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HIV Integrase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HIV (47) HIV Integrase (57) Bacterial (1) Dynamin (1) Endogenous Metabolite (2) GLUT (1) Isotope-Labeled Compounds (11) OAT (3) Tyrosinase (1)
By Research Areas:	Cancer (7) Infection (63) Inflammation/Immunology (3) Metabolic Disease (2)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

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Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: HIV Integrase HIV HIV Protease

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107485

HIV-1 integrase inhibitor 8	HIV Integrase	Infection
HIV-1 integrase inhibitor 8 is a **HIV-1 integrase** inhibitor, compound 8 .

HY-13025

HIV-1 integrase inhibitor 1 Publications Verification	HIV HIV Integrase	Infection
HIV-1 integrase inhibitor is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130760

HIV-1 integrase inhibitor 7	HIV Integrase	Infection
HIV-1 integrase inhibitor 7 is a potent **HIV-1 integrase inhibitor, with an IC₅₀** of 33.3 nM .

HY-159092

HIV-1 integrase inhibitor 13	HIV Integrase	Infection
HIV-1 integrase inhibitor 13 (Compound 15) is an inhibitor for **HIV-1 integrase with an IC₅₀** of 1.8 nM. HIV-1 integrase inhibitor 13 inhibits the HIV-1 WT and HIV-1 T125A, with IC₅₀ of 21 and 580 nM, respectively .

HY-108817

HIV-1 integrase inhibitor 3	HIV Integrase HIV	Infection
HIV-1 integrase inhibitor 3 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC₅₀ of 2.7 nM.

HY-108820

HIV-1 integrase inhibitor 4	HIV Integrase HIV	Infection
HIV-1 integrase inhibitor 4 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC₅₀ of 3.7 nM.

HY-150079

HIV-1 integrase inhibitor 10	HIV Integrase	Infection
HIV-1 integrase inhibitor 10 is an orally active **HIV-1 allosteric integrase** inhibitor (ALLINI). HIV-1 integrase inhibitor 10 can inhibit viral outgrowth of the NLRepRluc virus in MT-2 cells with EC₅₀ values of 3-5 nM. HIV-1 integrase inhibitor 10 can be used for the research of Human immunodeficiency virus-1 (HIV-1) .

HY-W507252

HIV-1 integrase inhibitor 11	HIV Integrase	Infection
HIV-1 integrase inhibitor 11 (compound 5) is a potent inhibitor of **HIV-1 integrase, with the IC₅₀** of 125 μM .

HY-159091

HIV-1 integrase inhibitor 12	HIV Integrase	Infection
HIV-1 integrase inhibitor 12 (Compound 17) is an inhibitor for **HIV-1 integrase with an IC₅₀** of 1.4 nM. HIV-1 integrase inhibitor 12 inhibits the HIV-1 WT and HIV-1 T125A, with IC₅₀ of 7.4 and 120 nM, respectively. HIV-1 integrase inhibitor 12 exhibits metabolic stability and Caco-2 permeability, and good pharmacokinetic characteristics with good bioavailability (64%) and low clearance (0.16 L/hr/kg) in rats .

HY-132572

HIV-1 integrase inhibitor 9	HIV	Infection
HIV-1 integrase inhibitor 9 (compound 8a) is a potent HIV-1 RNase H inhibitor with an IC₅₀ of 12.3 μM. HIV-1 integrase inhibitor 9 shows an antiviral activity .

HY-108818

XZ426	HIV Integrase	Infection
XZ426 is a potent integrase strand transfer inhibitor with anti- *HIV* activity .

HY-161945

IN-RNA-IN-2	HIV HIV Integrase	Infection
IN-RNA-IN-2 (compound 1a) is an inhibitor (IC₅₀=70 nM) of the interaction between **HIV-1 integrase and the viral RNA genome. IN-RNA-IN-2 exerts its anti-HIV** activity by inhibiting the viral replication process .

HY-123572

Bis-T-23 AG1717	Dynamin HIV Integrase	Infection Metabolic Disease Inflammation/Immunology
Bis-T-23 (AG1717), tyrphostin derivative, is an **HIV-I integrase** inhibitor. Bis-T-23 can promote actin-dependent dynamin oligomerization. Bis-T-23 can be used for the research of HIV and chronic kidney diseases (CKD) .

HY-153247

GSK3839919A	HIV Integrase	Infection Inflammation/Immunology
GSK3839919A is a potent and allosteric *HIV-1integrase* inhibitor .

HY-N7330

Integracin B	HIV Integrase HIV	Infection
Integracin B is a potent dimeric alkyl aromatic inhibitor of **HIV-1 integrase** discovered from the screening of fungal extracts using an in vitro assay. Integracin B inhibits both coupled and strand transfer activity of HIV-1 integrase .

HY-147653

Integrase-LEDGF/p75 allosteric inhibitor 1	HIV Integrase	Infection
Integrase-LEDGF/p75 allosteric inhibitor 1 (Compound 31h) is an orally active integrase-LEDGF/p75 (IN-LEDGF/p75) allosteric inhibitor. Integrase-LEDGF/p75 allosteric inhibitor 1 inhibits HIV-1 DNA integration and shows antiviral activity with an EC₅₀ of 3.9 nM against HIV-1 recombinant molecular clone NL432 .

HY-17605

Bictegravir 5+ Cited Publications GS-9883	HIV HIV Integrase	Infection
Bictegravir (GS-9883) is a potent inhibitor of **HIV-1 integrase with an IC₅₀** of 7.5 nM.

HY-10353

Raltegravir 15+ Cited Publications MK-0518	HIV Integrase HIV	Infection Cancer
Raltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection.

HY-18595

BI 224436 5+ Cited Publications	HIV HIV Integrase	Infection
BI 224436 is a novel *HIV-1* noncatalytic site integrase inhibitor with EC₅₀ values of less than 15 nM against different HIV-1 laboratory strains.

HY-17605A

Bictegravir sodium 5+ Cited Publications GS-9883 sodium	HIV Integrase HIV	Infection
Bictegravir sodium is a potent inhibitor of **HIV-1 integrase, with an IC₅₀** of 7.5 nM. Bictegravir sodium exhibits potent and selective anti-HIV activity and low cytotoxicity .

HY-10353A

Raltegravir potassium 15+ Cited Publications MK 0518 potassium	HIV Integrase HIV	Infection Cancer
Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection.

HY-B1408

Salicylanilide 2 Publications Verification 2-Hydroxybenzanilide	HIV Integrase HIV	Infection
Salicylanilide demonstrates a wide range of biological activities including antiviral potency which can inhibit HIV virus by targeting **HIV-1 integrase or reverse transcriptase**.

HY-N0457A

L-Chicoric Acid 1 Publications Verification (-)-Chicoric acid; trans-Caffeoyltartaric acid	HIV Integrase HIV Endogenous Metabolite	Infection Cancer
L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible **HIV-1 integrase inhibitor with an IC₅₀ of ~100 nM. L-Chicoric Acid inhibits HIV-1** replication in tissue culture .

HY-10353B

Raltegravir sodium MK 0518 sodium	HIV Integrase HIV	Infection
Raltegravir (MK 0518) sodium is a potent and orally active integrase (IN) inhibitor, used to treat HIV infection.

HY-14740

Elvitegravir 5+ Cited Publications GS-9137; JTK-303; D06677	HIV Integrase HIV	Infection
Elvitegravir (GS-9137; JTK-303; D06677) is an **HIV integrase** inhibitor for HIV-1_IIIB, HIV-2_EHO and HIV-2_ROD with IC₅₀ of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

HY-17605R

Bictegravir (Standard)	HIV HIV Integrase	Infection
Bictegravir (Standard) is the analytical standard of Bictegravir. This product is intended for research and analytical applications. Bictegravir (GS-9883) is a potent inhibitor of **HIV-1 integrase with an IC₅₀** of 7.5 nM.

HY-17605S1

Bictegravir-d5 GS-9883-d₅	HIV HIV Integrase Isotope-Labeled Compounds	Infection
Bictegravir-d₅ is deuterated labeled Bictegravir (HY-17605). Bictegravir (GS-9883) is a potent inhibitor of **HIV-1 integrase with an IC₅₀** of 7.5 nM.

HY-17605S2

Bictegravir-d4 GS-9883-d₄	HIV HIV Integrase	Infection
Bictegravir-d4 is a deuterium of Bictegravir (HY-17605). Bictegravir (GS-9883) is a potent inhibitor of *HIV-1* integrase with an IC₅₀ of 7.5 nM .

HY-12108

S 1360	HIV Integrase HIV	Infection
S 1360 is a potent and selective inhibitor of **HIV-1 integrase*. S 1360 inhibits the catalytic activity of purified integrase* ( IC₅₀: 20 nM). The EC₅₀, and CC₅₀ of S 1360 in MTT assay (MT-4 cells infected with HIV-1 IIIB) are 200 nM and 12 μM, respectively. S 1360 has antiviral activity against both X4 tropic and R5 tropic strains, as well as NRTI, NNRTI and PI drug-resistant variants .

HY-10353S

Raltegravir-d4	Isotope-Labeled Compounds HIV Integrase HIV	Infection
Raltegravir-d₄ is deuterium labeled Raltegravir. Raltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection.

HY-13238

Dolutegravir Maximum Cited Publications 22 Publications Verification S/GSK1349572	HIV Integrase HIV	Infection
Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC₅₀ of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC₅₀ of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC₅₀=3.6-5.8 nM) .

HY-163177

HIV-1 inhibitor-63	HIV	Infection
HIV-1 inhibitor-63 (compound S17) is a potent *HIV-1* inhibitor. HIV-1 inhibitor-63 inhibits integrase-Ku70 complex formation with an IC₅₀ value of 12 µM. HIV-1 inhibitor-63 inhibits HIV-1 post-integration DNA repair .

HY-14740S

Elvitegravir-d8 GS-9137-d₈; JTK-303-d₈; D06677-d₈	Isotope-Labeled Compounds HIV Integrase HIV	Infection
Elvitegravir-d₈ is deuterium labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

HY-P2379

His-Cys-Lys-Phe-Trp-Trp	HIV Integrase	Infection
His-Cys-Lys-Phe-Trp-Trp is an inhibitor for the human immunodeficiency virus (HIV) integrase with an IC₅₀ of 2 μM .

HY-10353S1

Raltegravir-d6 MK-0518-d₆	Isotope-Labeled Compounds HIV HIV Integrase	Infection
Raltegravir-d6 is a deuterated labeled Raltegravir . Raltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection.

HY-13238A

Dolutegravir sodium Maximum Cited Publications 22 Publications Verification S/GSK1349572 sodium	HIV Integrase HIV	Infection
Dolutegravir sodium (S/GSK1349572 sodium) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC₅₀ of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir sodium (S/GSK1349572 sodium) inhibits HIV-1 viral replication with an IC₅₀ of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir sodium (S/GSK1349572 sodium) retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC₅₀=3.6-5.8 nM) .

HY-14740R

Elvitegravir (Standard)	HIV Integrase HIV	Infection
Elvitegravir (Standard) is the analytical standard of Elvitegravir. This product is intended for research and analytical applications. Elvitegravir (GS-9137; JTK-303; D06677) is an **HIV integrase** inhibitor for HIV-1_IIIB, HIV-2_EHO and HIV-2_ROD with IC₅₀ of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

HY-153094

BDM-2	HIV HIV Integrase	Infection
BDM-2 is an IN-LEDGF allosteric inhibitor (INLAI) of *HIV-1* *integrase* (IN refers to integrase) (IC₅₀=47 nM) with potent anti-Retroviral (ARV) activity. BDM-2 shows IN multimerization activation effect with an AC₅₀ value of 20 nM. BDM-2 blocks the interaction between the catalytic core domain of IN (IN-CCD) and the Integrase binding domain of LEDGF/p75 (IBD), with an IC₅₀ value of 0.15 μM. BDM-2 exhibits highly selective and favorable cytotoxicity .

HY-100083

Dolutegravir intermediate-1	HIV	Others
Dolutegravir intermediate-1 is a synthetic intermediate of Dolutegravir extracted from patent WO 2016125192 A2. Dolutegravir is an integrase inhibitor developed for the treatment of human immunodeficiency virus (HIV)-1 infection.

HY-10522

LEDGIN6 4 Publications Verification CX05168; CX04328	HIV HIV Integrase	Infection
LEDGIN6 (CX05168) is a quinoline-based protein-protein interaction inhibitor of LEDGF/p75 and **HIV integrase** .

HY-13238R

Dolutegravir (Standard)	HIV Integrase HIV	Infection
Dolutegravir (Standard) is the analytical standard of Dolutegravir. This product is intended for research and analytical applications. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC₅₀ of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC₅₀ of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC₅₀=3.6-5.8 nM) .

HY-13238S1

Dolutegravir-d3 S/GSK1349572-d₃	Isotope-Labeled Compounds HIV Integrase HIV	Infection
Dolutegravir-d₃ is the deuterium labeled Dolutegravir. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM)[1][2].

HY-13238S2

Dolutegravir-d5 S/GSK1349572-d₅	Isotope-Labeled Compounds HIV Integrase HIV	Infection
Dolutegravir-d₅ is deuterium labeled Dolutegravir. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM)[1][2].

HY-W103287

2-Hydroxyisoquinoline-1,3(2H,4H)-dione	HIV Integrase	Infection
Hydroxyisoquinoline-1,3(2H,4H)-dione (compound 6a) is a HIV-1 integrase (IN) and HIV-1 reverse transcriptase (RT) ribonuclease H (RNase H) inhibitor with an IC₅₀ value of 6.32, 5.9 µM, respectively .

HY-N0457AR

L-Chicoric Acid (Standard)	HIV Integrase HIV Endogenous Metabolite	Infection Cancer
L-Chicoric Acid (Standard) is the analytical standard of L-Chicoric Acid. This product is intended for research and analytical applications. L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC₅₀ of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture .

HY-122229

GS-9822	HIV	Infection
GS-9822 is a potent antivira agent with nanomolar activity against wild-type *HIV-1* viruses. GS-9822 potently inhibits the *LEDGF/p75-integrase* interaction with an IC₅₀ of 0.07 μM. GS-9822 has high in vitro metabolic stability and favorable oral pharmacokinetic profiles with low systemic clearance in rats, dogs, and monkeys .

HY-16907

GSK-364735 S/GSK-364735	HIV HIV Integrase	Infection
GSK-364735 is a potent antiretroviral agent against human immunodeficiency virus type 1 (HIV-1) and serves as an *integrase* inhibitor with an IC₅₀ of 8 ± 2 nM. GSK-364735 can be utilized in antiviral research .

HY-N11288

Methyl salvionolate A	HIV	Infection
Methyl salvionolate A is a potent inhibitor of *HIV-1. Methyl salvionolate A inhibits P24* antigen in HIV-1 infected MT-4 cell with an EC₅₀ of 1.62 μg/ml. Methyl salvionolate A also inhibits HIV-1 reverse transcriptase, protease and integrase with IC₅₀s of 50.58, 10.73 and 7.58 μg/ml, respectively .

HY-10353AS

Raltegravir-d3 potassium MK 0518-d₃ potassium	Isotope-Labeled Compounds HIV Integrase HIV	Infection
Raltegravir-d₃ (potassium) is the deuterium labeled Raltegravir potassium. Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection[1][2].

HY-10353AR

Raltegravir potassium (Standard)	HIV Integrase HIV	Infection Cancer
Raltegravir (potassium) (Standard) is the analytical standard of Raltegravir (potassium). This product is intended for research and analytical applications. Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection.

Cat. No.	Product Name	Target	Research Area

HY-P2379

His-Cys-Lys-Phe-Trp-Trp	HIV Integrase	Infection
His-Cys-Lys-Phe-Trp-Trp is an inhibitor for the human immunodeficiency virus (HIV) integrase with an IC₅₀ of 2 μM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0457A

L-Chicoric Acid 1 Publications Verification (-)-Chicoric acid; trans-Caffeoyltartaric acid	Structural Classification other families Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	HIV Integrase HIV Endogenous Metabolite
L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible **HIV-1 integrase inhibitor with an IC₅₀ of ~100 nM. L-Chicoric Acid inhibits HIV-1** replication in tissue culture .

HY-N6711

Equisetin	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	HIV Integrase Bacterial
Equisetin is an N-methylserine-derived acyltramic acid isolated from the terrestrial fungus Fusarium equiseti NRRL 5537. As a tetrad-containing natural product, it has antibacterial and antiviral activities, inhibiting the growth of Gram-positive bacteria and *HIV-1* integrase activity, but not Gram-negative bacteria. Equisetin is a quorum sensing inhibitor (QSI) that attenuates the QS-regulated virulence phenotype in Pseudomonas aeruginosa without affecting bacterial growth, and is a leading compound for studying Pseudomonas aeruginosa infection. In addition, equisetin inhibits the enzymatic activity of 11b-hydroxysteroid dehydrogenase type 1 (11b-HSD1) without affecting food intake, blood pressure, or heart rate, exerting anti-obesity effects on adipose tissue .

HY-N7330

Integracin B	Infection Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields	HIV Integrase HIV
Integracin B is a potent dimeric alkyl aromatic inhibitor of **HIV-1 integrase** discovered from the screening of fungal extracts using an in vitro assay. Integracin B inhibits both coupled and strand transfer activity of HIV-1 integrase .

HY-N0457AR

L-Chicoric Acid (Standard)	Structural Classification other families Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Plants	HIV Integrase HIV Endogenous Metabolite
L-Chicoric Acid (Standard) is the analytical standard of L-Chicoric Acid. This product is intended for research and analytical applications. L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC₅₀ of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture .

HY-N11288

Methyl salvionolate A	Structural Classification Labiatae Source classification Phenols Polyphenols Salvia yunnanensis C. H. Wright Plants	HIV
Methyl salvionolate A is a potent inhibitor of *HIV-1. Methyl salvionolate A inhibits P24* antigen in HIV-1 infected MT-4 cell with an EC₅₀ of 1.62 μg/ml. Methyl salvionolate A also inhibits HIV-1 reverse transcriptase, protease and integrase with IC₅₀s of 50.58, 10.73 and 7.58 μg/ml, respectively .

Cat. No.	Product Name	Chemical Structure

HY-13238S1

Dolutegravir-d3

Dolutegravir-d₃ is the deuterium labeled Dolutegravir. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM)[1][2].

HY-17605S1

Bictegravir-d5
Bictegravir-d₅ is deuterated labeled Bictegravir (HY-17605). Bictegravir (GS-9883) is a potent inhibitor of **HIV-1 integrase with an IC₅₀** of 7.5 nM.

HY-17605S2

Bictegravir-d4
Bictegravir-d4 is a deuterium of Bictegravir (HY-17605). Bictegravir (GS-9883) is a potent inhibitor of *HIV-1* integrase with an IC₅₀ of 7.5 nM .

HY-10353S

Raltegravir-d4
Raltegravir-d₄ is deuterium labeled Raltegravir. Raltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection.

HY-14740S

Elvitegravir-d8
Elvitegravir-d₈ is deuterium labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

HY-10353S1

Raltegravir-d6
Raltegravir-d6 is a deuterated labeled Raltegravir . Raltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection.

HY-13238S2

Dolutegravir-d5

Dolutegravir-d₅ is deuterium labeled Dolutegravir. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM)[1][2].

HY-10353AS

Raltegravir-d3 potassium
Raltegravir-d₃ (potassium) is the deuterium labeled Raltegravir potassium. Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection[1][2].

HY-15592AS

Cabotegravir-d3 sodium
Cabotegravir-d₃ (sodium) is the deuterium labeled Cabotegravir sodium. Cabotegravir sodium is a highly potent HIV integrase inhibitor with an IC50 value of 2.5 nM for HIVADA. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltr

HY-10353AS1

Raltegravir-13C,d3 potassium
Raltegravir- ¹³C,d₃ potassium is ¹³C labeled Raltegravir potassium (HY-10353A). Raltegravir (MK 0518) potassium is a potent integrase (IN) inhibitor, used to treat HIV infection.

HY-15592S2

Cabotegravir-d3-1
Cabotegravir d3-1 (GSK-1265744-d3-1) is a deuterium substitute of Cabotegravir. Cabotegravir is a potent **HIV integrase** inhibitor used in AIDS research

HY-17605S

Bictegravir-15N,d2
Bictegravir- ¹⁵N,d₂ (GS-9883- ¹⁵N,d₂) is the ¹⁵N and deuterium labeled Bictegravir (HY-17605) . Bictegravir (GS-9883) is a potent inhibitor of **HIV-1 integrase with an IC₅₀** of 7.5 nM .

Cat. No.	Product Name		Classification

HY-13025

HIV-1 integrase inhibitor 1 Publications Verification		Azide
HIV-1 integrase inhibitor is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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