Search Result
Results for "
Tachykinins
" in MedChemExpress (MCE) Product Catalog:
1
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-151413
-
|
Neurokinin Receptor
|
Neurological Disease
|
MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.
|
-
-
- HY-P10599
-
|
Neurokinin Receptor
|
Neurological Disease
|
Scyliorhinin I is a tachykinin-1 (NK-1) and tachykinin-2 (NK-2) receptor agonist with a Ki value of 0.9 nM for rat submandibular gland NK-1 receptor and 2 nM for hamster bladder NK-2 receptor. Scyliorhinin I has the ability to contract the longitudinal muscles of the guinea pig ileum .
|
-
-
- HY-116958
-
|
Neurokinin Receptor
|
Inflammation/Immunology
|
SCH 206272 is a selective antagonist of the tachykinin (NK) receptor. SCH 206272 inhibits binding at human tachykinin NK(1), NK(2), and NK(3) receptors (Ki = 1.3, 0.4, and 0.3 nM, respectively). SCH 206272 has an orally active .
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-
-
- HY-P10268
-
|
Neurokinin Receptor
|
Cardiovascular Disease
Neurological Disease
|
Neuropeptide K, human, porcine, rat exhibits bioactivity in gallbladder contraction, protein extravasation, hypotension and brcnchial smooth muscle spasm. Neuropeptide K, human, porcine, rat is concentrated in brain and acts as tachykinin neuromessenger .
|
-
-
- HY-P3092
-
|
Neurokinin Receptor
|
Neurological Disease
|
Phyllomedusin, an tachykinin decapeptide, is a NK1 receptor agonist. Phyllomedusin has vasodilating activity and provokes the contraction of the pylorus .
|
-
-
- HY-108479
-
SR140333
|
Neurokinin Receptor
|
Neurological Disease
|
Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin NK1 receptor antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation .
|
-
-
- HY-P3851
-
-
-
- HY-P1193
-
|
Neurokinin Receptor
|
Neurological Disease
|
GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist . GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats .
|
-
-
- HY-P2475
-
-
-
- HY-120308
-
SR140603
|
Neurokinin Receptor
|
Neurological Disease
|
(R)-Nolpitantium is the R-enantiomer of Nolpitantium (HY-108479). Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin NK1 receptor antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation .
|
-
-
- HY-P10619
-
-
-
- HY-P3802
-
|
Neurokinin Receptor
|
Neurological Disease
|
[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist with Ki values of 1 μM, 1.3 μM, and ~9 μM for NK-1, NK-2,and NK-3 receptor, respectively .
|
-
-
- HY-P3848
-
-
-
- HY-14406A
-
|
Neurokinin Receptor
|
Neurological Disease
Cancer
|
L-733060 hydrochloride is a potent tachykinin NK1 receptor antagonist. L-733060 hydrochloride inhibits neurogenic plasma extravasation at doses that do not cause adverse cardiovascular effects in rodents and also acts as an antitumoral agent .
|
-
-
- HY-108482
-
-
-
- HY-P0236
-
-
-
- HY-P0236A
-
-
-
- HY-N7574
-
-
-
- HY-U00207
-
-
-
- HY-14770
-
-
-
- HY-19670
-
-
-
- HY-U00392
-
-
-
- HY-P0255
-
-
-
- HY-P1017
-
-
-
- HY-P0250
-
-
-
- HY-P1186
-
Eledoisin-Related Peptide; Eledoisin RP
|
Neurokinin Receptor
|
Neurological Disease
|
Eledoisin Related Peptide is a Substance P analog that excites neurons and triggers behavioral responses. Eledoisin Related Peptide is also a tachykinin receptor ligand.
|
-
-
- HY-P1012
-
-
-
- HY-P10062
-
|
Biochemical Assay Reagents
|
Metabolic Disease
|
Hylambatin, a tachykinin, increases both plasma glucose and plasma insulin, whereas the secretion of glucagon was not affected. Hylambatin can be used in diabetes research .
|
-
-
- HY-P1012A
-
-
-
- HY-P1276
-
Neurokinin-2 receptor antagonist
|
Neurokinin Receptor
|
Endocrinology
|
Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor.
|
-
-
- HY-P3806
-
-
-
- HY-107693
-
-
-
- HY-151413A
-
|
Neurokinin Receptor
|
Neurological Disease
|
MEN 10207 (acetate) is a selective antagonist of the NK-2 tachykinin receptor. MEN 10207 (acetate) induces tachykinin-induced contractions in rat bladder and guinea pig airways in vivo. MEN 10207 (acetate) inhibits [β-Ala 8 ]-NKA (4-10)-induced enhancement of bladder motility in anesthetized rats and [β-Ala 8 ]-NKA (4-10)-induced enhancement of bronchoconstriction in anesthetized guinea pigs .
|
-
-
- HY-W010922
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-Dap(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bicyclic peptide tachykinin NK2 antagonists .
|
-
-
- HY-P1379
-
-
-
- HY-P1276A
-
Neurokinin-2 receptor antagonist TFA
|
Neurokinin Receptor
|
Endocrinology
|
Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor .
|
-
-
- HY-12142
-
-
-
- HY-P1763
-
Uru-TK II
|
Bacterial
|
Infection
|
Urechistachykinin II (Uru-TK II), an invertebrate tachykinin-related peptides (TRPs) isolated from echiuroid worms, shows antimicrobial activities without a hemolytic effect .
|
-
-
- HY-P1768
-
Uru-TK I
|
Bacterial
|
Infection
|
Urechistachykinin I (Uru-TK I), an invertebrate tachykinin-related peptides (TRPs) isolated from echiuroid worms, shows antimicrobial activities without a hemolytic effect .
|
-
-
- HY-P0197
-
Substance K; Neurokinin α; Neuromedin L; NKA
|
Neurokinin Receptor
|
Neurological Disease
Endocrinology
|
Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues .
|
-
-
- HY-P0197A
-
Substance K TFA; Neurokinin α TFA; Neuromedin L TFA; NKA TFA
|
Neurokinin Receptor
|
Neurological Disease
Endocrinology
|
Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues .
|
-
-
- HY-119005A
-
-
-
- HY-P3890
-
-
-
- HY-116822
-
|
Neurokinin Receptor
|
Neurological Disease
|
SSR 146977 is a potent and selective antagonist of the tachykinin NK3 receptor. SSR 146977 inhibits the binding of radioactive neurokinin B to NK3 receptors in Chinese hamster ovary cells, with a Ki of 0.26 nM .
|
-
-
- HY-P3890A
-
|
Neurokinin Receptor
|
Neurological Disease
|
Substance P (5-11) TFA TFA, the C-terminal heptapeptide of Substance P (HY-P0201), is a neuropeptide. Substance P (5-11) TFA TFA binds to NK-1 tachykinin receptor .
|
-
-
- HY-P3861
-
|
Neurokinin Receptor
|
Neurological Disease
|
Biotin-NeurokininA is a biotinylated Neurokinin A (HY-P0197). Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues .
|
-
-
- HY-P0242
-
-
-
- HY-P0242A
-
-
-
- HY-P1192
-
-
-
- HY-P1198
-
|
Neurokinin Receptor
|
Neurological Disease
|
Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia .
|
-
- HY-169501
-
-
- HY-P3889
-
|
Neurokinin Receptor
|
Neurological Disease
|
Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (HY-P0201). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect .
|
-
- HY-P1198A
-
|
Neurokinin Receptor
|
Neurological Disease
|
Hemokinin 1, human TFA is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human TFA is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human TFA can produces an opioid-independent analgesia .
|
-
- HY-P3799
-
|
Neurokinin Receptor
|
Neurological Disease
|
[Glp6] Substance P (6-11) is an analogue of substance P (6-11). Substance P (6-11) stimulates [3H]-inositol monophosphate ([3H]-IP1) formation in rat urinary bladder by acting on the 'septide-sensitive' tachykinin receptors .
|
-
- HY-P1379A
-
|
Neurokinin Receptor
|
Neurological Disease
|
C14TKL-1 acetate is the acetate salt form of C14TKL-1 (HY-P1379). C14TKL-1 acetate is a tachykinin-like peptide and exhibits an agonistic activity for neurokinin receptor 1 (NK-1) .
|
-
- HY-12142S
-
rac-GR 205171-d3
|
Isotope-Labeled Compounds
Neurokinin Receptor
|
Others
|
rac-Vofopitant-d3 (rac-GR 205171-d3) is the deuterium labeled Vofopitant (HY-12142) . Vofopitant is potent tachykinin NK1 receptor antagonist, with pKis of 10.6, 9.5, and 9.8 for human, rat and ferret NK1 receptor, respectively .
|
-
- HY-12143
-
GR 205171A
|
Neurokinin Receptor
|
Neurological Disease
Endocrinology
Cancer
|
Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [ 3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent .
|
-
- HY-19633
-
|
Neurokinin Receptor
|
Infection
Endocrinology
|
CS-003 Free base (CS-003), a triple tachykinin receptor antagonist, shows high affinities for human (Neurokinin) NK1, NK2 and NK3 receptors with Ki values of 2.3 nM, 0.54 nM and 0.74 nM, respectively. CS-003 Free base (CS-003) has therapeutic efficacy on respiratory diseases associated with neurokinins.
|
-
- HY-12145
-
|
Endogenous Metabolite
Neurokinin Receptor
p38 MAPK
|
Neurological Disease
|
CP-99994 hydrochloride is a Tachykinin neurokinin 1 (NK-1) receptor antagonist with a Ki of 0.25 nM. CP-99994 hydrochloride prevents colorectal sensitization in the context of visceral hypersensitivity. CP-99994 hydrochloride reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity .
|
-
- HY-107691
-
|
Neurokinin Receptor
|
Neurological Disease
Endocrinology
Cancer
|
GR 159897 is a highly potent, selective, competitive, brain-penetrated non-peptide neurokinin 2 (NK2) receptor antagonist. GR 159897 has little or no affinity for NK1 and NK3 receptors. GR 159897 inhibits binding of [ 3H]GR100679 to human NK2 (hNK2)-CHO cells and rat colon membranes with pKis of 9.51 and 10, respectively. Antagonizes bronchoconstriction. Anxiolytic-like and anti-tumor effects .
|
-
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-151413
-
|
Neurokinin Receptor
|
Neurological Disease
|
MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.
|
-
- HY-P3857
-
|
Peptides
|
Neurological Disease
|
Carassin is a 21 amino acid tachykinin-related peptide, it can be isolated from the goldfish brain. Carassin has moderate affinity for rat tachykinin binding sites .
|
-
- HY-P10599
-
|
Neurokinin Receptor
|
Neurological Disease
|
Scyliorhinin I is a tachykinin-1 (NK-1) and tachykinin-2 (NK-2) receptor agonist with a Ki value of 0.9 nM for rat submandibular gland NK-1 receptor and 2 nM for hamster bladder NK-2 receptor. Scyliorhinin I has the ability to contract the longitudinal muscles of the guinea pig ileum .
|
-
- HY-P10268
-
|
Neurokinin Receptor
|
Cardiovascular Disease
Neurological Disease
|
Neuropeptide K, human, porcine, rat exhibits bioactivity in gallbladder contraction, protein extravasation, hypotension and brcnchial smooth muscle spasm. Neuropeptide K, human, porcine, rat is concentrated in brain and acts as tachykinin neuromessenger .
|
-
- HY-P3092
-
|
Neurokinin Receptor
|
Neurological Disease
|
Phyllomedusin, an tachykinin decapeptide, is a NK1 receptor agonist. Phyllomedusin has vasodilating activity and provokes the contraction of the pylorus .
|
-
- HY-P3851
-
-
- HY-P1193
-
|
Neurokinin Receptor
|
Neurological Disease
|
GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist . GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats .
|
-
- HY-P2475
-
-
- HY-P10619
-
-
- HY-P3802
-
|
Neurokinin Receptor
|
Neurological Disease
|
[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist with Ki values of 1 μM, 1.3 μM, and ~9 μM for NK-1, NK-2,and NK-3 receptor, respectively .
|
-
- HY-P3848
-
-
- HY-P3633
-
Lom-TK II
|
Peptides
|
Neurological Disease
|
Locustatachykinin II (Lom-TK II) is an insect neuropeptide with homology to peptides of the vertebrate tachykinin family. Locustatachykinin II can be used for the research of insect endocrine .
|
-
- HY-P1183
-
|
Peptides
|
Neurological Disease
Endocrinology
|
Locustatachykinin I is a insect tachykinin-related peptide isolated from Locusta migratoria. Locustatachykinin I exhibits sequence homologies with the vertebrate tachykinins. In Lacanobia, Locustatachykinin I is also a substrate for a deamidase .
|
-
- HY-P1183A
-
|
Peptides
|
Neurological Disease
Endocrinology
|
Locustatachykinin I TFA is a insect tachykinin-related peptide isolated from Locusta migratoria. Locustatachykinin I TFA exhibits sequence homologies with the vertebrate tachykinins. In Lacanobia, Locustatachykinin I TFA is also a substrate for a deamidase .
|
-
- HY-P0236
-
-
- HY-P3855
-
-
- HY-P0236A
-
-
- HY-P1017
-
-
- HY-P0250
-
-
- HY-P1186
-
Eledoisin-Related Peptide; Eledoisin RP
|
Neurokinin Receptor
|
Neurological Disease
|
Eledoisin Related Peptide is a Substance P analog that excites neurons and triggers behavioral responses. Eledoisin Related Peptide is also a tachykinin receptor ligand.
|
-
- HY-P1012
-
-
- HY-P10062
-
|
Biochemical Assay Reagents
|
Metabolic Disease
|
Hylambatin, a tachykinin, increases both plasma glucose and plasma insulin, whereas the secretion of glucagon was not affected. Hylambatin can be used in diabetes research .
|
-
- HY-P1012A
-
-
- HY-P1276
-
Neurokinin-2 receptor antagonist
|
Neurokinin Receptor
|
Endocrinology
|
Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor.
|
-
- HY-P3806
-
-
- HY-151413A
-
|
Neurokinin Receptor
|
Neurological Disease
|
MEN 10207 (acetate) is a selective antagonist of the NK-2 tachykinin receptor. MEN 10207 (acetate) induces tachykinin-induced contractions in rat bladder and guinea pig airways in vivo. MEN 10207 (acetate) inhibits [β-Ala 8 ]-NKA (4-10)-induced enhancement of bladder motility in anesthetized rats and [β-Ala 8 ]-NKA (4-10)-induced enhancement of bronchoconstriction in anesthetized guinea pigs .
|
-
- HY-W010922
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-Dap(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bicyclic peptide tachykinin NK2 antagonists .
|
-
- HY-P1379
-
-
- HY-P1276A
-
Neurokinin-2 receptor antagonist TFA
|
Neurokinin Receptor
|
Endocrinology
|
Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor .
|
-
- HY-P1763
-
Uru-TK II
|
Bacterial
|
Infection
|
Urechistachykinin II (Uru-TK II), an invertebrate tachykinin-related peptides (TRPs) isolated from echiuroid worms, shows antimicrobial activities without a hemolytic effect .
|
-
- HY-P1768
-
Uru-TK I
|
Bacterial
|
Infection
|
Urechistachykinin I (Uru-TK I), an invertebrate tachykinin-related peptides (TRPs) isolated from echiuroid worms, shows antimicrobial activities without a hemolytic effect .
|
-
- HY-P0197
-
Substance K; Neurokinin α; Neuromedin L; NKA
|
Neurokinin Receptor
|
Neurological Disease
Endocrinology
|
Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues .
|
-
- HY-P0197A
-
Substance K TFA; Neurokinin α TFA; Neuromedin L TFA; NKA TFA
|
Neurokinin Receptor
|
Neurological Disease
Endocrinology
|
Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues .
|
-
- HY-P3890
-
-
- HY-P3890A
-
|
Neurokinin Receptor
|
Neurological Disease
|
Substance P (5-11) TFA TFA, the C-terminal heptapeptide of Substance P (HY-P0201), is a neuropeptide. Substance P (5-11) TFA TFA binds to NK-1 tachykinin receptor .
|
-
- HY-P3861
-
|
Neurokinin Receptor
|
Neurological Disease
|
Biotin-NeurokininA is a biotinylated Neurokinin A (HY-P0197). Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues .
|
-
- HY-P0242
-
-
- HY-P0242A
-
-
- HY-P1192
-
-
- HY-P1198
-
|
Neurokinin Receptor
|
Neurological Disease
|
Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia .
|
-
- HY-P3889
-
|
Neurokinin Receptor
|
Neurological Disease
|
Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (HY-P0201). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect .
|
-
- HY-P1198A
-
|
Neurokinin Receptor
|
Neurological Disease
|
Hemokinin 1, human TFA is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human TFA is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human TFA can produces an opioid-independent analgesia .
|
-
- HY-P3799
-
|
Neurokinin Receptor
|
Neurological Disease
|
[Glp6] Substance P (6-11) is an analogue of substance P (6-11). Substance P (6-11) stimulates [3H]-inositol monophosphate ([3H]-IP1) formation in rat urinary bladder by acting on the 'septide-sensitive' tachykinin receptors .
|
-
- HY-P1379A
-
|
Neurokinin Receptor
|
Neurological Disease
|
C14TKL-1 acetate is the acetate salt form of C14TKL-1 (HY-P1379). C14TKL-1 acetate is a tachykinin-like peptide and exhibits an agonistic activity for neurokinin receptor 1 (NK-1) .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-12142S
-
|
rac-Vofopitant-d3 (rac-GR 205171-d3) is the deuterium labeled Vofopitant (HY-12142) . Vofopitant is potent tachykinin NK1 receptor antagonist, with pKis of 10.6, 9.5, and 9.8 for human, rat and ferret NK1 receptor, respectively .
|
-
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