Search Result

Results for "

dihydropyridine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AP-1 (1) Apoptosis (3) Autophagy (16) Biochemical Assay Reagents (1) Calcium Channel (64) Calmodulin (1) Chloride Channel (1) DNA/RNA Synthesis (2) Isotope-Labeled Compounds (19) MEK (1) NF-κB (3) p38 MAPK (3) Parasite (1) Reactive Oxygen Species (6) TRP Channel (1)
By Research Areas:	Cancer (21) Cardiovascular Disease (58) Infection (2) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (13)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N4226

*1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid*	AP-1	Inflammation/Immunology Cancer
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid is from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function .

HY-118594

*Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate*	Others	Metabolic Disease
Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate is a mouse-modeling drug that can induce Mallory body (MB) formation. MBs reached maximum concentration on day 5 of refeeding. Liver cell regeneration increased on the third day of refeeding .

HY-17404

Cilnidipine 1 Publications Verification FRC-8653	Calcium Channel	Cardiovascular Disease
Cilnidipine is a long-acting, second-generation dihydropyridine Ca ²⁺-channel blocker on L and N-type Ca ²⁺ channel . Antihypertensive effects .

HY-B0265

Nimodipine Maximum Cited Publications 12 Publications Verification BAY-e 9736	Autophagy Calcium Channel	Cardiovascular Disease Cancer
Nimodipine (BAY-e 9736) is an orally active, well-tolerated and light-sensitive dihydropyridine calcium antagonist. Nimodipine can be used for the research of cerebrovascular disorders .

HY-B0317

Amlodipine 5+ Cited Publications	Calcium Channel	Cardiovascular Disease Cancer
Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer .

HY-B0317B

Amlodipine besylate 5+ Cited Publications Amlodipine benzenesulfonate	Calcium Channel	Cardiovascular Disease Cancer
Amlodipine besylate (Amlodipine benzenesulfonate), an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine besylate can be used for the research of high blood pressure and cancer .

HY-W168915S

*1-(3-Fluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid-d3*	Isotope-Labeled Compounds	Others
1-(3-Fluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid-d₃ is deuterium labeled 1-(3-Fluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid.

HY-B0317C

Amlodipine mesylate	Calcium Channel	Cardiovascular Disease Cancer
Amlodipine mesylate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine mesylate can be used for the research of high blood pressure and cancer .

HY-17404R

Cilnidipine (Standard)	Calcium Channel	Cardiovascular Disease
Cilnidipine (Standard) is the analytical standard of Cilnidipine. This product is intended for research and analytical applications. Cilnidipine is a long-acting, second-generation dihydropyridine Ca ²⁺-channel blocker on L and N-type Ca ²⁺ channel . Antihypertensive effects .

HY-B0317R

Amlodipine (Standard)	Calcium Channel	Cardiovascular Disease Cancer
Amlodipine (Standard) is the analytical standard of Amlodipine. This product is intended for research and analytical applications. Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer .

HY-B0317S1

Amlodipine-d4	Isotope-Labeled Compounds	Cancer
Amlodipine-d₄ is a deuterium labeled Amlodipine (HY-B0317). Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer .

HY-B0265R

Nimodipine (Standard)	Autophagy Calcium Channel	Cardiovascular Disease Cancer
Nimodipine (Standard) is the analytical standard of Nimodipine. This product is intended for research and analytical applications. Nimodipine (BAY-e 9736) is an orally active, well-tolerated and light-sensitive dihydropyridine calcium antagonist. Nimodipine can be used for the research of cerebrovascular disorders .

HY-136448

SJ000025081	Parasite	Infection
SJ000025081 is a dihydropyridine and acts as a potent antimalarial agent. SJ000025081 results in an obvious suppression of the parasitemia in a murine malaria model infected with P. yoelii .

HY-W699942

*3-(2-Hydroxy-2-(methyl-d3)propyl-3,3,3-d3) 5-methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate*	Isotope-Labeled Compounds	Others
3-(2-Hydroxy-2-(methyl-d₃)propyl-3,3,3-d₃) 5-methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate is deuterated labeled 3-(2-Hydroxy-2-(methyl.

HY-B0309

Felodipine 1 Publications Verification	Calcium Channel Autophagy	Cardiovascular Disease
Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier .

HY-B0309R

Felodipine (Standard)	Calcium Channel Autophagy	Cardiovascular Disease
Felodipine (Standard) is the analytical standard of Felodipine. This product is intended for research and analytical applications. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier .

HY-B0233

Isradipine PN 200-110	Calcium Channel Autophagy	Cardiovascular Disease Neurological Disease
Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .

HY-B0233S2

Isradipine-d7 PN 200-110-d₇	Calcium Channel Autophagy Isotope-Labeled Compounds	Cardiovascular Disease Neurological Disease
Isradipine-d₇ is deuterated labeled Isradipine (HY-B0233). Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .

HY-B0233R

Isradipine (Standard)	Calcium Channel Autophagy	Cardiovascular Disease Neurological Disease
Isradipine (Standard) is the analytical standard of Isradipine. This product is intended for research and analytical applications. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .

HY-U00034

PCA50941	Others	Cardiovascular Disease
PCA50941 is a 1,4-dihydropyridine derivative, used for treatment for cardiovascular disease.

HY-19664

Pranidipine OPC-13340	Calcium Channel	Cardiovascular Disease
Pranidipine (OPC-13340) is a potent, long acting 1,4-dihydropyridine calcium channel blocker with antihypertensive activity .

HY-120411

Sadopine	Calcium Channel	Others
Sadopine is an allosteric modulator for dihydropyridine receptor ((-)Sadopine as positive allosteric modulator and (+)Sadopine as negative allosteric modulator). Sadopine interacts with dihydropyridine (DHP)-sensitive L-type calcium channels .

HY-W002765

2-Hydroxy-isonicotinic acid	Biochemical Assay Reagents	Others
2-Oxo-1,2-dihydropyridine-4-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-19663

Lemildipine NB-818; NPK-1886	Calcium Channel	Cardiovascular Disease
Lemildipine is a new dihydropyridine calcium entry blocker.

HY-17436

Clevidipine	Calcium Channel	Cardiovascular Disease Cancer
Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ).

HY-19025

CV-159	Calmodulin	Inflammation/Immunology
CV-159 is a unique dihydropyridine Ca ²⁺ antagonist with an anti-calmodulin (CaM) action, and has antiinflammatory activities.

HY-14744C

Levamlodipine hydrobromide (S)-Amlodipine hydrobromide; Levoamlodipine hydrobromide	Calcium Channel	Cardiovascular Disease Others
Levamlodipine hydrobromide is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina .

HY-14744

Levamlodipine 1 Publications Verification (S)-Amlodipine; Levoamlodipine	Calcium Channel	Cardiovascular Disease Others
Levamlodipine ((S)-Amlodipine) is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina .

HY-U00137

YS-201	Calcium Channel	Cardiovascular Disease
YS-201 is a dihydropyridine-type calcium channel antagonist. YS-201 has the potential for angina pectoris and hypertension treatment.

HY-106808

Cerebrocrast IOS-1.1212	Calcium Channel Chloride Channel	Neurological Disease
Cerebrocrast (IOS-1.1212) is a 1,4-dihydropyridine (DHP) derivative. Cerebrocrast has a high affinity for the membrane lipid bilayer and it can easily penetrate the blood-brain barrier and incorporate into the plasma and organelle membranes, including those of mitochondria. Cerebrocrast promotes the cotransport of H+ and Cl- in rat liver mitochondria. Cerebrocrast also exhibits neuroprotective and cognition enhancer properties .

HY-135218

AV-153	DNA/RNA Synthesis	Cancer
AV-153, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 has anti-cancer activity .

HY-B0317F

Amlodipine hydrochloride	Calcium Channel	Infection
Amlodipine hydrochloride is a biologically active drug used to lower blood pressure and prevent chest pain. Amlodipine hydrochloride has shown synergistic effects with antimicrobial drugs in in vitro studies, especially against carbene peptide-resistant Acinetobacter baumannii. Amlodipine hydrochloride can be used in combination with other antibiotics to enhance the inhibitory effect against resistant bacteria. The use of amlodipine hydrochloride helps reduce the dosage requirements of the drug, reduce toxic effects, and delay the emergence of drug resistance .

HY-120926

BBR 2160	Others	Others
BBR 2160 is a compound with cardiac electrophysiological effects and is a dihydropyridine calcium antagonist that can reduce myocardial contractility and action potential duration and has calcium antagonist properties.

HY-136189

UK-59811 hydrochloride	Calcium Channel	Neurological Disease
UK-59811 hydrochloride, a Br-dihydropyridine derivative, is a potent bacterial homotetrameric model voltage-gated Ca ²⁺ (Ca_V) channel Ca_VAb inhibitor with an IC₅₀ of 194 nM .

HY-111084

UK 52831	Calcium Channel	Cardiovascular Disease Inflammation/Immunology
UK 52831 is a long acting dihydropyridine calcium channel antagonist. UK 52831 can be used for cardiovascular disease (such as hypertension and myocardial ischemia) and anti-inflammatory research .

HY-135218A

AV-153 free base 1 Publications Verification	DNA/RNA Synthesis	Cancer
AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity .

HY-121604

(Rac)-MEM 1003	Calcium Channel	Others
(Rac)-MEM 1003 is the racemate of MEM 1003. MEM 1003, a dihydropyridine compound, is a potent L-type Ca ²⁺ channel antagonist and has the potential for Alzheimer’s disease research .

HY-17436R

Clevidipine (Standard)	Calcium Channel	Cardiovascular Disease Cancer
Clevidipine (Standard) is the analytical standard of Clevidipine. This product is intended for research and analytical applications. Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ).

HY-14744S

Levamlodipine-d4 (S)-Amlodipine-d₄; Levoamlodipine-d₄	Isotope-Labeled Compounds Calcium Channel	Others
Levamlodipine-d₄ is the deuterium labeled Levamlodipine. Levamlodipine ((S)-Amlodipine) is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina[1].

HY-B0023R

Azelnidipine (Standard)	Calcium Channel	Cardiovascular Disease
Azelnidipine (Standard) is the analytical standard of Azelnidipine. This product is intended for research and analytical applications. Azelnidipine (CS 905; Calblock) is a dihydropyridine derivative, an L-type calcium channel blocker, and can fight hypertension.

HY-B0424

Nitrendipine 1 Publications Verification BAY-E-5009	Calcium Channel Autophagy	Cardiovascular Disease
Nitrendipine (BAY-E-5009), an analogue of Nifedipine (HY-B0284), is a dihydropyridine calcium channel blocker with vasodilator action. Nitrendipine has antihypertensive effect .

HY-106832

Vatanidipine Watanidipine; AE0047 free base	Calcium Channel	Cardiovascular Disease Neurological Disease
Vatanidipine (Watanidipine) is an orally active dihydropyridine (DHP)-type calcium channel blocker and a useful antihypertensive agent. Vatanidipine shows vasodilatory effects and also suppresses noradrenaline release from sympathetic nerve endings .

HY-17402S

Nisoldipine-d6 BAY-k 5552-d₆	Isotope-Labeled Compounds Calcium Channel Reactive Oxygen Species	Cardiovascular Disease
Nisoldipine-d₆ is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with an IC50 of 10 nM.

HY-110145

MRS 1477	TRP Channel	Cancer
MRS 1477, a dihydropyridine derivative, is a positive allosteric modulator of TRPV1 in the presence of capsaicin. MRS 1477 itself does not induce apoptosis, but the co-existence of MRS 1477 and capsaicin can induce apoptosis .

HY-106832A

Vatanidipine hydrochloride Watanidipine hydrochloride; AE0047	Calcium Channel	Cardiovascular Disease Neurological Disease
Vatanidipine (Watanidipine) hydrochloride is an orally active dihydropyridine (DHP)-type calcium channel blocker and a useful antihypertensive agent. Vatanidipine hydrochloride shows vasodilatory effects and also suppresses noradrenaline release from sympathetic nerve endings .

HY-B0265S

Nimodipine-d7	Autophagy Calcium Channel	Cardiovascular Disease Cancer
Nimodipine-d₇ is the deuterium labeled Nimodipine. Nimodipine (BAY-e 9736) is an orally active, well-tolerated and light-sensitive dihydropyridine calcium antagonist. Nimodipine can be used for the research of cerebrovascular disorders[1].

HY-17436S1

Clevidipine-d7	Isotope-Labeled Compounds Calcium Channel	Cardiovascular Disease
Clevidipine-d₇ is the deuterium labeled Clevidipine. Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension[1][2].

HY-B0612DS1

Lercanidipine-d3 hydrochloride	Isotope-Labeled Compounds Calcium Channel	Cardiovascular Disease
Lercanidipine-d₃ (hydrochloride) is the deuterium labeled Lercanidipine. Lercanidipine is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine has long lasting antihypertensive action and reno-protective effect[1][2][3].

HY-17436S4

Clevidipine-15N,d10	Calcium Channel Isotope-Labeled Compounds	Cardiovascular Disease Cancer
Clevidipine- ¹⁵N,d₁₀ is ¹⁵N and deuterated labeled Clevidipine (HY-17436). Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H)=-40 mV ).

HY-B0424S

Nitrendipine-d5 AY-E-5009-d₅	Calcium Channel Autophagy	Cardiovascular Disease
Nitrendipine-d₅ is the deuterium labeled Nitrendipine. Nitrendipine (BAY-E-5009), an analogue of Nifedipine (HY-B0284), is a dihydropyridine calcium channel blocker with vasodilator action. Nitrendipine has antihypertensive effect[1][2][3][4].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4226

*1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid*	Structural Classification Microorganisms other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer	AP-1
1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid is from Cordyceps bassiana, which is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid targets to block AP-1-mediated luciferase activity, implying it has an anti-inflammatory function .

HY-14744

Levamlodipine 1 Publications Verification (S)-Amlodipine; Levoamlodipine	Cardiovascular Disease Classification of Application Fields Disease Research Fields	Calcium Channel
Levamlodipine ((S)-Amlodipine) is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina .

Cat. No.	Compare	Product Name	Species	Source

HY-P72109

	CACNA2D1 Protein, Human (His-SUMO) CA2D1_HUMAN; CACN A2; CACNA2; Cacna2d1; CACNL2A; Calcium channel L type alpha 2 polypeptide; Calcium channel voltage dependent alpha 2/delta subunit 1; CCHL2A; dihydropyridine receptor alpha 2 subunit; dihydropyridine sensitive L type calcium channel alpha 2/delta subunit; dihydropyridine sensitive L type calcium channel subunits alpha 2/delta; L type calcium channel subunit alpha 2; MHS 3; MHS3; Voltage dependent calcium channel subunit alpha 2/delta 1; Voltage gated calcium channel subunit alpha 2/delta 1; Voltage-dependent calcium channel subunit delta-1; Voltage-gated calcium channel subunit alpha-2/delta-1	Human	E. coli
	The CACNA2D1 protein, particularly its α-2/δ subunit, plays a key role in regulating calcium current density and activation/deactivation kinetics of voltage-dependent calcium channels. It contributes to excitation-contraction coupling, coordinating cellular processes. CACNA2D1 Protein, Human (His-SUMO) is the recombinant human-derived CACNA2D1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of CACNA2D1 Protein, Human (His-SUMO) is 141 a.a., with molecular weight of ~32.3 kDa.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-B0317S1

Amlodipine-d4
Amlodipine-d₄ is a deuterium labeled Amlodipine (HY-B0317). Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer .

HY-14744S

Levamlodipine-d4
Levamlodipine-d₄ is the deuterium labeled Levamlodipine. Levamlodipine ((S)-Amlodipine) is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina[1].

HY-B0265S

Nimodipine-d7
Nimodipine-d₇ is the deuterium labeled Nimodipine. Nimodipine (BAY-e 9736) is an orally active, well-tolerated and light-sensitive dihydropyridine calcium antagonist. Nimodipine can be used for the research of cerebrovascular disorders[1].

HY-B0612DS1

Lercanidipine-d3 hydrochloride
Lercanidipine-d₃ (hydrochloride) is the deuterium labeled Lercanidipine. Lercanidipine is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine has long lasting antihypertensive action and reno-protective effect[1][2][3].

HY-W168915S

*1-(3-Fluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid-d3*
1-(3-Fluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid-d₃ is deuterium labeled 1-(3-Fluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid.

HY-W699942

*3-(2-Hydroxy-2-(methyl-d3)propyl-3,3,3-d3) 5-methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate*
3-(2-Hydroxy-2-(methyl-d₃)propyl-3,3,3-d₃) 5-methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate is deuterated labeled 3-(2-Hydroxy-2-(methyl.

HY-B0233S2

Isradipine-d7
Isradipine-d₇ is deuterated labeled Isradipine (HY-B0233). Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .

HY-17402S

Nisoldipine-d6
Nisoldipine-d₆ is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with an IC50 of 10 nM.

HY-17436S1

Clevidipine-d7
Clevidipine-d₇ is the deuterium labeled Clevidipine. Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension[1][2].

HY-17436S4

Clevidipine-15N,d10
Clevidipine- ¹⁵N,d₁₀ is ¹⁵N and deuterated labeled Clevidipine (HY-17436). Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H)=-40 mV ).

HY-B0424S

Nitrendipine-d5
Nitrendipine-d₅ is the deuterium labeled Nitrendipine. Nitrendipine (BAY-E-5009), an analogue of Nifedipine (HY-B0284), is a dihydropyridine calcium channel blocker with vasodilator action. Nitrendipine has antihypertensive effect[1][2][3][4].

HY-17404S

Cilnidipine-d7
Cilnidipine-d₇ is deuterium labeled Cilnidipine. Cilnidipine is a long-acting, second-generation dihydropyridine Ca2+-channel blocker on L and N-type Ca2+ channel[1][2][3][4]. Antihypertensive effects[5].

HY-B0612AS1

Lercanidipine-13C,d3-1 hydrochloride
Lercanidipine- ¹³C,d₃-1 (hydrochloride) is deuterium labeled Lercanidipine (hydrochloride). Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect[1][2][3].

HY-17436S3

(R)-Clevidipine-13C,d3
(R)-Clevidipine- ¹³C,d₃ is the deuterium and ¹³C labeled Clevidipine[1]. Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension[2].

HY-17402S1

Nisoldipine-d4
Nisoldipine-d₄ (BAY-k 5552-d4) is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM[1][2].

HY-17402S2

Nisoldipine-d7
Nisoldipine-d₇ (BAY-k 5552-d7) is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM[1][2].

HY-B0612AS

Lercanidipine-13C,d3 hydrochloride
Lercanidipine- ¹³C,d₃ (hydrochloride) is the deuterium and ¹³C labeled Lercanidipine hydrochloride[1]. Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect[2][3][4].

HY-B0317AS

Amlodipine-d4 maleate
Amlodipine-d₄ (maleate) is the deuterium labeled Amlodipine maleate. Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer[1][2][3].

HY-B0309S2

Felodipine-d3
Felodipine-d₃ is the deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].

HY-B0309S1

Felodipine-d5
Felodipine-d₅ is deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].

HY-B0233S1

Isradipine-d6
Isradipine-d₆ is the deuterium labeled Isradipine[1]. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease[2][3][4].

HY-B0317AS1

Amlodipine-d9 maleate

Amlodipine-d₉ maleate is deuterated labeled Amlodipine maleate (HY-B0317A). Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer .

HY-B0317S

Amlodipine-1,1,2,2-d4 maleate
Amlodipine-1,1,2,2-d₄ (maleate) is the deuterium labeled Amlodipine. Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer[1][2][3].

HY-B0317BS

Amlodipine-d4 besylate

Amlodipine-d₄ (besylate) is the deuterium labeled Amlodipine besylate. Amlodipine besylate (Amlodipine benzenesulfonate), an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine besylate can be used for the research of high blood pressure and cancer[1][2][3].

HY-132670S

(R)-(-)-Felodipine-d5

(R)-(-)-Felodipine-d₅ is the deuterium labeled (R)-(-)-Felodipine. (R)-(-)-Felodipine is the S enantiomer of Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].

HY-B0233S

Isradipine-d3

Isradipine-d₃ (PN 200-110-d3) is the deuterium labeled Isradipine. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease[1][2][3].

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks