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Ginsenoside

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (6) Apoptosis (15) Autophagy (4) Bacterial (2) Bcl-2 Family (2) Biochemical Assay Reagents (1) Calcium Channel (5) Caspase (3) COX (8) Cytochrome P450 (3) DNA/RNA Synthesis (1) Endogenous Metabolite (17) Estrogen Receptor/ERR (1) Free Fatty Acid Receptor (2) GABA Receptor (2) Glucocorticoid Receptor (1) HSV (3) IFNAR (1) IGF-1R (2) Influenza Virus (2) Interleukin Related (4) IRAK (2) JAK (2) JNK (2) Keap1-Nrf2 (2) LXR (1) MDM-2/p53 (1) Mitophagy (2) MMP (3) Na+/K+ ATPase (2) NF-κB (18) NO Synthase (3) PI3K (2) Potassium Channel (1) PPAR (1) Prostaglandin Receptor (2) Reactive Oxygen Species (1) Sodium Channel (1) TNF Receptor (4)
By Research Areas:	Cancer (42) Cardiovascular Disease (11) Endocrinology (5) Infection (5) Inflammation/Immunology (32) Metabolic Disease (4) Neurological Disease (13)

By Targets:

Amyloid-β (6)

Apoptosis (15)

Autophagy (4)

Bacterial (2)

Bcl-2 Family (2)

Biochemical Assay Reagents (1)

Calcium Channel (5)

Caspase (3)

COX (8)

Cytochrome P450 (3)

DNA/RNA Synthesis (1)

Endogenous Metabolite (17)

Estrogen Receptor/ERR (1)

Free Fatty Acid Receptor (2)

GABA Receptor (2)

Glucocorticoid Receptor (1)

HSV (3)

IFNAR (1)

IGF-1R (2)

Influenza Virus (2)

Interleukin Related (4)

IRAK (2)

JAK (2)

JNK (2)

Keap1-Nrf2 (2)

LXR (1)

MDM-2/p53 (1)

Mitophagy (2)

MMP (3)

Na+/K+ ATPase (2)

NF-κB (18)

NO Synthase (3)

PI3K (2)

Potassium Channel (1)

PPAR (1)

Prostaglandin Receptor (2)

Reactive Oxygen Species (1)

Sodium Channel (1)

TNF Receptor (4)

By Research Areas:

Cancer (42)

Cardiovascular Disease (11)

Endocrinology (5)

Infection (5)

Inflammation/Immunology (32)

Metabolic Disease (4)

Neurological Disease (13)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N4262

Ginsenoside Rh7	Others	Others
Ginsenoside Rh7 is a minor saponin isolated from the leaves of Panax ginseng .

HY-N6580

Ginsenoside Rg4	Bacterial	Infection Metabolic Disease Inflammation/Immunology
Ginsenoside Rg4 is a major protopanaxatriol type ginsenoside isolated from the leaves of Panax ginseng C. A. Meyer. The protopanaxatriol type ginsenosides (such as Ginsenoside Rg4) exhibits various biological activities including anti-septic, anti-diabetic, wound healing, immune-stimulatory, and anti-antioxidant activity .

HY-N0044

Ginsenoside Re 2 Publications Verification Ginsenoside B2; Panaxoside Re; Sanchinoside Re	Amyloid-β NF-κB JNK Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Ginsenoside Re (Ginsenoside B2) is an extract from Panax notoginseng. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB.

HY-N0606

Ginsenoside Rh3 1 Publications Verification	Keap1-Nrf2	Inflammation/Immunology
Ginsenoside Rh3 is a bacterial metabolite of Ginsenoside Rg5. Ginsenoside Rh3 treatment in human retinal cells induces Nrf2 activation.

HY-N12015

Ginsenoside Ra6 Ginsenoside IV	Others	Others
Ginsenoside Ra6 (Ginsenoside IV) is a panaxadiol-type ginsenoside that can be isolated from the roots of ginseng .

HY-N12365

Ginsenoside Rs2	Others	Others
Ginsenoside Rs2 is extracted from Panax ginseng root .

HY-N12366

Ginsenoside Rs1	Others	Others
Ginsenoside Rs1 is extracted from Panax ginseng root .

HY-N0601R

Ginsenoside Rf (Standard)	Calcium Channel Endogenous Metabolite	Neurological Disease Cancer
Ginsenoside Rf (Standard) is the analytical standard of Ginsenoside Rf. This product is intended for research and analytical applications. Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.

HY-N12516

Ginsenoside Mc	Others	Cancer
Ginsenoside Mc is a natural product, that can be prepared by removal of two glucose molecules at 3-C of ginsenoside Rc (HY-N0042). Ginsenoside Mc has anti-tumor activity .

HY-N0042R

Ginsenoside Rc (Standard)	GABA Receptor TNF Receptor Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
Ginsenoside Rc (Standard) is the analytical standard of Ginsenoside Rc. This product is intended for research and analytical applications. Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptorA (GABAA)-mediated ion channel currents (IGABA). Ginsenoside Rc inhibits the expression of TNF-α and IL-1β.

HY-N0040

Ginsenoside Rb2 2 Publications Verification Ginsenoside C	Influenza Virus Endogenous Metabolite Free Fatty Acid Receptor	Infection Metabolic Disease Inflammation/Immunology
Ginsenoside Rb2 is one of the main bioactive components of ginseng extracts. Rb2 can upregulate GPR120 gene expression. Ginsenoside Rb2 has antiviral effects.

HY-N0606R

Ginsenoside Rh3 (Standard)	Keap1-Nrf2	Inflammation/Immunology
Ginsenoside Rh3 (Standard) is the analytical standard of Ginsenoside Rh3. This product is intended for research and analytical applications. Ginsenoside Rh3 is a bacterial metabolite of Ginsenoside Rg5. Ginsenoside Rh3 treatment in human retinal cells induces Nrf2 activation.

HY-N0044R

Ginsenoside Re (Standard) Ginsenoside B2(Standard); Panaxoside Re(Standard); Sanchinoside Re (Standard)	Amyloid-β NF-κB JNK Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Ginsenoside Re (Standard) is the analytical standard of Ginsenoside Re. This product is intended for research and analytical applications. Ginsenoside Re (Ginsenoside B2) is an extract from Panax notoginseng. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB.

HY-N0905

Ginsenoside Rh4	Bcl-2 Family Caspase Apoptosis Autophagy Endogenous Metabolite	Cancer
Ginsenoside Rh4 is a rare saponin obtained from Panax notoginseng. Ginsenoside Rh4 activates Bax, caspase 3, caspase 8, and caspase 9. Ginsenoside Rh4 also induces autophagy.

HY-N0605R

Ginsenoside Rh2 (Standard) 20(S)-Ginsenoside Rh2(Standard); 20(S)-Rh2(Standard); Ginsenoside-Rh2 (Standard)	Caspase Apoptosis Endogenous Metabolite	Cancer
Ginsenoside Rh2 (Standard) is the analytical standard of Ginsenoside Rh2. This product is intended for research and analytical applications. Ginsenoside Rh2 induces the activation of caspase-8 and caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis in a multi-path manner.

HY-N0607R

Ginsenoside Ro (Standard)	Calcium Channel Prostaglandin Receptor	Cardiovascular Disease Endocrinology
Ginsenoside Ro (Standard) is the analytical standard of Ginsenoside Ro. This product is intended for research and analytical applications. Ginsenoside Ro (Polysciasaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V) exhibits a Ca2+-antagonistic antiplatelet effect with an IC50 of 155 μM. Ginsenoside Ro reduces the production of TXA2 more than it reduces the activities of COX-1 and TXAS.

HY-N0040R

Ginsenoside Rb2 (Standard)	Influenza Virus Endogenous Metabolite Free Fatty Acid Receptor	Infection Metabolic Disease Inflammation/Immunology
Ginsenoside Rb2 (Standard) is the analytical standard of Ginsenoside Rb2. This product is intended for research and analytical applications. Ginsenoside Rb2 is one of the main bioactive components of ginseng extracts. Rb2 can upregulate GPR120 gene expression. Ginsenoside Rb2 has antiviral effects.

HY-N0598

Ginsenoside F1 20(S)-Ginsenoside F1	Cytochrome P450 Endogenous Metabolite	Cancer
Ginsenoside F1, an enzymatically modified derivative of Ginsenoside Rg1, demonstrates competitive inhibition of CYP3A4 activity and weaker inhibition of CYP2D6 activity.

HY-125848

Ginsenoside F2	Apoptosis Autophagy Endogenous Metabolite	Cancer
Ginsenoside F2, a metabolite from Ginsenoside Rb1, induces apoptosis accompanied by protective autophagy in breast cancer stem cells .

HY-N0605

Ginsenoside Rh2 3 Publications Verification 20(S)-Ginsenoside Rh2; 20(S)-Rh2; Ginsenoside-Rh2	Caspase Apoptosis Endogenous Metabolite	Cancer
Ginsenoside Rh2 induces the activation of caspase-8 and caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis in a multi-path manner.

HY-N0601

Ginsenoside Rf Panaxoside Rf	Calcium Channel Endogenous Metabolite	Neurological Disease Cancer
Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca ²⁺ channel.

HY-N0042

Ginsenoside Rc Panaxoside Rc	GABA Receptor TNF Receptor Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances GABA receptor_A (GABA_A)-mediated ion channel currents (I_GABA). Ginsenoside Rc inhibits the expression of TNF-α and IL-1β.

HY-N0904

Ginsenoside C-K 5 Publications Verification Ginsenoside compound K; Ginsenoside K	COX NO Synthase Cytochrome P450	Inflammation/Immunology
Ginsenoside C-K, a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects by reducing iNOS and COX-2. Ginsenoside C-K exhibits an inhibition against the activity of CYP2C9 and CYP2A6 in human liver microsomes with IC₅₀s of 32.0±3.6 μM and 63.6±4.2 μM, respectively.

HY-N0908R

Ginsenoside Rg5 (Standard)	IGF-1R NF-κB COX	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Ginsenoside Rg5 (Standard) is the analytical standard of Ginsenoside Rg5. This product is intended for research and analytical applications. Ginsenoside Rg5 is the main component of Red ginseng and IGF-1R agonist. Ginsenoside Rg5 compets for the binding site of IGF-1R and blocks the binding of IGF-1 to IGF-1R (IC50 about 90 nM). Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65.

HY-N0907

Ginsenoside Rg6	NF-κB Apoptosis	Inflammation/Immunology Cancer
Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional activity with an IC₅₀ of 29.34 μM in HepG2 cells. Ginsenoside Rg6 also exhibits apoptosis-inducing effect.

HY-N0906

Ginsenoside Rk3	NF-κB	Cardiovascular Disease Inflammation/Immunology
Ginsenoside Rk3 is present in the roots Panax ginseng herbs. Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC₅₀ of 14.24±1.30 μM in HepG2 cells.

HY-N2515R

Ginsenoside Rk1 (Standard)	NF-κB PI3K JAK Apoptosis	Inflammation/Immunology Cancer
Ginsenoside Rk1 (Standard) is the analytical standard of Ginsenoside Rk1. This product is intended for research and analytical applications. Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .

HY-N4260

Ginsenoside Ra2	Others	Inflammation/Immunology
Ginsenoside Ra2 is a component from Panax ginseng .

HY-125570

Ginsenoside Rs3	Apoptosis	Cancer
Ginsenoside Rs3 is a natural diol-type ginseng saponin with anticancer effects. Ginsenoside Rs3 selectively elevates protein levels of p53 and p21WAF1 leading to induction of apoptosis in SK-HEP-1 cells .

HY-N0908

Ginsenoside Rg5 2 Publications Verification	IGF-1R NF-κB COX	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Ginsenoside Rg5 is the main component of Red ginseng and IGF-1R agonist. Ginsenoside Rg5 compets for the binding site of IGF-1R and blocks the binding of IGF-1 to IGF-1R (IC₅₀ about 90 nM). Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65.

HY-N0041R

Ginsenoside Rb3 (Standard) Gypenoside IV (Standard)	NF-κB COX NO Synthase	Inflammation/Immunology Cancer
Ginsenoside Rb3 (Standard) is the analytical standard of Ginsenoside Rb3. This product is intended for research and analytical applications. Ginsenoside Rb3 is extracted from steamed Panax ginseng C. A. Meyer. Ginsenoside Rb3 exhibits inhibitory effect on TNFα-induced NF-κB transcriptional activity with an IC₅₀ of 8.2 μM in 293T cell lines. Ginsenoside Rb3 also inhibits the induction of COX-2 and iNOS mRNA.

HY-N2515

Ginsenoside Rk1 5 Publications Verification	NF-κB PI3K JAK Apoptosis	Inflammation/Immunology Cancer
Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .

HY-N2516

Ginsenoside Rd2	Others	Inflammation/Immunology
Ginsenoside Rd2 is a saponin found in Panax japonicus with anti-inflammatory actions .

HY-N0041

Ginsenoside Rb3 Gypenoside IV	NF-κB COX NO Synthase	Inflammation/Immunology Cancer
Ginsenoside Rb3 is extracted from steamed Panax ginseng C. A. Meyer. Ginsenoside Rb3 exhibits inhibitory effect on TNFα-induced NF-κB transcriptional activity with an IC₅₀ of 8.2 μM in 293T cell lines. Ginsenoside Rb3 also inhibits the induction of COX-2 and iNOS mRNA.

HY-N0039R

Ginsenoside Rb1 (Standard) Gypenoside III (Standard)	Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV	Inflammation/Immunology Cancer
Ginsenoside Rb1 (Standard) is the analytical standard of Ginsenoside Rb1. This product is intended for research and analytical applications. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

HY-N4259

Ginsenoside Ra3	Endogenous Metabolite	Cancer
Ginsenoside Ra3, isolated from Panax ginseng, possesses anti-cancer activity .

HY-N2503

Ginsenoside F4	Apoptosis MMP	Inflammation/Immunology
Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis . Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues .

HY-N0043

Ginsenoside Rd 1 Publications Verification Gypenoside VIII	NF-κB COX Calcium Channel Cytochrome P450 Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Cancer
Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC₅₀ of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca ²⁺ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC₅₀s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.

HY-N2504

Ginsenoside Rk2	Others	Inflammation/Immunology Cancer
Ginsenoside Rk2 is a dammarane glycoside isolated from the processed ginseng (SG; Sun Ginseng) .

HY-N0045

Ginsenoside Rg1 Maximum Cited Publications 7 Publications Verification Panaxoside A; Panaxoside Rg1	Amyloid-β NF-κB Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Ginsenoside Rg1 is one of the major active components of Panax ginseng. Ginsenoside Rg1 ameliorates the impaired cognitive function, displays promising effects by reducing cerebral Aβ levels. Ginsenoside Rg1 also reduces NF-κB nuclear translocation.

HY-N0039

Ginsenoside Rb1 5+ Cited Publications Gypenoside III	Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV	Inflammation/Immunology Cancer
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

HY-N2506

Ginsenoside Ra1	Others	Cardiovascular Disease
Ginsenoside Ra1 is a component from ginseng, inhibits protein tyrosine kinase (PTK) activation induced by hypoxia/reoxygenation .

HY-108277

Ginsenoside F5	Apoptosis	Cancer
Ginsenoside F5, from crude extracts of flower buds of Panax ginseng, remarkably inhibits the growth of HL-60 cells by the apoptosis pathway .

HY-N0602

Ginsenoside Rg2 3 Publications Verification Chikusetsusaponin I; Panaxoside Rg2; Prosapogenin C2	NF-κB Amyloid-β	Cardiovascular Disease Neurological Disease Cancer
Ginsenoside Rg2 is one of the major active components of ginseng. Ginsenoside Rg2 inhibits VCAM-1 and ICAM-1 expressions stimulated with lipopolysaccharide (LPS). Ginsenoside Rg2 also reduces Aβ_1-42 accumulation.

HY-N0167

Gynostemma Extract Ginsenoside C-Mx1; Gypenoside IX	Endogenous Metabolite	Cancer
Gynostemma Extract (Ginsenoside C-Mx1) is a natural product.

HY-N0602R

Ginsenoside Rg2 (Standard) Chikusetsusaponin I(Standard); Panaxoside Rg2(Standard); Prosapogenin C2 (Standard)	NF-κB Amyloid-β	Cardiovascular Disease Neurological Disease Cancer
Ginsenoside Rg2 (Standard) is the analytical standard of Ginsenoside Rg2. This product is intended for research and analytical applications. Ginsenoside Rg2 is one of the major active components of ginseng. Ginsenoside Rg2 inhibits VCAM-1 and ICAM-1 expressions stimulated with lipopolysaccharide (LPS). Ginsenoside Rg2 also reduces Aβ_1-42 accumulation.

HY-N0600

Ginsenoside F3	Interleukin Related IFNAR	Inflammation/Immunology
Ginsenoside F3, a component of PPTGs (an minor saponin in the leaves of Panax ginseng), has immunoenhancing activity by regulating production and gene expression of type 1 cytokines (IL-2, IFN-gamma) and type 2 cytokines (IL-4 and IL-10) .

HY-N0607

Ginsenoside Ro 1 Publications Verification Polysciasaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V	Calcium Channel Prostaglandin Receptor	Cardiovascular Disease Endocrinology
Ginsenoside Ro (Polysciasaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V) exhibits a Ca ²⁺-antagonistic antiplatelet effect with an IC₅₀ of 155 ?μM. Ginsenoside Ro reduces the production of TXA₂ more than it reduces the activities of COX-1 and TXAS.

HY-N0541

Pseudoginsenoside F11 1 Publications Verification Ginsenoside A1	Endogenous Metabolite	Others
Pseudoginsenoside F11 (Ginsenoside A1), a component of Panax quinquefolium (American ginseng), has been demonstrated to antagonize the learning and memory deficits induced by scopolamine, morphine and methamphetamine in mice.

HY-N0604

Ginsenoside Rh1 3 Publications Verification Prosapogenin A2; Sanchinoside B2; Sanchinoside Rh1	Interleukin Related PPAR TNF Receptor Endogenous Metabolite	Inflammation/Immunology
Ginsenoside Rh1 (Prosapogenin A2) inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β.

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