-dependent manner. 6-Deoxyisojacareubin is also a natural product that can be obtained from Garcinia nervosa. 6-Deoxyisojacareubin can be used in cancer research .
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- HY-N9892
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Sirtuin
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Others
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Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC50: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC50: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla .
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- HY-N10965
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Others
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Cancer
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Gambogic acid B is an active compound. Gambogic acid B can be isolated from the resin of Garcinia hanburyi.. Gambogic acid B has cytotoxicity against A549, HCT116 and MDA MB 231 cells with IC50 values of 1.60 μM, 6.88 μM and 0.87 μM, respectively .
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- HY-W009156
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- HY-B1295
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- HY-N0987
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Bacterial
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Infection
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1,4, 6-trihydroxy-5-methoxy-7-prenylxanthone is an antimicrobial agent that can be isolated from the genus garcinia. 1,4, 6-trihydroxy-5-methoxy-7-prenylxanthone inhibits S. aureus and B. cereus with MIC values of 128 μg/mL and 200 μg/mL, respectively .
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- HY-N7347R
-
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ATP Citrate Lyase
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Metabolic Disease
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(-)-Hydroxycitric acid lactone (Standard) is the analytical standard of (-)-Hydroxycitric acid lactone. This product is intended for research and analytical applications. (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .
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- HY-W009156R
-
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ATP Citrate Lyase
HIF/HIF Prolyl-Hydroxylase
Bacterial
Endogenous Metabolite
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Infection
Metabolic Disease
Inflammation/Immunology
Cancer
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Citric acid (tripotassium hydrate) (Standard) is the analytical standard of Citric acid (tripotassium hydrate). This product is intended for research and analytical applications. Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia. Hydroxycitric acid tripotassium hydrate competitively inhibits ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects .
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- HY-N0087
-
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Beta-Guttiferrin
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Bcl-2 Family
Autophagy
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Cancer
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Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.
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- HY-N0985
-
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Others
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Cancer
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1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone is a xanthone that can be isolated from Garcinia xanthochymus. 1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone shows moderate cytotoxicities against MDA-MB-435S and A549 cell lines with IC50s of 1.3 and 3.86 μg/ml, respectively .
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- HY-N10677
-
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Others
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Cancer
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S-30-Hydroxygambogic acid is polyprenylated xanthone epimer that can be isolated from gamboges of Garcinia hanburyi. S-30-Hydroxygambogic acid shows cytotoxicities to Human Leukemia K562 cell lines of IC50 values of 4.49 and 3.61 μM for K562/R and K562/S, respectively. S-30-Hydroxygambogic acid can be used for the research of cancer .
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- HY-N10678
-
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Others
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Cancer
|
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R-30-Hydroxygambogic acid is polyprenylated xanthone epimer that can be isolated from gamboges of Garcinia hanburyi. R-30-Hydroxygambogic acid shows cytotoxicities to Human Leukemia K562 cell lines of IC50 values of 2.89 and 1.27 μM for K562/R and K562/S, respectively. R-30-Hydroxygambogic acid can be used for the research of cancer .
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- HY-122324
-
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(+)-(S)-Tylophorine; DCB-3500; NSC-717335
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Others
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Cancer
|
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Tylophorine and its analogs are benzoindole alkaloids, most of which are derived from Garcinia plants. Tylophorine analogs all show potent growth inhibition against human hepatocellular carcinoma HepG2 and human nasopharyngeal carcinoma KB cell lines. Tylophorine analogs can also induce increased albumin expression and inhibit α-fetoprotein expression in HepG2 cells, and have the potential to induce HepG2 cell differentiation .
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- HY-107569
-
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Cholinesterase (ChE)
Histone Acetyltransferase
Apoptosis
Endogenous Metabolite
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Inflammation/Immunology
Cancer
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Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively . Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity .
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-
- HY-N0087R
-
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Bcl-2 Family
Autophagy
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Cancer
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Gambogic Acid (Standard) is the analytical standard of Gambogic Acid. This product is intended for research and analytical applications. Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.
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-
- HY-N0986
-
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Others
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Cancer
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1,4,5,6-Tetrahydroxy-7-(3-methylbut-2-enyl)xanthone is a nature product that could be isolated from the stem barks of Garcinia xanthochymus. 1,4,5,6-Tetrahydroxy-7-(3-methylbut-2-enyl)xanthone has antiproliferative active. 1,4,5,6-Tetrahydroxy-7-(3-methylbut-2-enyl)xanthone can be used in research of cancer .
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- HY-N6954
-
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ATM/ATR
STAT
CDK
Hedgehog
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Inflammation/Immunology
Cancer
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Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active .
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- HY-N6954R
-
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ATM/ATR
STAT
CDK
Hedgehog
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Cancer
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Garcinone C (Standard) is the analytical standard of Garcinone C. This product is intended for research and analytical applications. Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active .
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| Cat. No. |
Product Name |
Type |
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- HY-B1295
-
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Litarex tetrahydrate
|
Biochemical Assay Reagents
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Lithium citrate (Litarex) tetrahydrate is the major active ingredient of Garcinia cambogia. Lithium citrate tetrahydrate competitively inhibits ATP citrate lyase with weight loss benefits. Lithium citrate tetrahydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects .
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-16007
-
-
-
- HY-N7347
-
-
-
- HY-N5115
-
-
-
- HY-N3347
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-
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- HY-N4094
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-
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- HY-N14035
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Structural Classification
Natural Products
Guttiferae
Source classification
Garcinia cambogia Desr.
Plants
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ATP Citrate Lyase
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Garcinia cambogia extract contains several active compounds, including hydroxycitric acid (HCA) (an ECC inhibitor), xanthones, benzophenones, hydroxycitric acid (an ATP-citrate lyase inhibitor). Garcinia cambogia extract lowers the body weight gain, visceral fat accumulation, blood and hepatic lipid concentrations, and plasma insulin and leptin levels in a high-fat diet (HFD)-induced obesity mouse model. Garcinia cambogia extract is promising for research of fatty liver, dyslipidemia, hyperinsulinemia and hyperleptinemia rendered by HFD .
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- HY-N9045
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- HY-N8878
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- HY-N3465
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- HY-N3637
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-
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- HY-124537
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-
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- HY-N10398
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-
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- HY-N6247
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-
-
- HY-N3189
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-
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- HY-N9152
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-
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- HY-N1437
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-
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- HY-N1197
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- HY-N8557
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- HY-N8891
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- HY-N9219
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- HY-N6248
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- HY-N10673
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- HY-N1868
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- HY-N4094R
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- HY-N3324
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- HY-N3482
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-
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- HY-N9454
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-
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- HY-N1647
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- HY-N1000
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- HY-N4292
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-
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- HY-N8857
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- HY-N2702
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- HY-N8455
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- HY-N8338
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- HY-N2768
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- HY-N2058
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- HY-N9261
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-
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- HY-N8876
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- HY-N10676
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- HY-N9113
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- HY-N15370
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- HY-N3974
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- HY-N12436
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- HY-N8475
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-
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- HY-N9892
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- HY-N10965
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- HY-W009156
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- HY-B1295
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- HY-N0987
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- HY-N7347R
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Structural Classification
other families
Ketones, Aldehydes, Acids
Source classification
Plants
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ATP Citrate Lyase
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(-)-Hydroxycitric acid lactone (Standard) is the analytical standard of (-)-Hydroxycitric acid lactone. This product is intended for research and analytical applications. (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .
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- HY-W009156R
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- HY-N0087
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- HY-N0985
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- HY-N10677
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- HY-N10678
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- HY-122324
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(+)-(S)-Tylophorine; DCB-3500; NSC-717335
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Apocynaceae
Source classification
Plants
Tylophora
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Others
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Tylophorine and its analogs are benzoindole alkaloids, most of which are derived from Garcinia plants. Tylophorine analogs all show potent growth inhibition against human hepatocellular carcinoma HepG2 and human nasopharyngeal carcinoma KB cell lines. Tylophorine analogs can also induce increased albumin expression and inhibit α-fetoprotein expression in HepG2 cells, and have the potential to induce HepG2 cell differentiation .
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- HY-107569
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- HY-N0087R
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- HY-N0986
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- HY-N6954
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- HY-N6954R
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Structural Classification
other families
Xanthones
Garcinia oblongifolia Champ. ex Benth.
Guttiferae
Source classification
Phenols
Polyphenols
Plants
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ATM/ATR
STAT
CDK
Hedgehog
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Garcinone C (Standard) is the analytical standard of Garcinone C. This product is intended for research and analytical applications. Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active .
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