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Isoforms Recommended:	H₂ Receptor

Results for "

H2-receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (2) Bacterial (9) Caspase (1) Cytochrome P450 (4) Drug Metabolite (2) Histamine Receptor (63) Isotope-Labeled Compounds (2) NF-κB (1) NO Synthase (1) p38 MAPK (1) SARS-CoV (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (6) Endocrinology (32) Infection (6) Inflammation/Immunology (24) Metabolic Disease (18) Neurological Disease (5)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0281A

Ranitidine hydrochloride 1 Publications Verification	Histamine Receptor Cytochrome P450 Bacterial	Infection Cardiovascular Disease Metabolic Disease Endocrinology Cancer
Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist with an IC₅₀ of 3.3 μM that inhibits gastric secretion. Ranitidine hydrochloride is a weak inhibitor of *CYP2C19* and *CYP2C9* ^[2].

HY-B0693

Ranitidine 1 Publications Verification	Histamine Receptor Bacterial Cytochrome P450	Infection Metabolic Disease Endocrinology Cancer
Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC₅₀ of 3.3 μM that inhibits gastric secretion. Ranitidine is a weak inhibitor of *CYP2C19* and *CYP2C9* ^[2].

HY-15539

Niperotidine	Histamine Receptor	Metabolic Disease Endocrinology
Niperotidine is a histamine H2-receptor antagonist.

HY-15538

Ebrotidine FI3542	Histamine Receptor	Inflammation/Immunology Endocrinology
Ebrotidine(FI 3542) is a competitive H2-receptor antagonist (Ki= 127.5 nM) with a potent antisecretory activity and evidenced gastroprotection.

HY-15540

Metiamide SK&F 92058	Histamine Receptor	Endocrinology
Metiamide (SK&F 92058) is a histamine H2-receptor antagonist developed from another H2 antagonist, burimamide.

HY-B0377

Famotidine 4 Publications Verification MK-208	Histamine Receptor	Cardiovascular Disease Metabolic Disease Endocrinology Cancer
Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.

HY-B0281AR

Ranitidine hydrochloride (Standard)	Histamine Receptor Cytochrome P450 Bacterial	Infection Metabolic Disease Endocrinology Cancer
Ranitidine (hydrochloride) (Standard) is the analytical standard of Ranitidine (hydrochloride). This product is intended for research and analytical applications. Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist with an IC₅₀ of 3.3 μM that inhibits gastric secretion. Ranitidine hydrochloride is a weak inhibitor of *CYP2C19* and *CYP2C9* ^[2].

HY-106078

Oxmetidine SKF 92994	Histamine Receptor	Inflammation/Immunology
Oxmetidine (SKF 92994) is an orally active *H2-receptor* antagonist, and is an anti-ulcer agent .

HY-19048

CP-66948	Histamine Receptor	Endocrinology
CP-66948 is a histamine H2-receptor antagonist with gastric antisecretory activity and mucosal protective properties.

HY-105027

Sufotidine AH 25352X	Histamine Receptor	Inflammation/Immunology
Sufotidine (AH 25352X) is a potent competitive antagonist of H2-receptor. Sufotidine has acid inhibitory activity .

HY-U00238

FRG8701	Histamine Receptor	Inflammation/Immunology Endocrinology
FRG-8701 is a new Histamine H₂-receptor antagonist with an IC₅₀ of ranging from 0.25 to 0.43 μM.

HY-121450

Lavoltidine Loxtidine; AH-234844	Histamine Receptor	Cancer
Lavoltidine (Loxtidine) is an an orally active, irreversible and highly potent histamine H2-receptor antagonist. Lavoltidine strongly inhibits gastric acid secretion and also induces hypergastrinemia .

HY-136338

Cimetidine sulfoxide Cimetidine sulphoxide	Histamine Receptor	Inflammation/Immunology
Cimetidine sulfoxide (Cimetidine sulphoxide) is a sulfoxide metabolite of Cimetidine. Cimetidine is a histamine H₂-receptor antagonist. Cimetidine has the potential for peptic ulcer disease and upper gastrointestinal haemorrhage treatment .

HY-B0160

Lafutidine FRG-8813	Histamine Receptor	Metabolic Disease Endocrinology
Lafutidine (FRG-8813) is a histamine H2-receptor antagonist (H₂RA), with proven gastric mucosal protective effects. Lafutidine can be used for the research of gastroesophageal reflux disease .

HY-B0377R

Famotidine (Standard)	Histamine Receptor	Metabolic Disease Endocrinology Cancer
Famotidine (Standard) is the analytical standard of Famotidine. This product is intended for research and analytical applications. Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.

HY-W011245

Ranitidine S-oxide	Drug Metabolite	Metabolic Disease
Ranitidine S-oxide is the metabolite of Ranitidine (HY-B0693). Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC₅₀ of 3.3 μM that inhibits gastric secretion ^[2].

HY-B0377S

Famotidine-13C,d3	Isotope-Labeled Compounds Histamine Receptor	Metabolic Disease Endocrinology
Famotidine- ¹³C,d₃ is the ¹³C- and deuterium labeled Famotidine. Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.

HY-101232

Tiotidine ICI 125211	Histamine Receptor	Cardiovascular Disease
Tiotidine (ICI 125211) is a potent and selective antagonist of histamine H2-receptor (pA₂=7.3-7.8 for guinea-pig right atrium). Tiotidine has low affinity for both the H1 and the H3 receptors ^[2].

HY-B0160S

Lafutidine-d10	Isotope-Labeled Compounds Histamine Receptor	Metabolic Disease Endocrinology
Lafutidine-d₁₀ is deuterium labeled Lafutidine. Lafutidine (FRG-8813) is a histamine H2-receptor antagonist (H2RA), with proven gastric mucosal protective effects. Lafutidine can be used for the research of gastroesophageal reflux disease[1].

HY-B0160R

Lafutidine (Standard)	Histamine Receptor	Metabolic Disease Endocrinology
Lafutidine (Standard) is the analytical standard of Lafutidine. This product is intended for research and analytical applications. Lafutidine (FRG-8813) is a histamine H2-receptor antagonist (H₂RA), with proven gastric mucosal protective effects. Lafutidine can be used for the research of gastroesophageal reflux disease .

HY-136338R

Cimetidine sulfoxide (Standard)	Histamine Receptor	Inflammation/Immunology
Cimetidine sulfoxide (Standard) is the analytical standard of Cimetidine sulfoxide. This product is intended for research and analytical applications. Cimetidine sulfoxide (Cimetidine sulphoxide) is a sulfoxide metabolite of Cimetidine. Cimetidine is a histamine H2-receptor antagonist. Cimetidine has the potential for peptic ulcer disease and upper gastrointestinal haemorrhage treatment .

HY-B0305A

Roxatidine Acetate Hydrochloride HOE 760	Histamine Receptor	Metabolic Disease Inflammation/Immunology Cancer
Roxatidine Acetate Hydrochloride is a potent, selective, competitive and orally active histamine _H2-receptor antagonist. Roxatidine Acetate Hydrochloride has antisecretory potency against gastric acid secretion. Roxatidine Acetate Hydrochloride can also suppress inflammatory responses and can be used for gastric and duodenal ulcers research. Roxatidine Acetate Hydrochloride has antitumor activity ^[2] .

HY-B0305

Roxatidine acetate	Histamine Receptor	Metabolic Disease Inflammation/Immunology Cancer
Roxatidine acetate is a potent, selective, competitive and orally active histamine _H2-receptor antagonist. Roxatidine acetate has antisecretory potency against gastric acid secretion. Roxatidine acetate can also suppress inflammatory responses and can be used for gastric and duodenal ulcers research. Roxatidine acetate has antitumor activity ^[2] .

HY-B0281AS

Ranitidine-d6 hydrochloride	Histamine Receptor Cytochrome P450 Bacterial	Infection Metabolic Disease Endocrinology
Ranitidine-d₆ (hydrochloride) is the deuterium labeled Ranitidine hydrochloride. Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine hydrochloride is a weak inhibitor of CYP2C19 and CYP2C9[1][2].

HY-W011245R

Ranitidine S-oxide (Standard)	Drug Metabolite	Metabolic Disease
Ranitidine S-oxide (Standard) is the analytical standard of Ranitidine S-oxide. This product is intended for research and analytical applications. Ranitidine S-oxide is the metabolite of Ranitidine (HY-B0693). Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion ^[2].

HY-137941

Roxatidine	Histamine Receptor Caspase NF-κB p38 MAPK	Inflammation/Immunology
Roxatidine is an active metabolite of Roxatidine acetate hydrochloride, is an orally active histamine *H2-receptor* antagonist. Roxatidine, an anti-ulcer agent, suppresses histamine release (thus inhibiting proton secretion) and inhibits the production of VEGF-1, an important marker of inflammation and angiogenesis. Anti-allergic inflammatory effect. Roxatidine is promising for research of gastric and duodenal ulcers ^[2] .

HY-B0693A

Ranitidine bismuth citrate	Histamine Receptor Bacterial SARS-CoV	Infection
Ranitidine bismuth citrate is an orally active Histamine H2-receptor antagonist with an IC₅₀ of 3.3 μM. Ranitidine bismuth citrate has high selectivity for SARS-CoV-2-infected cells. Ranitidine bismuth citrate is a commonly used agent anti-Helicobacter pylori infection with an MIC₉₀ value of 16 ng/L ^[2] .

HY-137941R

Roxatidine (Standard)	Histamine Receptor	Inflammation/Immunology
Roxatidine (Standard) is the analytical standard of Roxatidine. This product is intended for research and analytical applications. Roxatidine is an active metabolite of Roxatidine acetate hydrochloride, is a histamine *H2-receptor* antagonist. Roxatidine, an anti-ulcer agent, suppresses histamine release (thus inhibiting proton secretion) and inhibits the production of VEGF-1, an important marker of inflammation and angiogenesis. Anti-allergic inflammatory effect .

HY-B0377G

Famotidine (GMP) MK-208 (GMP)	Histamine Receptor	Inflammation/Immunology Cancer
Famotidine GMP (MK-208 GMP) is Famotidine (HY-B0377) produced in GMP guideline. Famotidine GMP is a competitive histamine H2-receptor antagonist, inhibits gastric secretion, activates the gastric mucosal defensive mechanisms. Famotidine GMP ameliorates peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD) in rats model ^[2].

HY-124517

Burimamide	Histamine Receptor Adrenergic Receptor	Neurological Disease Inflammation/Immunology
Burimamide is a blocker of histamine H2-receptor. Burimamide inhibits gastric acid secretion evoked by Pentagastrin (HY-A0261) or Gastrin. Burimamide also has alpha-adrenoceptor blocking activity. Burimamide in combination with the H1-receptor antagonist Mepyramine (HY-B1281) shows anti-inflammatory activity in a rat paw edema model induced by Compound 48/80 (HY-115768) ^[2].

HY-101167

Aminopotentidine	Histamine Receptor	Others
Aminopotentidine is a histamine H2 receptor antagonist with K_B values of 220 nM and 280 nM for human and guinea pig H2 receptors, respectively. It can also serve as a precursor for the synthesis of [125I] iodo derivatives .

HY-100191

BMY-25271	Histamine Receptor	Inflammation/Immunology Endocrinology
BMY-25271 is a histamine H2 receptor antagonist.

HY-19580

Ramixotidine CM 57755A	Histamine Receptor	Endocrinology
Ramisotidine is a histamine H₂ receptor antagonist that can inhibit gastric acid secretion stimulated by pentagastrin .

HY-15541

Zaltidine CP-57361	Histamine Receptor	Endocrinology
Zaltidine dihydrochloride (CP-5736 dihydrochloride) is a highly specific H2 receptor antagonist with antisecretion activity. Zaltidine dihydrochloride reduces the stimulant effect of histamine on gastric acid secretion by binding to histamine H2 receptors on gastric parietal cells, thus reducing gastric acid production. Zaltidine dihydrochloride can be used in the study of gastric acid-related diseases such as duodenal ulcers .

HY-160979

Bisfentidine DA-5047	Histamine Receptor	Others Endocrinology
Bisfentidine is an H2 receptor antagonist, Bisfentidine can block the H2 receptor on the cells of the stomach wall, and reduce the secretion of stomach acid. Bisfentidine binds to cytochrome P-450 in liver microsomes and affects drug metabolism. Bisfentidine can be used in the study of metabolic processes of drugs, lipid peroxidation processes and peptic ulcers diseases .

HY-15541A

Zaltidine dihydrochloride CP-5736 dihydrochloride	Histamine Receptor	Endocrinology
Zaltidine (CP-5736) dihydrochloride is a highly specific H2 receptor antagonist with antisecretion activity. Zaltidine dihydrochloride reduces the stimulant effect of histamine on gastric acid secretion by binding to histamine H2 receptors on gastric parietal cells, thus reducing gastric acid production. Zaltidine dihydrochloride can be used in the study of gastric acid-related diseases such as duodenal ulcers .

HY-142090

Donetidine SK&F 93574	Histamine Receptor	Others
Donetidine (SK&F 93574) is an antagonist for histamine H2 receptor, that promotes histamine release in beagle dog models .

HY-116777A

Impromidine hydrochloride SKF 92676 hydrochloride	Histamine Receptor	Others
Impromidine hydrochloride is a potent agonist for histamine H2 receptor. Impromidine hydrochloride induces gastric mucosal blood flow and acid secretion ^[2].

HY-116777

Impromidine SKF 92676	Histamine Receptor	Others
Impromidine (SKF 92676) is a potent agonist for histamine H2 receptor. Impromidine induces gastric mucosal blood flow and acid secretion ^[2].

HY-136818

DA 4643 dihydrochloride	Others	Endocrinology
DA 4643 (hydrochloride) is an H2 receptor antagonist with the chemical name 2-guanidino-4 (3-methylaminomethyleneiminophenyl) thiazole dihydrochloride. It has a weak interaction with cytochrome P-450 and has a less inhibitory effect on P-450 than cimetidine and tiotidine. DA 4643 (hydrochloride) is able to inhibit both enzymatic and non-enzymatic lipid peroxidation reactions. This inhibition may not be achieved by inhibiting agent metabolizing enzymes, but rather due to the antioxidant properties of the compound itself. Compared with other H2 receptor antagonists such as cimetidine, ranitidine and tiotidine, DA 4643 (hydrochloride) shows a unique effect in lipid peroxidation inhibition. These properties make DA 4643 (hydrochloride) a potential H2 receptor antagonist with multiple mechanisms of action.

HY-B1478

Dimaprit dihydrochloride	Histamine Receptor NO Synthase	Endocrinology
Dimaprit dihydrochloride is a selective histamine H2 receptor agonist, it also inhibits nNOS with an IC₅₀ of 49 μM. Dimaprit dihydrochloride can stimulate gastric acid secretion ^[2].

HY-121406

(Z)-Lafutidine (Z)-FRG-8813	Histamine Receptor	Inflammation/Immunology
(Z)-Lafutidine ((Z)-FRG-8813) is a potent histamine H2 receptor antagonist. (Z)-Lafutidine shows anti-secretory and gastroprotective activities .

HY-116208

Dalcotidine KU-1257	Histamine Receptor	Inflammation/Immunology
Dalcotidine (KU-1257) is an orally active and competitive histamine H2 receptor antagonist. Dalcotidine promotes the healing of chronic ulcers and inhibits gastric acid secretion ^[2].

HY-167653

FR-145715	Histamine Receptor Bacterial	Infection
FR-145715 is a histamine H2 receptor antagonist, with specific anti-Helicobacter pylori activities. FR-145715 can be used for the research of gastric lesions .

HY-124910

BU-E-75	Histamine Receptor Adrenergic Receptor	Cardiovascular Disease
BU-E-75 is a guanidine-type *H₂ receptor* agonist that exhibits antagonism at postsynaptic α-adrenoceptors, which can relax the noradrenaline-precontracted vessels .

HY-19007

Mifentidine DA 4577	Histamine Receptor	Endocrinology
Mifentidine (DA 4577) is a potent and selective H2 Receptor antagonist. Mifentidine has an anti-secretion effect and can antagonize the acid-promoting activity of histamine with EC₅₀ 3.28 μM .

HY-101234

ICI 162846	Histamine Receptor	Inflammation/Immunology
ICI 162846 is an orally active antagonist of *H₂ receptor*. ICI 162846 inhibits acid production accompanied by an increase in the secretion of histamine in chronic duodenal ulcer (CDU) models. ICI 162846 is effective in preventing CDU ^[2].

HY-101052

HTMT dimaleate	Histamine Receptor	Inflammation/Immunology
HTMT (dimaleate) is a potent histamine H1 and H2 receptor agonist. HTMT (dimaleate) is 4 x 10 ⁴ times more active than histamine in H2-mediated effects in natural suppressor cells .

HY-107559

GT-2016	Histamine Receptor	Neurological Disease
GT-2016 is a potent, selective, and brain penetrant histamine H3 receptor antagonist with a K_i of 43.8 nM. GT-2016 displays selectivity against H1 and H2 receptors, and has non-active against histamine methyltransferase .

HY-B0310

Nizatidine	Histamine Receptor	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Nizatidine is a potent and orally active histamine H₂ receptor antagonist, can be used for the research of stomach?and?intestines ulcers. Nizatidine works by decreasing the secretion of gastric?acid the stomach makes and prevent ulcers from coming back after they have healed in animal models .

Cat. No.	Product Name	Type

HY-B0377G

Famotidine (GMP) MK-208 (GMP)	Fluorescent Dye
Famotidine GMP (MK-208 GMP) is Famotidine (HY-B0377) produced in GMP guideline. Famotidine GMP is a competitive histamine H2-receptor antagonist, inhibits gastric secretion, activates the gastric mucosal defensive mechanisms. Famotidine GMP ameliorates peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD) in rats model ^[2].

Cat. No.	Product Name	Type

HY-B0377G

Famotidine (GMP) MK-208 (GMP)	Biochemical Assay Reagents
Famotidine GMP (MK-208 GMP) is Famotidine (HY-B0377) produced in GMP guideline. Famotidine GMP is a competitive histamine H2-receptor antagonist, inhibits gastric secretion, activates the gastric mucosal defensive mechanisms. Famotidine GMP ameliorates peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD) in rats model ^[2].

Cat. No.	Product Name	Chemical Structure

HY-B0281AS

Ranitidine-d6 hydrochloride
Ranitidine-d₆ (hydrochloride) is the deuterium labeled Ranitidine hydrochloride. Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine hydrochloride is a weak inhibitor of CYP2C19 and CYP2C9[1][2].

HY-B0310S

Nizatidine-d3
Nizatidine-d₃ is the deuterium labeled Nizatidine. Nizatidine is a potent and orally active histamine H2 receptor antagonist, can be used for the research of stomach and intestines ulcers. Nizatidine works by decreasing the secretion of gastric acid the stomach makes and prevent ulcers from coming back after they have healed in animal models[1].

HY-B0377S

Famotidine-13C,d3
Famotidine- ¹³C,d₃ is the ¹³C- and deuterium labeled Famotidine. Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.

HY-B0160S

Lafutidine-d10
Lafutidine-d₁₀ is deuterium labeled Lafutidine. Lafutidine (FRG-8813) is a histamine H2-receptor antagonist (H2RA), with proven gastric mucosal protective effects. Lafutidine can be used for the research of gastroesophageal reflux disease[1].

HY-14289S

Cimetidine-d3
Cimetidine-d₃ is the deuterium labeled Cimetidine. Cimetidine (SKF-92334) is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine is an inverse agonist. Cimetidine has anti-cancer and anti-inflammatory activity[1][2][5].

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