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Results for "

Genotoxicity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Aldehyde Dehydrogenase (ALDH) (1) Androgen Receptor (1) Antibiotic (1) Apoptosis (6) Bacterial (8) Bcl-2 Family (1) Biochemical Assay Reagents (4) Cytochrome P450 (2) DNA Alkylator/Crosslinker (3) DNA/RNA Synthesis (3) Drug Metabolite (3) Endogenous Metabolite (9) Estrogen Receptor/ERR (2) Fluorescent Dye (5) Fungal (1) Histone Acetyltransferase (1) Histone Methyltransferase (1) IAP (1) Interleukin Related (1) Isotope-Labeled Compounds (7) mTOR (1) Necroptosis (1) NF-κB (1) Parasite (3) PARP (1) PI3K (1) PPAR (1) Reactive Oxygen Species (1) Survivin (1) TNF Receptor (1) Topoisomerase (2)
By Research Areas:	Cancer (26) Cardiovascular Disease (1) Infection (15) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (4)

By Targets:

Akt (1)

Aldehyde Dehydrogenase (ALDH) (1)

Androgen Receptor (1)

Antibiotic (1)

Apoptosis (6)

Bacterial (8)

Bcl-2 Family (1)

Biochemical Assay Reagents (4)

Cytochrome P450 (2)

DNA Alkylator/Crosslinker (3)

DNA/RNA Synthesis (3)

Drug Metabolite (3)

Endogenous Metabolite (9)

Estrogen Receptor/ERR (2)

Fluorescent Dye (5)

Fungal (1)

Histone Acetyltransferase (1)

Histone Methyltransferase (1)

IAP (1)

Interleukin Related (1)

Isotope-Labeled Compounds (7)

mTOR (1)

Necroptosis (1)

NF-κB (1)

Parasite (3)

PARP (1)

PI3K (1)

PPAR (1)

Reactive Oxygen Species (1)

Survivin (1)

TNF Receptor (1)

Topoisomerase (2)

By Research Areas:

Cancer (26)

Cardiovascular Disease (1)

Infection (15)

Inflammation/Immunology (3)

Metabolic Disease (3)

Neurological Disease (4)

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119329

Glycidamide Oxiranecarboxamide; 2,3-Epoxypropanamide	Others	Others
Glycidamide is the genotoxic metabolite of Acrylamide. Glycidamide can react with proteins, such as hemoglobin, or with DNA, and induces genotoxic effects .

HY-N8022

Lucidin primeveroside Lucidin 3-O-β-primeveroside	Biochemical Assay Reagents	Cancer
Lucidin primeveroside (Lucidin 3-O-β-primeveroside) is an anthraquinone derivative present in madder root, which has been used as a coloring agent and food additive. Lucidin primeveroside can be metabolically converted to genotoxic compound Lucidin, which subsequently forms lucidin-specific DNA adducts .

HY-N2081

Skimmianine 2 Publications Verification	Others	Inflammation/Immunology Cancer
Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect. Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity .

HY-114517

3-Acetyl-2,5-dimethylfuran	Others	Metabolic Disease
3-Acetyl-2,5-dimethylfuran is a flavoring agent exhibiting genotoxic potential in vitro assays .

HY-133647

Dibromoacetaldehyde	Others	Others
Dibromoacetaldehyde, a halogenated product, is a byproduct in drinking water and has genotoxicity .

HY-133648

Bromochloroacetaldehyde	Others	Others
Bromochloroacetaldehyde belongs to dihalogenated acetaldehyde and is a byproduct in drinking water. Bromochloroacetaldehyde has genotoxicity .

HY-133649

Dibromochloroacetaldehyde	Others	Others
Dibromochloroacetaldehyde belongs to trihalogenated acetaldehyde and is a byproduct in drinking water. Dibromochloroacetaldehyde has genotoxicity .

HY-121345

Homobaldrinal	Others	Neurological Disease Cancer
Homobaldrinal is a decomposition product of Valepotriate (HY-N0718). Homobaldrinal exhibits genotoxic activity in the Salmonella/microsome test .

HY-400785

Dapagliflozin impurity A	Others	Cancer
Dapagliflozin impurity A (Compound A) is a dapagliflozin peroxide, a genotoxic impurity, can cause damage to human genetic material at very low concentrations, leading to genetic mutations and possibly tumorigenesis .

HY-151628

MRV03-068	Others	Cancer
MRV03-068 (Compound 2) is a selective colibactin-activated peptidase (ClbP) inhibitor that blocks the genotoxic effect of Colibactin (HY-145930) on eukaryotic cells. MRV03-068 can be used in colorectal cancer research .

HY-151629

MRV03-069	Others	Cancer
MRV03-069 (Compound 3) is a selective colibactin-activated peptidase (ClbP) inhibitor that blocks the genotoxic effect of Colibactin (HY-145930) on eukaryotic cells. MRV03-069 can be used in colorectal cancer research .

HY-119635

Albicanol	Others	Cancer
Albicanol is a sesquiterpenoid with potent antioxidant and antagonistic activities against heavy metal toxicity. Albicanol shows cytotoxicity. Albicanol suppress profenofos (HY-B0832) induced genotoxicity in grass carp hepatocytes .

HY-133787

Levofloxacin N-oxide	Drug Metabolite	Infection
Levofloxacin N-oxide is a minor metabolite of Levofloxacin (HY-B0330). Levofloxacin N-oxide does not exhibit significantly genotoxic risks. Levofloxacin is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria .

HY-N2081R

Skimmianine (Standard)	Others	Inflammation/Immunology Cancer
Skimmianine (Standard) is the analytical standard of Skimmianine. This product is intended for research and analytical applications. Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect. Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity .

HY-125098

Illudin S 1 Publications Verification	DNA Alkylator/Crosslinker Apoptosis	Infection Cancer
Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells .

HY-N6714

Alternariol	Topoisomerase Androgen Receptor Estrogen Receptor/ERR Apoptosis	Infection Cancer
Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects .

HY-146121

Antitubercular agent-26	Bacterial	Infection
Antitubercular agent-26 (Compound 32) is an orally active anti-tubercular agent with an extracellular IC₅₀ of 0.50 μM and an intracellular IC₅₀ of 0.51 μM against M. tuberculosis H37Rv. Antitubercular agent-26 shows good metabolic stability, low risk of cardiotoxicity and no genotoxicity .

HY-W014940

Ethylene glycol dimethacrylate	Reactive Oxygen Species Apoptosis	Others
Ethylene glycol dimethacrylate is a methacrylate monomer, exhibits cytotoxic and genotoxic effects on human gingival fibroblasts (HGFs). Ethylene glycol dimethacrylate increases intracellular reactive oxygen species (ROS) production, causes DNA damage, increases apoptosis and causes cell cycle arrest in G1/G0 phase .

HY-W795264

FR900098	Parasite	Infection
FR900098 is an antimalarial agent that inhibits 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase. FR900098 has no significant acute toxicity or genotoxicity, and does not have the ability to cause chromosome breakage or heterogeneity. FR900098 has no effect on bone marrow red blood cells in NMRI mice .

HY-122817

FR900098 sodium	Antibiotic Parasite	Infection
FR900098 sodium is an antimalarial agent that inhibits 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase. FR900098 sodium has no significant acute toxicity or genotoxicity, and does not have the ability to cause chromosome breakage or heterogeneity. FR900098 sodium has no effect on bone marrow red blood cells in NMRI mice .

HY-W103488

Chloridazon	Others	Others
Chloridazon is a herbicide with an LD₅₀ value of 76.6 ppm at genotoxicity assay .

HY-124489S1

2-Hydroxyestradiol-d5	Endogenous Metabolite	Infection
2-Hydroxyestradiol-d₅ is the deuterium labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[[1][3][4].

HY-124489S

2-Hydroxyestradiol-13C6	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
2-Hydroxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[1][3].

HY-121213

Erysolin	Cytochrome P450	Cancer
Erysolin is a CYP1A inhibitor with antigenic toxicity. Erysolin reduces benzo(a)pyrene-induced genotoxicity .

HY-131102

Mequindox	Bacterial DNA/RNA Synthesis	Infection
Mequindox is an antimicrobial agent . Mequindox acts as an inhibitor of DNA synthesis. Mequindox induces genotoxicity and carcinogenicity in mice .

HY-W010553

2,5-Dimethyl-3(2H)-furanone	Others	Others
2,5-Dimethyl-3(2H)-furanone is a flavouring substance without genotoxicity .

HY-Y0069

N-Acetylglycine Aceturic acid; Acetamidoacetic acid	Endogenous Metabolite	Others
N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics.

HY-N4183

Licoflavone C	Others	Cancer
Licoflavone C is a prenyl-flavone extracted from Genista ephedroides, reduces the genotoxicity of cancer agents in human peripheral lymphocytes .

HY-136375

Cyanazine	Others	Others
Cyanazine, a triazine herbicide cyanazine, is used to control a variety of grass weeds and broadleaf weed. Cyanazine is proved non-genotoxic .

HY-122099

Riddelline	DNA/RNA Synthesis	Others
Riddelline, a pyrrolizidine alkaloid, is a potent genotoxic agent. Riddelline induces significant elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver .

HY-118948

MSN-50	Bcl-2 Family	Neurological Disease
MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 efficiently inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection .

HY-D0211

Phenolphthalein	Fluorescent Dye	Cancer
Phenolphthalein is an acid-base indicator that is colorless in an acidic environment and pink in an alkaline environment. Phenolphthalein is genotoxic and potentially carcinogenic to mice. In addition, phenolphthalein is also a blood indicator .

HY-116108

Musk tibetene Musk tibetine	Others	Cancer
Musk tibetene (Musk tibetine) is a nitro musk compound with carcinogenic activity. Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell line .

HY-124489

2-Hydroxyestradiol	Endogenous Metabolite	Metabolic Disease
2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .

HY-136375S

Cyanazine-d5	Isotope-Labeled Compounds	Others
Cyanazine-d₅ is deuterium labeled Cyanazine. Cyanazine, a triazine herbicide cyanazine, is used to control a variety of grass weeds and broadleaf weed. Cyanazine is proved non-genotoxic[1].

HY-154958

mTOR inhibitor-12	mTOR	Neurological Disease
mTOR inhibitor-12 (Compound 11) is a selective brain penetrant mTOR inhibitor without genotoxicity risk. mTOR inhibitor-12 can be used for the research of CNS diseases .

HY-Y0069S

N-Acetylglycine-d5 Aceturic acid-d₅; Acetamidoacetic acid-d₅	Isotope-Labeled Compounds Endogenous Metabolite	Others
N-Acetylglycine-d₅ is the deuterium labeled N-Acetylglycine. N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics.

HY-131102R

Mequindox (Standard)	Bacterial DNA/RNA Synthesis	Infection
Mequindox (Standard) is the analytical standard of Mequindox. This product is intended for research and analytical applications. Mequindox is an antimicrobial agent . Mequindox acts as an inhibitor of DNA synthesis. Mequindox induces genotoxicity and carcinogenicity in mice .

HY-136375R

Cyanazine (Standard)	Others	Others
Cyanazine (Standard) is the analytical standard of Cyanazine. This product is intended for research and analytical applications. Cyanazine, a triazine herbicide cyanazine, is used to control a variety of grass weeds and broadleaf weed. Cyanazine is proved non-genotoxic .

HY-125815

Reactive Blue 4 1 Publications Verification	Fluorescent Dye	Others
Reactive Blue 4 is an anthraquinone dye, as a single colorimetric chemosensor for sequential determination of multiple analytes with different optical responses in aqueous media. Reactive Blue 4 is phytotoxic, cytotoxic and genotoxic. Reactive Blue 4 .

HY-Y0069R

N-Acetylglycine (Standard)	Endogenous Metabolite	Others
N-Acetylglycine (Standard) is the analytical standard of N-Acetylglycine. This product is intended for research and analytical applications. N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics.

HY-151626

MRV03-037	Bacterial	Infection
MRV03-037 is a selective colibactin-activated peptidase (ClbP) inhibitor that blocks the genotoxic effect of Colibactin (HY-145930) on eukaryotic cells. MRV03-037 prevents gut bacterial genotoxin production .

HY-W612269S

Isonicotinoyl chloride-d4	Isotope-Labeled Compounds	Others
Isonicotinoyl chloride-d₄ is the deuterated labeled Isonicotinoyl chloride (HY-W612269). N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics .

HY-N2627

Isorhamnetin 3-O-robinobioside	Others	Cancer
Isorhamnetin 3-O-robinobioside is a flavonoid compound. Isorhamnetin shows a protective effect against lipid peroxidation induced by H₂O₂. Isorhamnetin 3-O-robinobioside also inhibits the genotoxicity induced by hydroxyl radicals .

HY-B0928

Homosalate 1 Publications Verification Homomenthyl salicylate	Biochemical Assay Reagents	Others
Homosalate (Homomenthyl salicylate) is an organic compound used as a sunscreen to filter UV rays and protect the skin from sun damage. Homosalate has anti-inflammatory activity .

HY-D0249

Sunset Yellow FCF 1 Publications Verification Orange Yellow S; Food Yellow 3; CI 15985	Fluorescent Dye	Others
Sunset Yellow FCF (Orange Yellow S) is an orange azo dye with a maximum absorption wavelength of 480 nm. Sunset Yellow FCF can be used in food, cosmetics and pharmaceuticals .

HY-136440

Hydroxymetronidazole Metronidazole-OH	Bacterial Parasite	Infection
Hydroxymetronidazole (Metronidazole-OH) is a metabolite of Metronidazole belonging to the class of nitroimidazoles. Hydroxymetronidazole can be used for the research of certain bacterial and protozoal diseases in poultry, swine dysentery and genital trichomoniasis in cattle .

HY-136440S1

Hydroxymetronidazole-d2 Metronidazole-OH-d₂	Isotope-Labeled Compounds	Infection
Hydroxymetronidazole-d2 is the deuterium labeled Hydroxymetronidazole(HY-136440).Hydroxymetronidazole (Metronidazole-OH) is a metabolite of Metronidazole belonging to the class of nitroimidazoles. Hydroxymetronidazole can be used for the research of certain bacterial and protozoal diseases in poultry, swine dysentery and genital trichomoniasis in cattle .

HY-D0249R

Sunset Yellow FCF (Standard)	Fluorescent Dye	Others
Sunset Yellow FCF (Standard) is the analytical standard of Sunset Yellow FCF. This product is intended for research and analytical applications. Sunset Yellow FCF (Orange Yellow S) is an orange azo dye with a maximum absorption wavelength of 480 nm. Sunset Yellow FCF can be used in food, cosmetics and pharmaceuticals .

HY-139149

NiCur	Histone Acetyltransferase	Cancer
NiCur is a potent and selective CBP histone acetyltransferase (HAT) inhibitor with an IC₅₀ value of 0.35 μΜ. NiCur, which blocks CBP HAT activity and downregulates p53 activation upon genotoxic stress. NiCur can be used for performing mechanistic studies without affecting the expression of target proteins .

Cat. No.	Product Name	Type