Search Result

Results for "

Sesquiterpene lactone

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (6) Apoptosis (12) Autophagy (4) Bacterial (2) Caspase (1) Endogenous Metabolite (2) Ferroptosis (4) Fungal (1) Glutathione Peroxidase (1) HCV (4) Histone Demethylase (1) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) Mitophagy (2) MMP (2) mTOR (1) NF-κB (11) Parasite (5) PI3K (2) Platelet-activating Factor Receptor (PAFR) (1) RAR/RXR (1) Reactive Oxygen Species (4) SARS-CoV (1) STAT (2) TGF-beta/Smad (1) TNF Receptor (2)
By Research Areas:	Cancer (40) Cardiovascular Disease (2) Infection (11) Inflammation/Immunology (12) Metabolic Disease (2) Neurological Disease (7)

By Targets:

Akt (6)

Apoptosis (12)

Autophagy (4)

Bacterial (2)

Caspase (1)

Endogenous Metabolite (2)

Ferroptosis (4)

Fungal (1)

Glutathione Peroxidase (1)

HCV (4)

Histone Demethylase (1)

Isotope-Labeled Compounds (1)

Keap1-Nrf2 (1)

Mitophagy (2)

MMP (2)

mTOR (1)

NF-κB (11)

Parasite (5)

PI3K (2)

Platelet-activating Factor Receptor (PAFR) (1)

RAR/RXR (1)

Reactive Oxygen Species (4)

SARS-CoV (1)

STAT (2)

TGF-beta/Smad (1)

TNF Receptor (2)

By Research Areas:

Cancer (40)

Cardiovascular Disease (2)

Infection (11)

Inflammation/Immunology (12)

Metabolic Disease (2)

Neurological Disease (7)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N8187

Eupalinolide O	Apoptosis	Cancer
Eupalinolide O is a sesquiterpene lactone with anticancer activities. Eupalinolide O induces cell apoptosis in human MDA-MB-468 breast cancer cells .

HY-N9357

Granilin	Bacterial Fungal	Infection
Granilin, a sesquiterpene lactone, can be found in the flower buds of Carpesium triste. Granilin can be used as the bactericide and fungicide .

HY-N11800

Transilin	Others	Others
Transilin is a sesquiterpene lactone. Transilin can be isolated from the whole plant of Lepisorus contortus (Christ) Ching .

HY-122776

Deacetylmatricarin Desacetylmatricarin; Austricin	Others	Infection
Deacetylmatricarin (Austricin) is a sesquiterpene lactone that can be isolated from Artemisia .

HY-N3579

Chlorantholide C	Others	Others
Chlorantholide C, an eudesmane-type sesquiterpene lactone, can be isolated from Chloranthus elatior .

HY-N8485

Pungiolide A	Others	Others
Pungiolide A is a sesquiterpene lactones that can be isolated from Xanthium sibiricum .

HY-N9263

Diacetylpiptocarphol	Others	Infection
Diacetylpiptocarphol (compound 4) is a sesquiterpene lactone compound. Diacetylpiptocarphol has anti-leishmaniasis activity .

HY-N10919

Tenulin	Others	Others
Tenulin is a sesquiterpene lactone. Tenulin can be isolated from Helenium amarum .

HY-N10967

Isoatriplicolide tiglate	Others	Neurological Disease
Isoatriplicolide tiglate is a bioactive **sesquiterpene lactone*. Isoatriplicolide tiglate can be isolated from Paulownia coreana*. Isoatriplicolide tiglate has neuroprotective effect .

HY-N8900

Vernolide B	Others	Cancer
Vernolide-B has cytoxicity (ED₅₀s: 3.78, 5.88, 6.42 μg/mL for KB, NCI-661, and HeLa cells respectively). Vernolide B is sesquiterpene lactone that can be isolated from Vernonia cinerea .

HY-N6955

Eupalinilide B	Others	Cancer
Eupalinilide B is a guaiane type sesquiterpene lactone that can be found in Eupatorium lindleyanum. Eupalinilide B shows potent cytotoxicity against P-388 and A-549 tumor cell lines .

HY-N10483

Telekin	Apoptosis	Cancer
Telekin is an eucalyptus-type sesquiterpene lactone compound found in Carpesium divaricatum. Telekin can activate mitochondria-mediated cell apoptosis and has anticancer activity .

HY-N8619

Minimolide F	Others	Cancer
Minimolide F is a **sesquiterpene lactone**. Minimolide F has inhibitory activity against human nasopharyngeal cancer cells. Minimolide F can be used for the research of cancer .

HY-N10073

Eupahualin C	Others	Cancer
Eupahualin C is a sesquiterpene lactone that can be isolated from Eupatorium hualienense. Eupahualin C shows cytotoxicity to K562 and U2OS cancer cells .

HY-122915

Zedoarondiol	Reactive Oxygen Species	Cardiovascular Disease
Zedoarondiol, a sesquiterpene lactone compound, with antioxidant and anti-inflammatory activity. Zedoarondiol can be used for atherosclerosis research .

HY-N9121

8β-(4-Acetoxy-5-hydroxytigloyloxy)costunolide	Others	Others
8β-(4-Acetoxy-5-hydroxytigloyloxy)costunolide (compound 5) is a sesquiterpene lactone that can be isolated from Stevia alpina var. glutinosa .

HY-N10959

4,15-Isoatriplicolide methylacrylate	Others	Cancer
4,15-Isoatriplicolide methylacrylate is a germacrane-type sesquiterpene lactone. 4,15-Isoatriplicolide methylacrylate also is a cytotoxic agent. 4,15-Isoatriplicolide methylacrylate has cytotoxic activity for MCF-7 human breast cancer cell line .

HY-122295

Dehydroleucodine	Apoptosis	Inflammation/Immunology Cancer
Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects .

HY-N9699

8α-Hydroxyhirsutinolide	NF-κB	Inflammation/Immunology
8α-Hydroxyhirsutinolide is a sesquiterpene lactone. 8α-Hydroxyhirsutinolide inhibits TNF-α-induced NF-κB activity (IC₅₀: 1.9 μM) and NO production. 8α-Hydroxyhirsutinolide can be isolated from Vernonia cinerea .

HY-N0591

Dehydrocostus Lactone 1 Publications Verification (-)-Dehydrocostus lactone; Epiligulyl oxide	Others	Cancer
Dehydrocostus Lactone is a major sesquiterpene lactone isolated from the roots of Saussurea costus.

HY-N4015

Ilicic acid	Others	Others
Ilicic acid is a sesquiterpene lactones. Ilicic acid can be isolated Ambrosia camphorat .

HY-N1247

Scabertopin	Others	Cancer
Scabertopin is a sesquiterpene lactone. Scabertopin has been found to be prominent anticancer constituents .

HY-N2596

Isoscabertopin	Others	Inflammation/Immunology Cancer
Isoscabertopin is a sesquiterpene lactone isolated from Elephantopus scaber L and shows anti-tumor activities .

HY-N7595

Microhelenin C	Others	Cancer
Microhelenin C is a sesquiterpene lactone that can be isolated from Helenium microcephalum, with antitumor activity .

HY-N8149

Eupalinolide H	Others	Inflammation/Immunology
Eupalinolide H, a sesquiterpene lactone, has the potential to be used as natural anti-inflammatory agent .

HY-N9215

1-Oxo-4-hydroxy-2-en-4-ethylcyclohexa-5,8-olide	Others	Inflammation/Immunology
1-Oxo-4-hydroxy-2-en-4-ethylcyclohexa-5,8-olide (compound 8) is a potent anti-ulcer agent .

HY-N8290

Lactupicrin Lactucopicrin	Others	Neurological Disease Metabolic Disease
Lactupicrin (Lactucopicrin) is a characteristic bitter sesquiterpene lactone that can relieve pain. Lactupicrin exhibits atheroprotective effect .

HY-126156

Leucodin Desacetoxymatricarin	Others	Cancer
Leucodin is a sesquiterpene lactone derived from Gynoxys verrucosa. Leucodin has cytotoxic activity on human leukemia cells .

HY-N10912

Shizukanolide	Others	Infection
Shizukanolide, a sesquiterpene lactone, can be isolated from Chloranthus japonicus (Chloranthaceae). The dehydro-compound of Shizukanolide, shows moderate antifungal activity .

HY-N2240

Eupalinolide K	STAT	Cancer
Eupalinolide K, a sesquiterpene lactones compound from Eupatorium lindleyanum, is a STAT3 inhibitor. Eupalinolide K is a Michael reaction acceptor (MRA) .

HY-N10924

Strychnistenolide	Others	Others
Strychnistenolide is a sesquiterpene lactone that can be isolated from the roots of Lindera strychnifolia. Strychnistenolide exists as a single stereoisomer in CHCl₃, but exomeric in pyridine .

HY-N3623

Corianin	Bacterial	Infection
Corianin is a sesquiterpene lactone that can be isolated from the fruits of Coriaria ruscifolia. Corianin shows antibacterial activity against S. aureus and S. epidermis .

HY-118019

Scandenolide	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
Scandenolide is a sesquiterpene lactone that can be found in Philippines medicinal plant Mikania cordata. Scandenolide inhibits leukotriene and platelet activating factor synthesis in leukocytes .

HY-N8284

Tomentosin	Apoptosis Reactive Oxygen Species	Cancer
Tomentosin is a antiphlogistic sesquiterpene lactone that can be isolated from Inula falconeri.Tomentosin induces apoptosis and inhibits proliferation, migration and invasion of pancreatic cancer cells .

HY-N0847

Micheliolide 4 Publications Verification	NF-κB PI3K Akt TGF-beta/Smad	Inflammation/Immunology Cancer
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .

HY-N8290R

Lactupicrin (Standard)	Others	Neurological Disease Metabolic Disease
Lactupicrin (Standard) is the analytical standard of Lactupicrin. This product is intended for research and analytical applications. Lactupicrin (Lactucopicrin) is a characteristic bitter sesquiterpene lactone that can relieve pain. Lactupicrin exhibits atheroprotective effect .

HY-N9159

Piptocarphin F	Others	Cancer
Piptocarphin F (Compound 5) is a sesquiterpene lactone. Piptocarphin F shows cytotoxic activity on human leukemia cell line HL-60 (IC₅₀=5.69 μmol*L ^-1) .

HY-N2585

Isodeoxyelephantopin	Reactive Oxygen Species NF-κB Autophagy	Cancer
Isodeoxyelephantopin is a sesquiterpene lactone isolated from Elephantopus scaber. Isodeoxyelephantopin induces ROS generation, suppresses NF-κB activation. Isodeoxyelephantopin also modulates LncRNA expression and exhibit activities against breast cancer .

HY-N0141

Parthenolide Maximum Cited Publications 26 Publications Verification (-)-Parthenolide	NF-κB Autophagy Mitophagy Apoptosis	Cancer
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.

HY-N6893

Ergolide 2 Publications Verification	NF-κB	Inflammation/Immunology
Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica. Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB .

HY-116506

Bigelovin	RAR/RXR Reactive Oxygen Species Apoptosis Autophagy	Cancer
Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation .

HY-129228

Lychnopholide	Parasite	Infection
Lychnopholide is a sesquiterpene lactone derived from the Asteraceae, Lychnopholide exhibits anti-trypanosomal activity against Trypanosoma cruzi. lychnopholide encapsulated in nanocapsules reduces its toxicity to mammalian cells. Lychnopholide ameliorates Chagas disease in mouse models .

HY-N11496

*17(13→14)-Abeo-ent-3S,13S,16-trihydroxystrob-8(15)-ene*	Others	Inflammation/Immunology
17(13→14)-Abeo-ent-3S,13S,16-trihydroxystrob-8(15)-ene is a natural sesquiterpene lactone with anti-inflammatory activity .

HY-N1012

(-)-11,13-Dehydroeriolin	Others	Cancer
(-)-11,13-Dehydroeriolin (compound 9), a sesquiterpene lactone, is a nature product that could be isolated from Carpesium abrotanoides L. (-)-11,13-Dehydroeriolin has antiproliferative active. (-)-11,13-Dehydroeriolin can be used in research of cancer .

HY-N0036

Costunolide 5 Publications Verification (+)-Costunolide; Costus lactone	Apoptosis Endogenous Metabolite	Cancer
Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells .

HY-N6842

ArnicolideC	Others	Infection Cancer
ArnicolideC is a sesquiterpene lactone isolated Centipeda minima . ArnicolideC exertes a cytotoxic effect on the panel of Nasopharyngeal carcinoma (NPC) cells, significantly inhibiting cell growth in a dose- and time- dependent manner. ArnicolideC also exhibits inhibitory effects on NPC proliferation .

HY-N2491

Deoxyelephantopin	NF-κB	Cancer
Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling .

HY-137984

Cnicin	SARS-CoV	Cancer
Cnicin is a sesquiterpene lactone. Cnicin has antiproliferative effects, and induces cell death in primary myeloma cells. Cnicin also has anti-SARS-CoV-2 activity. Cnicin inhibits viral replication of SARS CoV-2 with an IC₅₀ of 1.18 μg/mL .

HY-119970

Helenalin 5 Publications Verification	NF-κB	Inflammation/Immunology Cancer
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .

HY-N10847

1-O-Acetyl-6beta-O-Isobutyrylbritannilactone	Others	Cancer
1-O-Acetyl-6beta-O-Isobutyrylbritannilactone (compound 5), a sesquiterpene lactone, can be isolated from the flowers of Inula britannica. 1-O-Acetyl-6beta-O-Isobutyrylbritannilactone shows significant cytotoxicity to tumor cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8187

Eupalinolide O	Structural Classification Classification of Application Fields Melilotus albus Desr. Terpenoids Sesquiterpenes Source classification Plants Compositae Disease Research Fields Cancer	Apoptosis
Eupalinolide O is a sesquiterpene lactone with anticancer activities. Eupalinolide O induces cell apoptosis in human MDA-MB-468 breast cancer cells .

HY-N9357

Granilin	Infection Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Disease Research Fields Erythrina arborescens Roxb.	Bacterial Fungal
Granilin, a sesquiterpene lactone, can be found in the flower buds of Carpesium triste. Granilin can be used as the bactericide and fungicide .

HY-N11800

Transilin	Structural Classification Flavonoids Lepisorus contortus (Christ) Ching Flavones Source classification Polypodiaceae Plants	Others
Transilin is a sesquiterpene lactone. Transilin can be isolated from the whole plant of Lepisorus contortus (Christ) Ching .

HY-122776

Deacetylmatricarin Desacetylmatricarin; Austricin	Structural Classification Terpenoids Sesquiterpenes Source classification Artemisia cana Pursh Plants Compositae	Others
Deacetylmatricarin (Austricin) is a sesquiterpene lactone that can be isolated from Artemisia .

HY-N3579

Chlorantholide C	Structural Classification Natural Products Source classification Chloranthus erectus (Buchanan-Hamilton) Verdcourt Chloranthaceae Plants	Others
Chlorantholide C, an eudesmane-type sesquiterpene lactone, can be isolated from Chloranthus elatior .

HY-N8485

Pungiolide A	Structural Classification Terpenoids Pterocarpus soyauxii Taub. Sesquiterpenes Source classification Plants Compositae	Others
Pungiolide A is a sesquiterpene lactones that can be isolated from Xanthium sibiricum .

HY-N9263

Diacetylpiptocarphol	Source classification Plants Compositae Cyrtocymura cincta var. cincta	Others
Diacetylpiptocarphol (compound 4) is a sesquiterpene lactone compound. Diacetylpiptocarphol has anti-leishmaniasis activity .

HY-N10919

Tenulin	Structural Classification Prosopis juliflora (Sw.) DC. Terpenoids Sesquiterpenes Source classification Plants Compositae	Others
Tenulin is a sesquiterpene lactone. Tenulin can be isolated from Helenium amarum .

HY-N10967

Isoatriplicolide tiglate	Structural Classification Paulownia tomentosa (Thunb.) Steud. Terpenoids Sesquiterpenes Source classification Scrophulariaceae Plants	Others
Isoatriplicolide tiglate is a bioactive **sesquiterpene lactone*. Isoatriplicolide tiglate can be isolated from Paulownia coreana*. Isoatriplicolide tiglate has neuroprotective effect .

HY-N8900

Vernolide B	Structural Classification Ketones, Aldehydes, Acids Source classification Plants Compositae Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Others
Vernolide-B has cytoxicity (ED₅₀s: 3.78, 5.88, 6.42 μg/mL for KB, NCI-661, and HeLa cells respectively). Vernolide B is sesquiterpene lactone that can be isolated from Vernonia cinerea .

HY-N6955

Eupalinilide B	Structural Classification Classification of Application Fields Melilotus albus Desr. Terpenoids Sesquiterpenes Source classification Plants Compositae Disease Research Fields Cancer	Others
Eupalinilide B is a guaiane type sesquiterpene lactone that can be found in Eupatorium lindleyanum. Eupalinilide B shows potent cytotoxicity against P-388 and A-549 tumor cell lines .

HY-N10483

Telekin	Terpenoids Sesquiterpenes Source classification Bauhinia thonningii Plants Compositae	Apoptosis
Telekin is an eucalyptus-type sesquiterpene lactone compound found in Carpesium divaricatum. Telekin can activate mitochondria-mediated cell apoptosis and has anticancer activity .

HY-N8619

Minimolide F	Structural Classification Terpenoids Sesquiterpenes Euchresta horsfieldii (Lesch.) J. Benn. Plants Compositae	Others
Minimolide F is a **sesquiterpene lactone**. Minimolide F has inhibitory activity against human nasopharyngeal cancer cells. Minimolide F can be used for the research of cancer .

HY-N10073

Eupahualin C	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Erythrina herbacea	Others
Eupahualin C is a sesquiterpene lactone that can be isolated from Eupatorium hualienense. Eupahualin C shows cytotoxicity to K562 and U2OS cancer cells .

HY-122915

Zedoarondiol	Terpenoids Sesquiterpenes Source classification Plants Curcuma aromatica Salisb. Zingiberaceae	Reactive Oxygen Species
Zedoarondiol, a sesquiterpene lactone compound, with antioxidant and anti-inflammatory activity. Zedoarondiol can be used for atherosclerosis research .

HY-N9121

8β-(4-Acetoxy-5-hydroxytigloyloxy)costunolide	Structural Classification Terpenoids Sesquiterpenes Source classification Stevia alpina Griseb. Plants Compositae Guilandina minax (Hance) G. P. Lewis	Others
8β-(4-Acetoxy-5-hydroxytigloyloxy)costunolide (compound 5) is a sesquiterpene lactone that can be isolated from Stevia alpina var. glutinosa .

HY-N10959

4,15-Isoatriplicolide methylacrylate	Structural Classification Terpenoids Andira inermis (W.Wright) DC. Sesquiterpenes Source classification Plants Compositae	Others
4,15-Isoatriplicolide methylacrylate is a germacrane-type sesquiterpene lactone. 4,15-Isoatriplicolide methylacrylate also is a cytotoxic agent. 4,15-Isoatriplicolide methylacrylate has cytotoxic activity for MCF-7 human breast cancer cell line .

HY-122295

Dehydroleucodine	Structural Classification other families Artemisia douglasiana Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Apoptosis
Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects .

HY-N9699

8α-Hydroxyhirsutinolide	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	NF-κB
8α-Hydroxyhirsutinolide is a sesquiterpene lactone. 8α-Hydroxyhirsutinolide inhibits TNF-α-induced NF-κB activity (IC₅₀: 1.9 μM) and NO production. 8α-Hydroxyhirsutinolide can be isolated from Vernonia cinerea .

HY-N0591

Dehydrocostus Lactone 1 Publications Verification (-)-Dehydrocostus lactone; Epiligulyl oxide	Saussurea costus (Falc.) Lipsch. Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Plants Compositae Disease Research Fields Cancer	Others
Dehydrocostus Lactone is a major sesquiterpene lactone isolated from the roots of Saussurea costus.

HY-N4015

Ilicic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Ambrosia camphorata (Greene) W.W.Payne Plants Compositae	Others
Ilicic acid is a sesquiterpene lactones. Ilicic acid can be isolated Ambrosia camphorat .

HY-N1247

Scabertopin	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Amorpha fruticosaL. Plants Compositae Disease Research Fields Cancer	Others
Scabertopin is a sesquiterpene lactone. Scabertopin has been found to be prominent anticancer constituents .

HY-N2596

Isoscabertopin	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Amorpha fruticosaL. Plants Compositae Disease Research Fields Inflammation/Immunology	Others
Isoscabertopin is a sesquiterpene lactone isolated from Elephantopus scaber L and shows anti-tumor activities .

HY-N7595

Microhelenin C	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Plants Helenium microcephalum Disease Research Fields Cancer	Others
Microhelenin C is a sesquiterpene lactone that can be isolated from Helenium microcephalum, with antitumor activity .

HY-N8149

Eupalinolide H	Structural Classification Classification of Application Fields Melilotus albus Desr. Terpenoids Sesquiterpenes Source classification Plants Compositae Inflammation/Immunology Disease Research Fields	Others
Eupalinolide H, a sesquiterpene lactone, has the potential to be used as natural anti-inflammatory agent .

HY-N8290

Lactupicrin Lactucopicrin	Structural Classification Monophenols Terpenoids Genista quadriflora Munby Sesquiterpenes Source classification Phenols Plants Compositae	Others
Lactupicrin (Lactucopicrin) is a characteristic bitter sesquiterpene lactone that can relieve pain. Lactupicrin exhibits atheroprotective effect .

HY-126156

Leucodin Desacetoxymatricarin	Structural Classification Gynoxys verrucosa Sch.Bip. ex Wedd. Terpenoids Sesquiterpenes Source classification Plants Compositae	Others
Leucodin is a sesquiterpene lactone derived from Gynoxys verrucosa. Leucodin has cytotoxic activity on human leukemia cells .

HY-N10912

Shizukanolide	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Lauraceae Lindera aggregata (Sims) Kosterm.	Others
Shizukanolide, a sesquiterpene lactone, can be isolated from Chloranthus japonicus (Chloranthaceae). The dehydro-compound of Shizukanolide, shows moderate antifungal activity .

HY-N2240

Eupalinolide K	Structural Classification Classification of Application Fields Melilotus albus Desr. Terpenoids Sesquiterpenes Source classification Plants Compositae Disease Research Fields Cancer	STAT
Eupalinolide K, a sesquiterpene lactones compound from Eupatorium lindleyanum, is a STAT3 inhibitor. Eupalinolide K is a Michael reaction acceptor (MRA) .

HY-N10924

Strychnistenolide	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Lauraceae Lindera aggregata (Sims) Kosterm.	Others
Strychnistenolide is a sesquiterpene lactone that can be isolated from the roots of Lindera strychnifolia. Strychnistenolide exists as a single stereoisomer in CHCl₃, but exomeric in pyridine .

HY-N3623

Corianin	Structural Classification Natural Products Source classification Coriaria nepalensis Wall. Coriariaceae Plants Coriaria japonica A.Gray	Bacterial
Corianin is a sesquiterpene lactone that can be isolated from the fruits of Coriaria ruscifolia. Corianin shows antibacterial activity against S. aureus and S. epidermis .

HY-118019

Scandenolide	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Ballota glandulosissima Hub.-Mor. & Patzak Compositae	Platelet-activating Factor Receptor (PAFR)
Scandenolide is a sesquiterpene lactone that can be found in Philippines medicinal plant Mikania cordata. Scandenolide inhibits leukotriene and platelet activating factor synthesis in leukocytes .

HY-N8284

Tomentosin	Sesquiterpenes Source classification Plants Compositae Desmodium sandwicense	Apoptosis Reactive Oxygen Species
Tomentosin is a antiphlogistic sesquiterpene lactone that can be isolated from Inula falconeri.Tomentosin induces apoptosis and inhibits proliferation, migration and invasion of pancreatic cancer cells .

HY-N0847

Micheliolide 4 Publications Verification	Structural Classification Other Monoterpenes other families Classification of Application Fields Terpenoids Source classification Other Diseases Plants Disease Research Fields	NF-κB PI3K Akt TGF-beta/Smad
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .

HY-N8290R

Lactupicrin (Standard)	Structural Classification Monophenols Terpenoids Genista quadriflora Munby Sesquiterpenes Source classification Phenols Plants Compositae	Others
Lactupicrin (Standard) is the analytical standard of Lactupicrin. This product is intended for research and analytical applications. Lactupicrin (Lactucopicrin) is a characteristic bitter sesquiterpene lactone that can relieve pain. Lactupicrin exhibits atheroprotective effect .

HY-N9159

Piptocarphin F	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Dalbergia frutescens (Vell.) Britton	Others
Piptocarphin F (Compound 5) is a sesquiterpene lactone. Piptocarphin F shows cytotoxic activity on human leukemia cell line HL-60 (IC₅₀=5.69 μmol*L ^-1) .

HY-N2585

Isodeoxyelephantopin	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Amorpha fruticosaL. Plants Compositae Disease Research Fields Cancer	Reactive Oxygen Species NF-κB Autophagy
Isodeoxyelephantopin is a sesquiterpene lactone isolated from Elephantopus scaber. Isodeoxyelephantopin induces ROS generation, suppresses NF-κB activation. Isodeoxyelephantopin also modulates LncRNA expression and exhibit activities against breast cancer .

HY-N0141

Parthenolide Maximum Cited Publications 26 Publications Verification (-)-Parthenolide	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Euchresta formosana (Hayata) Ohwi Disease Research Fields Cancer	NF-κB Autophagy Mitophagy Apoptosis
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.

HY-N6893

Ergolide 2 Publications Verification	Phyllodium pulchellum (L.) Desv. Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Compositae Inflammation/Immunology Disease Research Fields Piptanthus nepalensis (Hook.) D. Don	NF-κB
Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica. Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB .

HY-116506

Bigelovin	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Acacia auriculiformis A.Cunn. ex Benth Plants Compositae Disease Research Fields Cancer	RAR/RXR Reactive Oxygen Species Apoptosis Autophagy
Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation .

HY-129228

Lychnopholide	Lychnophora pseudovillosissima Semir & Leitão Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae	Parasite
Lychnopholide is a sesquiterpene lactone derived from the Asteraceae, Lychnopholide exhibits anti-trypanosomal activity against Trypanosoma cruzi. lychnopholide encapsulated in nanocapsules reduces its toxicity to mammalian cells. Lychnopholide ameliorates Chagas disease in mouse models .

HY-N11496

*17(13→14)-Abeo-ent-3S,13S,16-trihydroxystrob-8(15)-ene*	Structural Classification Terpenoids Source classification Bituminaria morisiana (Pignatti & Metlesics) Greuter Diterpenoids Plants Compositae	Others
17(13→14)-Abeo-ent-3S,13S,16-trihydroxystrob-8(15)-ene is a natural sesquiterpene lactone with anti-inflammatory activity .

HY-N1012

(-)-11,13-Dehydroeriolin	Structural Classification Terpenoids Dalbergia velutina Benth. Sesquiterpenes Source classification Plants Compositae	Others
(-)-11,13-Dehydroeriolin (compound 9), a sesquiterpene lactone, is a nature product that could be isolated from Carpesium abrotanoides L. (-)-11,13-Dehydroeriolin has antiproliferative active. (-)-11,13-Dehydroeriolin can be used in research of cancer .

HY-N0036

Costunolide 5 Publications Verification (+)-Costunolide; Costus lactone	Structural Classification Classification of Application Fields Erythrina subumbrans (Hassk.) Merr. Terpenoids Sesquiterpenes Source classification Plants Compositae Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite
Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells .

HY-N6842

ArnicolideC	Infection Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Euchresta horsfieldii (Lesch.) J. Benn. Source classification Plants Compositae Disease Research Fields Cancer	Others
ArnicolideC is a sesquiterpene lactone isolated Centipeda minima . ArnicolideC exertes a cytotoxic effect on the panel of Nasopharyngeal carcinoma (NPC) cells, significantly inhibiting cell growth in a dose- and time- dependent manner. ArnicolideC also exhibits inhibitory effects on NPC proliferation .

HY-N2491

Deoxyelephantopin	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Amorpha fruticosaL. Plants Compositae Disease Research Fields Cancer	NF-κB
Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling .

HY-137984

Cnicin	Structural Classification Natural Products Source classification Centaurea benedicta (L.) L. Plants Compositae	SARS-CoV
Cnicin is a sesquiterpene lactone. Cnicin has antiproliferative effects, and induces cell death in primary myeloma cells. Cnicin also has anti-SARS-CoV-2 activity. Cnicin inhibits viral replication of SARS CoV-2 with an IC₅₀ of 1.18 μg/mL .

HY-119970

Helenalin 5 Publications Verification	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Inflammation/Immunology Disease Research Fields	NF-κB
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .

HY-N10847

1-O-Acetyl-6beta-O-Isobutyrylbritannilactone	Other Terpenoids Phyllodium pulchellum (L.) Desv. Structural Classification Terpenoids Source classification Plants Compositae	Others
1-O-Acetyl-6beta-O-Isobutyrylbritannilactone (compound 5), a sesquiterpene lactone, can be isolated from the flowers of Inula britannica. 1-O-Acetyl-6beta-O-Isobutyrylbritannilactone shows significant cytotoxicity to tumor cells .

HY-N0781

Linderalactone 1 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Lauraceae Lindera aggregata (Sims) Kosterm. Disease Research Fields Cancer	Apoptosis
Linderalactone is an important sesquiterpene lactone isolated from Lindera aggregata. Linderalactone inhibits cancer growth by modulating the expression of apoptosis-related proteins and inhibition of JAK/STAT signalling pathway. Linderalactone also inhibits the proliferation of the lung cancer A-549 cells with an IC₅₀ of 15 μM .

Cat. No.	Product Name	Chemical Structure

HY-B0094S

Artemisinin-d3

Artemisinin-d₃ is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].

HY-B0094S3

Artemisinin-13C,d4

Artemisinin- ¹³C,d₄ is ¹³C and deuterated labeled Artemisinin (HY-B0094). Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Sesquiterpene lactone

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products