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SGK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SGK (16) Akt (1) Apoptosis (1) Autophagy (2) Casein Kinase (2) CDK (2) Endogenous Metabolite (3) Glucocorticoid Receptor (2) iGluR (2) Influenza Virus (1) JNK (1) PI3K (1) Pim (1) PROTAC Linkers (4) PROTACs (2) Ribosomal S6 Kinase (RSK) (2) ROCK (1) Small Interfering RNA (siRNA) (7)
By Research Areas:	Cancer (15) Cardiovascular Disease (1) Endocrinology (2) Infection (1) Inflammation/Immunology (9) Metabolic Disease (4) Neurological Disease (3)
Oligonucleotides:	Pre-designed siRNA Sets (7) siRNAs (7)

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Targets Recommended: SGK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18607

SGK1-IN-1 1 Publications Verification	SGK	Inflammation/Immunology
SGK1-IN-1 is a highly active and selective inhibitor of *SGK-1, with an IC₅₀* of 1 nM.

HY-142687

SGK1-IN-4 1 Publications Verification	SGK	Inflammation/Immunology
SGK1-IN-4 (compound 17a) is a highly selective, orally active *SGK1* inhibitor. SGK1-IN-4 can be used for osteoarthritis research .

HY-125878

*PROTAC SGK3 degrader-1* 4 Publications Verification SGK3-PROTAC1	PROTACs SGK	Cancer
PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a von Hippel-Lindau ligand-based SKG3 PROTAC composed of a PEG3-C4-OBn (HY-130620) alkyl linker, an SGK3 degrader (red structure), and a VHL ligand (HY-150803, blue structure). PROTAC SGK3 degrader-1 (0.3 μM) induced 50% endogenous SGK3 degradation within 2 hours, and 80% SGK3 degradation was observed at 8 hours, accompanied by loss of phosphorylation of NDRG1 (SGK3 substrate) .

HY-142686A

SGK1-IN-3 hydrochloride	SGK	Inflammation/Immunology
SGK1-IN-3 hydrochloride (compound 3a) is a potent and orally active inhibitor of *SGK1. The serine/threonine kinase SGK1 is an activator of the β-catenin pathway and a powerful stimulator of cartilage degradation that is found to be upregulated under genomic control in diseased osteoarthritic cartilage. SGK*1-IN-3 hydrochloride has the potential for the research of osteoarthritis .

HY-135893

SGK1-IN-2	SGK	Inflammation/Immunology
SGK1-IN-2 (14h) is a selective SGK1 (serum and glucocorticoid regulated kinase 1) inhibitor, with an IC₅₀ of 5 nM at 10 μM ATP concentration .

HY-128221

SGK1-IN-5	SGK	Inflammation/Immunology
SGK1-IN-5 (Compound 1) is an inhibitor for serum and glucocorticoid regulated kinase SGK 1 with an IC₅₀ of 3 nM. SGK1-IN-5 inhibits SGK-1 dependent phosphorylation of GSK3β in U2OS cells with an IC₅₀ of 1.4 μM. SGK1-IN-5 can be used in research about osteoarthritis or rheumatism .

HY-142686

SGK1-IN-3	SGK	Inflammation/Immunology
SGK1-IN-3 (compound 3a) is a potent and orally active inhibitor of *SGK1. The serine/threonine kinase SGK1 is an activator of the β-catenin pathway and a powerful stimulator of cartilage degradation that is found to be upregulated under genomic control in diseased osteoarthritic cartilage. SGK*1-IN-3 has the potential for the research of osteoarthritis .

HY-RS12798

SGK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SGK1 Human Pre-designed siRNA Set A contains three designed siRNAs for SGK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SGK1 Human Pre-designed siRNA Set A SGK1 Human Pre-designed siRNA Set A

HY-RS12799

Sgk1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sgk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sgk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sgk1 Mouse Pre-designed siRNA Set A Sgk1 Mouse Pre-designed siRNA Set A

HY-RS12800

Sgk1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sgk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sgk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sgk1 Rat Pre-designed siRNA Set A Sgk1 Rat Pre-designed siRNA Set A

HY-RS12801

SGK2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SGK2 Human Pre-designed siRNA Set A contains three designed siRNAs for SGK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SGK2 Human Pre-designed siRNA Set A SGK2 Human Pre-designed siRNA Set A

HY-RS12802

SGK3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SGK3 Human Pre-designed siRNA Set A contains three designed siRNAs for SGK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SGK3 Human Pre-designed siRNA Set A SGK3 Human Pre-designed siRNA Set A

HY-RS12803

Sgk3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sgk3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sgk3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sgk3 Mouse Pre-designed siRNA Set A Sgk3 Mouse Pre-designed siRNA Set A

HY-RS12804

SGK3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SGK3 Rat Pre-designed siRNA Set A contains three designed siRNAs for SGK3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

SGK3 Rat Pre-designed siRNA Set A SGK3 Rat Pre-designed siRNA Set A

HY-W011109

CKI-7	Casein Kinase CDK SGK Ribosomal S6 Kinase (RSK)	Cancer
CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC₅₀ of 6 μM and a K_i of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits *SGK, ribosomal S6 kinase-1 (S6K1)* and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases .

HY-15192

GSK 650394 15+ Cited Publications	SGK Influenza Virus	Infection Cancer
GSK 650394 is a novel *SGK* inhibitor with IC₅₀ of 62 nM and 103 nM for SGK1 and SGK2 in the SPA assay respectively. GSK 650394 also inhibits influenza virus replication.

HY-133028

CKI-7 free base 1 Publications Verification	Casein Kinase CDK SGK Ribosomal S6 Kinase (RSK)	Cancer
CKI-7 free base is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC₅₀ of 6 μM and a K_i of 8.5 μM. CKI-7 free base is a selective Cdc7 kinase inhibitor. CKI-7 free base also inhibits *SGK, ribosomal S6 kinase-1 (S6K1)* and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 free base has a much weaker effect on casein kinase II and other protein kinases .

HY-15193

EMD638683 10+ Cited Publications	SGK	Metabolic Disease Cancer
EMD638683 is a highly selective *SGK1* inhibitor, with an IC₅₀ value of 3 μM.

HY-117357

SI-113	SGK	Cancer
SI-113 is a *SGK1* inhibitor, with an IC₅₀ of 600 nM. SI113 induces autophagy .

HY-143898

PIM1-IN-4	Pim	Cancer
PIM1-IN-4 (Compound 8) is a potent inhibitor of PIM1. PIM1-IN-4 reveals strong inhibition of five other enzymes, i.e., SGK-1, PKA, CaMK-1, GSK3β, and MSK1. PIM1-IN-4 has the potential for the research of cancer diseases .

HY-15193A

EMD638683 R-Form 2 Publications Verification	SGK	Metabolic Disease
EMD638683 R-Form is the R-form of EMD638683. EMD638683 is a highly selective *SGK1* inhibitor with IC₅₀ of 3 μM.

HY-15193B

EMD638683 S-Form	SGK	Metabolic Disease
EMD638683 S-Form is the S-form of EMD638683. EMD638683 is a highly selective *SGK1* inhibitor with IC₅₀ of 3 μM.

HY-130620

PEG3-C4-OBn	PROTAC Linkers	Cancer
PEG3-C4-OBn is a polyethylene glycol (PEG)-based PROTAC linker. PEG3-C4-OBn can be used in the synthesis of the PROTAC SGK3 degrader-1 (HY-125878). PROTAC SGK3 degrader-1 is a potent SKG3 degrader based on PROTAC .

HY-130621

OTs-C6-OBn	PROTAC Linkers	Cancer
OTs-C6-OBn is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC SGK3 degrader-1 (HY-125878) .

HY-167832

PT109	JNK SGK ROCK	Neurological Disease Inflammation/Immunology Cancer
PT109 is a multi-kinase inhibitor. PT109 inhibits JNK (JNK1: IC₅₀=0.143 μM; JNK2: IC₅₀=0.831 μM; JNK3: IC₅₀=0.285 μM) and other kinases (SGK1: IC₅₀=1.34 μM; *SGK2: IC₅₀=5.6 μM; SGK3: IC₅₀=26.4 μM; ROCK2: IC₅₀=34 μM) and plays an important role in anti-inflammation, anti-oxidation, neurogenesis, synaptogenesis, etc. In addition, PT109 also reprograms glioblastoma multiforme (GBM) into oligodendrocytes through the PTBP1/PKM1/2* pathway and changes the metabolic pattern of GBM, exerting anti-glioma activity .

HY-113447

11-Dehydrocorticosterone 1 Publications Verification	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
11-Dehydrocorticosterone is a endogenous corticosteroid. 11-Dehydrocorticosterone can be a source of transcriptionally active glucocorticoid in cardiac myocytes and fibroblasts. 11-Dehydrocorticosterone can increase SGK mRNA expression in cardiac fibroblast .

HY-130770

Ald-CH2-PEG3-CH2-Boc	PROTAC Linkers	Cancer
Ald-CH2-PEG3-CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of SGK3 kinase PROTAC degrader .

HY-145752

HaloPROTAC-E 1 Publications Verification	PROTACs SGK Autophagy	Cancer
HaloPROTAC-E is a potent Halo PROTAC degrader that reversibly induces degradation of two endoplasmic reticulum-localized proteins, *SGK3* and VPS34, with a DC₅₀ of 3-10 nM. HaloPROTAC-E significantly and selectively induces degradation of endogenous VPS34 complexes (VPS34, VPS15, Beclin1, and ATG14) labeled with Halo and inhibits autophagy.

HY-B1618

Corticosterone Maximum Cited Publications 32 Publications Verification 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B	Glucocorticoid Receptor Endogenous Metabolite iGluR	Neurological Disease Inflammation/Immunology Endocrinology
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via *SGK*-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect .

HY-B1618R

Corticosterone (Standard) 17-Deoxycortisol(Standard); 11β,21-Dihydroxyprogesterone(Standard); Kendall's compound B (Standard)	Glucocorticoid Receptor Endogenous Metabolite iGluR	Neurological Disease Inflammation/Immunology Endocrinology
Corticosterone (Standard) is the analytical standard of Corticosterone. This product is intended for research and analytical applications. Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via *SGK*-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect .

HY-126257

AKT-IN-3	Akt Apoptosis	Cancer
AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells .

HY-12795

Vps34-IN-1 5+ Cited Publications	PI3K Autophagy	Cancer
Vps34-IN-1 is a potent and selective inhibitor of class III Vps34 PI3K. Vps34-IN-1 inhibits phosphorylation of PtdIns by recombinant insect cell expressed Vps34-Vps15 complex with an IC₅₀ of ~25 nM. Vps34-IN-1 can suppress SGK3 activation by reducing PtdIns(3)P levels via lowering phosphorylation of T-loop and hydrophobic motifs. Vps34-IN-1 modulates autophagy .

HY-130619

Boc-C1-PEG3-C4-OBn	PROTAC Linkers	Cancer
Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) is a PROTAC linker, which refers to the PEG composition. Boc-C1-PEG3-C4-OBn can be used in the synthesis of a series of PROTACs, such as PROTAC SGK3 degrader-1 (HY-125878). PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins .

Cat. No.	Product Name	Target	Research Area

HY-P10054

SGKtide	Peptides	Others
SGKtide is used as an SGK(Serum and glucocorticoid-inducible kinase) substrate .

11-Dehydrocorticosterone 1 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
11-Dehydrocorticosterone is a endogenous corticosteroid. 11-Dehydrocorticosterone can be a source of transcriptionally active glucocorticoid in cardiac myocytes and fibroblasts. 11-Dehydrocorticosterone can increase SGK mRNA expression in cardiac fibroblast .

Corticosterone Maximum Cited Publications 32 Publications Verification 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B	Structural Classification Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Glucocorticoid Receptor Endogenous Metabolite iGluR
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via *SGK*-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect .

Corticosterone (Standard) 17-Deoxycortisol(Standard); 11β,21-Dihydroxyprogesterone(Standard); Kendall's compound B (Standard)	Structural Classification Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Glucocorticoid Receptor Endogenous Metabolite iGluR
Corticosterone (Standard) is the analytical standard of Corticosterone. This product is intended for research and analytical applications. Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via *SGK*-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect .

Species:	Human (11)
Tag:	His (7) Tag Free (1) GST (10)
Source:	Sf9 insect cells (11)

Cat. No.	Compare	Product Name	Species	Source

HY-P701783

	SGK Protein, Human (Sf9) SGK1; Serine/threonine-protein kinase SGK1; Serum/glucocorticoid-regulated kinase 1	Human	Sf9 insect cells
	SGK protein is a multifunctional serine/threonine protein kinase that complexly controls multiple cellular processes, including ion channel and transporter regulation, enzymatic activity, transcription factors, neuronal excitability, cell growth, proliferation, survival, and migration. and apoptosis. SGK Protein, Human (Sf9) is the recombinant human-derived SGK protein, expressed by Sf9 insect cells , with tag free. The total length of SGK Protein, Human (Sf9) is 371 a.a., .

HY-P76063

	SGK3 Protein, Human (sf9, GST) Serine/threonine-protein kinase SGK3; Cytokine-independent survival kinase; SGK3; CISK; SGKL	Human	Sf9 insect cells
	The SGK3 protein is an important serine/threonine protein kinase that complexly controls diverse ion channels, transporters, and key cellular processes, affecting growth, proliferation, survival, and migration. SGK3 exhibits multiple effects by upregulating channels such as Na(+), K(+), epithelial Ca(2+), chloride, and transporters such as creatine. SGK3 Protein, Human (sf9, GST) is the recombinant human-derived SGK3 protein, expressed by Sf9 insect cells , with GST tag.

HY-P701782

	SGK2 Protein, Human (Sf9, GST) SGK2; Serine/threonine-protein kinase SGK2; Serum/glucocorticoid-regulated kinase 2	Human	Sf9 insect cells
	The SGK2 protein is a serine/threonine protein kinase that complexly regulates multiple cellular processes, overseeing ion channels, membrane transporters, and critical aspects of cell growth, survival, and proliferation. Its effects include upregulation of key components such as Na(+) and K(+) channels, amino acid and glutamate transporters, receptors, Na(+)/H(+) exchangers, and Na(+)/K(+) ATPase. SGK2 Protein, Human (Sf9, GST) is the recombinant human-derived SGK2 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of SGK2 Protein, Human (Sf9, GST) is 426 a.a., .

HY-P701784

	SGK Protein, Human (Sf9, His, GST) SGK1; Serine/threonine-protein kinase SGK1; Serum/glucocorticoid-regulated kinase 1	Human	Sf9 insect cells
	SGK protein is a multifunctional serine/threonine protein kinase that complexly controls multiple cellular processes, including ion channel and transporter regulation, enzymatic activity, transcription factors, neuronal excitability, cell growth, proliferation, survival, and migration. and apoptosis. SGK Protein, Human (Sf9, His, GST) is the recombinant human-derived SGK protein, expressed by Sf9 insect cells , with N-8*His, N-GST labeled tag. The total length of SGK Protein, Human (Sf9, His, GST) is 371 a.a., .

HY-P703019

	SGK3 Protein, Human (Unactive, sf9, GST) CISK; SGKL	Human	Sf9 insect cells
	The SGK3 protein is an important serine/threonine protein kinase that complexly controls diverse ion channels, transporters, and key cellular processes, affecting growth, proliferation, survival, and migration. SGK3 exhibits multiple effects by upregulating channels such as Na(+), K(+), epithelial Ca(2+), chloride, and transporters such as creatine. SGK3 Protein, Human (Unactive, sf9, GST) is the recombinant human-derived SGK3, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P703639

	POMK Protein, Human (Sf9, His, GST) SGK196	Human	Sf9 insect cells
	POMK Protein, Human (Sf9, His, GST) is the recombinant human-derived POMK, expressed by Sf9 insect cells , with His, GST labeled tag. ,

HY-P703411

	MYLK4 Protein, Human (Active, Sf9, His, GST) SGK085	Human	Sf9 insect cells
	MYLK4 Protein, Human (Active, Sf9, His, GST) is the recombinant human-derived MYLK4, expressed by Sf9 insect cells , with His, GST labeled tag. ,

HY-P703483

	SBK2 Protein, Human (Active, Sf9, His, GST) SGK069	Human	Sf9 insect cells
	SBK2 Protein, Human (Active, Sf9, His, GST) is the recombinant human-derived SBK2, expressed by Sf9 insect cells , with His, GST labeled tag. ,

HY-P703631

	STK31 Protein, Human (Inactive, Sf9, His, GST) SGK396	Human	Sf9 insect cells
	STK31 Protein, Human (Inactive, Sf9, His, GST) is the recombinant human-derived STK31, expressed by Sf9 insect cells , with His, GST labeled tag. ,

HY-P76098

	STK40 Protein, Human (sf9, His-GST) Serine/threonine-protein kinase 40; Sugen kinase 495; SGK495; STK40; SGK495; SHIK	Human	Sf9 insect cells
	The STK40 protein functions as a potential negative regulator, inhibiting NF-kappa-B and p53-mediated gene transcription. Its regulatory role implies fine-tuning of signaling pathways, indicating regulation of gene expression. STK40 Protein, Human (sf9, His-GST) is the recombinant human-derived STK40 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P703396

	STKLD1 Protein, Human (Sf9, His, GST) C9orf96; SGK071	Human	Sf9 insect cells
	STKLD1 Protein, Human (Sf9, His, GST) is the recombinant human-derived STKLD1, expressed by Sf9 insect cells , with His, GST labeled tag. ,

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HY-P81780

	SGK1 Antibody (YA1525) SGK1; SGK; Serine/threonine-protein kinase SGK1; Serum/glucocorticoid-regulated kinase 1	WB, IHC-P, IP, FC	Human, Mouse, Rat
	SGK1 Antibody (YA1525) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1525), targeting SGK1, with a predicted molecular weight of 49 kDa. SGK1 Antibody (YA1525) can be used for WB, IHC-P, IP, FC experiment in human, mouse, rat background.

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