TRX

By Targets:	ADC Linker (1) Amyloid-β (1) Angiotensin-converting Enzyme (ACE) (2) Apoptosis (2) Caspase (1) CD3 (1) Fluorescent Dye (4) HIF/HIF Prolyl-Hydroxylase (1) MEK (1) Microtubule/Tubulin (1) Nucleoside Antimetabolite/Analog (1) PARP (1) PROTAC Linkers (1) TrxR (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (4) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (2)
Click Chemistry:	ADC Synthesis (1) DBCO (1) PROTAC Synthesis (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1254

Trx-red NBL-SS perchlorate	Fluorescent Dye	Others
Trx-red (NBL-SS perchlorate) is a red-emitting fluorescent probe derivatized from the nile blue fluorophore. Trx-red is used for selectively imaging thioredoxin (Trx) in live cells and in vivo (λex=615 nm, λem=661 nm) .

HY-157800

Trilexium TRX-E-009-1	Microtubule/Tubulin Apoptosis PARP Caspase	Cancer
Trilexium (TRX-E-009-1) is a third-generation of benzopyran structurally related to TRX-E-002-1 (HY-114250). Trilexium increases p21 protein expression and induces apoptosis. Trilexium depolymerizes microtubules. Trilexium shows broad anti-cancer activity .

HY-114250

Cantrixil TRX-E-002-1	Apoptosis	Cancer
Cantrixil (TRX-E-002-1), an active enantiomer of TRX-E-002, is a second-generation super-benzopyran (SBP) compound. Cantrixil increases phosphorylated c-Jun levels resulting in caspase-mediated apoptosis in ovarian cancer cells. Cantrixil has potent pan anti-cancer activity against a broad range of cancer phenotypes .

HY-19948

Leucomethylene blue mesylate 5+ Cited Publications TRX0237 mesylate; Methylene blue leuco base mesylate	Amyloid-β	Neurological Disease
Leucomethylene blue (TRx0237) mesylate, an orally active second-generation tau protein aggregation inhibitor (K_i of 0.12 μM), could be used for the study of Alzheimer's Disease. Leucomethylene blue mesylate is a common reduced form of Methylene Blue, Methylene Blue is a member of the thiazine class of dyes .

HY-P99211

Otelixizumab ChAglyCD3; TRX 4	CD3	Metabolic Disease
Otelixizumab (ChAglyCD3) is an anti-human CD3 monoclonal antibody and can be used for the research of type 1 diabetes .

HY-115688A

(S)-TXNIP-IN-1 1 Publications Verification	Others	Cardiovascular Disease Others
(S)-TXNIP-IN-1 is the less active S-enantiomer of TXNIP-IN-1 (HY-115688). TXNIP-IN-1 is a TXNIP-TRX complex inhibitor which can be used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease

HY-115688

TXNIP-IN-1 1 Publications Verification	Others	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
TXNIP-IN-1 is *TXNIP-TRX* (thioredoxin-interacting protein- thioredoxin) complex** inhibitor extracted from patent US20200085800A1, Compound 1. TXNIP-IN-1 can be used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease .

HY-160414

TRX-COBI (R,R)-TRX-COBI; TRX-cobimetinib	MEK	Cancer
TRX-COBI ((R,R)-TRX-COBI; Trx-cobimetinib) is a MEK inhibitor targeting TRX fragments based on Fe ²⁺. TRX-COBI has antitumor activity .

HY-156998

Troxacitabine triphosphate TRX-TP	Nucleoside Antimetabolite/Analog	Cancer
Troxacitabine triphosphate (TRX-TP) is a good substrate for replicative and repair DNA polymerases in vitro .

HY-110212

BODIPY TR-X BODIPY TR-X NHS Ester	Fluorescent Dye	Others
BODIPY TR-X (BODIPY TR-X NHS Ester) is a potent fluorescent dye. BODIPY TR-X can be used to label the primary amines (R-NH₂) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. BODIPY TR-X binds to protein or antibody and has bright, red fluorescent light. (λ_ex=545 nm, λ_em=560 nm) .

HY-D1260

FM-red PSH-red	Fluorescent Dye	Neurological Disease
FM-red (PSH-red) is a red-emitting and environment-sensitive probe for selectively detecting and labeling protein thiols. FM-red can be used to image protein sulfhydryl groups in live cells and in vivo. FM-red also could be used to measure of the redox states of thioredoxin (Trx) .

HY-164259

AJM 290	HIF/HIF Prolyl-Hydroxylase	Cancer
AJM 290 is a *Trx-1* inhibitor. AJM 290 is an inhibitor of the HIF-1α COOH-terminal transactivation domain, and blocks HIF-1 binding to DNA .

HY-13734

PX-12 Maximum Cited Publications 7 Publications Verification IV-2	Others	Cancer
PX-12(IV-2) is an irreversible inhibitor of Thioredoxin-1 (Trx-1); inhibits the growth of MCF-7 and HT-29 cells with IC₅₀ values of 1.9 and 2.9 μM, respectively.

HY-108534

PMX464 AW 464	TrxR	Inflammation/Immunology Cancer
PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of *thioredoxin-thioredoxin reductase (Trx/TrxR) system*. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells .

HY-110211

BODIPY TMR-X SE	Fluorescent Dye	Others
BODIPY TMR-X SE is a potent fluorescent dye. BODIPY TMR-X SE can be used to label the primary amines (R-NH₂) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. BODIPY TR-X binds to protein or antibody and has bright, orange fluorescent light. (λ_ex=544 nm, λ_em=570 nm) .

HY-124386

DBCO-NHCO-PEG4-amine	ADC Linker PROTAC Linkers	Cancer
DBCO-NHCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB−MMAE and DBCO-TRX−MMAE with EC₅₀s of 280 nM and 22 nM in SKBR3 cells, respectively) .

HY-B0384

Temocapril hydrochloride	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Temocapril hydrochloride is an orally active angiotensin-converting enzyme (ACE) inhibitor. Temocapril hydrochloride can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases .

HY-100713

Temocapril	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Temocapril is an orally active angiotensin-converting enzyme (ACE) inhibitor. Temocapril can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases .

Cat. No.	Product Name	Type

HY-D1254

Trx-red NBL-SS perchlorate	Fluorescent Dyes/Probes
Trx-red (NBL-SS perchlorate) is a red-emitting fluorescent probe derivatized from the nile blue fluorophore. Trx-red is used for selectively imaging thioredoxin (Trx) in live cells and in vivo (λex=615 nm, λem=661 nm) .

HY-19948

Leucomethylene blue mesylate 5+ Cited Publications TRX0237 mesylate; Methylene blue leuco base mesylate	Chromogenic Assays
Leucomethylene blue (TRx0237) mesylate, an orally active second-generation tau protein aggregation inhibitor (K_i of 0.12 μM), could be used for the study of Alzheimer's Disease. Leucomethylene blue mesylate is a common reduced form of Methylene Blue, Methylene Blue is a member of the thiazine class of dyes .

HY-D1260

FM-red PSH-red	Fluorescent Dyes/Probes
FM-red (PSH-red) is a red-emitting and environment-sensitive probe for selectively detecting and labeling protein thiols. FM-red can be used to image protein sulfhydryl groups in live cells and in vivo. FM-red also could be used to measure of the redox states of thioredoxin (Trx) .

HY-110211

BODIPY TMR-X SE	Protein Labeling
BODIPY TMR-X SE is a potent fluorescent dye. BODIPY TMR-X SE can be used to label the primary amines (R-NH₂) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. BODIPY TR-X binds to protein or antibody and has bright, orange fluorescent light. (λ_ex=544 nm, λ_em=570 nm) .

HY-110212

BODIPY TR-X BODIPY TR-X NHS Ester	Protein Labeling
BODIPY TR-X (BODIPY TR-X NHS Ester) is a potent fluorescent dye. BODIPY TR-X can be used to label the primary amines (R-NH₂) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. BODIPY TR-X binds to protein or antibody and has bright, red fluorescent light. (λ_ex=545 nm, λ_em=560 nm) .

Cat. No.	Product Name	Target	Research Area

HY-P99211

Otelixizumab ChAglyCD3; TRX 4	CD3	Metabolic Disease
Otelixizumab (ChAglyCD3) is an anti-human CD3 monoclonal antibody and can be used for the research of type 1 diabetes .

HY-P990353

*Anti-CD4 Antibody (TRX1)* TRX1	Inhibitory Antibodies	Inflammation/Immunology

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-115688A

(S)-TXNIP-IN-1 1 Publications Verification	Cardiovascular Disease Classification of Application Fields Disease Research Fields	Others
(S)-TXNIP-IN-1 is the less active S-enantiomer of TXNIP-IN-1 (HY-115688). TXNIP-IN-1 is a TXNIP-TRX complex inhibitor which can be used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease

Species:	Human (16) Mouse (2) E.coli (2)
Tag:	His (15) Tag Free (3) Trx (12)
Source:	E. coli (20)

Cat. No.	Compare	Product Name	Species	Source

HY-P73431

	Thioredoxin/TXN Protein, Human (Solution) Thioredoxin; TXN; TRX; ADF; TRX1; SASP	Human	E. coli
	Thioredoxin/TXN protein participates in multiple redox reactions, utilizing its active center dithiol for reversible oxidation and disulfide bond formation. It catalyzes important dithiol-disulfide exchange and plays a key role in S-nitrosylation of cysteine residues in response to intracellular nitric oxide. Thioredoxin/TXN Protein, Human (Solution) is the recombinant human-derived Thioredoxin/TXN protein, expressed by E. coli , with tag free. The total length of Thioredoxin/TXN Protein, Human (Solution) is 105 a.a., with molecular weight of ~14 kDa.

HY-P7802

	Thioredoxin/TXN Protein, E.coli (His) rEcoThioredoxin/TXN, His; TRX; ADF; TRX1	E.coli	E. coli
	Thioredoxin/TXN Protein, E.coli (His) is a hydrogen carrier protein and exists widely in organism. Thioredoxin suppression disbalances insulin responsiveness in chicken cardiomyocytes through PI3K/Akt pathway inhibition.

HY-P73432A

	*Thioredoxin/TRX* Protein, Mouse (N-His)** Thioredoxin; TXN; TRX; ADF; TRX1; SASP	Mouse	E. coli
	Thioredoxin/TRX proteins participate in multiple redox reactions, utilizing their reactive dithiol centers for reversible oxidation and disulfide bond formation.It catalyzes important dithiol-disulfide exchange and plays a key role in S-nitrosylation of cysteine residues in response to intracellular nitric oxide.Thioredoxin/TRX Protein, Mouse (N-His) is the recombinant mouse-derived Thioredoxin/TRX protein, expressed by E.coli , with N-6*His labeled tag.

HY-P73431A

	Thioredoxin/TXN Protein, Human 1 Publications Verification Thioredoxin; TXN; TRX; ADF; TRX1; SASP	Human	E. coli
	Thioredoxin/TXN Protein participates in diverse redox reactions, using its active center dithiol for reversible oxidation and disulfide bond formation. It catalyzes crucial dithiol-disulfide exchanges and plays a pivotal role in S-nitrosylation of cysteine residues, responding to intracellular nitric oxide. Thioredoxin regulates caspase-3 activity by nitrosylating CASP3's active site cysteine. It also influences FOS/JUN AP-1 DNA binding and augments interleukin-2 receptor expression, showcasing its multifaceted cellular role beyond redox regulation. Thioredoxin/TXN Protein, Human is the recombinant human-derived Thioredoxin/TXN protein, expressed by E. coli, with tag free. The total length of Thioredoxin/TXN Protein, Human is 105 a.a., with molecular weight of ~14 kDa.

HY-P7422

	Thioredoxin/TXN Protein, Human (His) rHuThioredoxin/TXN, His; TRX; ADF; TRX1	Human	E. coli
	Thioredoxin/TXN Protein, Human (His) is a thiol-oxidoreductase enzyme which control cellular redox homeostasis.

HY-P7776

	*CD105/Endoglin Protein, Human (Trx-His)* rHuCD105, TRX, His; Endoglin; END; CD105; ENG	Human	E. coli
	CD105/Endoglin Protein, Human (Trx-His) is an accessory receptor for transforming growth factor beta (TGF-β), and is expressed on endothelial cells.

HY-P71393

	TXN2 Protein, Human (His) Thioredoxin Mitochondrial; MTRX; Mt-TRX; Thioredoxin-2; TXN2; TRX2	Human	E. coli
	As a monomer, the TXN2 protein is critical for maintaining mitochondrial reactive oxygen species (ROS) homeostasis, regulating apoptosis, and ensuring cell viability.Its unique dithiol reducing activity fine-tunes cellular redox balance, making a significant contribution to overall cellular health.TXN2 Protein, Human (His) is the recombinant human-derived TXN2 protein, expressed by E.coli , with tag free.

HY-P73432

	*Thioredoxin/TRX* Protein, Mouse** Thioredoxin; TXN; TRX; ADF; TRX1; SASP	Mouse	E. coli
	Thioredoxin/TRX proteins participate in multiple redox reactions, utilizing their reactive dithiol centers for reversible oxidation and disulfide bond formation.It catalyzes important dithiol-disulfide exchange and plays a key role in S-nitrosylation of cysteine residues in response to intracellular nitric oxide.Thioredoxin/TRX Protein, Mouse is the recombinant mouse-derived Thioredoxin/TRX protein, expressed by E.coli , with tag free.

HY-P7621

	*ABCB5 Protein, Human (Trx)* rHuABCB5, N-TRX; ATP-binding cassette sub-family B member 5; P-glycoprotein ABCB5; ABCB5	Human	E. coli
	ABCB5, N-Trx Protein, Human is a plasma membrane-spanning protein that in humans is encoded by the ABCB5 gene. ABCB5 is an ABC transporter and P-glycoprotein family member principally expressed in physiological skin and human malignant melanoma.

HY-P72711

	*CD72 Protein, Human (Trx, His)* B-cell differentiation antigen CD72; Lyb-2; CD72	Human	E. coli
	CD72 Protein plays a key role in orchestrating B-cell proliferation and differentiation, forming homodimers with disulfide linkages and interacting with CD5. It engages in tyrosine phosphorylation interactions with PTPN6/SHP-1, indicating its modulation of cellular responses through phosphorylation-based regulatory mechanisms. This underscores the multifaceted role of CD72 in the dynamic landscape of B-cell function and signaling. CD72 Protein, Human (N-Trx-6His) is the recombinant human-derived CD72 protein, expressed by E. coli , with N-Trx, N-His labeled tag. The total length of CD72 Protein, Human (N-Trx-6His) is 110 a.a., with molecular weight of 26-35 kDa.

HY-P71223

	*PPIC Protein, Human (Trx-His)* Peptidyl-Prolyl Cis-Trans Isomerase C; PPIase C; Cyclophilin C; Rotamase C; PPIC; CYPC	Human	E. coli
	PPIC protein is a peptidyl-prolyl cis-trans isomerase (PPIase) that actively catalyzes the cis-trans isomerization of prolyl imide peptide bonds, which is a key step in protein folding. Its role in promoting conformational changes ensures correct folding and maturation of proteins, contributing to cellular proteostasis. PPIC Protein, Human (Trx-His) is the recombinant human-derived PPIC protein, expressed by E. coli , with N-Trx, N-6*His labeled tag. The total length of PPIC Protein, Human (Trx-His) is 152 a.a., with molecular weight of ~34.0 kDa.

HY-P73633

	*SOCS3 Protein, Human (His-Trx)* Suppressor of cytokine signaling 3; SOCS-3; CIS-3; SSI-3	Human	E. coli
	SOCS3 is a member of the SOCS family that operates in a negative feedback loop to regulate cytokine signaling, particularly in the JAK/STAT pathway. It inhibits cytokine signaling by binding to receptors such as IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF, and leptin receptors. SOCS3 Protein, Human (His-Trx) is the recombinant human-derived SOCS3 protein, expressed by E. coli , with N-Trx, N-His labeled tag. The total length of SOCS3 Protein, Human (His-Trx) is 225 a.a., with molecular weight of ~46 kDa.

HY-P7896A

	*CD20/MS4A1 Protein, Human (Trx-His)* rHuB-lymphocyte antigen CD20/CD20, TRX-His; MS4A1; CD20; MS4A-1; B1; Bp35; CVID5; LEU-16; MS4A2; S7	Human	E. coli
	CD20/MS4A1 protein is a B lymphocyte membrane protein that plays a crucial regulatory role in cellular calcium influx, which is essential for the development, differentiation and activation of B lymphocytes. As part of a store-operated calcium (SOC) channel, it promotes calcium influx upon B cell receptor/BCR activation. CD20/MS4A1 Protein, Human (Trx-His) is the recombinant human-derived CD20/MS4A1 protein, expressed by E. coli , with N-Trx, N-6*His labeled tag.

HY-P71496

	Thioredoxin-1/TRXA Protein, E.coli (His) TRXA; fipA; tsnC; b3781; JW5856; Thioredoxin 1; TRX-1	E.coli	E. coli
	Thioredoxin-1/TRXA Protein participates in diverse redox reactions, facilitating reversible oxidation of its active center dithiol to form a disulfide bond and catalyzing critical dithiol-disulfide exchanges. Operating as a monomer, Thioredoxin-1 exhibits versatility in redox functions and interacts with bacteriophage T3 DNA polymerase, suggesting broader involvement in molecular processes beyond its primary redox activities. Thioredoxin-1/TRXA Protein, E.coli (His) is the recombinant E. coli-derived Thioredoxin-1/TRXA protein, expressed by E. coli , with N-His labeled tag.

HY-P7896

	*CD20/MS4A1 Protein, Human (Trx-His, Solution)* rHuB-lymphocyte antigen CD20/CD20, TRX-His; MS4A1; CD20; MS4A-1; B1; Bp35; CVID5; LEU-16; MS4A2; S7	Human	E. coli
	CD20/MS4A-1 Protein,Human (Trx-His) is an integral membrane protein expressed during B lymphocyte development.

HY-P70932

	*HAO1 Protein, Human (Trx-His)* Hydroxyacid Oxidase 1; HAOX1; Glycolate Oxidase; GOX; HAO1; GOX1; HAOX1	Human	E. coli
	The HAO1 protein is a (S)-2-hydroxyacid oxidase with broad substrate specificity that facilitates glycolate oxidation. This activity produces glyoxylic acid, a key precursor for glycine synthesis. HAO1 Protein, Human (Trx-His) is the recombinant human-derived HAO1 protein, expressed by E. coli , with N-Trx, N-6*His labeled tag. The total length of HAO1 Protein, Human (Trx-His) is 370 a.a., with molecular weight of ~56.0 kDa.

HY-P71041

	*ACAT2 Protein, Human (Trx-His)* Acetyl-CoA acetyltransferase cytosolic; Acetyl-CoA transferase-like protein; Cytosolic acetoacetyl-CoA thiolase; ACTL; ACAT2	Human	E. coli
	ACAT2, Human (Trx-His) is the major ACAT enzyme in human hepatocytes. ACAT2, Human is an important regulator of susceptibility to the development of atherosclerosis.

HY-P70970

	*Serpin B6 Protein, Human (Trx-His)* Serpin B6; Cytoplasmic Antiproteinase; CAP; Peptidase Inhibitor 6; PI-6; Placental Thrombin Inhibitor; SERPINB6; PI6; PTI	Human	E. coli
	Serpin B6 protein acts as a potential modulator of serine proteases in the brain or blood. It inhibits cathepsin G, kallikrein 8, and thrombin, suggesting a role in protease regulation. Serpin B6 Protein, Human (Trx-His) is the recombinant human-derived Serpin B6 protein, expressed by E. coli , with N-Trx, N-6*His labeled tag. The total length of Serpin B6 Protein, Human (Trx-His) is 376 a.a., with molecular weight of 58-60 kDa.

HY-P702780

	*NR3C1 Protein, Human (His, Trx)* GCCR; GCR; GCR_HUMAN; GCRST; glucocorticoid nuclear receptor variant 1; Glucocorticoid receptor; GR; GRL; Grl1; nr3c1; Nuclear receptor subfamily 3 group C member 1	Human	E. coli
	NR3C1 Protein, Human (His, Trx) is the recombinant human-derived NR3C1, expressed by E. coli , with N-Trx, N-6*His labeled tag. ,

HY-P72140

	*CHRNA1 Protein, Human (His-Trx)* Acetylcholine receptor subunit alpha; ACHA_HUMAN; AChR; ACHRA; ACHRD; CHNRA; Cholinergic receptor nicotinic alpha 1 subunit; Cholinergic receptor nicotinic alpha polypeptide 1; Cholinergic receptor; nicotinic; alpha polypeptide 1 muscle; ; Chrna1; CMS1A; CMS1B; CMS2A; FCCMS; Nicotinic cholinergic receptor alpha 1; SCCMS; Schizophrenia neurophysiologic defect candidate	Human	E. coli
	The CHRNA1 Protein undergoes a substantial conformational shift upon acetylcholine binding, influencing all subunits and leading to the activation of an ion-conducting channel. Yet, the acetylcholine receptor alpha subunit of CHRNA1 can be non-functional in certain cases, underscoring the need to comprehend the factors governing its functionality and integration into fully operational acetylcholine-gated cation-selective channels. CHRNA1 Protein, Human (His-Trx) is the recombinant human-derived CHRNA1 protein, expressed by E. coli , with N-Trx, N-6*His labeled tag. The total length of CHRNA1 Protein, Human (His-Trx) is 235 a.a., with molecular weight of ~44.1 kDa.

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HY-P80912

	Thioredoxin Antibody TXN; ADF; ATL-derived factor; SASP; Thioredoxin; TRX1; Thioredoxin delta 3; TRX; TXN delta 3; TRDX	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	Thioredoxin Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 12 kDa, targeting to Thioredoxin. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human.

HY-P81042

	Trx Tag Antibody (YA888)	WB	Species independent
	Trx Tag Antibody (YA888) is an unconjugated, mouse-derived, anti-Trx Tag (YA888) monoclonal antibody. Trx Tag Antibody (YA888) can be used for: WB expriments in species-independent background without labeling.

HY-P82447

	Thioredoxin 2 Antibody (YA2192) TXN; MTRX; TRX2; MT-TRX; COXPD29	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Thioredoxin 2 Antibody (YA2192) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2192), targeting Thioredoxin 2, with a predicted molecular weight of 18 kDa (observed band size: 13 kDa). Thioredoxin 2 Antibody (YA2192) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, mouse, rat background.

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HY-124386

DBCO-NHCO-PEG4-amine		PROTAC Synthesis ADC Synthesis DBCO
DBCO-NHCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB−MMAE and DBCO-TRX−MMAE with EC₅₀s of 280 nM and 22 nM in SKBR3 cells, respectively) .

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