Search Result
Results for "
fatty acyls
" in MedChemExpress (MCE) Product Catalog:
10
Biochemical Assay Reagents
6
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-134136A
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Biochemical Assay Reagents
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Cancer
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Octanoyl coenzyme A lithium is a fatty acyl coenzyme A derivative. Octanoyl coenzyme A lithium can inhibit citrate synthase (CS) and glutamate dehydrogenase (GDH) with IC50 values of 0.4-1.6 mM .
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- HY-128851B
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Endogenous Metabolite
Fatty Acid Synthase (FASN)
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Metabolic Disease
Cancer
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Coenzyme A (CoASH) sodium is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids .
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- HY-128851
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Endogenous Metabolite
Fatty Acid Synthase (FASN)
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Metabolic Disease
Cancer
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Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids .
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- HY-128851A
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Endogenous Metabolite
Fatty Acid Synthase (FASN)
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Metabolic Disease
Cancer
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Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids .
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- HY-113085
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- HY-113367
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- HY-148869A
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- HY-134428
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Endogenous Metabolite
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Metabolic Disease
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Arachidonoyl coenzyme A lithium is an unsaturated fatty acyl coenzyme A, formed by the condensation of the thiol group of coenzyme A with the carboxyl group of arachidonic acid .
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- HY-134438
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Endogenous Metabolite
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Metabolic Disease
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Hexanoyl coenzyme A trilithium is a hexanoyl-based medium-chain fatty acyl coenzyme A that is present in all organisms. Hexanoyl coenzyme A trilithium can be used as a precursor for cannabinoid biosynthesis and acts as a competitive inhibitor of medium-chain acyl coenzyme A dehydrogenase (MCAD) .
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- HY-134136
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Endogenous Metabolite
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Metabolic Disease
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Octanoyl coenzyme A is a fatty acyl coenzyme A derivative. Octanoyl coenzyme A can inhibit citrate synthase (CS) and glutamate dehydrogenase (GDH) with IC50 values of 0.4-1.6 mM .
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- HY-CE00049
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- HY-CE00003
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- HY-162298
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- HY-E70274
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- HY-CE00178
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- HY-CE00120
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- HY-CE00180
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- HY-CE00054
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- HY-W783829
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Hex-2-trans-enoyl-CoA
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Endogenous Metabolite
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Metabolic Disease
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(2E)-Hexenoyl-CoA (Hex-2-trans-enoyl-CoA) is an intermediate in fatty acid metabolism. (2E)-Hexenoyl-CoA is the substrate of the enzymes enoyl-coenzyme A reductase, acyl-CoA oxidase, acyl-CoA dehydrogenase, long-chain-acyl-CoA dehydrogenase and Oxidoreductases .
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- HY-CE00115
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- HY-CE00125
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- HY-E70246
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- HY-CE00072
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- HY-107396
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Acyltransferase
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Cardiovascular Disease
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YM-750 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50=0.18 μM). ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A .
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- HY-E70247
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- HY-E70523
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Valeryl-CoA; Valeryl-Coenzyme A; Pentanoyl Coenzyme A free acid
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Endogenous Metabolite
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Metabolic Disease
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Pentanoyl Coenzyme A (pentanoyl-CoA) is a short-chain fatty acyl-CoA. Pentanoyl Coenzyme A is a metabolite of 3-oxovalproyl-CoA .
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- HY-P2832
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ACS
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Endogenous Metabolite
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Metabolic Disease
Cancer
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Acyl coenzyme A synthetase (ACS), namely acetyl coenzyme A synthetase, is often used in biochemical research. Acyl coenzyme A synthetase can catalyze the activation of fatty acids by coenzyme A through a two-step thioesterification reaction to produce acyl coenzyme A, and then participate in a variety of anabolic and catabolic lipid metabolism pathways, and participate in the TCA cycle in aerobic respiration .
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- HY-E70268
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- HY-E70271
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- HY-113367S1
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Endogenous Metabolite
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Metabolic Disease
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Suberylglycine-d2 is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid[1][2].
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- HY-113367S
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Endogenous Metabolite
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Metabolic Disease
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Suberylglycine-d4 is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid[1][2].
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- HY-CE00066A
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- HY-130405
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Drug Derivative
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Metabolic Disease
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PtdIns-(1,2-dipalmitoyl) ammonium (DPPI) is a derivative of phosphatidylinositol (PtdIns) that contains C16:0 fatty acyl chains .
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- HY-113166
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(-)-Lauroylcarnitine
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Endogenous Metabolite
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Metabolic Disease
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Dodecanoylcarnitine is present in fatty acid oxidation disorders such as long-chain acyl CoA dehydrogenase deficiency, carnitine palmitoyltransferase I/II deficiency, and is also associated with celiac disease.
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- HY-111199
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FAAH
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Neurological Disease
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JP83 is an irreversible fatty acyl amide hydrolase (FAAH) inhibitor with an IC50 of 1.6 nM in competitive activity-based protein profiling (ABPP) experiments .
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- HY-E70278
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Biochemical Assay Reagents
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Metabolic Disease
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(9Z-Octadecenyl)-CoA triammonium is a coenzyme. (9Z-Octadecenyl)-CoA triammonium is a long-chain acyl-CoA esters. Long-chain acyl-CoA esters are involved in regulation of fatty acid synthesis, enzyme systems, vesicle trafficking, ion channels and ion pumps .
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- HY-CE00070
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- HY-CE00044
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3-Oxo-(13Z)-eicosenoyl-CoA; (13Z)-3-Ketoicosenoyl-CoA
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Biochemical Assay Reagents
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Others
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(13Z)-3-Oxoicosenoyl-CoA (3-Oxo-(13Z)-eicosenoyl-CoA) is an unsaturated fatty acyl-CoA.
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- HY-CE00197A
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- HY-CE00103
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(11Z,14Z)-Icosadienoyl-coenzyme A; (11Z,14Z)-Eicosadienoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(11Z,14Z)-Icosadienoyl-CoA ((11Z,14Z)-Icosadienoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
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- HY-CE00143C
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(2E,5Z)-Tetradecadienoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(2E,5Z)-Tetradecadienoyl-CoA ((2E,5Z)-Tetradecadienoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
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- HY-CE00002
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(15Z)-3-Oxotetracosenoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(15Z)-3-Oxotetracosenoyl-CoA ((15Z)-3-Oxotetracosenoyl-coenzyme A) is a 3-oxo-fatty acyl-CoA.
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- HY-CE00242A
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(2E,7Z)-Hexadecadienoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(2E,7Z)-Hexadecadienoyl-CoA ((2E,7Z)-Hexadecadienoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
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- HY-CE00037
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(13Z)-3-Ketodocosenoyl-CoA; (13Z)-3-Oxodocosenoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(13Z)-3-Oxodocosenoyl-CoA ((13Z)-3-Ketodocosenoyl-CoA) is a 3-oxo-fatty acyl-CoA.
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- HY-CE00203A
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(2E,11Z)-Icosadienoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(2E,11Z)-Icosadienoyl-CoA ((2E,11Z)-Icosadienoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
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- HY-153203
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20:5 Coenzyme A triammonium
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Others
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Others
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Eicosapentaenoyl-CoA triammonium (C20:5-CoA) is an unsaturated fatty acyl-CoA that can assist in the measurement of enzymatic activity of the TrWSD4 enzyme .
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- HY-CE00009B
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(10E,12Z)-Hexadecadienoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(10E,12Z)-Hexadecadienoyl-CoA ((10E,12Z)-Hexadecadienoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
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- HY-CE00143A
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(2E,5E)-Tetradecadienoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(2E,5E)-Tetradecadienoyl-CoA ((2E,5E)-Tetradecadienoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
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- HY-CE00220A
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- HY-CE00244
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(2E,9Z)-Octadecadienoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(2E,9Z)-Octadecadienoyl-CoA ((2E,9Z)-Octadecadienoyl-coenzyme A) is a polyunsaturated fatty acyl-CoA.
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- HY-CE00240
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(2E,9Z)-Hexadecadienoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(2E,9Z)-Hexadecadienoyl-CoA ((2E,9Z)-Hexadecadienoyl-coenzyme A) is a polyunsaturated fatty acyl-CoA.
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- HY-D1570
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Fluorescent Dye
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Others
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BODIPYFL C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 480/508 nm .
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- HY-CE00191A
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- HY-126833B
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14:0 Coenzyme A
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Drug Metabolite
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Metabolic Disease
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Myristoyl coenzyme A triammonium (14:0 Coenzyme A) is a type of long-chain acyl-CoA, which is the activated form of long-chain fatty acids and serves as a crucial lipid metabolite .
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- HY-E70009
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ACO
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Others
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Others
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Acyl-CoA oxidase (ACO) catalyses the first and rate-determining step of the peroxisomal beta-oxidation of fatty acids and a major producer of hydrogen peroxide (H2O2) .
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- HY-E70023
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Endogenous Metabolite
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Metabolic Disease
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Sphingolipid ceramide N-deacylase (SCDase) cleaves the N-acyl linkage between fatty acids and sphingosine bases in various glycosphingolipids. Sphingolipid ceramide N-deacylase catalyzes glycosphingolipids to lysoglycosphingolipids .
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- HY-146003
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Bacterial
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Infection
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FAAL-IN-1 (compound 32) is a selective inhibitor of fatty acyl-AMP ligase (FAAL), with a Ki of 0.7 μM for FAAL28. FAAL-IN-1 shows antimycobacterial activity .
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- HY-CE00064A
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(11Z)-18-Hydroxyoctadec-11-enoyl-CoA; (11Z)-18-Hydroxyoctadecenoyl-coenzyme A; (11Z)-18-Hydroxyoctadec-11-enoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(11Z)-18-Hydroxyoctadecenoyl-CoA ((11Z)-18-Hydroxyoctadec-11-enoyl-CoA) is an omega-hydroxy fatty acyl-CoA.
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- HY-165081
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N-(2-Hydroxyethyl)-13Z-docosenamide
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Others
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Others
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Docosaenoyl ethanolamide (N-(2-Hydroxyethyl)-13Z-docosenamide) is one of a fatty N-acyl ethanolamines. Ethanolamines can be detected at relatively high levels in rat cerebrospinal fluid .
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- HY-CE00116
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C20:3(Omega-3)-CoA; Cis-(omega-3)-icosatrienoyl-CoA
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Biochemical Assay Reagents
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Others
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(11Z,14Z,17Z)-Icosatrienoyl-CoA (C20:3(Omega-3)-CoA) is an unsaturated fatty acyl-CoA.
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- HY-W339206
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Endogenous Metabolite
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Others
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1,2-Dinonanoyl-sn-glycero-3-phosphocholine, a specific phosphatidylcholine, features fatty acyl configurations that can influence the physical properties of membranes, making it a key component for generating eicosanoids. As a phospholipid abundant in membranes, it has fatty acids attached to glycerol at the sn-1 and sn-2 positions via ester bonds.
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- HY-113873
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- HY-CE00136
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(3R)-3-Isopropenyl-6-oxoheptanoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(3R)-3-Isopropenyl-6-oxoheptanoyl-CoA ((3R)-3-Isopropenyl-6-oxoheptanoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
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- HY-CE00181
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(3R,11Z)-3-hydroxyoctadecenoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(3R,11Z)-3-hydroxyoctadecenoyl-CoA ((3R,11Z)-3-hydroxyoctadecenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
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- HY-CE00215
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(3R,13Z)-3-Hydroxyicosenoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(3R,13Z)-3-Hydroxyicosenoyl-CoA ((3R,13Z)-3-Hydroxyicosenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
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- HY-CE00059
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- HY-CE00121A
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- HY-CE00198A
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(2E,11Z,14Z)-Icosatrienoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(2E,11Z,14Z)-Icosatrienoyl-CoA ((2E,11Z,14Z)-Icosatrienoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
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- HY-CE00025A
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(10Z,13Z,16Z)-Docosatrienoyl-coenzyme A; C22:3(Omega-6)-coenzyme A
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Biochemical Assay Reagents
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Others
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(10Z,13Z,16Z)-Docosatrienoyl-CoA ((10Z,13Z,16Z)-Docosatrienoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
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- HY-163033
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Bacterial
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Infection
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Antitubercular agent-42(19) is a selective fatty acyl-AMP ligase (FAAL) inhibitor (MIC90 = 1.4 µg/mL for M. tuberculosis H37Rv). Antitubercular agent-42 shows antitubercular activity .
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- HY-CE00179
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(3R,11Z)-3-Hydroxyicosenoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(3R,11Z)-3-Hydroxyicosenoyl-CoA ((3R,11Z)-3-Hydroxyicosenoyl-coenzyme A) is a 3-hydroxy fatty acyl-CoA.
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- HY-CE00068A
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(11Z)-3-Ketoicosa-11-enoyl-CoA; 3-Oxo-(11Z)-eicos-11-enoyl-CoA
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Biochemical Assay Reagents
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Others
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(11Z)-3-Oxoicosa-11-enoyl-CoA ((11Z)-3-Ketoicosa-11-enoyl-CoA) is a 3-oxo-fatty acyl-CoA.
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- HY-113166R
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Endogenous Metabolite
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Metabolic Disease
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Dodecanoylcarnitine (Standard) is the analytical standard of Dodecanoylcarnitine. This product is intended for research and analytical applications. Dodecanoylcarnitine is present in fatty acid oxidation disorders such as long-chain acyl CoA dehydrogenase deficiency, carnitine palmitoyltransferase I/II deficiency, and is also associated with celiac disease.
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- HY-CE00214
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(3R,13Z)-3-Hydroxydocosenoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(3R,13Z)-3-Hydroxydocosenoyl-CoA ((3R,13Z)-3-Hydroxydocosenoyl-coenzyme A) is a 3-hydroxy fatty acyl-CoA.
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- HY-CE00023
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- HY-CE00069
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- HY-CE00186
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(2S,6R,10R)-Trimethyl-hendecanoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(2S,6R,10R)-Trimethyl-hendecanoyl-CoA ((2S,6R,10R)-Trimethyl-hendecanoyl-coenzyme A) is a fatty acyl-CoA.
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- HY-CE00012
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- HY-115358
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Tetracosanoic acid monoethanolamide
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Endogenous Metabolite
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Metabolic Disease
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Lignoceroyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids. Whereas lignoceric acid has been detected at relatively high levels in rat cerebrospinal fluid, the specific role and relative importance of its ethanolamine metabolite have not been determined.
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- HY-CE00008
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(2-Trans,6-cis)-dodeca-2,6-dienoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(2-Trans,6-cis)-dodeca-2,6-dienoyl-CoA ((2-Trans,6-cis)-dodeca-2,6-dienoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
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- HY-126720
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Endogenous Metabolite
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Metabolic Disease
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N-Lignoceroyl Taurine is an arachidonoyl amino acid and taurine conjugate with a fatty acid that can be isolated from bovine brain. N-Lignoceroyl Taurine is one of several novel taurine-conjugated fatty acids discovered during mass spectrometry lipidomic analysis of the brain and spinal cord of wild-type and fatty acid amide hydrolase (FAAH) knockout mice. N-Lignoceroyl Taurine levels were 23-26-fold higher in FAAH -/- mice compared to wild-type mice, suggesting that FAAH utilizes N-Lignoceroyl Taurine as a substrate. However, in vitro experiments with purified FAAH showed that N-Lignoceroyl Taurine was hydrolyzed 2,000-fold slower in FAAH compared to oleoylethanolamide. N-Acyl Taurines with polyunsaturated acyl chains can activate members of the transient receptor potential (TRP) calcium channel family, including TRPV1 and TRPV4.
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- HY-136821
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Bacterial
Antibiotic
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Infection
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Polymyxin D2 is an antibiotic discovered from Bacillus polymyxa, exhibiting antibacterial activity. Its core structure consists of a cyclic heptapeptide moiety and a tripeptide side chain with a fatty acyl residue. Polymyxin D2 can be used in anti-infective research .
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- HY-CE00060
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- HY-124081
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Apoptosis
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Metabolic Disease
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N-Oleoyl-L-Serine is an endogenous amide of long-chain fatty acids with ethanolamine (N-acyl amides). N-Oleoyl-L-Serine is a lipid regulator of bone remodeling and stimulates osteoclast apoptosis. N-Oleoyl-L-Serine can be used for antiosteoporotic drug discovery development .
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- HY-120965
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Endogenous Metabolite
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Metabolic Disease
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Several different arachidonoyl amino acids, including N-arachidonoyl dopamine (NADA) and N-arachidonoyl serine (ARA-S), have been isolated and characterized from bovine brain.1 During mass spectral lipidomic analysis of rat brain, a series of fatty acyl amides of a third amino acid, taurine, is discovered. N-Palmitoyl taurine is a prominent amino-acyl endocannabinoid isolated from rat brain during lipidomics profiling. Its function is currently under investigation.
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- HY-137411
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(E/Z)-Linoleoyl Coenzyme A; (E/Z)-9,12-Octadecadienoyl Coenzyme A
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Endogenous Metabolite
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Others
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(E/Z)-Linoleoyl-CoA is a substrate used to study the specificity and kinetics of acyl-CoA. (E/Z)-Linoleoyl-CoA has the ability to replace substrates, and its specificity can be changed by amino acid substitution, thereby affecting the reaction with different desaturases. The study of (E/Z)-Linoleoyl-CoA helps to understand the substrate specificity of mammalian front-end fatty acid desaturases and provides support for the efficient production of value-added fatty acids .
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- HY-CE00015
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- HY-CE00062
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C32:5(Omega-3)-coenzyme A
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Biochemical Assay Reagents
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Others
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(17Z,20Z,23Z,26Z,29Z)-Dotriacontapentaenoyl-CoA (C32:5(Omega-3)-coenzyme A) is an unsaturated fatty acyl-CoA.
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- HY-CE00093
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- HY-CE00075
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- HY-CE00021
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(10Z,13Z,16Z)-3-Oxodocosatrienoyl-coenzyme A; 3-Oxo-C22:3(omega-6)-CoA; (10Z,13Z,16Z)-3-Ketodocosatrienoyl-CoA
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Biochemical Assay Reagents
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Others
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(10Z,13Z,16Z)-3-Oxodocosatrienoyl-CoA ((10Z,13Z,16Z)-3-Oxodocosatrienoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
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- HY-CE00018
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3-Oxo-C24:4(omega-3)-CoA
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Biochemical Assay Reagents
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Others
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(12Z,15Z,18Z,21Z)-3-Oxotetracosatetraenoyl-CoA (3-Oxo-C24:4(omega-3)-CoA) is an unsaturated fatty acyl-CoA.
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- HY-160679
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Bacterial
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Infection
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BaENR-IN-1 (Compound 5) is an inhibitor of Enoyl-Acyl Carrier Protein Reductase (ENR) (IC50= 7.7 μM). BaENR-IN-1 blocks the synthesis of fatty acids essential for bacterial growth by inhibiting the bacterial enzyme ENR. BaENR-IN-1 shows activity against bacteria .
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- HY-CE00067
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3-Oxo-C28:4(omega-6)-CoA
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Biochemical Assay Reagents
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Others
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(13Z,16Z,19Z,22Z)-3-Oxooctacosatetraenoyl-CoA (3-Oxo-C28:4(omega-6)-CoA) is an unsaturated fatty acyl-CoA.
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- HY-B0399S
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(R)-Carnitine-d9; Levocarnitine-d9
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Isotope-Labeled Compounds
Endogenous Metabolite
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Neurological Disease
Metabolic Disease
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L-Carnitine-d9 is the deuterium labeled L-Carnitine. L-Carnitine (Levocarnitine) is an endogenous molecule involved in fatty acid metabolism, biosynthesized within the human body using amino acids: L-lysine and L-methionine, as substrates. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2].
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- HY-CE00206
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(3R,11Z,14Z)-3-Hydroxyicosadienoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(3R,11Z,14Z)-3-Hydroxyicosadienoyl-CoA ((3R,11Z,14Z)-3-Hydroxyicosadienoyl-coenzyme A) is a 3-hydroxy fatty acyl-CoA.
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- HY-CE00235
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(2E,8Z,11Z,14Z)-Icosatetraenoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(2E,8Z,11Z,14Z)-Icosatetraenoyl-CoA ((2E,8Z,11Z,14Z)-Icosatetraenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
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- HY-CE00032
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(23Z,26Z,29Z,32Z)-Octatriacontatetraenoyl-coenzyme A
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Biochemical Assay Reagents
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Others
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(23Z,26Z,29Z,32Z)-Octatriacontatetraenoyl-CoA ((23Z,26Z,29Z,32Z)-Octatriacontatetraenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
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- HY-CE00028
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(15Z,18Z,21Z,24Z)-Triacontatetraenoyl-coenzyme A; C30:4(Omega-6)-coenzyme A
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Biochemical Assay Reagents
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Others
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(15Z,18Z,21Z,24Z)-Triacontatetraenoyl-CoA ((15Z,18Z,21Z,24Z)-Triacontatetraenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
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- HY-CE00112A
-
(11Z,14Z,17Z)-3-Oxoeicosatrienoyl-CoA; (11Z,14Z,17Z)-3-Ketoeicosatrienoyl-CoA
|
Biochemical Assay Reagents
|
Others
|
(11Z,14Z,17Z)-3-Oxoicosatrienoyl-CoA ((11Z,14Z,17Z)-3-Oxoeicosatrienoyl-CoA) is a 3-oxo-fatty acyl-CoA.
|
-
- HY-E70254
-
|
Others
|
Others
|
Tricosanoyl-CoA triammonium is a very long-chain fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A (HY-128851) with the carboxy group of tricosanoic acid (HY-W009081). Tricosanoyl-CoA is functionally related to a tricosanoic acid. Tricosanoyl-CoA is a conjugate acid of a tricosanoyl-CoA(4-).
|
-
- HY-CE00055
-
(17Z,20Z,23Z,26Z)-Dotriacontatetraenoyl-coenzyme A; C32:4(Omega-6)-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(17Z,20Z,23Z,26Z)-Dotriacontatetraenoyl-CoA ((17Z,20Z,23Z,26Z)-Dotriacontatetraenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00085
-
(19Z,22Z,25Z,28Z)-Tetratriacontatetraenoyl-coenzyme A; C34:4(omega-6)-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(19Z,22Z,25Z,28Z)-Tetratriacontatetraenoyl-CoA ((19Z,22Z,25Z,28Z)-Tetratriacontatetraenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00036A
-
(10Z,13Z,16Z,19Z)-Docosatetraenoyl-coenzyme A; C22:4(omega-3)-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(10Z,13Z,16Z,19Z)-Docosatetraenoyl-CoA ((10Z,13Z,16Z,19Z)-Docosatetraenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00016
-
(21Z,24Z,27Z,30Z)-Hexatriacontatetraenoyl-coenzyme A; C36:4(Omega-6)-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(21Z,24Z,27Z,30Z)-Hexatriacontatetraenoyl-CoA ((21Z,24Z,27Z,30Z)-Hexatriacontatetraenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-134136B
-
|
Biochemical Assay Reagents
|
Metabolic Disease
|
Octanoyl coenzyme A triammonium is a medium-chain acyl coenzyme A. Octanoyl coenzyme A triammonium can inhibit citrate synthase (CS) and glutamate dehydrogenase (GDH) with IC50 values of 0.4-1.6 mM .
|
-
- HY-CE00033
-
-
- HY-CE00101
-
-
- HY-CE00047
-
C34:6(Omega-3)-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(16Z,19Z,22Z,25Z,28Z,31Z)-Tetratriacontahexaenoyl-CoA (C34:6(Omega-3)-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00045A
-
-
- HY-B1119
-
|
Bacterial
Fungal
Antibiotic
Apoptosis
|
Infection
Cancer
|
Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
|
-
- HY-CE00094A
-
(11Z,14Z)-3-Ketoeicosa-11,14-dienoyl-CoA
|
Biochemical Assay Reagents
|
Others
|
(11Z,14Z)-3-Oxoicosa-11,14-dienoyl-CoA ((11Z,14Z)-3-Ketoeicosa-11,14-dienoyl-CoA) is a 3-oxo-fatty acyl-CoA.
|
-
- HY-CE00071
-
3-Oxo-C28:5(omega-3)-CoA
|
Biochemical Assay Reagents
|
Others
|
(13Z,16Z,19Z,22Z,25Z)-3-Oxooctacosapentaenoyl-CoA (3-Oxo-C28:5(omega-3)-CoA) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00239A
-
Delta2-THA-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosaheptaenoyl-CoA (Delta2-THA-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00014
-
3-Oxo-C26:5(omega-3)-CoA
|
Biochemical Assay Reagents
|
Others
|
(11Z,14Z,17Z,20Z,23Z)-3-Oxohexacosapentaenoyl-CoA (3-Oxo-C26:5(omega-3)-CoA) is an unsaturated fatty acyl-CoA.
|
-
- HY-141699
-
|
FATP
|
Metabolic Disease
|
FATP1-IN-1 (compound 5k) is a fatty acid transport protein 1 (FATP1) inhibitor. FATP1-IN-1 is an inhibition of recombinant human or mouse acyl-CoA synthetase activity of FATP1, with the IC50 values of 0.046 μM or 0.60 μM, respectively .
|
-
- HY-120964
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Several different arachidonoyl amino acids, including N-arachidonoyl dopamine (NADA) and N-arachidonoyl serine (ARA-S), have been isolated and characterized from bovine brain.1 During mass spectral lipidomic analysis of rat brain, a series of fatty acyl amides of a third amino acid, taurine, is discovered.2 This novel class of compounds is present in kidney and activates members of the transient receptor potential (TRP) family of calcium channels.3 N-Stearoyl taurine is a prominent amino-acyl endocannabinoid isolated from rat brain during lipidomics profiling.
|
-
- HY-120963
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Several different arachidonoyl amino acids, including N-arachidonoyl dopamine and N-arachidonoyl serine, have been isolated and characterized from bovine brain.1 During mass spectral lipidomics analysis of rat brain, a series of fatty acyl amides of a third amino acid, taurine, were discovered.2 This novel class of compounds is present in kidney and activates members of the transient receptor potential (TRP) family of calcium channels.3 N-Oleoyl taurine is an amino-acyl endocannabinoid isolated from rat brain that may activate TRPV1 and TRPV4.
|
-
- HY-CE00005
-
(15Z,18Z,21Z,24Z)-3-Oxotriacontatetraenoyl-coenzyme A; 3-Oxo-C30:4(omega-6)-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(15Z,18Z,21Z,24Z)-3-Oxotriacontatetraenoyl-CoA ((15Z,18Z,21Z,24Z)-3-Oxotriacontatetraenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00052
-
(17Z,20Z,23Z,26Z)-3-Oxodotriacontatetraenoyl-coenzyme A; 3-Oxo-C32:4(omega-6)-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(17Z,20Z,23Z,26Z)-3-Oxodotriacontatetraenoyl-CoA ((17Z,20Z,23Z,26Z)-3-Oxodotriacontatetraenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00078
-
3-Oxo-C36:6(Omega-3)-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(18Z,21Z,24Z,27Z,30Z,33Z)-3-Oxohexatriacontahexaenoyl-CoA (3-Oxo-C36:6(Omega-3)-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00207
-
(3R,11Z,14Z,17Z)-3-Hydroxyicosatrienoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(3R,11Z,14Z,17Z)-3-Hydroxyicosatrienoyl-CoA ((3R,11Z,14Z,17Z)-3-Hydroxyicosatrienoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00081
-
(19Z,22Z,25Z,28Z)-3-Oxotetratriacontatetraenoyl-coenzyme A; 3-Oxo-C34:4(omega-6)-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(19Z,22Z,25Z,28Z)-3-Oxotetratriacontatetraenoyl-CoA ((19Z,22Z,25Z,28Z)-3-Oxotetratriacontatetraenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00011
-
3-Oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA
|
Biochemical Assay Reagents
|
Others
|
(11Z,14Z,17Z,20Z)-3-Oxohexacosatetraenoyl-CoA (3-Oxo-(11Z,14Z,17Z,20Z)-hexacosatetraenoyl-CoA) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00031
-
(10Z,13Z,16Z,19Z)-3-Oxodocosatetraenoyl-coenzyme A; 3-Oxo-C22:4(omega-3)-coenzyme A; 3-Oxo-all-cis-(omega-3)-docosatetraenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(10Z,13Z,16Z,19Z)-3-Oxodocosatetraenoyl-CoA ((10Z,13Z,16Z,19Z)-3-Oxodocosatetraenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00029
-
(23Z,26Z,29Z,32Z)-3-Oxooctatriacontatetraenoyl-coenzyme A; 3-Oxo-C38:4(omega-6)-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(23Z,26Z,29Z,32Z)-3-Oxooctatriacontatetraenoyl-CoA ((23Z,26Z,29Z,32Z)-3-Oxooctatriacontatetraenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00097
-
3-Oxo-C32:6(omega-3)-CoA
|
Biochemical Assay Reagents
|
Others
|
(14Z,17Z,20Z,23Z,26Z,29Z)-3-Oxodotriacontahexaenoyl-CoA (3-Oxo-C32:6(omega-3)-CoA) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00013A
-
(21Z,24Z,27Z,30Z)-3-Oxohexatriacontatetraenoyl-coenzyme A; 3-Oxo-C36:4(omega-6)-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(21Z,24Z,27Z,30Z)-3-Oxohexatriacontatetraenoyl-CoA ((21Z,24Z,27Z,30Z)-3-Oxohexatriacontatetraenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00041A
-
3-Oxo-C28:6(omega-3)-CoA
|
Biochemical Assay Reagents
|
Others
|
(10Z,13Z,16Z,19Z,22Z,25Z)-3-Oxooctacosahexaenoyl-CoA (3-Oxo-C28:6(omega-3)-CoA) is an unsaturated fatty acyl-CoA.
|
-
- HY-W653962
-
|
Isotope-Labeled Compounds
Apoptosis
Antibiotic
Fungal
Bacterial
|
Infection
Cancer
|
Triclosan- 13C6 is 13C labeled Triclosan. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
|
-
- HY-W747491
-
|
Isotope-Labeled Compounds
Antibiotic
Apoptosis
Bacterial
Fungal
|
Cancer
|
Triclosan- 13C12 is 13C labeled Triclosan. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
|
-
- HY-B1119R
-
|
Bacterial
Fungal
Antibiotic
Apoptosis
|
Infection
Cancer
|
Triclosan (Standard) is the analytical standard of Triclosan. This product is intended for research and analytical applications. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
|
-
- HY-CE00230
-
(2E,8Z,11Z,14Z,17Z)-Icosapentaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,8Z,11Z,14Z,17Z)-Icosapentaenoyl-CoA ((2E,8Z,11Z,14Z,17Z)-Icosapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-B0399
-
L-Carnitine
Maximum Cited Publications
16 Publications Verification
(R)-Carnitine; Levocarnitine
|
Endogenous Metabolite
|
Neurological Disease
Cancer
|
L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism .
|
-
- HY-CE00196A
-
(2E,11Z,14Z,17Z,20Z)-Hexacosapentaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,11Z,14Z,17Z,20Z)-Hexacosapentaenoyl-CoA ((2E,11Z,14Z,17Z,20Z)-Hexacosapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00243A
-
(2E,19Z,22Z,25Z,28Z)-Tetratriacontapentaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,19Z,22Z,25Z,28Z)-Tetratriacontapentaenoyl-CoA ((2E,19Z,22Z,25Z,28Z)-Tetratriacontapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-B2246
-
(R)-Carnitine hydrochloride; Levocarnitine hydrochloride
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism .
|
-
- HY-CE00089
-
(19Z,22Z,25Z,28Z,31Z)-Tetratriacontapentaenoyl-coenzyme A; C34:5(Omega-3)-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(19Z,22Z,25Z,28Z,31Z)-Tetratriacontapentaenoyl-CoA ((19Z,22Z,25Z,28Z,31Z)-Tetratriacontapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00205A
-
(2E,4E,8Z,11Z,14Z)-Icosapentaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,4E,8Z,11Z,14Z)-Icosapentaenoyl-CoA (2E,4E,8Z,11Z,14Z)-Icosapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00010A
-
(20Z,23Z,26Z,29Z,32Z)-Octatriacontapentaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(20Z,23Z,26Z,29Z,32Z)-Octatriacontapentaenoyl-CoA ((20Z,23Z,26Z,29Z,32Z)-Octatriacontapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00042
-
(16Z,19Z,22Z,25Z,28Z)-Tetratriacontapentaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(16Z,19Z,22Z,25Z,28Z)-Tetratriacontapentaenoyl-CoA ((16Z,19Z,22Z,25Z,28Z)-Tetratriacontapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00038
-
(23Z,26Z,29Z,32Z,35Z)-Octatriacontapentaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(23Z,26Z,29Z,32Z,35Z)-Octatriacontapentaenoyl-CoA ((23Z,26Z,29Z,32Z,35Z)-Octatriacontapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-122643
-
|
Bacterial
|
Infection
|
NITD-916, a 4-hydroxy-2-pyridone derivative, is an orally active and highly lipophilic mycobacterial enoyl reductase InhA inhibitor with an IC50 of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to block access to the fatty acyl substrate binding pocket. NITD-916 has potent anti-tuberculosis effects .
|
-
- HY-CE00039A
-
(10Z,13Z,16Z,19Z,22Z)-Octacosapentaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(10Z,13Z,16Z,19Z,22Z)-Octacosapentaenoyl-CoA ((10Z,13Z,16Z,19Z,22Z)-Octacosapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00027
-
(12Z,15Z,18Z,21Z,24Z)-Triacontapentaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(12Z,15Z,18Z,21Z,24Z)-Triacontapentaenoyl-CoA ((12Z,15Z,18Z,21Z,24Z)-Triacontapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00076
-
(18Z,21Z,24Z,27Z,30Z)-Hexatriacontapentaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(18Z,21Z,24Z,27Z,30Z)-Hexatriacontapentaenoyl-CoA ((18Z,21Z,24Z,27Z,30Z)-Hexatriacontapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00127
-
(3E,5Z,8Z,11Z,14Z)-Icosapentaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(3E,5Z,8Z,11Z,14Z)-Icosapentaenoyl-CoA ((3E,5Z,8Z,11Z,14Z)-Icosapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00219A
-
(2E,15Z,18Z,21Z,24Z)-Triacontapentaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,15Z,18Z,21Z,24Z)-Triacontapentaenoyl-CoA ((2E,15Z,18Z,21Z,24Z)-Triacontapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00228A
-
(2E,17Z,20Z,23Z,26Z)-Dotriacontapentaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,17Z,20Z,23Z,26Z)-Dotriacontapentaenoyl-CoA ((2E,17Z,20Z,23Z,26Z)-Dotriacontapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00024
-
(21Z,24Z,27Z,30Z,33Z)-Hexatriacontapentaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(21Z,24Z,27Z,30Z,33Z)-Hexatriacontapentaenoyl-CoA ((21Z,24Z,27Z,30Z,33Z)-Hexatriacontapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00249A
-
(2E,21Z,24Z,27Z,30Z)-Hexatriacontapentaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,21Z,24Z,27Z,30Z)-Hexatriacontapentaenoyl-CoA ((2E,21Z,24Z,27Z,30Z)-Hexatriacontapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00201A
-
(2E,23Z,26Z,29Z,32Z)-Octatriacontapentaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,23Z,26Z,29Z,32Z)-Octatriacontapentaenoyl-CoA ((2E,23Z,26Z,29Z,32Z)-Octatriacontapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-169794
-
|
DNA/RNA Synthesis
|
Others
|
N-Palmitoyl-phenylalanine is an N-acyl amide that contains the long-chain saturated fatty acid Palmitic acid (HY-N0830) conjugated via an amide bond to the essential amino acid L-Phenylalanine (HY-N0215). N-Palmitoyl-phenylalanine inhibits pre-mRNA splicing in HeLa cell nuclear lysates (IC50 > 400 μM) but has no splicing activity in intact HeLa cells .
|
-
- HY-B1212
-
Dibromohydroxyquinoline; 5,7-Dibromo-8-hydroxyquinoline
|
Parasite
Influenza Virus
|
Infection
|
Broxyquinoline (Dibromohydroxyquinoline) is an effective inhibitor of severe fever with thrombocytopenia syndrome virus (SFTSV) with an IC50 of 5.8 µM. Additionally, Broxyquinoline is an inhibitor of CpACBP1 with an IC50 of 64.9 μM. CpACBP1 is a fatty acyl-CoA binding protein of Cryptosporidium parvum, thus Broxyquinoline has the potential to inhibit parasite growth. Broxyquinoline shows promise for research in the field of infectious diseases .
|
-
- HY-CE00034
-
(15Z,18Z,21Z,24Z,27Z)-3-Oxotriacontapentaenoyl-coenzyme A; 3-Oxo-C30:5(omega-3)-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(15Z,18Z,21Z,24Z,27Z)-3-Oxotriacontapentaenoyl-CoA ((15Z,18Z,21Z,24Z,27Z)-3-Oxotriacontapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00020
-
(21Z,24Z,27Z,30Z,33Z)-3-Oxohexatriacontapentaenoyl-coenzyme A; 3-Oxo-C36:5(omega-3)-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(21Z,24Z,27Z,30Z,33Z)-3-Oxohexatriacontapentaenoyl-CoA ((21Z,24Z,27Z,30Z,33Z)-3-Oxohexatriacontapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00035
-
(23Z,26Z,29Z,32Z,35Z)-3-Oxooctatriacontapentaenoyl-coenzyme A; 3-Oxo-C38:5(omega-3)-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(23Z,26Z,29Z,32Z,35Z)-3-Oxooctatriacontapentaenoyl-CoA ((23Z,26Z,29Z,32Z,35Z)-3-Oxooctatriacontapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00087
-
(19Z,22Z,25Z,28Z,31Z)-3-Oxotetratriacontapentaenoyl-coenzyme A; 3-Oxo-C34:5(omega-3)-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(19Z,22Z,25Z,28Z,31Z)-3-Oxotetratriacontapentaenoyl-CoA ((19Z,22Z,25Z,28Z,31Z)-3-Oxotetratriacontapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00128A
-
(2E,23Z,26Z,29Z,32Z,35Z)-Octatriacontahexaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,23Z,26Z,29Z,32Z,35Z)-Octatriacontahexaenoyl-CoA ((2E,23Z,26Z,29Z,32Z,35Z)-Octatriacontahexaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00246A
-
(2E,19Z,22Z,25Z,28Z,31Z)-Tetratriacontahexaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,19Z,22Z,25Z,28Z,31Z)-Tetratriacontahexaenoyl-CoA ((2E,19Z,22Z,25Z,28Z,31Z)-Tetratriacontahexaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00079
-
(18Z,21Z,24Z,27Z,30Z,33Z)-Hexatriacontahexaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(18Z,21Z,24Z,27Z,30Z,33Z)-Hexatriacontahexaenoyl-CoA ((18Z,21Z,24Z,27Z,30Z,33Z)-Hexatriacontahexaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00232A
-
(2E,17Z,20Z,23Z,26Z,29Z)-Dotriacontahexaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,17Z,20Z,23Z,26Z,29Z)-Dotriacontahexaenoyl-CoA ((2E,17Z,20Z,23Z,26Z,29Z)-Dotriacontahexaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00217
-
(3R,13Z,16Z,19Z,22Z)-3-Hydroxyoctacosatetraenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(3R,13Z,16Z,19Z,22Z)-3-Hydroxyoctacosatetraenoyl-CoA ((3R,13Z,16Z,19Z,22Z)-3-Hydroxyoctacosatetraenoyl-coenzyme A) is a 3-hydroxy fatty acyl-CoA.
|
-
- HY-CE00208
-
(3R,11Z,14Z,17Z,20Z)-3-Hydroxyhexacosatetraenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(3R,11Z,14Z,17Z,20Z)-3-Hydroxyhexacosatetraenoyl-CoA ((3R,11Z,14Z,17Z,20Z)-3-Hydroxyhexacosatetraenoyl-coenzyme A) is a 3-hydroxy fatty acyl-CoA.
|
-
- HY-CE00195A
-
(2E,11Z,14Z,17Z,20Z,23Z)-Hexacosahexaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,11Z,14Z,17Z,20Z,23Z)-Hexacosahexaenoyl-CoA ((2E,11Z,14Z,17Z,20Z,23Z)-Hexacosahexaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00221A
-
(2E,15Z,18Z,21Z,24Z,27Z)-Triacontahexaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,15Z,18Z,21Z,24Z,27Z)-Triacontahexaenoyl-CoA ((2E,15Z,18Z,21Z,24Z,27Z)-Triacontahexaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00189A
-
(2E,13Z,16Z,19Z,22Z,25Z)-Octacosahexaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,13Z,16Z,19Z,22Z,25Z)-Octacosahexaenoyl-CoA ((2E,13Z,16Z,19Z,22Z,25Z)-Octacosahexaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00234A
-
(2E,6Z,9Z,12Z,15Z,18Z)-Tetracosahexaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,6Z,9Z,12Z,15Z,18Z)-Tetracosahexaenoyl-CoA ((2E,6Z,9Z,12Z,15Z,18Z)-Tetracosahexaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-W127461
-
Gangliotriosylceramide
|
Biochemical Assay Reagents
|
Others
|
Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.
|
-
- HY-B2246S
-
(R)-Carnitine-d9 chloride; Levocarnitine-d9 chloride
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
L-Carnitine-d9 (chloride)e is the deuterium labeled L-Carnitine chloride. L-Carnitine chloride, a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine chloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine chloride is an antioxidant. L-Carnitine chloride can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2][3].
|
-
- HY-B0399G
-
(R)-Carnitine; Levocarnitine
|
Endogenous Metabolite
|
Neurological Disease
Cancer
|
L-Carnitine (GMP) is L-Carnitine (HY-B0399) produced by using GMP guidelines. L-Carnitine, a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism .
|
-
- HY-127146
-
|
Antibiotic
Bacterial
|
Infection
|
Platensimycin is an antibiotic produced by S. platensis that inhibits gram-positive bacteria by selectively inhibiting cellular lipid biosynthesis (IC50=0.1 μM). Platensimycin targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s=48 nM and 160 nM for S.aureus and E.coli enzymes, respectively). Platensimycin is a promising agent for overcoming antibiotic resistance.
|
-
- HY-131701
-
C18 Lactosyl(β) Ceramide; Lactosyl Sphingosine; Lyso-Lactosylceramide (synthetic)
|
Endogenous Metabolite
|
Metabolic Disease
|
Lactosyl-C18-sphingosine (C18 Lactosyl(β) Ceramide; Lactosyl Sphingosine) is a bioactive sphingolipid that is a form of lactosylceramide but lacks the fatty acyl group. Lysolactosylceramide (1-50 μM) reduces the viability of human neutrophils in a concentration-dependent manner. Unlike lactosylceramide, Lactosyl-C18-sphingosine has no effect on protein synthesis and cell proliferation in cardiomyocytes. Lactosyl-C18-sphingosine is a lysoganglioside GM3.
|
-
- HY-B0399R
-
|
Endogenous Metabolite
|
Neurological Disease
Cancer
|
L-Carnitine (Standard) is the analytical standard of L-Carnitine. This product is intended for research and analytical applications. L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism .
|
-
- HY-B2246R
-
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
L-Carnitine (hydrochloride) (Standard) is the analytical standard of L-Carnitine (hydrochloride). This product is intended for research and analytical applications. L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism .
|
-
- HY-114773
-
|
Biochemical Assay Reagents
|
Others
|
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C11-HSL has a rare odd-numbered acyl carbon chain and may be a minor quorum-sensing signaling molecule in Pseudomonas aeruginosa strains.
|
-
- HY-128851R
-
-
- HY-CE00223A
-
(2E,16Z,19Z,22Z,25Z,28Z,31Z)-Tetratriacontaheptaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,16Z,19Z,22Z,25Z,28Z,31Z)-Tetratriacontaheptaenoyl-CoA ((2E,16Z,19Z,22Z,25Z,28Z,31Z)-Tetratriacontaheptaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00238A
-
(2E,18Z,21Z,24Z,27Z,30Z,33Z)-Hexatriacontaheptaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,18Z,21Z,24Z,27Z,30Z,33Z)-Hexatriacontaheptaenoyl-CoA ((2E,18Z,21Z,24Z,27Z,30Z,33Z)-Hexatriacontaheptaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00209
-
(3R,11Z,14Z,17Z,20Z,23Z)-3-Hydroxyhexacosapentaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(3R,11Z,14Z,17Z,20Z,23Z)-3-Hydroxyhexacosapentaenoyl-CoA ((3R,11Z,14Z,17Z,20Z,23Z)-3-Hydroxyhexacosapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00188A
-
(2E,14Z,17Z,20Z,23Z,26Z,29Z)-Dotriacontaheptaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,14Z,17Z,20Z,23Z,26Z,29Z)-Dotriacontaheptaenoyl-CoA ((2E,14Z,17Z,20Z,23Z,26Z,29Z)-Dotriacontaheptaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00193A
-
(2E,12Z,15Z,18Z,21Z,24Z,27Z)-Triacontaheptaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,12Z,15Z,18Z,21Z,24Z,27Z)-Triacontaheptaenoyl-CoA ((2E,12Z,15Z,18Z,21Z,24Z,27Z)-Triacontaheptaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00043
-
(16Z,19Z,22Z,25Z,28Z,31Z)-3-Oxotetratriacontahexaenoyl-coenzyme A; 3-Oxo-C34:6(omega-3)-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(16Z,19Z,22Z,25Z,28Z,31Z)-3-Oxotetratriacontahexaenoyl-CoA ((16Z,19Z,22Z,25Z,28Z,31Z)-3-Oxotetratriacontahexaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00225
-
(2E,8Z,11Z,14Z,17Z,20Z,23Z)-Hexacosaheptaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,8Z,11Z,14Z,17Z,20Z,23Z)-Hexacosaheptaenoyl-CoA ((2E,8Z,11Z,14Z,17Z,20Z,23Z)-Hexacosaheptaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00200A
-
(2E,10Z,13Z,16Z,19Z,22Z,25Z)-Octacosaheptaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(2E,10Z,13Z,16Z,19Z,22Z,25Z)-Octacosaheptaenoyl-CoA ((2E,10Z,13Z,16Z,19Z,22Z,25Z)-Octacosaheptaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-W127393
-
|
Biochemical Assay Reagents
|
Others
|
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in nutrient-rich Luria-Bertani broth (LB) medium.
|
-
- HY-W127487
-
|
Biochemical Assay Reagents
|
Others
|
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C18-HSL, one of four lipophilic long acyl side chain AHLs produced by the LuxI AHL synthase homolog SinI, is involved in quorum-sensing signaling in strains of Rhizobium meliloti (a nitrogen-fixing bacterial symbiont of the legume M. sativa) . C18-HSL and other hydrophobic AHLs tend to localize in the relatively lipophilic environment of bacterial cells and cannot diffuse freely across the cell membrane. Long-chain N-acyl homoserine lactones can be exported from cells by efflux pumps, or can be transported between communicating cells by extracellular outer membrane vesicles.
|
-
- HY-CE00175
-
(3R,10Z,13Z,16Z,19Z,22Z,25Z)-3-Hydroxyoctacosahexaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(3R,10Z,13Z,16Z,19Z,22Z,25Z)-3-Hydroxyoctacosahexaenoyl-CoA ((3R,10Z,13Z,16Z,19Z,22Z,25Z)-3-Hydroxyoctacosahexaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-CE00211
-
(3R,12Z,15Z,18Z,21Z,24Z,27Z)-3-Hydroxytriacontahexaenoyl-coenzyme A
|
Biochemical Assay Reagents
|
Others
|
(3R,12Z,15Z,18Z,21Z,24Z,27Z)-3-Hydroxytriacontahexaenoyl-CoA ((3R,12Z,15Z,18Z,21Z,24Z,27Z)-3-Hydroxytriacontahexaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.
|
-
- HY-156041
-
Lyso-PE (egg); LPE (egg); L-α-lysophosphatidylethanolamine
|
Endogenous Metabolite
|
Metabolic Disease
|
Lysophosphatidylethanolamine (LPE) is a naturally-occurring lysophospholipid that can be generated via deacylation of phosphatidylethanolamine by phospholipase A2 (PLA2). It increases the phosphorylation of ERK1/2 in PC12 cells, an effect that can be blocked by the MEK inhibitors U-0126 (HY-12031A) and PD 98059 (HY-12028) and the EGFR inhibitor AG-1478 (HY-13524).1 LPE also increases neurite outgrowth and expression of neurofilament M in PC12 cells. LPE inhibits the activity of phospholipase D (PLD) partially purified from cabbage.3 This product contains lysophosphatidylethanolamine molecular species with variable fatty acyl chain lengths at the sn-1 position and a hydroxy group at the sn-2 position.
|
-
- HY-112747
-
LPI; PE (soy)
|
Phospholipase
|
Infection
|
Phosphatidylethanolamine is the most abundant phospholipid in prokaryotes and the second most abundant found in the membrane of mammalian, plant, and yeast cells, comprising approximately 25% of total mammalian phospholipids. In the brain, phosphatidylethanolamine comprises almost half of the total phospholipids. It is synthesized mainly through the cytidine diphosphate-ethanolamine and phosphatidylserine decarboxylation pathways, which occur in the endoplasmic reticulum (ER) and mitochondrial membranes, respectively. It is a precursor in the synthesis of phosphatidylcholine and arachidonoyl ethanolamide and is a source of ethanolamine used in various cellular functions. In E. coli, phosphatidylethanolamine deficiency prevents proper assembly of lactose permease, suggesting a role as a lipid chaperone. It is a cofactor in the propagation of prions in vitro and can convert recombinant mammalian proteins into infectious molecules even in the absence of RNA. This product contains phosphatidylethanolamine molecular species with variable fatty acyl chain lengths at the sn-1 and sn-2 positions.
|
-
Cat. No. |
Product Name |
Type |
-
- HY-D1570
-
|
Fluorescent Dyes/Probes
|
BODIPYFL C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 480/508 nm .
|
Cat. No. |
Product Name |
Type |
-
- HY-134136A
-
|
Enzyme Substrates
|
Octanoyl coenzyme A lithium is a fatty acyl coenzyme A derivative. Octanoyl coenzyme A lithium can inhibit citrate synthase (CS) and glutamate dehydrogenase (GDH) with IC50 values of 0.4-1.6 mM .
|
-
- HY-128851B
-
|
Enzyme Substrates
|
Coenzyme A (CoASH) sodium is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids .
|
-
- HY-128851A
-
|
Enzyme Substrates
|
Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids .
|
-
- HY-134428
-
|
Enzyme Substrates
|
Arachidonoyl coenzyme A lithium is an unsaturated fatty acyl coenzyme A, formed by the condensation of the thiol group of coenzyme A with the carboxyl group of arachidonic acid .
|
-
- HY-134438
-
|
Enzyme Substrates
|
Hexanoyl coenzyme A trilithium is a hexanoyl-based medium-chain fatty acyl coenzyme A that is present in all organisms. Hexanoyl coenzyme A trilithium can be used as a precursor for cannabinoid biosynthesis and acts as a competitive inhibitor of medium-chain acyl coenzyme A dehydrogenase (MCAD) .
|
-
- HY-134136
-
|
Enzyme Substrates
|
Octanoyl coenzyme A is a fatty acyl coenzyme A derivative. Octanoyl coenzyme A can inhibit citrate synthase (CS) and glutamate dehydrogenase (GDH) with IC50 values of 0.4-1.6 mM .
|
-
- HY-W127461
-
Gangliotriosylceramide
|
Drug Delivery
|
Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.
|
-
- HY-114773
-
|
Microbial Culture
|
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C11-HSL has a rare odd-numbered acyl carbon chain and may be a minor quorum-sensing signaling molecule in Pseudomonas aeruginosa strains.
|
-
- HY-W127393
-
|
Biochemical Assay Reagents
|
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in nutrient-rich Luria-Bertani broth (LB) medium.
|
-
- HY-W127487
-
|
Drug Delivery
|
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C18-HSL, one of four lipophilic long acyl side chain AHLs produced by the LuxI AHL synthase homolog SinI, is involved in quorum-sensing signaling in strains of Rhizobium meliloti (a nitrogen-fixing bacterial symbiont of the legume M. sativa) . C18-HSL and other hydrophobic AHLs tend to localize in the relatively lipophilic environment of bacterial cells and cannot diffuse freely across the cell membrane. Long-chain N-acyl homoserine lactones can be exported from cells by efflux pumps, or can be transported between communicating cells by extracellular outer membrane vesicles.
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-124081
-
|
Apoptosis
|
Metabolic Disease
|
N-Oleoyl-L-Serine is an endogenous amide of long-chain fatty acids with ethanolamine (N-acyl amides). N-Oleoyl-L-Serine is a lipid regulator of bone remodeling and stimulates osteoclast apoptosis. N-Oleoyl-L-Serine can be used for antiosteoporotic drug discovery development .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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