From 11:00 pm to 12:00 pm EST ( 8:00 pm to 9:00 pm PST ) on January 6th, the website will be under maintenance. We are sorry for the inconvenience. Please arrange your schedule properly.
IGF2BP1-IN-1 (Compound A11) is a IGF2BP1 inhibitor and inhibits downstream signaling. IGF2BP1-IN-1 binds to IGF2BP1 protein with a KD value of 2.88 nM. IGF2BP1-IN-1 inhibits cancer cells proliferation (IC50: 9 nM for A549 cell, 34 nM for HCT116). IGF2BP1-IN-1 induces cancer cell apoptosis. GF2BP1-IN-1 inhibits tumor growth in A549 xenograft mouse model .
Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) is a recombinant a human monoclonal antibody that targets IGF ligands IGF1 and IGF2. Xentuzumab inhibits both of IGF1 and IGF2 growth-promoting signalling and suppresses AKT activation .
Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor(IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer .
IGF2 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
IGF2R Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
IGF2BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
IGF2BP2 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2BP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
IGF2BP3 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2BP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
INS-IGF2 Human Pre-designed siRNA Set A contains three designed siRNAs for INS-IGF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Chromeceptin (94G6) is an IGF signaling pathway inhibitor. Chromeceptin suppresses IGF2 expression at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the phosphorylation levels of AKT and mTOR .
AVJ16 is a cancer cell migration inhibitor that targets the insulin-like growth factor 2 mRNA binding protein IGF2BP1 to inhibit the migration of H1299 cells with high endogenous IGF2BP1 expression. AVJ16 interferes with IGF2BP1 binding target mRNA to regulate gene expression and translation .
CWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects .
CWI1-2 is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects .
Dalotuzumab (MK-0646) is a recombinant humanized monoclonal antibody (IgG1 type) targeting IGF-1R. Dalotuzumab acts by inhibiting IGF-1- and IGF-2-mediated tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation. Dalotuzumab also induces apoptosis and cycle arrest. Dalotuzumab in combination with other anticancer agents such as statins can enhance the antitumor activity of Dalotuzumab in vitro and in vivo [2] .
Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) is a recombinant a human monoclonal antibody that targets IGF ligands IGF1 and IGF2. Xentuzumab inhibits both of IGF1 and IGF2 growth-promoting signalling and suppresses AKT activation .
Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor(IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer .
Dalotuzumab (MK-0646) is a recombinant humanized monoclonal antibody (IgG1 type) targeting IGF-1R. Dalotuzumab acts by inhibiting IGF-1- and IGF-2-mediated tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation. Dalotuzumab also induces apoptosis and cycle arrest. Dalotuzumab in combination with other anticancer agents such as statins can enhance the antitumor activity of Dalotuzumab in vitro and in vivo [2] .
Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) is a recombinant a human monoclonal antibody that targets IGF ligands IGF1 and IGF2. Xentuzumab inhibits both of IGF1 and IGF2 growth-promoting signalling and suppresses AKT activation .
Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor(IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer .
Dalotuzumab (MK-0646) is a recombinant humanized monoclonal antibody (IgG1 type) targeting IGF-1R. Dalotuzumab acts by inhibiting IGF-1- and IGF-2-mediated tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation. Dalotuzumab also induces apoptosis and cycle arrest. Dalotuzumab in combination with other anticancer agents such as statins can enhance the antitumor activity of Dalotuzumab in vitro and in vivo [2] .
The IGF-II protein plays a crucial role in glucose-mediated insulin secretion, acting together with insulin as a physiological amplifier. Furthermore, it exhibits osteogenic properties by enhancing osteoblast mitotic activity through phosphorylation of MAPK1 and MAPK3. Animal-Free IGF-II Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIGF-II protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free IGF-II Protein, Mouse (His) is 67 a.a., with molecular weight of ~8.20 kDa.
IGF2 Protein, Human is a mitogenic cytokine, binds to IGF type 1 receptor, and modulates growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone.
The IGF2BP2 protein is an RNA-binding factor that coordinates the recruitment of target transcripts into cytoplasmic mRNP, promoting mRNA transport and transient storage. It regulates the contact of target transcripts with the translation machinery and protects them from microRNA-mediated degradation. IGF2BP2 Protein, Human (T7-His) is the recombinant human-derived IGF2BP2 protein, expressed by E. coli , with N-T7, C-6*His labeled tag.
IGF2R Protein orchestrates cellular processes by transporting phosphorylated lysosomal enzymes from the Golgi complex to lysosomes. Lysosomal enzymes, with phosphomannosyl residues, bind to mannose-6-phosphate receptors in the Golgi, forming a complex transported to an acidic prelysosomal compartment. The low pH facilitates complex dissociation, and the receptor is recycled via interaction with the retromer. IGF2R also binds IGF2, positively regulates T-cell coactivation with DPP4, and engages with HA-I and HA-II plasma membrane adapters, showcasing its versatile molecular interactions in intracellular transport. IGF2R Protein, Human (HEK293, His-Avi) is the recombinant human-derived IGF2R protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of IGF2R Protein, Human (HEK293, His-Avi) is 1462 a.a., with molecular weight of 165-200 kDa.
The IGF2BP2 protein is an RNA-binding factor that coordinates the recruitment of target transcripts into cytoplasmic mRNP, promoting mRNA transport and transient storage. It regulates the contact of target transcripts with the translation machinery and protects them from microRNA-mediated degradation. IGF2BP2 Protein, Human (sf9, His-GST) is the recombinant human-derived IGF2BP2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of IGF2BP2 Protein, Human (sf9, His-GST) is 599 a.a., with molecular weight of ~90 kDa.
IGF2R proteins coordinate cellular processes by transporting phosphorylated lysosomal enzymes from the Golgi complex to lysosomes. Lysosomal enzymes with phosphomannosyl residues bind to mannose-6-phosphate receptors in the Golgi apparatus, form complexes, and transport to the acidic prelysosomal compartment. IGF2R Protein, Human (Domain 1-7, HEK293, His-Avi) is the recombinant human-derived IGF2R protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of IGF2R Protein, Human (Domain 1-7, HEK293, His-Avi) is 1033 a.a., with molecular weight of 120-160 kDa.
The IGF2 protein is an important member of the insulin-like growth factor family and plays an important role in mammalian growth, fetoplacental development, and adult glucose metabolism. Regulated by placental prolactin, affecting tissue differentiation. IGF2 Protein, Human (P.pastoris) is the recombinant human-derived IGF2 protein, expressed by P. pastoris , with tag free.
The IGF2 protein is an important member of the insulin-like growth factor family and plays an important role in mammalian growth, fetoplacental development, and adult glucose metabolism. Regulated by placental prolactin, affecting tissue differentiation. IGF2 Protein, Human (GST) is the recombinant human-derived IGF2 protein, expressed by E. coli , with N-GST labeled tag.
IGF2R Protein orchestrates cellular processes by transporting phosphorylated lysosomal enzymes from the Golgi complex to lysosomes. Lysosomal enzymes, with phosphomannosyl residues, bind to mannose-6-phosphate receptors in the Golgi, forming a complex transported to an acidic prelysosomal compartment. The low pH facilitates complex dissociation, and the receptor is recycled via interaction with the retromer. IGF2R also binds IGF2, positively regulates T-cell coactivation with DPP4, and engages with HA-I and HA-II plasma membrane adapters, showcasing its versatile molecular interactions in intracellular transport. IGF2R Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IGF2R protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of IGF2R Protein, Human (Biotinylated, HEK293, His-Avi) is 1462 a.a., with molecular weight of 165-200 kDa.
IGF2R Protein orchestrates cellular processes by transporting phosphorylated lysosomal enzymes from the Golgi complex to lysosomes. Lysosomal enzymes, with phosphomannosyl residues, bind to mannose-6-phosphate receptors in the Golgi, forming a complex transported to an acidic prelysosomal compartment. The low pH facilitates complex dissociation, and the receptor is recycled via interaction with the retromer. IGF2R also binds IGF2, positively regulates T-cell coactivation with DPP4, and engages with HA-I and HA-II plasma membrane adapters, showcasing its versatile molecular interactions in intracellular transport. IGF2R Protein, Human (Domain 1-3, HEK293, His-Avi) is the recombinant human-derived IGF2R protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of IGF2R Protein, Human (Domain 1-3, HEK293, His-Avi) is 422 a.a., with molecular weight of 55-65 kDa.
IGFBP‐2 is a member of a family of six insulin‐like growth factor (IGF) binding proteins. IGFBP-2 is the second most abundant IGFBP in the circulation and binds IGF-II with higher affinity than IGF-I. IGFBP-2 has been implicated in the regulation of IGF activity in most tissues and organs. IGFBP-2 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived IGFBP-2 protein, expressed by HEK293 , with C-His labeled tag.
The IGF2 protein is an important member of the insulin-like growth factor family and plays an important role in mammalian growth, fetoplacental development, and adult glucose metabolism. Regulated by placental prolactin, affecting tissue differentiation. Animal-Free IGF2 Protein, Human (His) is the recombinant human-derived animal-FreeIGF2 protein, expressed by E. coli , with N-His labeled tag.
IGF2BP1 Antibody (YA3071) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3071), targeting IGF2BP1, with a predicted molecular weight of 63 kDa (observed band size: 63 kDa). IGF2BP1 Antibody (YA3071) can be used for WB, IHC-P, IP experiment in human, mouse background.
C11orf43; IGF 2; IGF II; IGF2; INSIGF; Somatomedin A
WB, ICC/IF
Human
IGF2 Antibody (YA3192) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3192), targeting IGF2, with a predicted molecular weight of 20 kDa (observed band size: 20 kDa). IGF2 Antibody (YA3192) can be used for WB, ICC/IF experiment in human background.
Cancer/testis antigen 98; CT98; DKFZp686F1078; hKOC; IF2B3_HUMAN; IGF II mRNA binding protein 3; IGF-II mRNA-binding protein 3; IGF2 mRNA binding protein 3; IGF2 mRNA-binding protein 3; IGF2BP3; IMP 3; IMP-3; Insulin like growth factor 2 mRNA binding prot
WB, ICC/IF, IP, FC
Human, Mouse, Rat
IMP3 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 64 kDa, targeting to IMP3. It can be used for WB,ICC/IF,IP,FC assays with tag free, in the background of Human, Mouse, Rat.
IGF2BP2; IMP2; VICKZ2; Insulin-like growth factor 2 mRNA-binding protein 2; IGF2 mRNA-binding protein 2; IMP-2; Hepatocellular carcinoma autoantigen p62; IGF-II mRNA-binding protein 2; VICKZ family member 2
WB, IHC-P, ICC/IF
Human, Mouse, Rat
IGF2BP2 Antibody (YA2033) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2033), targeting IGF2BP2, with a predicted molecular weight of 66 kDa (observed band size: 66,62 kDa). IGF2BP2 Antibody (YA2033) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.
IGF2R Antibody (YA1499) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1499), targeting IGF2R, with a predicted molecular weight of 274 kDa (observed band size: 274 kDa). IGF2R Antibody (YA1499) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.
IGF2 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
IGF2R Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
IGF2BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
IGF2BP2 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2BP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
IGF2BP3 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2BP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
INS-IGF2 Human Pre-designed siRNA Set A contains three designed siRNAs for INS-IGF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Inquiry Online
Your information is safe with us. * Required Fields.