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Results for "

Melanogenesis

" in MedChemExpress (MCE) Product Catalog:

48

Inhibitors & Agonists

9

Peptides

26

Natural
Products

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0493
    Pectolinarigenin
    1 Publications Verification

    		 COX Lipoxygenase Inflammation/Immunology
    Pectolinarigenin is a dual inhibitor of COX-2/5-LOX. Anti-inflammatory activity . Pectolinarigenin has potent inhibitory activities on melanogenesis .
    Pectolinarigenin
  • HY-N2073
    Ethyl linolenate

    		MCHR1 (GPR24) Cardiovascular Disease
    Ethyl linolenate is a fatty acid ethyl ester (FAEE). Ethyl linolenate plays an active role in inhibition of the cellular production on melanin with an IC50 of 70 μM. Anti-melanogenesis Effects .
    Ethyl linolenate
  • HY-N0637A
    (±)-Eriodictyol

    (±)-Huazhongilexone; Dihydroluteolin

    		 Melanocortin Receptor Metabolic Disease
    (±)-Eriodictyol ((±)-Huazhongilexone), a flavonoid, is a potent melanogenesis inhibitor with an IC50 of 48 μM. (±)-Eriodictyol suppresses tyrosinase, TRP-1, and TRP-2 mRNA expression. (±)-Eriodictyol has strong anti-plasmin activities .
    (±)-Eriodictyol
  • HY-143459
    Tyrosinase-IN-5

    		Tyrosinase Cancer
    Tyrosinase-IN-5 (compound 16c) is a potent inhibitor of tyrosinase with an IC50 of 0.02 μM. Tyrosinase-IN-5 efficiently suppresses the melanogenesis without significant toxicity on cells .
    Tyrosinase-IN-5
  • HY-N3643
    Cryptomeridiol

    		Others Cancer
    Cryptomeridiol can be isolated from Phaulopsis imbricata. Cryptomeridiol has melanogenesis inhibitory activity in the α-MSH-stimulated B16 melanoma cells .
    Cryptomeridiol
  • HY-155189
    IIIM-8

    		Melanocortin Receptor Others
    IIIM-8 is a melanogenesis inhibitor. IIIM-8 inhibits pigment production both in vitro and in vivo without incurring any cytotoxicity in Human Adult Epidermal Melanocytes (HAEM). IIIM-8 can be used for hyperpigmentation disorders research .
    IIIM-8
  • HY-119808
    Terrein

    		Melanocortin Receptor Apoptosis Antibiotic Cancer
    Terrein is a melanogenesis inhibitor . Terrein induces apoptosis in breast cancer cell lines . Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa .
    Terrein
  • HY-N1873
    (E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol

    DMPB

    		 Others Metabolic Disease
    (E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol (DMPB) is a natural product that can be isolated from Zingiber cassumunar. (E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol can increas melanogenesis .
    (E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol
  • HY-161846
    Tyrosinase-IN-31

    		Tyrosinase Neurological Disease
    Tyrosinase-IN-31 (compound 2-06) is a central-targeting tyrosinase inhibitor (tyrosinase: monophenolase IC50=70.44 μM, diphenolase IC50=1.89 μM). Tyrosinase-IN-31 can inhibit the tyrosinase and melanogenesis. Tyrosinase-IN-31 can penetrate the BBB and enter the central nervous system (CNS). Tyrosinase-IN-31 shows neuroprotective effects and Parkinsonism behavior improving function .
    Tyrosinase-IN-31
  • HY-149698
    Tyrosinase-IN-17

    		Tyrosinase Cancer
    Tyrosinase-IN-17 (Compound 5b) is a lipophilic, skin-permeable, and non-cytotoxic Tyrosinase inhibitor (pIC50=4.99). Tyrosinase-IN-17 can be used for research on melanin-related diseases, such as melanoma, melanogenesis, etc .
    Tyrosinase-IN-17
  • HY-159107
    2-MNG

    2-Mercaptonicotinoyl glycine

    		 Others Others
    2-MNG (2-Mercaptonicotinoyl glycine) is an inhibitor for melanogenesis with an average IC50 of 49.5μM in normal human melanocytes. 2-MNG binds to melanin precursors, prevents the incorporation into growing melanin, and thereby inhibits the synthesis of eumelanin and pheomelanin. 2-MNG can be used in research about skin pigmentation .
    2-MNG
  • HY-N0493R
    Pectolinarigenin (Standard)

    		COX Lipoxygenase Inflammation/Immunology
    Pectolinarigenin (Standard) is the analytical standard of Pectolinarigenin. This product is intended for research and analytical applications. Pectolinarigenin is a dual inhibitor of COX-2/5-LOX. Anti-inflammatory activity . Pectolinarigenin has potent inhibitory activities on melanogenesis .
    Pectolinarigenin (Standard)
  • HY-W721119
    7-Methylsulfinylheptyl isothiocyanate

    		p38 MAPK Autophagy Inflammation/Immunology Cancer
    7-Methylsulfinylheptyl isothiocyanate is an activator for MAPK signaling pathway, which downregulates the melanogenesis related proteins and suppresses the melanin synthesis in B16-F1 cells. 7-Methylsulfinylheptyl isothiocyanate induces autophagy. 7-Methylsulfinylheptyl isothiocyanate is an inducer for phase II enzyme, which exhibits chemoprotective effect against carcinogen. 7-Methylsulfinylheptyl isothiocyanate can be used as cosmetic ingredient for skin whitening and anti-inflammation .
    7-Methylsulfinylheptyl isothiocyanate
  • HY-134046
    (-)-Isodocarpin

    Isodocarpin

    		 Melanocortin Receptor Metabolic Disease
    (-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC50 of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA .
    (-)-Isodocarpin
  • HY-P4497
    Prolylserine

    		ERK Cancer
    Prolylserine, a dipeptide, is an inhibitor of melanogenesis production in Mel-Ab cells. Prolylserine decreases expression of microphthalmia-associated transcription factor (MITF) and tyrosinase, induces phorphosylation of ERK, but not cAMP response element binding protein (CREB) .
    Prolylserine
  • HY-P0096
    Decapeptide-12

    		Tyrosinase Sirtuin Inflammation/Immunology Endocrinology
    Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .
    Decapeptide-12
  • HY-N7717
    (-)-N-methylcoclaurine

    (–)-(1R)-N-methylcoclaurine

    		 Others Metabolic Disease
    (-)-N-methylcoclaurine possesses melanogenesis inhibitory activity .
    (-)-N-methylcoclaurine
  • HY-N0113
    Hordenine
    1 Publications Verification

    Ordenina; Peyocactine

    		 Bacterial Antibiotic Infection Cardiovascular Disease
    Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .
    Hordenine
  • HY-N3425
    Kazinol U

    		AMPK Others
    Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK activation .
    Kazinol U
  • HY-N0113B
    Hordenine hydrochloride
    1 Publications Verification

    Ordenina hydrochloride; Peyocactine hydrochloride

    		 Antibiotic Infection
    Hordenine (hydrochloride), an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .
    Hordenine hydrochloride
  • HY-N5118
    Chimonanthine

    (-)-Chimonanthine

    		 Tyrosinase Cancer
    Chimonanthine is an alkaloid of Chimonanthus praecox, inhibits tyrosinase and tyrosine-related protein-1 mRNA expression, amd inhibits melanogenesis .
    Chimonanthine
  • HY-135743
    Apovincamine

    cis-Apovincamine; (+)-Apovincamine

    		 Others Cancer
    Apovincamine (cis-Apovincamine) is an indole alkaloid isolated from the Malaysian Alstonia pneumatophora (Apocynaceae). Apovincamine shows anti-melanogenesis activity .
    Apovincamine
  • HY-161969
    Tyrosinase-IN-34

    		Tyrosinase Cancer
    Tyrosinase-IN-34 (compound 5a) is a human tyrosinase inhibitor (IC50: 3.5 μM) with the potential to control melanogenesis and pigmentation .
    Tyrosinase-IN-34
  • HY-N3810
    ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid

    		Tyrosinase Others
    ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is an anti-melanin synthesis tyrosinase inhibitor, which can be isolated from Pteris fern. ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid regulates the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF). The 11α-OH, 15-oxo and 16-en moieties of ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid are key fragments that inhibit melanin synthesis. The 19-COOH moiety has been implicated in the inhibition of cytotoxicity associated with 11α-OH KA and related compounds .
    ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid
  • HY-158021
    Tyrosinase-IN-26

    		Tyrosinase Cancer
    Tyrosinase-IN-26 (compound 13) is a uncompetitive tyrosinase inhibitor with the an IC50 value of 68.86 µM. Tyrosinase-IN-26 can suppresses melanogenesis .
    Tyrosinase-IN-26
  • HY-117761
    MHY908

    		PPAR Metabolic Disease Cancer
    MHY908 is a potent dual agonist of PPARα and PPARγ . MHY908 also inhibits melanogenesis through inhibition of mushroom tyrosinase activity .
    MHY908
  • HY-I0400
    N-Acetylneuraminic acid
    3 Publications Verification

    NANA; Lactaminic acid

    		 Tyrosinase Ras Influenza Virus Endogenous Metabolite Cardiovascular Disease Inflammation/Immunology Cancer
    N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia .
    N-Acetylneuraminic acid
  • HY-N6069
    Raspberry ketone glucoside
    1 Publications Verification

    		 Others Inflammation/Immunology
    Raspberry ketone glucoside is a natural product in raspberry fruit. Raspberry ketone glucosidev has the inhibitory effect on the melanin synthesis .
    Raspberry ketone glucoside
  • HY-152194
    Tyrosinase-IN-10

    		Tyrosinase Cancer
    Tyrosinase-IN-10 (Compound 23) is a partially competitive tyrosinase inhibitor with an IC50 of 1.6 μM against tyrosinase activity from human melanoma cell lysates .
    Tyrosinase-IN-10
  • HY-N0113R
    Hordenine (Standard)

    Ordenina (Standard); Peyocactine (Standard)

    		 Bacterial Antibiotic Infection Cardiovascular Disease
    Hordenine (Standard) is the analytical standard of Hordenine. This product is intended for research and analytical applications. Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .
    Hordenine (Standard)
  • HY-N0113S
    Hordenine-d6

    Ordenina-d6; Peyocactine-d6

    		 Isotope-Labeled Compounds Bacterial Antibiotic Infection Cardiovascular Disease
    Hordenine-d6 (Ordenina-d6) is the deuterium labeled Hordenine. Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .
    Hordenine-d6
  • HY-P5247
    Palmitoyl tetrapeptide-20

    PTP20

    		 Melanocortin Receptor Metabolic Disease Inflammation/Immunology
    Palmitoyl tetrapeptide-20 (PTP20) is a biomimetic peptide that is an agonist for α-MSH. Palmitoyl tetrapeptide-20 can protect follicular melanocytes and activate melanogenesis by enhancing catalase expression .
    Palmitoyl tetrapeptide-20
  • HY-P5247A
    Palmitoyl tetrapeptide-20 TFA

    PTP20 TFA

    		 Melanocortin Receptor Neurological Disease Inflammation/Immunology
    Palmitoyl tetrapeptide-20 (PTP20) TFA is a biomimetic peptide that is an agonist for α-MSH. Palmitoyl tetrapeptide-20 TFA can protect follicular melanocytes and activate melanogenesis by enhancing catalase expression .
    Palmitoyl tetrapeptide-20 TFA
  • HY-135014
    Undecylenoyl phenylalanine

    		Melanocortin Receptor Adrenergic Receptor Others
    Undecylenoyl phenylalanine is an antagonist for α-melanocyte-stimulating hormone (MSH) and β-adrenergic receptor (β-ADR) to reduce the melanogenesis in melanocytes, reduces hyperpigmentation and thus ameliorates melasma lesions and solar lentigines .
    Undecylenoyl phenylalanine
  • HY-N11521
    7-Methoxy obtusifolin

    		Tyrosinase Cancer
    7-Methoxy obtusifolin (Compound 4) is a competitive tyrosinase inhibitor with an IC50 of 7.0 μM .
    7-Methoxy obtusifolin
  • HY-21268
    Methyl linolenate
    1 Publications Verification

    Linolenic acid methyl ester

    		 Others Metabolic Disease
    Methyl linolenate is a polyunsaturated fattly acid (PUFA). Methyl linolenate has an anti-melanogenesis activity with an IC50 of 60 μM. Methyl linolenate can also be used for studies of the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids .
    Methyl linolenate
  • HY-N2073S
    Ethyl linolenate-d5

    		MCHR1 (GPR24) Cardiovascular Disease
    Ethyl linolenate-d5 is the deuterium labeled Ethyl linolenate. Ethyl linolenate is a fatty acid ethyl ester (FAEE). Ethyl linolenate plays an active role in inhibition of the cellular production on melanin with an IC50 of 70 μM. Anti-melanogenesis Effects[1].
    Ethyl linolenate-d5
  • HY-N10016
    Chlorogenic acid butyl ester

    		Tyrosinase Cancer
    Chlorogenic acid butyl ester, a caffeoylquinic acid, is a potent melanogenesis inhibitor. Chlorogenic acid butyl ester inhibits the expression of microphtalmia-associated transcription factor (MITF), tyrosinase, tyrosinerelated protein 1 (TRP-1), and TRP-2. Chlorogenic acid butyl ester also shows antioxidant activity .
    Chlorogenic acid butyl ester
  • HY-126618
    Aspochalasin I

    		Tyrosinase Cancer
    Aspochalasin I exhibits cytotoxicity against cancer cells NCIH460, MCF-7 and SF-268, with IC50s of 22.1, 33.4 and 19.9 μM. Aspochalasin I inhibits melanogenesis (IC50 of 22.4 μM) through inhibition of tyrosinase, and can thus be used as whitening agent .
    Aspochalasin I
  • HY-21268R
    Methyl linolenate (Standard)

    		Others Metabolic Disease
    Methyl linolenate (Standard) is the analytical standard of Methyl linolenate. This product is intended for research and analytical applications. Methyl linolenate is a polyunsaturated fattly acid (PUFA). Methyl linolenate has an anti-melanogenesis activity with an IC50 of 60 μM. Methyl linolenate can also be used for studies of the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids .
    Methyl linolenate (Standard)
  • HY-N2996
    Ganodermanondiol

    		HIV Protease Infection
    Ganodermanondiol is a melanogenesis inhibitor isolated from the Ganoderma lucidum .Ganodermanondiol exhibits potent cytoprotective effects on tert-butyl hydroperoxide-induced hepatotoxicity . Ganodermanondiol shows significant anti-HIV-1 protease activity with an IC50 of 90 μM . Ganodermanondiol exhibits a strong anticomplement activity against the classical pathway of the complement system with an IC50 of 41.7μM .
    Ganodermanondiol
  • HY-N2466A
    Melanotan I acetate

    MT-I acetate; [Nle4,D-Phe7]-α-MSH acetate

    		 Melanocortin Receptor Cancer
    Melanotan I acetate is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I acetate is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I acetate can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I acetate can be used for sunlight-induced skin cancers research .
    Melanotan I acetate
  • HY-N2466
    Melanotan I
    1 Publications Verification

    MT-I; [Nle4,D-Phe7]-α-MSH

    		 Melanocortin Receptor Neurological Disease Cancer
    Melanotan I is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I can be used for the research of sun-induced skin cancer, melanoma, inflammation and male erectile dysfunction .
    Melanotan I
  • HY-N10802
    6-O-Isobutyrylbritannilactone

    		ERK Akt PI3K Epigenetic Reader Domain Cancer
    6-O-Isobutyrylbritannilactone is a natural melanogenesis inhibitor. 6-O-Isobutyrylbritannilactone, a sesquiterpene, can be isolated from the flowers of Inula britannica. 6-O-Isobutyrylbritannilactone inhibits IBMX (HY-12318)-induced melanin production in B16F10 cells. 6-O-Isobutyrylbritannilactone also regulates ERK, PI3K/AKT, and CREB, shows antimelanogenic activity in zebrafish embryos models .
    6-O-Isobutyrylbritannilactone
  • HY-N0113A
    Hordenine sulfate

    Ordenina sulfate; Peyocactine sulfate

    		 Antibiotic Others
    Hordenine sulfate (Ordenina sulfate) is an active compound extracted from malted barley that has melanin-inhibiting activity. Hordenine sulfate significantly reduced melanin content and reduced intracellular cAMP levels. Hordenine sulfate inhibits the expression of proteins related to melanogenesis, including microblind transcription factor (MITF), tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2. Therefore, Hordenine sulfate can be used as an active ingredient to inhibit pigmentation .
    Hordenine sulfate
  • HY-P0097A
    Nonapeptide-1 acetate salt
    2 Publications Verification

    Melanostatine-5 acetate salt

    		 Melanocortin Receptor Metabolic Disease Endocrinology Cancer
    Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM). Nonapeptide-1 acetate salt is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC50: 2.5 nM and 11 nM, respectively). Nonapeptide-1 acetate salt inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer .
    Nonapeptide-1 acetate salt
  • HY-P0097
    Nonapeptide-1
    2 Publications Verification

    Melanostatine-5

    		 Melanocortin Receptor Metabolic Disease Endocrinology Cancer
    Nonapeptide-1 (Melanostatine-5), a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM). Nonapeptide-1 is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC50: 2.5 nM and 11 nM, respectively). Nonapeptide-1 inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer .
    Nonapeptide-1
  • HY-N0998
    1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one

    		Others Cancer
    1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one (compound 6) shows antiproliferative activity with ED50s of 57.7, 78.8 μM for 26-L5 and HT-1080 cells, respectively. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one inhibits melanogenesis in B16 melanoma 4A5 cells. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one has the potential for the research of skin disorders .
    1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one

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