Search Result
Results for "
UT-15-<sup>13</sup>C<sub>2</sub>,d<sub>1</sub>
" in MedChemExpress (MCE) Product Catalog:
100
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-D0184S3
-
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Deoxycytidine-<sup>13sup>C<sub>9sub>,<sup>15sup>N<sub>3sub>; Cytosine deoxyriboside-<sup>13sup>C<sub>9sub>,<sup>15sup>N<sub>3sub>; Deoxyribose cytidine-<sup>13sup>C<sub>9sub>,<sup>15sup>N<sub>3sub>
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Isotope-Labeled Compounds
Endogenous Metabolite
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Others
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2'-Deoxycytidine- 13C9, 15N3 (Deoxycytidine- 13C9, 15N3; Cytosine deoxyriboside- 13C9, 15N3; Deoxyribose cytidine- 13C9, 15N3) is 13C and 15N-labeled 2'-Deoxycytidine (HY-D0184). 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu).
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-
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- HY-N1150S8
-
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DThyd-<sup>13sup>C<sub>10sub>,<sup>15sup>N<sub>2sub>; NSC-<sup>13sup>C<sub>10sub>,<sup>15sup>N<sub>2sub>
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DNA/RNA Synthesis
Endogenous Metabolite
Orthopoxvirus
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Cancer
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Thymidine- 13C10, 15N2 is the 13C and 15N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].
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-
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- HY-N0623S4
-
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Tryptophan-<sup>13sup>C<sub>11sub>,<sup>15sup>N<sub>2sub>; Tryptophane-<sup>13sup>C<sub>11sub>,<sup>15sup>N<sub>2sub>
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Endogenous Metabolite
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Metabolic Disease
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L-Tryptophan- 13C11, 15N2 is the 13C- and 15N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
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-
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- HY-N0097S6
-
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DL-Guanosine-<sup>13sup>C<sub>10sub>,<sup>15sup>N<sub>5sub>; Vernine-<sup>13sup>C<sub>10sub>,<sup>15sup>N<sub>5sub>
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HSV
Isotope-Labeled Compounds
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Infection
|
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Guanosine- 13C10, 15N5 is the 13C and 15N labeled Guanosine (HY-N0097). Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity .
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-
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- HY-108213S
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5'-IMP-<sup>13sup>C<sub>10sub>,<sup>15sup>N<sub>4sub> dilithium; IMP-<sup>13sup>C<sub>10sub>,<sup>15sup>N<sub>4sub> dilithium; Inosine 5'-dihydrogen phosphate-<sup>13sup>C<sub>10sub>,<sup>15sup>N<sub>4sub> dilithium
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Isotope-Labeled Compounds
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Metabolic Disease
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Inosinic acid- 13C10, 15N4 dilithium (5'-IMP-13C10,15N4 (dilithium); IMP-13C10,15N4 (dilithium); Inosine 5'-(dihydrogen phosphate)-13C10,15N4 (dilithium)) is 13C- and 15N-labeled Inosinic acid (HY-108213). Inosinic acid is an endogenous metabolite .
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-
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- HY-D0844S
-
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L-Glutathione oxidized-<sup>13sup>C<sub>4sub>,<sup>15sup>N<sub>2sub>; GSSG-<sup>13sup>C<sub>4sub>,<sup>15sup>N<sub>2sub>; Oxiglutatione-<sup>13sup>C<sub>4sub>,<sup>15sup>N<sub>2sub>
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Isotope-Labeled Compounds
Reactive Oxygen Species
Endogenous Metabolite
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Metabolic Disease
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Glutathione oxidized- 13C4, 15N2 is the 13C and 15N labeled Glutathione oxidized (HY-D0844). Glutathione oxidized is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of glutathione oxidized. Glutathione oxidized can be used for the research of sickle cells and erythrocytes .
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-
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- HY-13599S1
-
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2-Chloro-2′-deoxyadenosine-<sup>13sup>C<sub>5sub>,<sup>15sup>N<sub>2sub>; CldAdo-<sup>13sup>C<sub>5sub>,<sup>15sup>N<sub>2sub>; 2CdA-<sup>13sup>C<sub>5sub>,<sup>15sup>N<sub>2sub>
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Isotope-Labeled Compounds
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Cardiovascular Disease
Cancer
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Cladribine- 13C5, 15N2 (2-Chloro-2′-deoxyadenosine- 13C5, 15N2) is 13C and 15N labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis .
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-
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- HY-A0061S
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Trifluorothymidine-<sup>13sup>C,<sup>15sup>N<sub>2sub>; 5-Trifluorothymidine-<sup>13sup>C,<sup>15sup>N<sub>2sub>; TFT-<sup>13sup>C,<sup>15sup>N<sub>2sub>
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Thymidylate Synthase
Nucleoside Antimetabolite/Analog
HSV
Orthopoxvirus
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Cancer
|
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Trifluridine- 13C, 15N2 is the 13C and 15N labeled Trifluridine[1]. Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity[2].
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-
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- HY-110382S
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<sup>13sup>C<sub>20sub>,<sup>15sup>N<sub>10sub>-c-di-GMP, <sup>13sup>C<sub>20sub>,<sup>15sup>N<sub>10sub>-Cyclic diguaylate, <sup>13sup>C<sub>20sub>,<sup>15sup>N<sub>10sub>-3’,5’-Cyclic diguaylic Acid
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Isotope-Labeled Compounds
Endogenous Metabolite
STING
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Cancer
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13C20, 15N10-Cyclic di-GMP ( 13C20, 15N10-c-di-GMP) is 13C and 15N labeled Cyclic-di-GMP (disodium). Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research .
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-
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- HY-B1118S1
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RP-14539-<sup>13sup>C<sub>2sub>, <sup>15sup>N<sub>2sub>; PM-185184-<sup>13sup>C<sub>2sub>, <sup>15sup>N<sub>2sub>
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Isotope-Labeled Compounds
Parasite
Antibiotic
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Infection
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Secnidazole- 13C2, 15N2 is the 13C2, 15N2 labeled Secnidazole. Secnidazole (RP-14539;PM-185184) is an orally active azole antibiotic with a longer half-life than metronidazole (HY-B0318). Secnidazole is against the vaginosis-associated bacteria and has the potential for bacterial vaginosis research.
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-
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- HY-N0091S
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-
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- HY-17563S1
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Deoxyguanosine-<sup>13sup>C<sub>10sub>,<sup>15sup>N<sub>5sub>; Guanine deoxyriboside-<sup>13sup>C<sub>10sub>,<sup>15sup>N<sub>5sub>
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Isotope-Labeled Compounds
Endogenous Metabolite
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Cancer
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2'-Deoxyguanosine- 13C10, 15N5 (Deoxyguanosine- 13C10, 15N5; Guanine deoxyriboside- 13C10, 15N5) is a 13C- and 15N-labeled 2'-Deoxyguanosine (HY-17563).
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-
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- HY-N0001S2
-
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(-)-Epicatechol-<sup>13sup>C<sub>3sub>; Epicatechin-<sup>13sup>C<sub>3sub>; epi-Catechin-<sup>13sup>C<sub>3sub>
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Isotope-Labeled Compounds
Ferroptosis
Endogenous Metabolite
COX
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Inflammation/Immunology
Cancer
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(-)-Epicatechin- 13C3 ((-)-Epicatechol- 13C3) is 13C labeled (-)-Epicatechin. (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.
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-
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- HY-A0161S
-
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Clofedanol-<sup>13sup>C<sub>6sub>; Calmotusin-<sup>13sup>C<sub>6sub>; NSC 113595-<sup>13sup>C<sub>6sub>
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Isotope-Labeled Compounds
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Infection
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Chlophedianol- 13C6 is the 13C labeled Chlophedianol (HY-A0161). Chlophedianol is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs)[1][2][3].
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-
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- HY-N0667S2
-
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(-)-Asparagine-<sup>15sup>N<sub>2sub> monohydrate; Asn-<sup>15sup>N<sub>2sub> monohydrate; Asparamide-<sup>15sup>N<sub>2sub> monohydrate
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Endogenous Metabolite
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Neurological Disease
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L-Asparagine- 15N2 (monohydrate) is the 15N-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.
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-
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- HY-N0667S3
-
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(-)-Asparagine-<sup>13sup>C<sub>4sub> monohydrate; Asn-<sup>13sup>C<sub>4sub> monohydrate; Asparamide-<sup>13sup>C<sub>4sub> monohydrate
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Isotope-Labeled Compounds
Endogenous Metabolite
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Neurological Disease
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L-Asparagine- 13C4 (monohydrate) is the 13C-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.
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-
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- HY-N0898S
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(+)-Catechin-<sup>13sup>C<sub>3sub>; Cianidanol-<sup>13sup>C<sub>3sub>; Catechuic acid-<sup>13sup>C<sub>3sub>
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COX
Apoptosis
Influenza Virus
Endogenous Metabolite
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Cancer
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Catechin- 13C3 is the 13C-labeled Catechin. Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
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-
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- HY-D0184S6
-
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Deoxycytidine-<sup>13sup>C,<sup>15sup>N<sub>3sub>; Cytosine deoxyriboside-<sup>13sup>C,<sup>15sup>N<sub>3sub>; Deoxyribose cytidine-<sup>13sup>C,<sup>15sup>N<sub>3sub>
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Isotope-Labeled Compounds
Endogenous Metabolite
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Cancer
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2'-Deoxycytidine- 13C, 15N3 (Deoxycytidine- 13C, 15N3) is 13C and 15N labeled 2'-Deoxycytidine. 2'-Deoxycytidine, a deoxyribonucleoside, can inhibit biological effects of Bromodeoxyuridine (Brdu). 2'-Deoxycytidine is essential for the synthesis of nucleic acids, that can be used for the research of cancer .
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- HY-13458S1
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L-DOPS-<sup>13sup>C<sub>2sub>,<sup>15sup>N hydrochloride; DOPS-<sup>13sup>C<sub>2sub>,<sup>15sup>N hydrochloride; SM5688-<sup>13sup>C<sub>2sub>,<sup>15sup>N hydrochloride
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Adrenergic Receptor
Isotope-Labeled Compounds
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Neurological Disease
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Droxidopa- 13C2, 15N (hydrochloride) is deuterium labeled Droxidopa. Droxidopa(L-DOPS), the mixture of Droxidopa (w/w80%) and Pharmaceutical starch (w/w20%), acts as a proagent to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); Droxidopa(L-DOPS) is capable of crossing the protective blood-brain barrier .
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- HY-66005S4
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Paracetamol-<sup>13sup>C<sub>2sub>,<sup>15sup>N; 4-Acetamidophenol-<sup>13sup>C<sub>2sub>,<sup>15sup>N; 4'-Hydroxyacetanilide-<sup>13sup>C<sub>2sub>,<sup>15sup>N
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COX
Bacterial
Histone Acetyltransferase
Parasite
Endogenous Metabolite
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Inflammation/Immunology
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Acetaminophen- 13C2, 15N is the 13C and 15N labeled Acetaminophen[1]. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM;is a widely used antipyretic and analgesic agent[2][3][4]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[5].
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- HY-107372S
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UTP-<sup>13sup>C<sub>9sub>,<sup>15sup>N<sub>2sub> sodium; Uridine 5'-triphosphate-<sup>13sup>C<sub>9sub>,<sup>15sup>N<sub>2sub> sodium
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DNA/RNA Synthesis
Nucleoside Antimetabolite/Analog
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Infection
Cancer
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Uridine triphosphate- 13C9, 15N2 (sodium) is a labeled Uridine triphosphate sodium. Uridine triphosphate sodium can be used in nucleic acid synthesis.
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-
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- HY-118560S
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NSC 6598-<sup>13sup>C<sub>2sub>; Herbaflorat-<sup>13sup>C<sub>2sub>; Greenyl acetate-<sup>13sup>C<sub>2sub>; Verdyl acetate-<sup>13sup>C<sub>2sub>
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Isotope-Labeled Compounds
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Others
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Tricyclodecenyl acetate- 13C2 is 13C labeled 2-Acetylthiazole.
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-
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- HY-W011240S1
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Methforylthiazidine-<sup>15sup>N<sub>2sub>,<sup>13sup>C,d<sub>2sub>; Rontyl-<sup>15sup>N<sub>2sub>,<sup>13sup>C,d<sub>2sub>
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Isotope-Labeled Compounds
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Others
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Hydroflumethiazide- 15N2, 13C,d2 is the 13C- and 15N-labeled Hydroflumethiazide[1].
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-
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- HY-B0152S2
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6-Aminopurine-<sup>13sup>C<sub>5sub>,<sup>15sup>N<sub>5sub>; Vitamin B4-<sup>13sup>C<sub>5sub>,<sup>15sup>N<sub>5sub>
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Isotope-Labeled Compounds
DNA/RNA Synthesis
Endogenous Metabolite
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Cancer
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Adenine- 13C5,15C5 (6-Aminopurine- 13C5,15C5; Vitamin B4- 13C5,15C5) is 13C-labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
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-
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- HY-B0456S
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Vitamin B2-<sup>13sup>C<sub>4sub>,<sup>15sup>N<sub>2sub>; E101-<sup>13sup>C<sub>4sub>,<sup>15sup>N<sub>2sub>
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Isotope-Labeled Compounds
Endogenous Metabolite
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Others
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Riboflavin- 13C4, 15N2is the 13C-labeled and 15N-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
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-
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- HY-Y0219S
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s-Triazole<sup>13sup>C<sub>2sub>,<sup>15sup>N<sub>3sub>; Pyrrodiazole<sup>13sup>C<sub>2sub>,<sup>15sup>N<sub>3sub>
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Isotope-Labeled Compounds
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Others
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NSC 83128- 13C2, 15N3 is the 13C and 15N labeled NSC 83128[1].
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-
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- HY-B0389S14
-
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Glucose-<sup>13sup>C<sub>2sub>; D-(+)-Glucose-<sup>13sup>C<sub>2sub>; Dextrose-<sup>13sup>C<sub>2sub>
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Endogenous Metabolite
|
Metabolic Disease
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D-Glucose- 13C2 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
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- HY-W653970
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-
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- HY-B0375S1
-
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MD-805-<sup>13sup>C<sub>6sub> hydrochloride; MCI-9038-<sup>13sup>C<sub>6sub> hydrochloride; Argipidine-<sup>13sup>C<sub>6sub> hydrochloride
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Thrombin
Isotope-Labeled Compounds
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Cardiovascular Disease
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Argatroban- 13C6 hydrochloride is 13C labeled Argatroban (HY-B0375). Argatroban (MD-805) is a direct, selective thrombin inhibitor.
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-
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- HY-66005S3
-
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Paracetamol-<sup>13sup>C<sub>6sub>; 4-Acetamidophenol-<sup>13sup>C<sub>6sub>; 4'-Hydroxyacetanilide-<sup>13sup>C<sub>6sub>
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Isotope-Labeled Compounds
COX
Histone Acetyltransferase
Endogenous Metabolite
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Inflammation/Immunology
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Acetaminophen-13C6 (Paracetamol-13C6) is the 13C-labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .
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-
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- HY-W779019
-
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D-(+)-Xylose-<sup>13sup>C<sub>5sub>; (+)-Xylose-<sup>13sup>C<sub>5sub>; Wood sugar-<sup>13sup>C<sub>5sub>
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Isotope-Labeled Compounds
Endogenous Metabolite
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Metabolic Disease
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Xylose- 13C5 (D-(+)-Xylose- 13C5) is 13C labeled Xylose. Xylose (D-(+)-Xylose) is a natural pentose sugar that is catalyzed by xylose isomerase to form xylulose, which is a key step in the anaerobic ethanol fermentation of Xylose. Xylose can be used by microorganisms to produce fuels, chemicals, and bulk industrial enzymes. Xylose provides the substances and energy for cells, as a carbon source for the biosynthesis of high-value chemicals and biofuel. Xylose can be used to fully explore lignocellulose resources and provide a new direction for microbia fermentation .
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- HY-13458S2
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L-DOPS-<sup>13sup>C<sub>6sub>; DOPS-<sup>13sup>C<sub>6sub>; SM5688-<sup>13sup>C<sub>6sub>
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Isotope-Labeled Compounds
Adrenergic Receptor
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Cardiovascular Disease
Neurological Disease
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Droxidopa- 13C6 (L-DOPS- 13C6) is 13C labeled Droxidopa. Droxidopa (L-DOPS; SM5688) is a potent, orally active norepinephrine precursor. Droxidopa increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder) .
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- HY-10572S1
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-
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- HY-B0389A
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Glucose-<sup>13sup>C<sub>6sub>; D-(+)-Glucose-<sup>13sup>C<sub>6sub>; Dextrose-<sup>13sup>C<sub>6sub>
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Endogenous Metabolite
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Others
Metabolic Disease
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D-Glucose- 13C6 is a stable isotope-labeled counterpart of D-glucose (HY-B0389). D-Glucose- 13C6 can be used as a metabolic tracer to trace glucose-related synthetic catabolism or as synthesis ingredient, minimal media reagent, and internal standard .
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- HY-Y1250S6
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Fmoc glycine-<sup>13sup>C<sub>2sub>,<sup>15sup>N; N-(9-Fluorenylmethoxycarbonyl)glycine-<sup>13sup>C<sub>2sub>,<sup>15sup>N; N-Fluorenylmethoxycarbonylglycine-<sup>13sup>C<sub>2sub>,<sup>15sup>N; NPC 14692-<sup>13sup>C<sub>2sub>-<sup>15sup>N; NSC 334288-<sup>13sup>C<sub>2sub>,<sup>15sup>N; [[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]acetic acid-<sup>13sup>C<sub>2sub>,<sup>15sup>N
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Isotope-Labeled Compounds
Influenza Virus
Bacterial
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Infection
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Fmoc-Gly-OH- 13C2, 15N is a 15N-labeled and 13C-labled Crystal Violet. Crystal violet (Basic Violet 3) is a triarylmethane dye. Crystal Violet (Gentian Violet) has antiviral effects against H1N1 and also has prominent bactericidal activities.
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-
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- HY-150712S
-
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UTP-<sup>13sup>C<sub>9sub>,<sup>15sup>N<sub>2sub> dilithium; Uridine 5'-triphosphate-<sup>13sup>C<sub>9sub>,<sup>15sup>N<sub>2sub> dilithium
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Isotope-Labeled Compounds
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Others
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Uridine triphosphate- 13C9, 15N5 dilithium is the 13C and 15N labeled Uridine triphosphate dilithium .
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-
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- HY-B0141S4
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β-Estradiol-<sup>13sup>C<sub>6sub>; E2-<sup>13sup>C<sub>6sub>; 17β-Estradiol-<sup>13sup>C<sub>6sub>; 17β-Oestradiol-<sup>13sup>C<sub>6sub>
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Isotope-Labeled Compounds
Estrogen Receptor/ERR
Endogenous Metabolite
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Endocrinology
Cancer
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Estradiol- 13C6 is the 13C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].
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- HY-B0141S5
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β-Estradiol-<sup>13sup>C<sub>2sub>; E2-<sup>13sup>C<sub>2sub>; 17β-Estradiol-<sup>13sup>C<sub>2sub>; 17β-Oestradiol-<sup>13sup>C<sub>2sub>
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Isotope-Labeled Compounds
Estrogen Receptor/ERR
Endogenous Metabolite
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Endocrinology
Cancer
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Estradiol- 13C2 is the 13C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].
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-
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- HY-N0650S3
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(-)-Serine-<sup>13sup>C<sub>3sub>,<sup>15sup>N,d<sub>3sub>; (S)-Serine-<sup>13sup>C<sub>3sub>,<sup>15sup>N,d<sub>3sub>
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Isotope-Labeled Compounds
Endogenous Metabolite
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Cancer
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L-Serine- 13C3, 15N,d3 is the deuterium, 13C-, and 15-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
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-
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- HY-16973S
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A1443-<sup>13sup>C<sub>2sub>,<sup>15sup>N,d<sub>3sub>; AH252723-<sup>13sup>C<sub>2sub>,<sup>15sup>N,d<sub>3sub>
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Isotope-Labeled Compounds
Parasite
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Infection
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Fluralaner- 13C2, 15N,d3 is the deuterium, 13C-, and 15-labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.
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-
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- HY-W067028S
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Aminourea-<sup>13sup>C,<sup>15sup>N<sub>2sub> hydrochloride; Hydrazinecarboxamide-<sup>13sup>C,<sup>15sup>N<sub>2sub> hydrochloride
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Isotope-Labeled Compounds
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Others
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Semicarbazide- 13C, 15N2 hydrochloride is 15N and 13C labeled Semicarbazide.
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-
-
- HY-13578S
-
|
Bromovinyldeoxyuridine-<sup>13sup>C,<sup>15sup>N<sub>2sub>; BVDU-<sup>13sup>C,<sup>15sup>N<sub>2sub>
|
Isotope-Labeled Compounds
CMV
|
Infection
Cancer
|
|
Brivudine- 13C, 15N2 (Bromovinyldeoxyuridine- 13C, 15N2) is 13C and 15N labeled Brivudine. Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster.
|
-
-
- HY-D0184S5
-
|
Deoxycytidine-<sup>13sup>C<sub>9sub>; Cytosine deoxyriboside-<sup>13sup>C<sub>9sub>; Deoxyribose cytidine-<sup>13sup>C<sub>9sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
2'-Deoxycytidine- 13C9 (Deoxycytidine- 13C9; Cytosine deoxyriboside- 13C9; Deoxyribose cytidine- 13C9) is 13C-labeled 2'-Deoxycytidine (HY-D0184). 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu).
|
-
-
- HY-D0184S2
-
|
Deoxycytidine-<sup>15sup>N<sub>3sub>; Cytosine deoxyriboside-<sup>15sup>N<sub>3sub>; Deoxyribose cytidine-<sup>15sup>N<sub>3sub>
|
Endogenous Metabolite
|
Others
|
|
2'-Deoxycytidine- 15N3 is the 15N labeled 2'-Deoxycytidine[1]. 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu)[2].
|
-
-
- HY-12008S1
-
|
CP-358774-<sup>13sup>C<sub>6sub> hydrochloride; NSC 718781-<sup>13sup>C<sub>6sub> hydrochloride; OSI-774-<sup>13sup>C<sub>6sub> hydrochloride
|
EGFR
Autophagy
|
Cancer
|
|
Erlotinib- 13C6 (hydrochloride) is the 13C labeled Erlotinib Hydrochloride[1]. Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM[2]. Erlotinib-13C6 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
-
- HY-15027S2
-
|
Mesalamine-<sup>13sup>C<sub>6sub>; 5-ASA-<sup>13sup>C<sub>6sub>; Mesalazine-<sup>13sup>C<sub>6sub>
|
PPAR
PAK
NF-κB
Endogenous Metabolite
|
Inflammation/Immunology
|
|
5-Aminosalicylic acid- 13C6 is the 13C labeled 5-Aminosalicylic Acid[1]. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[2][3][4].
|
-
-
- HY-B0083S1
-
-
-
- HY-14740S2
-
|
GS-9137-<sup>13sup>C<sub>6sub> ; JTK-303-<sup>13sup>C<sub>6sub> ; D06677-<sup>13sup>C<sub>6sub>
|
Isotope-Labeled Compounds
HIV Integrase
HIV
|
Infection
|
|
Elvitegravir- 13C6 (GS-9137- 13C6) is 13C labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.
|
-
-
- HY-143704S
-
|
Mesalamine-<sup>13sup>C<sub>6sub> hydrochloride; 5-ASA-<sup>13sup>C<sub>6sub> hydrochloride; Mesalazine-<sup>13sup>C<sub>6sub> hydrochloride
|
PPAR
NF-κB
PAK
|
Metabolic Disease
|
|
5-Aminosalicylic acid-13C6 hydrochloride?(Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride) is the 13C labeled 5-Aminosalicylic Acidhydrochloride. 5-Aminosalicylic acid-13C6 hydrochloride?acts as a PPARγ agonist, and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .
|
-
-
- HY-10574S1
-
|
R278474-<sup>13sup>C<sub>6sub>; TMC278-<sup>13sup>C<sub>6sub>; DB08864-<sup>13sup>C<sub>6sub>
|
Isotope-Labeled Compounds
HIV
Reverse Transcriptase
|
Infection
|
|
Rilpivirine- 13C6 (R278474- 13C6) is 13C labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .
|
-
- HY-50896S1
-
|
CP-358774-<sup>13sup>C<sub>6sub>; NSC 718781-<sup>13sup>C<sub>6sub>; OSI-774-<sup>13sup>C<sub>6sub>
|
Isotope-Labeled Compounds
EGFR
Autophagy
|
Cancer
|
|
Erlotinib- 13C6 is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1].
|
-
- HY-10392S
-
|
PNU-100480-<sup>13sup>C<sub>4sub>; U-100480-<sup>13sup>C<sub>4sub>; PF-02341272-<sup>13sup>C<sub>4sub>
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Infection
|
|
Sutezolid- 13C4 (PNU-100480- 13C4) is 13C labeled Sutezolid. Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis .
|
-
- HY-A0070AS1
-
|
Triiodothyronine-<sup>13sup>C<sub>9sub>,<sup>15sup>N; 3,3',5-Triiodo-L-thyronine-<sup>13sup>C<sub>9sub>,<sup>15sup>N; T3-<sup>13sup>C<sub>9sub>,<sup>15sup>N
|
Thyroid Hormone Receptor
Endogenous Metabolite
|
Cancer
|
|
Liothyronine- 13C9, 15N is the 13C and 15N labeled Liothyronine[1]. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[2][3][4].
|
-
- HY-B0035S2
-
-
- HY-A0253S
-
-
- HY-Y0271S
-
|
Carbamide-<sup>15sup>N<sub>2sub>; Carbonyldiamide-<sup>15sup>N<sub>2sub>
|
Endogenous Metabolite
|
Cardiovascular Disease
Cancer
|
|
Urea- 15N2 is the 15N-labeled Urea. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
|
-
- HY-N1150S9
-
|
DThyd-<sup>15sup>N<sub>2sub>; NSC-<sup>15sup>N<sub>2sub>
|
DNA/RNA Synthesis
Endogenous Metabolite
Orthopoxvirus
|
Cancer
|
|
Thymidine- 15N2 is the 15N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].
|
-
- HY-13417S
-
|
Acadesine-<sup>13sup>C<sub>2sub>,<sup>15sup>N; AICA Riboside-<sup>13sup>C<sub>2sub>,<sup>15sup>N
|
Isotope-Labeled Compounds
Endogenous Metabolite
YAP
AMPK
Mitophagy
Autophagy
|
Others
|
|
AICAR- 13C2, 15N (Acadesine- 13C2, 15N; AICA Riboside- 13C2, 15N) is the 13C and 15N labeled AICAR (HY-13417) . AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor .
|
-
- HY-B0150S1
-
|
Niacinamide-<sup>15sup>N,<sup>13sup>C<sub>3sub>; Nicotinic acid amide-<sup>15sup>N,<sup>13sup>C<sub>3sub>
|
Endogenous Metabolite
Sirtuin
|
Neurological Disease
Cancer
|
|
Nicotinamide- 15N, 13C3 is the 13C-labeled and 15N-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
|
-
- HY-40354S1
-
|
Tasocitinib-<sup>13sup>C<sub>3sub>,<sup>15sup>N; CP-690550-<sup>13sup>C<sub>3sub>,<sup>15sup>N
|
Isotope-Labeled Compounds
JAK
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Tofacitinib- 13C3, 15N (Tasocitinib- 13C3, 15N) is 13C and 15N labeled Tofacitinib. Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively.
|
-
- HY-W778058
-
|
DL-Guanosine-<sup>13sup>C,<sup>15sup>N<sub>2sub>; Vernine-<sup>13sup>C,<sup>15sup>N<sub>2sub>
|
Isotope-Labeled Compounds
|
Others
|
|
Guanosine- 13C, 15N2 (DL-Guanosine- 13C, 15N2) is 13C and 15N labeled Guanosine .
|
-
- HY-N0733S5
-
-
- HY-B0139AS
-
|
5-Fluorocytosine-<sup>15sup>N<sub>3sub> hydrochloride; NSC 103805-<sup>15sup>N<sub>3sub> hydrochloride; Ro 2-9915-<sup>15sup>N<sub>3sub> hydrochloride
|
Isotope-Labeled Compounds
|
Others
|
|
Flucytosine- 15N3 hydrochloride is 15N labeled Flucytosine.
|
-
- HY-17413S1
-
|
Azidothymidine-<sup>13sup>C,d<sub>3sub>; AZT-<sup>13sup>C,d<sub>3sub>; ZDV-<sup>13sup>C,d<sub>3sub>
|
Isotope-Labeled Compounds
HIV
CRISPR/Cas9
|
Infection
Cancer
|
|
Zidovudine- 13C,d3 is the 13C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.
|
-
- HY-B0511S3
-
|
Vitamin B7-<sup>13sup>C<sub>5sub>; Vitamin H-<sup>13sup>C<sub>5sub>; D-Biotin-<sup>13sup>C<sub>5sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Biotin- 13C5 (Vitamin B7- 13C5) is 13C labeled Biotin. Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .
|
-
- HY-106950S1
-
|
Diphosphofructose-<sup>13sup>C<sub>6sub> tetrasodium hydrate; Esafosfan-<sup>13sup>C<sub>6sub> tetrasodium hydrate; FDP-<sup>13sup>C<sub>6sub> tetrasodium hydrate
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Fosfructose- 13C6 (tetrasodium hydrate) is the 13C labeled Fosfructose (HY-106950). Fosfructose is a cytoprotective natural sugar phosphate for the potential treatment of cardiovascular ischemia, sickle cell anemia and asthma[1].
|
-
- HY-B1290S3
-
|
Phenylethyl alcohol-<sup>13sup>C<sub>2sub>; Phenethyl alcohol-<sup>13sup>C<sub>2sub>; Benzyl carbinol-<sup>13sup>C<sub>2sub>
|
Bacterial
Virus Protease
Isotope-Labeled Compounds
|
Infection
|
|
2-Phenylethanol- 13C2 is 13C labeled β-Caryophyllene (HY-B1290). β-Caryophyllene is a CB2 receptor agonist.
|
-
- HY-B1431S1
-
|
Butyl parahydroxybenzoate-<sup>13sup>C<sub>6sub>; Butyl paraben-<sup>13sup>C<sub>6sub>; Butyl 4-hydroxybenzoate-<sup>13sup>C<sub>6sub>
|
Bacterial
Endogenous Metabolite
|
Infection
|
|
Butylparaben- 13C6 is the 13C labeled Butylparaben[1]. Butylparaben is an organic compound, has proven to be a highly successful antimicrobial preservative in cosmetics, also used in medication suspensions, and as a flavoring additive in food.
|
-
- HY-B0456S1
-
|
Vitamin B2-<sup>13sup>C<sub>4sub>,<sup>15sup>N<sub>2sub>-1; E101-<sup>13sup>C<sub>4sub>,<sup>15sup>N<sub>2sub>-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Riboflavin-5-Phosphate- 13C4, 15N2-1 is the 13C-labeled and 15N-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
|
-
- HY-101400S2
-
|
dCTP-<sup>13sup>C<sub>9sub>,<sup>15sup>N<sub>3sub> dilithium; 2′-Deoxycytidine-5′-triphosphate-<sup>13sup>C<sub>9sub>,<sup>15sup>N<sub>3sub> dilithium
|
Isotope-Labeled Compounds
Nucleoside Antimetabolite/Analog
DNA/RNA Synthesis
Endogenous Metabolite
|
Metabolic Disease
|
|
Deoxycytidine triphosphate- 13C9, 15N3 (dCTP- 13C9, 15N3 dilithium; 2′-Deoxycytidine-5′-triphosphate- 13C9, 15N3) dilithium is 13C and 15N-labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
|
-
- HY-W009162S5
-
|
5'-Cytidylic acid-<sup>13sup>C<sub>9sub>,<sup>15sup>N<sub>3sub> dilithium; 5'-CMP-<sup>13sup>C<sub>9sub>,<sup>15sup>N<sub>3sub> dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Cytidine 5′-monophosphate- 13C9, 15N3 (5'-Cytidylic acid- 13C9, 15N3 dilithium; 5'-CMP- 13C9, 15N3) dilithium is 13C and 15N-labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
|
-
- HY-B0158S5
-
|
Cytosine β-D-riboside-<sup>13sup>C<sub>9sub>,<sup>15sup>N<sub>3sub>; Cytosine-1-β-D-ribofuranoside-<sup>13sup>C<sub>9sub>,<sup>15sup>N<sub>3sub>
|
Nucleoside Antimetabolite/Analog
Endogenous Metabolite
|
Neurological Disease
|
|
Cytidine- 13C9, 15N3 is the 13C and 15N labeled Cytidine[1]. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function[2][3][4].
|
-
- HY-N5134S5
-
|
5'-GMP-<sup>13sup>C<sub>10sub>,<sup>15sup>N<sub>5sub> dilithium; 5'-guanosine monophosphate-<sup>13sup>C<sub>10sub>,<sup>15sup>N<sub>5sub> dilithium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
5'-Guanylic acid- 13C10, 15N5 (5'-GMP- 13C10, 15N5 dilithium; 5'-guanosine monophosphate- 13C10, 15N5) dilithium is 13C and 15N-labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.
|
-
- HY-B0579S3
-
|
Cyclosporine A-<sup>13sup>C<sub>2sub>,d<sub>4sub>; Ciclosporin A-<sup>13sup>C<sub>2sub>,d<sub>4sub>; CsA-<sup>13sup>C<sub>2sub>,d<sub>4sub>
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
Cyclosporin A- 13C2,d4 (Cyclosporine A- 13C2,d4; Ciclosporin A- 13C2,d4) is a 13C labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .
|
-
- HY-B0389S
-
-
- HY-B0389S22
-
|
Glucose-<sup>13sup>C<sub>2sub>,d<sub>2sub>; D-(+)-Glucose-<sup>13sup>C<sub>2sub>,d<sub>2sub>; Dextrose-<sup>13sup>C<sub>2sub>,d<sub>2sub>
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
D-Glucose- 13C2,d2 is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical si
|
-
- HY-B0139S
-
|
5-Fluorocytosine-<sup>13sup>C,15sup>N<sub>2sub>; NSC 103805-<sup>13sup>C,15sup>N<sub>2sub>; Ro 2-9915-<sup>13sup>C,15sup>N<sub>2sub>
|
Isotope-Labeled Compounds
Antibiotic
Fungal
|
Infection
|
|
Flucytosine- 13C, 15N2 (NSC 103805- 13C, 15N2; Ro 2-9915- 13C, 15N2) is a 13C- and 15N-labeled Flucytosine (HY-B0139).
|
-
- HY-13623S1
-
|
BMS200475-<sup>13sup>C<sub>2sub>,<sup>15sup>N; SQ34676-<sup>13sup>C<sub>2sub>,<sup>15sup>N
|
Isotope-Labeled Compounds
HBV
|
Infection
|
|
Entecavir- 13C2, 15N (BMS200475- 13C2, 15N; SQ34676- 13C2, 15N) is a 13C- and 15N-labeled Entecavir (HY-13623). Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.
|
-
- HY-B0178AS
-
|
Guanidinium-<sup>13sup>C,<sup>15sup>N<sub>3sub> (chloride); Aminoformamidine-<sup>13sup>C,<sup>15sup>N<sub>3sub> (hydrochloride)
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Guanidine- 13C, 15N3 (hydrochloride)is the 13C-labeled and 15N-labeled Guanidine hydrochloride. Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins[1][2].
|
-
- HY-N0650S5
-
|
(-)-Serine-<sup>13sup>C<sub>3sub>,<sup>15sup>N; (S)-Serine-<sup>13sup>C<sub>3sub>,<sup>15sup>N
|
Endogenous Metabolite
|
Cancer
|
|
L-Serine- 13C3, 15N is the 13C- and 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
|
-
- HY-B1473S1
-
|
5-Hydroxytryptamine-<sup>13sup>C<sub>2sub>,<sup>15sup>N hydrochloride; 5-HT-<sup>13sup>C<sub>2sub>,<sup>15sup>N hydrochloride
|
Isotope-Labeled Compounds
5-HT Receptor
COMT
Endogenous Metabolite
|
Neurological Disease
|
|
Serotonin- 13C2, 15N hydrochloride is the 13C- and 15N-labeled Serotonin hydrochloride (HY-B1473). Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM .
|
-
- HY-N0091S1
-
|
Purin-6-o-<sup>13sup>C,<sup>15sup>N<sub>2sub>; Sarcine-<sup>13sup>C,<sup>15sup>N<sub>2sub>
|
Bacterial
|
Infection
|
|
Hypoxanthine- 13C, 15N2 is a 15N-labeled and 13C-labled Furaltadone. Furaltadone, a nitrofuran agent, has the potential for the study in infections of chickens with salmonella enteritidis. Furaltadone is inhibitory and bactericidal in vitro for staphylococci
|
-
- HY-N0091S3
-
-
- HY-B0136S
-
|
FK-482-<sup>13sup>C,<sup>15sup>N<sub>2sub>; CI-983-<sup>13sup>C,<sup>15sup>N<sub>2sub>
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Infection
|
|
Cefdinir- 13C, 15N2 (FK-482- 13C, 15N2) is 13C and 15N labeled Cefdinir. Cefdinir (FK-482) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, which is proved to be effective for infections caused by several Gram-negative and Gram-positive bacteria. Cefdinir can be used for the research of common bacterial infections of the ear, sinus, throat, and skin .
|
-
- HY-14164S1
-
-
- HY-B0495S8
-
|
LTG-<sup>13sup>C<sub>7sub>,<sup>15sup>N; BW430C-<sup>13sup>C<sub>7sub>,<sup>15sup>N
|
Isotope-Labeled Compounds
Autophagy
Sodium Channel
|
Neurological Disease
Cancer
|
|
Lamotrigine- 13C7, 15N (LTG- 13C7, 15N) is 13C and 15N labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na + channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy,?focal seizure, et al .
|
-
- HY-13677S1
-
|
Mercaptopurine-<sup>13sup>C<sub>2sub>,<sup>15sup>N; 6-MP-<sup>13sup>C<sub>2sub>,<sup>15sup>N
|
Nucleoside Antimetabolite/Analog
Autophagy
Endogenous Metabolite
|
Cancer
|
|
6-Mercaptopurine- 13C2, 15N is the 13C- and 15N-labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.
|
-
- HY-Y0721S
-
|
m-Bromofluorobenzene-<sup>13sup>C<sub>6sub>; m-Fluorobromobenzene-<sup>13sup>C<sub>6sub>; m-Fluorophenyl bromide-<sup>13sup>C<sub>6sub>
|
Isotope-Labeled Compounds
|
Others
|
|
3-Bromofluorobenzene- 13C6 is the 13C labeled 3-Bromofluorobenzene[1].
|
-
- HY-N0055S
-
|
3-O-Caffeoylquinic acid-<sub>13sub>C<sup>3sup>; Heriguard-<sub>13sub>C<sup>3sup>; NSC-407296-<sub>13sub>C<sup>3sup>
|
Isotope-Labeled Compounds
|
Cancer
|
|
Chlorogenic acid- 13C3 (Heriguard- 13C3; NSC-407296- 13C3) is 13C- and 15N-labeled Chlorogenic acid (HY-N0055). Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb.. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension .
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-
- HY-W010450S5
-
|
5-Methyluacil-<sup>13sup>C<sub>5sub>,<sup>15sup>N,<sup>15sup>N<sub>2sub>
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
Thymine- 13C5, 15N2 (5-Methyluacil- 13C5, 15N2) is 13C and 15N labeled Thymine. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM .
|
-
- HY-N1150S11
-
|
DThyd-<sup>13sup>C<sub>10sub>; NSC 21548-<sup>13sup>C<sub>10sub>
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Endogenous Metabolite
Orthopoxvirus
|
Cancer
|
|
Thymidine- 13C10 (DThyd- 13C10; NSC 21548- 13C10) is 13C-labeled Thymidine (HY-N1150). Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.
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-
- HY-B0234S
-
|
E1-<sup>13sup>C<sub>3sub>; Oestrone-<sup>13sup>C<sub>3sub>
|
Estrogen Receptor/ERR
Endogenous Metabolite
|
Endocrinology
Cancer
|
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Estrone- 13C3 is the 13C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
|
-
- HY-W653853
-
|
ABT 538-<sup>13sup>C<sub>3sub>; RTV-<sup>13sup>C<sub>3sub>
|
Isotope-Labeled Compounds
Apoptosis
SARS-CoV
HIV Protease
HIV
|
Cancer
|
|
Ritonavir- 13C3 is 13C labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.61 μM .
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-
- HY-N0378S2
-
|
Mannitol-<sup>13sup>C<sub>6sub>; Mannite-<sup>13sup>C<sub>6sub>
|
Apoptosis
Endogenous Metabolite
|
Metabolic Disease
|
|
D-Mannitol- 13C6 is the 13C labeled D-Mannitol[1]. D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator[2][3][4].
|
-
- HY-N0097S3
-
|
DL-Guanosine-<sup>15sup>N<sub>5sub>; Vernine-<sup>15sup>N<sub>5sub>
|
HSV
Endogenous Metabolite
|
Infection
|
|
Guanosine- 15N5 is the 15N labeled Guanosine[1]. Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity[2].
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-
- HY-B0150S2
-
|
Niacinamide-<sup>13sup>C<sub>6sub>; Nicotinic acid amide-<sup>13sup>C<sub>6sub>
|
Endogenous Metabolite
Sirtuin
|
Neurological Disease
Cancer
|
|
Nicotinamide- 13C6 is the 13C-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
|
-
- HY-W779017
-
-
- HY-N0623S2
-
-
- HY-B0213S1
-
|
Sulfametoxydiazine-<sup>13sup>C<sub>6sub>; 5-Methoxysulfadiazine-<sup>13sup>C<sub>6sub>
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Infection
|
|
Sulfameter- 13C6 is the 13C6 labeled Sulfameter. Sulfameter (Sulfametoxydiazine; 5-Methoxysulfadiazine) is an effective long-acting sulfonamide antibiotic with antibacterial activities. Sulfameter can be used for the research of urinary tract infections and lepriasis.
|
-
- HY-100196S1
-
|
PQQ-<sup>13sup>C<sub>3sub> sodium; Methoxatin-<sup>13sup>C<sub>3sub> sodium
|
Endogenous Metabolite
|
Inflammation/Immunology
|
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Pyrroloquinoline quinone-13C3 (sodium) is an isotope of Pyrroloquinoline quinone. Pyrroloquinoline quinone (PQQ), a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function .
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-
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-D0184S3
-
|
|
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2'-Deoxycytidine- 13C9, 15N3 (Deoxycytidine- 13C9, 15N3; Cytosine deoxyriboside- 13C9, 15N3; Deoxyribose cytidine- 13C9, 15N3) is 13C and 15N-labeled 2'-Deoxycytidine (HY-D0184). 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu).
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-
-
- HY-N1150S8
-
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Thymidine- 13C10, 15N2 is the 13C and 15N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].
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-
-
- HY-N0623S4
-
|
|
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L-Tryptophan- 13C11, 15N2 is the 13C- and 15N-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
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-
-
- HY-N0097S6
-
|
|
|
Guanosine- 13C10, 15N5 is the 13C and 15N labeled Guanosine (HY-N0097). Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity .
|
-
-
- HY-108213S
-
|
|
|
Inosinic acid- 13C10, 15N4 dilithium (5'-IMP-13C10,15N4 (dilithium); IMP-13C10,15N4 (dilithium); Inosine 5'-(dihydrogen phosphate)-13C10,15N4 (dilithium)) is 13C- and 15N-labeled Inosinic acid (HY-108213). Inosinic acid is an endogenous metabolite .
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-
-
- HY-D0844S
-
|
|
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Glutathione oxidized- 13C4, 15N2 is the 13C and 15N labeled Glutathione oxidized (HY-D0844). Glutathione oxidized is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of glutathione oxidized. Glutathione oxidized can be used for the research of sickle cells and erythrocytes .
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-
-
- HY-13599S1
-
|
|
|
Cladribine- 13C5, 15N2 (2-Chloro-2′-deoxyadenosine- 13C5, 15N2) is 13C and 15N labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis .
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-
-
- HY-A0061S
-
|
|
|
Trifluridine- 13C, 15N2 is the 13C and 15N labeled Trifluridine[1]. Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity[2].
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-
-
- HY-110382S
-
|
|
|
13C20, 15N10-Cyclic di-GMP ( 13C20, 15N10-c-di-GMP) is 13C and 15N labeled Cyclic-di-GMP (disodium). Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research .
|
-
-
- HY-B1118S1
-
|
|
|
Secnidazole- 13C2, 15N2 is the 13C2, 15N2 labeled Secnidazole. Secnidazole (RP-14539;PM-185184) is an orally active azole antibiotic with a longer half-life than metronidazole (HY-B0318). Secnidazole is against the vaginosis-associated bacteria and has the potential for bacterial vaginosis research.
|
-
-
- HY-N0091S
-
|
|
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Hypoxanthine- 13C5, 15N4 is a 15N-labeled and 13C-labled Dansyl chloride.
|
-
-
- HY-17563S1
-
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|
|
2'-Deoxyguanosine- 13C10, 15N5 (Deoxyguanosine- 13C10, 15N5; Guanine deoxyriboside- 13C10, 15N5) is a 13C- and 15N-labeled 2'-Deoxyguanosine (HY-17563).
|
-
-
- HY-N0001S2
-
|
|
|
(-)-Epicatechin- 13C3 ((-)-Epicatechol- 13C3) is 13C labeled (-)-Epicatechin. (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.
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-
-
- HY-A0161S
-
|
|
|
Chlophedianol- 13C6 is the 13C labeled Chlophedianol (HY-A0161). Chlophedianol is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs)[1][2][3].
|
-
-
- HY-N0667S2
-
|
|
|
L-Asparagine- 15N2 (monohydrate) is the 15N-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.
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-
-
- HY-N0667S3
-
|
|
|
L-Asparagine- 13C4 (monohydrate) is the 13C-labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.
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-
-
- HY-N0898S
-
|
|
|
Catechin- 13C3 is the 13C-labeled Catechin. Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
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-
-
- HY-D0184S6
-
|
|
|
2'-Deoxycytidine- 13C, 15N3 (Deoxycytidine- 13C, 15N3) is 13C and 15N labeled 2'-Deoxycytidine. 2'-Deoxycytidine, a deoxyribonucleoside, can inhibit biological effects of Bromodeoxyuridine (Brdu). 2'-Deoxycytidine is essential for the synthesis of nucleic acids, that can be used for the research of cancer .
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-
-
- HY-13458S1
-
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|
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Droxidopa- 13C2, 15N (hydrochloride) is deuterium labeled Droxidopa. Droxidopa(L-DOPS), the mixture of Droxidopa (w/w80%) and Pharmaceutical starch (w/w20%), acts as a proagent to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); Droxidopa(L-DOPS) is capable of crossing the protective blood-brain barrier .
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-
-
- HY-66005S4
-
|
|
|
Acetaminophen- 13C2, 15N is the 13C and 15N labeled Acetaminophen[1]. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM;is a widely used antipyretic and analgesic agent[2][3][4]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[5].
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-
-
- HY-107372S
-
|
|
|
Uridine triphosphate- 13C9, 15N2 (sodium) is a labeled Uridine triphosphate sodium. Uridine triphosphate sodium can be used in nucleic acid synthesis.
|
-
-
- HY-118560S
-
|
|
|
Tricyclodecenyl acetate- 13C2 is 13C labeled 2-Acetylthiazole.
|
-
-
- HY-W011240S1
-
|
|
|
Hydroflumethiazide- 15N2, 13C,d2 is the 13C- and 15N-labeled Hydroflumethiazide[1].
|
-
-
- HY-B0152S2
-
|
|
|
Adenine- 13C5,15C5 (6-Aminopurine- 13C5,15C5; Vitamin B4- 13C5,15C5) is 13C-labeled Adenine (HY-B0152). Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
|
-
-
- HY-B0456S
-
|
|
|
Riboflavin- 13C4, 15N2is the 13C-labeled and 15N-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
|
-
-
- HY-Y0219S
-
|
|
|
NSC 83128- 13C2, 15N3 is the 13C and 15N labeled NSC 83128[1].
|
-
-
- HY-B0389S14
-
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|
|
D-Glucose- 13C2 is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
|
-
-
- HY-W653970
-
|
|
|
5-Azacytidine- 15N4 is 13C and 15N labeled 5-Azacytidine. 5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes. 5-Azacytidine induces cell autophagy .
|
-
-
- HY-B0375S1
-
|
|
|
Argatroban- 13C6 hydrochloride is 13C labeled Argatroban (HY-B0375). Argatroban (MD-805) is a direct, selective thrombin inhibitor.
|
-
-
- HY-66005S3
-
|
|
|
Acetaminophen-13C6 (Paracetamol-13C6) is the 13C-labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .
|
-
-
- HY-W779019
-
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|
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Xylose- 13C5 (D-(+)-Xylose- 13C5) is 13C labeled Xylose. Xylose (D-(+)-Xylose) is a natural pentose sugar that is catalyzed by xylose isomerase to form xylulose, which is a key step in the anaerobic ethanol fermentation of Xylose. Xylose can be used by microorganisms to produce fuels, chemicals, and bulk industrial enzymes. Xylose provides the substances and energy for cells, as a carbon source for the biosynthesis of high-value chemicals and biofuel. Xylose can be used to fully explore lignocellulose resources and provide a new direction for microbia fermentation .
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-
-
- HY-13458S2
-
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|
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Droxidopa- 13C6 (L-DOPS- 13C6) is 13C labeled Droxidopa. Droxidopa (L-DOPS; SM5688) is a potent, orally active norepinephrine precursor. Droxidopa increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder) .
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-
-
- HY-10572S1
-
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|
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Efavirenz- 13C6 is the 13C-labeled Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture[1].
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-
-
- HY-B0389A
-
Maximum Cited Publications
6 Publications Verification
|
|
D-Glucose- 13C6 is a stable isotope-labeled counterpart of D-glucose (HY-B0389). D-Glucose- 13C6 can be used as a metabolic tracer to trace glucose-related synthetic catabolism or as synthesis ingredient, minimal media reagent, and internal standard .
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-
-
- HY-Y1250S6
-
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|
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Fmoc-Gly-OH- 13C2, 15N is a 15N-labeled and 13C-labled Crystal Violet. Crystal violet (Basic Violet 3) is a triarylmethane dye. Crystal Violet (Gentian Violet) has antiviral effects against H1N1 and also has prominent bactericidal activities.
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-
-
- HY-150712S
-
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|
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Uridine triphosphate- 13C9, 15N5 dilithium is the 13C and 15N labeled Uridine triphosphate dilithium .
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-
-
- HY-B0141S4
-
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Estradiol- 13C6 is the 13C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].
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-
-
- HY-B0141S5
-
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|
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Estradiol- 13C2 is the 13C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].
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-
-
- HY-N0650S3
-
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L-Serine- 13C3, 15N,d3 is the deuterium, 13C-, and 15-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
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-
-
- HY-16973S
-
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Fluralaner- 13C2, 15N,d3 is the deuterium, 13C-, and 15-labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.
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-
-
- HY-W067028S
-
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Semicarbazide- 13C, 15N2 hydrochloride is 15N and 13C labeled Semicarbazide.
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-
-
- HY-13578S
-
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Brivudine- 13C, 15N2 (Bromovinyldeoxyuridine- 13C, 15N2) is 13C and 15N labeled Brivudine. Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster.
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-
-
- HY-D0184S5
-
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2'-Deoxycytidine- 13C9 (Deoxycytidine- 13C9; Cytosine deoxyriboside- 13C9; Deoxyribose cytidine- 13C9) is 13C-labeled 2'-Deoxycytidine (HY-D0184). 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu).
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-
-
- HY-D0184S2
-
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|
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2'-Deoxycytidine- 15N3 is the 15N labeled 2'-Deoxycytidine[1]. 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu)[2].
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-
-
- HY-12008S1
-
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Erlotinib- 13C6 (hydrochloride) is the 13C labeled Erlotinib Hydrochloride[1]. Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM[2]. Erlotinib-13C6 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
-
- HY-15027S2
-
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5-Aminosalicylic acid- 13C6 is the 13C labeled 5-Aminosalicylic Acid[1]. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[2][3][4].
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-
-
- HY-B0083S1
-
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|
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Leflunomide- 13C6 (HWA486- 13C6) is 13C labeled Leflunomide. Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic agent.
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-
-
- HY-14740S2
-
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Elvitegravir- 13C6 (GS-9137- 13C6) is 13C labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.
|
-
-
- HY-143704S
-
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|
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5-Aminosalicylic acid-13C6 hydrochloride?(Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride) is the 13C labeled 5-Aminosalicylic Acidhydrochloride. 5-Aminosalicylic acid-13C6 hydrochloride?acts as a PPARγ agonist, and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .
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-
-
- HY-10574S1
-
|
|
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Rilpivirine- 13C6 (R278474- 13C6) is 13C labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .
|
-
- HY-50896S1
-
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|
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Erlotinib- 13C6 is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1].
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-
- HY-10392S
-
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Sutezolid- 13C4 (PNU-100480- 13C4) is 13C labeled Sutezolid. Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis .
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-
- HY-A0070AS1
-
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|
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Liothyronine- 13C9, 15N is the 13C and 15N labeled Liothyronine[1]. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[2][3][4].
|
-
- HY-B0035S2
-
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|
|
Sulfamethazine- 13C6 is a 13C-labeled n-Acetyl-s-methyl-l-cysteine[1].
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-
- HY-A0253S
-
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|
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Cefacetrile- 13C3 is the 13C3 labeled Cefacetrile.
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-
- HY-Y0271S
-
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Urea- 15N2 is the 15N-labeled Urea. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
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-
- HY-N1150S9
-
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Thymidine- 15N2 is the 15N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].
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- HY-13417S
-
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|
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AICAR- 13C2, 15N (Acadesine- 13C2, 15N; AICA Riboside- 13C2, 15N) is the 13C and 15N labeled AICAR (HY-13417) . AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy, YAP and mitophagy inhibitor .
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-
- HY-B0150S1
-
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|
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Nicotinamide- 15N, 13C3 is the 13C-labeled and 15N-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
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-
- HY-40354S1
-
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Tofacitinib- 13C3, 15N (Tasocitinib- 13C3, 15N) is 13C and 15N labeled Tofacitinib. Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively.
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- HY-W778058
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Guanosine- 13C, 15N2 (DL-Guanosine- 13C, 15N2) is 13C and 15N labeled Guanosine .
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- HY-N0733S5
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Glucosamine- 13C6, 15N (hydrochloride) is the 13C and 15N labeled Glucosamine hydrochloride. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids,
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- HY-B0139AS
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Flucytosine- 15N3 hydrochloride is 15N labeled Flucytosine.
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- HY-17413S1
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Zidovudine- 13C,d3 is the 13C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.
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- HY-B0511S3
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Biotin- 13C5 (Vitamin B7- 13C5) is 13C labeled Biotin. Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .
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- HY-106950S1
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Fosfructose- 13C6 (tetrasodium hydrate) is the 13C labeled Fosfructose (HY-106950). Fosfructose is a cytoprotective natural sugar phosphate for the potential treatment of cardiovascular ischemia, sickle cell anemia and asthma[1].
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- HY-B1290S3
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2-Phenylethanol- 13C2 is 13C labeled β-Caryophyllene (HY-B1290). β-Caryophyllene is a CB2 receptor agonist.
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- HY-B1431S1
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Butylparaben- 13C6 is the 13C labeled Butylparaben[1]. Butylparaben is an organic compound, has proven to be a highly successful antimicrobial preservative in cosmetics, also used in medication suspensions, and as a flavoring additive in food.
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- HY-B0456S1
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Riboflavin-5-Phosphate- 13C4, 15N2-1 is the 13C-labeled and 15N-labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.
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- HY-101400S2
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Deoxycytidine triphosphate- 13C9, 15N3 (dCTP- 13C9, 15N3 dilithium; 2′-Deoxycytidine-5′-triphosphate- 13C9, 15N3) dilithium is 13C and 15N-labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
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- HY-W009162S5
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Cytidine 5′-monophosphate- 13C9, 15N3 (5'-Cytidylic acid- 13C9, 15N3 dilithium; 5'-CMP- 13C9, 15N3) dilithium is 13C and 15N-labeled Cytidine 5'-monophosphate (HY-W009162). Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group.
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- HY-B0158S5
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Cytidine- 13C9, 15N3 is the 13C and 15N labeled Cytidine[1]. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function[2][3][4].
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- HY-N5134S5
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5'-Guanylic acid- 13C10, 15N5 (5'-GMP- 13C10, 15N5 dilithium; 5'-guanosine monophosphate- 13C10, 15N5) dilithium is 13C and 15N-labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.
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- HY-B0579S3
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Cyclosporin A- 13C2,d4 (Cyclosporine A- 13C2,d4; Ciclosporin A- 13C2,d4) is a 13C labeled Cyclosporin A (HY-B0579) . Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM . Cyclosporin A also inhibits CD11a/CD18 adhesion .
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- HY-B0389S
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D-Glucose- 13C6,d7 is the deuterium and 13C labeled D-Glucose[1].
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- HY-B0389S22
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D-Glucose- 13C2,d2 is the deuterium and 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical si
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- HY-B0139S
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Flucytosine- 13C, 15N2 (NSC 103805- 13C, 15N2; Ro 2-9915- 13C, 15N2) is a 13C- and 15N-labeled Flucytosine (HY-B0139).
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- HY-13623S1
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Entecavir- 13C2, 15N (BMS200475- 13C2, 15N; SQ34676- 13C2, 15N) is a 13C- and 15N-labeled Entecavir (HY-13623). Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.
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- HY-B0178AS
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Guanidine- 13C, 15N3 (hydrochloride)is the 13C-labeled and 15N-labeled Guanidine hydrochloride. Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins[1][2].
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- HY-N0650S5
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L-Serine- 13C3, 15N is the 13C- and 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
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- HY-B1473S1
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Serotonin- 13C2, 15N hydrochloride is the 13C- and 15N-labeled Serotonin hydrochloride (HY-B1473). Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM .
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- HY-N0091S1
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Hypoxanthine- 13C, 15N2 is a 15N-labeled and 13C-labled Furaltadone. Furaltadone, a nitrofuran agent, has the potential for the study in infections of chickens with salmonella enteritidis. Furaltadone is inhibitory and bactericidal in vitro for staphylococci
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- HY-N0091S3
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Hypoxanthine- 13C2, 15N is a 15N-labeled and 13C-labled DL-Cystine[1].
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- HY-B0136S
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Cefdinir- 13C, 15N2 (FK-482- 13C, 15N2) is 13C and 15N labeled Cefdinir. Cefdinir (FK-482) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, which is proved to be effective for infections caused by several Gram-negative and Gram-positive bacteria. Cefdinir can be used for the research of common bacterial infections of the ear, sinus, throat, and skin .
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- HY-14164S1
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Zileuton- 13C2, 15N is 15N and 13C labeled Zileuton (HY-14164). Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.
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- HY-B0495S8
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Lamotrigine- 13C7, 15N (LTG- 13C7, 15N) is 13C and 15N labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na + channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy,?focal seizure, et al .
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- HY-13677S1
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6-Mercaptopurine- 13C2, 15N is the 13C- and 15N-labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.
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- HY-Y0721S
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3-Bromofluorobenzene- 13C6 is the 13C labeled 3-Bromofluorobenzene[1].
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- HY-N0055S
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Chlorogenic acid- 13C3 (Heriguard- 13C3; NSC-407296- 13C3) is 13C- and 15N-labeled Chlorogenic acid (HY-N0055). Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb.. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension .
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- HY-W010450S5
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Thymine- 13C5, 15N2 (5-Methyluacil- 13C5, 15N2) is 13C and 15N labeled Thymine. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM .
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- HY-N1150S11
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Thymidine- 13C10 (DThyd- 13C10; NSC 21548- 13C10) is 13C-labeled Thymidine (HY-N1150). Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.
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- HY-B0234S
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Estrone- 13C3 is the 13C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].
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- HY-W653853
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Ritonavir- 13C3 is 13C labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.61 μM .
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- HY-N0378S2
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D-Mannitol- 13C6 is the 13C labeled D-Mannitol[1]. D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator[2][3][4].
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- HY-N0097S3
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Guanosine- 15N5 is the 15N labeled Guanosine[1]. Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity[2].
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- HY-B0150S2
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Nicotinamide- 13C6 is the 13C-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
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- HY-W779017
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Thymidine- 13C5 (DThyd- 13C5; NSC 21548- 13C5) is 13C-labeled Thymidine (HY-N1150) .
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- HY-N0623S2
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L-Tryptophan- 13C11 is the 13C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3[1].
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- HY-B0213S1
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Sulfameter- 13C6 is the 13C6 labeled Sulfameter. Sulfameter (Sulfametoxydiazine; 5-Methoxysulfadiazine) is an effective long-acting sulfonamide antibiotic with antibacterial activities. Sulfameter can be used for the research of urinary tract infections and lepriasis.
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- HY-100196S1
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Pyrroloquinoline quinone-13C3 (sodium) is an isotope of Pyrroloquinoline quinone. Pyrroloquinoline quinone (PQQ), a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function .
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| Cat. No. |
Product Name |
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Classification |
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- HY-12008S1
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CP-358774-<sup>13sup>C<sub>6sub> hydrochloride; NSC 718781-<sup>13sup>C<sub>6sub> hydrochloride; OSI-774-<sup>13sup>C<sub>6sub> hydrochloride
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Alkynes
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Erlotinib- 13C6 (hydrochloride) is the 13C labeled Erlotinib Hydrochloride[1]. Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM[2]. Erlotinib-13C6 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-50896S1
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CP-358774-<sup>13sup>C<sub>6sub>; NSC 718781-<sup>13sup>C<sub>6sub>; OSI-774-<sup>13sup>C<sub>6sub>
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Alkynes
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Erlotinib- 13C6 is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1].
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- HY-17413S1
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Azidothymidine-<sup>13sup>C,d<sub>3sub>; AZT-<sup>13sup>C,d<sub>3sub>; ZDV-<sup>13sup>C,d<sub>3sub>
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Azide
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Zidovudine- 13C,d3 is the 13C- and deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.
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