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Results for "

Tetrapeptide

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (2) Amino Acid Derivatives (1) Aminopeptidase (1) Angiotensin-converting Enzyme (ACE) (3) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (4) Caspase (2) Cholecystokinin Receptor (1) DNA/RNA Synthesis (1) Elastase (1) Endogenous Metabolite (3) GnRH Receptor (1) HDAC (2) iGluR (1) Influenza Virus (1) Integrin (2) Interleukin Related (2) Isotope-Labeled Compounds (1) MALT1 (1) Melanocortin Receptor (3) Opioid Receptor (5) Parasite (3) Proteasome (2) Reactive Oxygen Species (1) Renin (1) Src (1) TGF-beta/Smad (1) TGF-β Receptor (2) Tyrosinase (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (3) Endocrinology (3) Infection (5) Inflammation/Immunology (13) Metabolic Disease (9) Neurological Disease (9)

By Targets:

ADC Linker (2)

Amino Acid Derivatives (1)

Aminopeptidase (1)

Angiotensin-converting Enzyme (ACE) (3)

Antibody-Drug Conjugates (ADCs) (1)

Apoptosis (4)

Caspase (2)

Cholecystokinin Receptor (1)

DNA/RNA Synthesis (1)

Elastase (1)

Endogenous Metabolite (3)

GnRH Receptor (1)

HDAC (2)

iGluR (1)

Influenza Virus (1)

Integrin (2)

Interleukin Related (2)

Isotope-Labeled Compounds (1)

MALT1 (1)

Melanocortin Receptor (3)

Opioid Receptor (5)

Parasite (3)

Proteasome (2)

Reactive Oxygen Species (1)

Renin (1)

Src (1)

TGF-beta/Smad (1)

TGF-β Receptor (2)

Tyrosinase (1)

By Research Areas:

Cancer (14)

Cardiovascular Disease (3)

Endocrinology (3)

Infection (5)

Inflammation/Immunology (13)

Metabolic Disease (9)

Neurological Disease (9)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3452

Tetrapeptide-30	Tyrosinase	Inflammation/Immunology
Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation .

HY-P5248

Tetrapeptide-1	Melanocortin Receptor	Metabolic Disease
Tetrapeptide-1 is a bioactive peptide with antioxidant effect and has been reported used as a cosmetic ingredient .

HY-125556

Tetragastrin Cholecystokinin Tetrapeptide; CCK-4	Cholecystokinin Receptor	Metabolic Disease
Tetragastrin (Cholecystokinin tetrapeptide; CCK-4) is the C-terminal tetrapeptide of gastrin. Tetragastrin can stimulate gastric secretion . Tetragastrin is a Cholecystokinin (CCK-4) receptor agonist . Gastric mucosal protection .

HY-P0095

*Acetyl tetrapeptide-5*	Angiotensin-converting Enzyme (ACE)	Others
Acetyl tetrapeptide-5 inhibits glycosylation and ACE-1 activity. Acetyl tetrapeptide-5 reduces edema and relieves vascular pressure by improving the vascular system and strengthening the skin under the eyes. Acetyl tetrapeptide-5 can be used in the research of Antioxidant, anti-aging skin care .

HY-P1626

*Acetyl tetrapeptide-15*	Opioid Receptor	Neurological Disease
Acetyl tetrapeptide-15 is a synthetic peptide used in the cosmetics for sensitive skin. Acetyl tetrapeptide-15 is derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist with selective anti-nociceptive effect. Acetyl tetrapeptide-15 reduces skin hyperreactivity producing inflammatory, chronic and neuropathic pain, by increasing the threshold of neuronal excitability in μ-opioid receptor via an endorphin-like pathway .

HY-P5247

*Palmitoyl tetrapeptide-20* PTP20	Melanocortin Receptor	Metabolic Disease Inflammation/Immunology
Palmitoyl tetrapeptide-20 (PTP20) is a biomimetic peptide that is an agonist for α-MSH. Palmitoyl tetrapeptide-20 can protect follicular melanocytes and activate melanogenesis by enhancing catalase expression .

HY-P10002

EWFW-ACC	Proteasome	Cancer
EWFW-ACC is the tetrapeptide substrate for the immunoproteasome and has selectivity for the LMP7 subunits .

HY-P5265

*Tetrapeptide*	DNA/RNA Synthesis	Metabolic Disease
Tetrapeptide, an analogue of α-MSH, induces melanin synthesis. Tetrapeptide diminishes DNA damage by reducing the production of reactive oxidative species and enhancing repair of DNA photoproducts .

HY-W108953

*Myristoyl tetrapeptide-12*	TGF-beta/Smad	Metabolic Disease
Myristoyl tetrapeptide-12 directly activates SMAD2 and induces the linking of SMAD3 with DNA. Myristoyl tetrapeptide-12 is capable of stimulating hair growth, especially at the level of eyelashes .

HY-P5247A

*Palmitoyl tetrapeptide-20 TFA* PTP20 TFA	Melanocortin Receptor	Neurological Disease Inflammation/Immunology
Palmitoyl tetrapeptide-20 (PTP20) TFA is a biomimetic peptide that is an agonist for α-MSH. Palmitoyl tetrapeptide-20 TFA can protect follicular melanocytes and activate melanogenesis by enhancing catalase expression .

HY-P3425

AGPV	Parasite	Infection
AGPV, a tetrapeptide, has the potential for prevention of schistosome parasite infection research .

HY-P3425A

AGPV TFA	Parasite	Infection
AGPV TFA, a tetrapeptide, has the potential for prevention of schistosome parasite infection research .

HY-P4126

Suc-Ala-Ala-Pro-Val-AMC	Elastase	Others
Suc-Ala-Ala-Pro-Val-AMC, a tetrapeptide, is an elastasesubstrate. Suc-Ala-Ala-Pro-Val-AMC can be used for determining elastase activity .

HY-165362

AO-1535	Reactive Oxygen Species	Inflammation/Immunology
AO-1535 is a semisynthetic monoglycosylceramide that inhibits the production of reactive oxygen intermediates in human monocytes and macrophages stimulated by phorbol ester and chemotactic tetrapeptide. AO-1535 can be used for the research of inflammatory dermatoses .

HY-P2698

1-Alaninechlamydocin	HDAC Apoptosis	Cancer
1-Alaninechlamydocin, a cyclic tetrapeptide, is a potent HDAC inhibitor (IC₅₀=6.4 nM). 1-Alaninechlamydocin induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells .

HY-120019

Ac-YVAD-CHO L-709049	Interleukin Related Apoptosis Caspase	Inflammation/Immunology
Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human K_i values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a caspase-1 inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ .

HY-120019A

Ac-YVAD-CHO acetate L-709049 acetate	Interleukin Related Caspase Apoptosis	Inflammation/Immunology
Ac-YVAD-CHO (L-709049) acetate is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human K_i values of 3.0 and 0.76 nM. Ac-YVAD-CHO acetate is also a caspase-1 inhibitor. Ac-YVAD-CHO acetate can suppress the production of mature IL-lβ .

HY-N10624

Koshidacin B	Parasite	Infection
Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against *P. falciparum* FCR3 and K1 strain with IC₅₀ values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection .

HY-P10007

Z-Gly-Pro-Phe-Leu-CHO Z-GPFL-CHO	Proteasome	Cancer
Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (K_i = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC₅₀ = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity) .

HY-P0240A

Tuftsin diacetate	Endogenous Metabolite	Inflammation/Immunology
Tuftsin diacetate, a tetrapeptide, is a macrophage/microglial activator.

HY-P0240

Tuftsin 2 Publications Verification	Endogenous Metabolite	Inflammation/Immunology
Tuftsin is a tetrapeptide. Tuftsin is a macrophage/microglial activator.

HY-P2024

CP-85339	Renin	Cardiovascular Disease
CP-85339 is a tetrapeptide renin inhibitor .

HY-129642

Hirsutide	Others	Others
Hirsutide is a cyclic tetrapeptide that can be found in spider-derived entomopathogenic fungus .

HY-125430

Padanamide A	Others	Others
Padanamide A is a linear tetrapeptide without proteinogenic amino acids. Padanamide A has the activity of inhibiting the biosynthesis of cysteine and methionine .

HY-P0266

N-Acetyl-Ser-Asp-Lys-Pro Ac-SDKP	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Inflammation/Immunology
N-Acetyl-Ser-Asp-Lys-Pro, an endogenous tetrapeptide secreted by bone marrow, is a specific substrate for the N-terminal site of ACE.

HY-124192

Amogastrin	Others	Cancer
Amogastrin is a tetrapeptide that stimulates gastric extraction of ^99mTc pertechnetate. Amogastrin can be used for the research of gastric mucosal disease imaging .

HY-12290

Arg-Gly-Asp-Ser 5 Publications Verification RGDS peptide; Fibronectin Tetrapeptide	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

HY-P0266A

N-Acetyl-Ser-Asp-Lys-Pro TFA Ac-SDKP TFA	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Inflammation/Immunology
N-Acetyl-Ser-Asp-Lys-Pro (TFA), an endogenous tetrapeptide secreted by bone marrow, is a specific substrate for the N-terminal site of ACE.

HY-P1449

Boc-Gly-Gly-Phe-Gly-OH	ADC Linker	Cancer
Boc-Gly-Gly-Phe-Gly-OH, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC).

HY-N6717

Tentoxin	Others	Infection
Tentoxin is a cyclic tetrapeptide isolated from Alternaria tenuis, acts as a herbicide, causes seedling chlorosis, inhibits cyclic photophosphorylation and functions as an energy transfer inhibitor .

HY-126856

HC-Toxin	HDAC Apoptosis	Cancer
HC-Toxin, a cyclic tetrapeptide, is a potent HDAC inhibitor with an IC₅₀ of 30 nM . HC-Toxin induces tumor cell apoptosis and has anticancer effects .

HY-P1449A

Boc-Gly-Gly-Phe-Gly-OH TFA	ADC Linker	Cancer
Boc-Gly-Gly-Phe-Gly-OH TFA, a self-assembly of N- and C-protected tetrapeptide, is a protease cleavable linker used for the antibody-drug conjugate (ADC).

HY-P3087

Tyr-W-MIF-1	Opioid Receptor	Neurological Disease
Tyr-W-MIF-1 is an opioid tetrapeptide with opiate and antiopiate activity. Tyr-W-MIF-1 can induce analgesia .

HY-P4393

H-Leu-Trp-Met-Arg-OH	Aminopeptidase	Others
H-Leu-Trp-Met-Arg-OH is a tetrapeptide. H-Leu-Trp-Met-Arg-OH can be used as a substrate for aminopeptidase-mediated hydrolysis studies .

HY-P10665

pYEEI	Src	Cancer
pYEEI is a phosphotyrosine-containing tetrapeptide binds to Src SH2 domain with the K_d of 100 nM and with the IC₅₀ of 6.5 μM. pYEEI plays an important role in cancer research .

HY-12290A

Arg-Gly-Asp-Ser TFA RGDS peptide TFA; Fibronectin Tetrapeptide TFA	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser (TFA) directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1 .

HY-P4290

Antiulcer Agent 2	Endogenous Metabolite	Endocrinology
Antiulcer Agent 2 is a tetrapeptide containing aspartic acid, alanine, histidine, and lysine. Antiulcer Agent 2 is present at the N-terminal of human albumin. Antiulcer Agent 2 has potential applications in ulcers and active oxygen generation .

HY-P7060

NT 13 TPPT	iGluR	Neurological Disease
NT 13 (TPPT) is a tetrapeptide having the amino acid sequence L-threonyl-L-prolyl-L-prolyl-L-threonine amide. NT 13 is a partial N-methyl-D-aspartate receptor (NMDAR) agonist used in the study of depression, anxiety, and other related diseases.

HY-P3674

LH-RH (7-10)	GnRH Receptor	Endocrinology
LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes .

HY-P1407

Z-VRPR-FMK TFA VRPR	MALT1 Influenza Virus	Infection Cancer
Z-VRPR-FMK (TFA) (VRPR), a tetrapeptide, is a selective and irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. Z-VRPR-FMK (TFA) can protect against influenza A virus (IAV) infection .

HY-P4107

Bilaid C	Opioid Receptor	Neurological Disease
Bilaid C, a tetrapeptide, can be isolated from the Australian estuarine isolate of Penicillium sp. MST-MF667. Bilaid C is also a potent and selective μ-Opioid Receptor (MOPr) agonist (K_i=210 nM, hMOPr) .

HY-W653894

Tentoxin-d3	Isotope-Labeled Compounds	Others
Tentoxin-d₃ is the deuterium-labeled Tentoxin (HY-N6717). Tentoxin-d₃ is a cyclic tetrapeptide isolated from Alternaria tenuis, acts as a herbicide, causes seedling chlorosis, inhibits cyclic photophosphorylation and functions as an energy transfer inhibitor .

HY-P3044

Bilaid A1e	Opioid Receptor	Neurological Disease
Bilaid A1e (Compound 1e) is a tetrapeptide agonist of the µ-opioid receptor (K_i = 750 nM). Bilaid A1e can be isolated from an Australian estuarine isolate of Penicillium sp. Bilaid A1e can be used for pain research .

HY-P3882

Fmoc-Ala-Glu-Gln-Lys-NH2	Amino Acid Derivatives	Neurological Disease
Fmoc-Ala-Glu-Gln-Lys-NH2 (AEQK) is a tetrapeptide. Fmoc-Ala-Glu-Gln-Lys-NH2 is the inactive control for Fmoc-Ala-Glu-Asn-Lys-NH2 (AENK) peptide inhibitor. AENK blocks proteolysis of UNC5C protein .

HY-P99813

Patritumab deruxtecan HER3-DXd; U3-1402	Antibody-Drug Conjugates (ADCs)	Cancer
Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity .

HY-P10555

(D-Arg2, Sar 4)-Dermorphin (1-4)	Opioid Receptor	Neurological Disease
(D-Arg2, Sar 4)-Dermorphin (1-4) is a tetrapeptide derivative of the peptide Dermorphin (HY-P0244) found in amphibian skin. (D-Arg2, Sar 4)-Dermorphin (1-4) has significant analgesic effects by binding to the μ-opioid receptor (MOR) in the body. (D-Arg2, Sar 4)-Dermorphin (1-4) can be used in the development of analgesic drugs .

HY-P0299A

LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA) Maximum Cited Publications 11 Publications Verification	TGF-β Receptor	Cancer
LSKL, Inhibitor of Thrombospondin (TSP-1) TFA is a latency-associated protein (LAP)-TGFβ derived tetrapeptide and a competitive TGF-β1 antagonist. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA inhibits the binding of TSP-1 to LAP and alleviates renal interstitial fibrosis and hepatic fibrosis. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA suppresses subarachnoid fibrosis via inhibition of TSP-1-mediated TGF-β1 activity, prevents the development of chronic hydrocephalus and improves long-term neurocognitive defects following subarachnoid hemorrhage (SAH). LSKL, Inhibitor of Thrombospondin (TSP-1) TFA can readily crosse the blood-brain barrier .

HY-P0299

LSKL, Inhibitor of Thrombospondin (TSP-1) Maximum Cited Publications 11 Publications Verification	TGF-β Receptor	Cancer
LSKL, Inhibitor of Thrombospondin (TSP-1) is a latency-associated protein (LAP)-TGFβ derived tetrapeptide and a competitive TGF-β1 antagonist. LSKL, Inhibitor of Thrombospondin (TSP-1) inhibits the binding of TSP-1 to LAP and alleviates renal interstitial fibrosis and hepatic fibrosis. LSKL, Inhibitor of Thrombospondin (TSP-1) suppresses subarachnoid fibrosis via inhibition of TSP-1-mediated TGF-β1 activity, prevents the development of chronic hydrocephalus and improves long-term neurocognitive defects following subarachnoid hemorrhage (SAH). LSKL, Inhibitor of Thrombospondin (TSP-1) can readily crosse the blood-brain barrier .

Cat. No.	Product Name	Target	Research Area