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Rosin (Standard) is the analytical standard of Rosin. This product is intended for research and analytical applications. Rosin is isolated from pine wood or pine stumps, Rosin is a frequent contact allergen which induces allergic contact dermatitis .
Thiohexam (Standard) is the analytical standard of Thiohexam. This product is intended for research and analytical applications. Thiohexam is a rubber cure accelerator. Thiohexam is also a known allergen and dermatological sensitizer .
Hydroxynaphthol Blue enables visual tube closure detection. Hydroxynaphthol Blue shows high specificity for the gene encoding Ara h 1 for visual field detection of peanut allergens .
Methyl Paraben is a standardized methyl paraben allergen isolated from Yunnan hemlock (Tsuga dumosa). Methyl Paraben is commonly used as a stable, non-volatile preservative. Methyl Paraben increases histamine release and cellular regulation of immunity, blocks sodium channels, and prevents ischemia-reperfusion injury .
PF-03654746 Tosylate is a potent and selective histamine H3 receptor antagonist with high brain penetration. PF-03654746 Tosylate reduces allergen-induced nasal symptoms . PF-03654746 Tosylate has potential for treatment of human cognitive disorders, improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD) .
PF-03654746 is a potent and selective histamine H3 receptor antagonist with high brain penetration.
PF-03654746 reduces allergen-induced nasal symptoms, might be a novel therapeutic strategy to further explore allergic rhinitis .
PF-03654746 improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD) .
Methyl paraben-d4 is the deuterium labeled Methyl Paraben[1]. Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, agents and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity[2].
Vilobelimab (CaCP-29, IFX-1) is a monoclonal anti-C5a antibody to the allergen C5a, a pro-inflammatory complement division product that plays a central role in mediating organ dysfunction. Vilobelimab acts as a C5a inhibitor, inhibiting neutrophil activation, chemotaxis, and reducing inflammatory signalling, and may be used in studies related to sepsis, COVID-19, etc .
Methyl paraben (Standard) is the analytical standard of Methyl paraben. This product is intended for research and analytical applications. Methyl Paraben is a standardized methyl paraben allergen isolated from Yunnan hemlock (Tsuga dumosa). Methyl Paraben is commonly used as a stable, non-volatile preservative. Methyl Paraben increases histamine release and cellular regulation of immunity, blocks sodium channels, and prevents ischemia-reperfusion injury .
GSK2245035 is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 has pEC50s of 9.3 and 6.5 for IFNα and TFNα. GSK2245035 effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 is used for asthma .
GSK2245035 maleate is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 maleate has pEC50s of 9.3 and 6.5 for IFNα and TFNα. GSK2245035 maleate effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 maleate is used for asthma .
Methyl Paraben- 13C6 (Methyl 4-hydroxybenzoate- 13C6) is a 13C labeled Methyl Paraben (HY-N0349) . Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, agents and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity .
HYDAMTIQ is a PARP-1/2 inhibitor (IC50: 29-38 nM) with anticancer, anti-inflammatory, and ischemic protective effects. HYDAMTIQ inhibits pulmonary PARP activity, is effective against allergen-induced cough and dyspnea, and inhibits bronchial hyperresponsiveness to methacholine. HYDAMTIQ has broad-spectrum tumor suppressor effects, including ovarian and breast cancers, prostate and pancreatic tumors, and glioblastoma multiforme. HYDAMTIQ has demonstrated in vivo efficacy in animal models of cerebral ischemia, asthma, cancer, and more .
FR900359 is a depsipeptide selective inhibitor of Gαq/11/14 in mammalia, can inhibits ERK pathway. FR900359 suppresses the proliferation of melanoma cells and decreases of blood pressure. FR900359 also protected against airway hyperreactivity in murine models of allergen sensitization in Ovalbumins(HY-W250978)–induced sensitization model of asthma. FR900359 can be used for cancer and cardiovascular disease research .
GS-6201 (CVT-6883) is a selective adenosine A2B receptor antagonist. GS-6201 displays high affinity and selectivity for the human adenosine A2B receptors (Ki=22 nM) . GS-6201 reduces caspase-1 activity in the heart, and attenuates cardiac remodeling after acute myocardial infarction (AMI) in the mouse . GS-62013 attenuates the airway reactivity induced by NECA, AMP, or allergen in sensitized mice .
BW B70C is a potent, selective and orally activearachidonic acid 5-lipoxygenase inhibitor. BW B70C inhibits both acute and allergic bronchoconstriction and late-phase eosinophil accumulation subsequent to allergen inhalation in guinea-pigs. BW B70C prevents leukotriene C4 synthesis and reduces leucocyte migration to the airways lumen as well as albumin microvascular leakage. BW B70C has the potential for the research of anti-asthma agent .
RO5101576 is a potent LTB4 receptor antagonist with activity to inhibit LTB4-induced calcium mobilization and chemotaxis of human neutrophils. RO5101576 significantly attenuated LTB4-induced pulmonary eosinophilia in guinea pigs. RO5101576 inhibited allergen- and ozone-induced pulmonary neutrophilia in nonhuman primates with efficacy comparable to that of budesonide. RO5101576 had no effect on LPS-induced neutrophilia in guinea pigs and cigarette smoke-induced neutrophilia in mice and rats. RO5101576 performed well in toxicology studies and was well tolerated .
Hydroxynaphthol Blue enables visual tube closure detection. Hydroxynaphthol Blue shows high specificity for the gene encoding Ara h 1 for visual field detection of peanut allergens .
Vilobelimab (CaCP-29, IFX-1) is a monoclonal anti-C5a antibody to the allergen C5a, a pro-inflammatory complement division product that plays a central role in mediating organ dysfunction. Vilobelimab acts as a C5a inhibitor, inhibiting neutrophil activation, chemotaxis, and reducing inflammatory signalling, and may be used in studies related to sepsis, COVID-19, etc .
Methyl Paraben is a standardized methyl paraben allergen isolated from Yunnan hemlock (Tsuga dumosa). Methyl Paraben is commonly used as a stable, non-volatile preservative. Methyl Paraben increases histamine release and cellular regulation of immunity, blocks sodium channels, and prevents ischemia-reperfusion injury .
FR900359 is a depsipeptide selective inhibitor of Gαq/11/14 in mammalia, can inhibits ERK pathway. FR900359 suppresses the proliferation of melanoma cells and decreases of blood pressure. FR900359 also protected against airway hyperreactivity in murine models of allergen sensitization in Ovalbumins(HY-W250978)–induced sensitization model of asthma. FR900359 can be used for cancer and cardiovascular disease research .
Rosin (Standard) is the analytical standard of Rosin. This product is intended for research and analytical applications. Rosin is isolated from pine wood or pine stumps, Rosin is a frequent contact allergen which induces allergic contact dermatitis .
Methyl paraben (Standard) is the analytical standard of Methyl paraben. This product is intended for research and analytical applications. Methyl Paraben is a standardized methyl paraben allergen isolated from Yunnan hemlock (Tsuga dumosa). Methyl Paraben is commonly used as a stable, non-volatile preservative. Methyl Paraben increases histamine release and cellular regulation of immunity, blocks sodium channels, and prevents ischemia-reperfusion injury .
DERP5 protein exhibits a monomeric structure and forms homodimeric trimers through concentration-dependent oligomerization, which plays a key role in allergic reactions. Multiple population studies have shown that DERP5 binds to IgE and is associated with mite allergy symptoms such as asthma and rhinitis. DERP5 Protein, Dermatophagoides pteronyssinus (His) is the recombinant DERP5 protein, expressed by E. coli , with N-His labeled tag. The total length of DERP5 Protein, Dermatophagoides pteronyssinus (His) is 132 a.a., with molecular weight of ~16.6 KDa.
Can f 1 Protein is a major dog allergen. It is a protein produced in the canine VonEbner's glands and the possible role of the protein is in taste reception. Can f 1 is mainly derived from dog dander, pelt hair and saliva. Exposure and sensitization to dog allergen is a significant cause of asthma. Can f 1 Protein, Canine (HEK293, His) is the recombinant canine-derived Can f 1 protein, expressed by HEK293 , with C-His labeled tag.
Blot21 Protein, representing a new group of allergens, is an important Blomia tropicalis allergen. Allergenic components from Blomia tropicalis are important triggers of allergies in the tropics. Blot21 is a paralog of the group 5 allergen Blot5. Blot21 has moderate sequence identity (40.7%) to Blot5 and low to moderate cross-reactivity to Blot5. Blot21 Protein, Blomia tropicalis (His) is the recombinant Blot21 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Blot21 Protein, Blomia tropicalis (His) is 113 a.a., with molecular weight of ~13.5 kDa.
Allergen Fel d 4 Protein, Cat (His-SUMO) is a recombinant protein with a His-SUMO tag. Fel d 4 is a lipocalin allergen produced by the cat, which binds IgE at relatively high frequency in cat-sensitive individuals.
Pollen allergen Phl p 5b protein, with ribonuclease activity, is speculated to participate in host-pathogen interactions. Its structural configuration involves a homodimer linked by disulfide bonds, highlighting its molecular arrangement in cellular processes. Pollen allergen Phl p 5b Protein, Phleum pratense (His-SUMO) is the recombinant Pollen allergen Phl p 5b protein, expressed by E. coli , with N-His, N-SUMO labeled tag.
The Minor allergen Can f 2 protein is found in tongue epithelial tissue and the parotid gland. Minor allergen Can f 2 protein, Dog (His-SUMO) is the recombinant dog-derived Minor allergen Can f 2 protein, expressed by E. coli , with N-His, N-SUMO labeled tag.
Pollen allergen Phl p 2 protein specifically expresses within pollen, intimately linked to plant reproductive structures and emphasizing its role in pollination processes. Pollen allergen Phl p 2 Protein, Phleum pratense (HEK293, His) is the recombinant Pollen allergen Phl p 2 protein, expressed by HEK293 , with N-6*His labeled tag. Pollen allergen Phl p 2 Protein, Phleum pratense (HEK293, His), has molecular weight of ~13.1 kDa.
BLOT5 protein exhibits potential homodimeric and homotrimeric forms and is detected in midgut and hindgut contents as well as fecal pellets. Its presence suggests a role in different physiological processes within these regions. BLOT5 Protein, Blomia tropicalis (P.pastoris, His) is the recombinant BLOT5 protein, expressed by P. pastoris , with C-His labeled tag. The total length of BLOT5 Protein, Blomia tropicalis (P.pastoris, His) is 117 a.a., with molecular weight of ~15.3 KDa.
The Pollen allergen Phl p 5 protein induces allergic reactions in humans, particularly contributing to grass pollen allergy. It is known to bind to immunoglobulin E (IgE) antibodies in individuals who are allergic to Phleum pratense (timothy grass), establishing a direct link between this allergen and the allergic responses observed in affected patients. Pollen allergen Phl p 5 Protein, Phleum pratense is the recombinant Pollen allergen Phl p 5 protein, expressed by E. coli , with tag free. Pollen allergen Phl p 5 Protein, Phleum pratense, has molecular weight of ~28.7 kDa.
Blot21 Protein, representing a new group of allergens, is an important Blomia tropicalis allergen. Allergenic components from Blomia tropicalis are important triggers of allergies in the tropics. Blot21 is a paralog of the group 5 allergen Blot5. Blot21 has moderate sequence identity (40.7%) to Blot5 and low to moderate cross-reactivity to Blot5. Blot21 Protein, Blomia tropicalis (HEK293, His) is the recombinant Blot21 protein, expressed by HEK293 , with N-6*His labeled tag.
Can f 4 Protein, Canine (HEK293, His), an IgE-binding dog dander protein, is an important respiratory allergen. Can f 4 Protein is a dog allergen of the lipocalin family. Can f 4 Protein, Canine (HEK293, His) is the recombinant canine-derived Can f 4 protein, expressed by HEK293 , with C-His, C-6*His labeled tag.
BLOT1 Protein, Blomia tropicalis (P.pastoris, His) is the recombinant BLOT1 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of BLOT1 Protein, Blomia tropicalis (P.pastoris, His) is 126 a.a., with molecular weight of ~37.7 KDa.
BLOT1 Protein is a Blomia tropicalis allergen and is highly homologous to cysteine proteases. BLOT1 may play a major role as an immunodominant allergen involved in dust mite-specific IgE-mediated hypersensitivity. BLOT1, like the other group 1 HDM allergens, is a digestive enzyme associated with mite fecal pellets. BLOT2 Protein, Blomia tropicalis (HEK293, His) is the recombinant BLOT2 protein, expressed by HEK293 , with N-6*His labeled tag. The total length of BLOT2 Protein, Blomia tropicalis (HEK293, His) is 144 a.a., with molecular weight of ~15 KDa.
DERP1 Protein, a thiol protease, selectively cleaves target proteins with distinct structural features, favoring substrates with a large hydrophobic side chain in the P2 position or basic residues. This specificity underscores DERP1's functional significance in cellular processes. DERP1 Protein, Dermatophagoides pteronyssinus (HEK293, His) is the recombinant DERP1 protein, expressed by HEK293 , with C-10*His, C-His labeled tag. The total length of DERP1 Protein, Dermatophagoides pteronyssinus (HEK293, His) is 320 a.a., with molecular weight of ~35.7 kDa.
Can f 6 is a novel dog lipid allergen that cross-reacts with horse and cat lipids. Can f 6 and homologous allergens may cause multiple sensitization and symptoms in individuals allergic to mammals. Can f 6 Protein, Canine (HEK293, His) is the recombinant canine-derived Can f 6 protein, expressed by HEK293 , with C-His labeled tag.
The oleosin L protein plays a structural role in stabilizing liposomes during seed drying, preventing oil coalescence and affecting liposome integrity. Its potential interactions with lipid and phospholipid moieties suggest the involvement of multiple molecules. Oleosin L Protein, Sesamum indicum (Cell-Free, His) is the recombinant Oleosin L protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of Oleosin L Protein, Sesamum indicum (Cell-Free, His) is 145 a.a., with molecular weight of 16.7 kDa.
DERP1 Protein, a thiol protease, selectively cleaves target proteins with distinct structural features, favoring substrates with a large hydrophobic side chain in the P2 position or basic residues. This specificity underscores DERP1's functional significance in cellular processes. DERP1 Protein, Dermatophagoides pteronyssinus (C132A, N150E, HEK293, His) is the recombinant DERP1 protein, expressed by HEK293 , with C-His labeled tag and C132A, N150E, , , mutation. The total length of DERP1 Protein, Dermatophagoides pteronyssinus (C132A, N150E, HEK293, His) is 320 a.a., with molecular weight of ~35.7 kDa.
The Der p 23 protein was identified as a member of the allergic house dust mite proteins and does not exhibit chitin-binding ability in vitro. This unique feature distinguishes Der p 23 from other proteins known for their affinity to chitin, emphasizing its unique properties. Der p 23 Protein, Dermatophagoides pteronyssinus (HEK293, His) is the recombinant Der p 23 protein, expressed by HEK293 , with C-His labeled tag. The total length of Der p 23 Protein, Dermatophagoides pteronyssinus (HEK293, His) is 69 a.a., with molecular weight of ~19 kDa.
Methyl Paraben- 13C6 (Methyl 4-hydroxybenzoate- 13C6) is a 13C labeled Methyl Paraben (HY-N0349) . Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, agents and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity .
Methyl paraben-d4 is the deuterium labeled Methyl Paraben[1]. Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, agents and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity[2].
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