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Results for "

ghrelin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	GHSR (30) Acyltransferase (1) Adrenergic Receptor (1) Amino Acid Derivatives (1) Biochemical Assay Reagents (1) Endogenous Metabolite (15) Free Fatty Acid Receptor (1) Isotope-Labeled Compounds (3) Somatostatin Receptor (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (3) Endocrinology (7) Inflammation/Immunology (4) Metabolic Disease (35) Neurological Disease (5)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Targets Recommended: GHSR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1366

des-Gln14-Ghrelin	GHSR	Metabolic Disease
des-Gln14-Ghrelin is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca ²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM .

HY-Y0337

L-Cysteine 4 Publications Verification Cysteine	Endogenous Metabolite	Metabolic Disease Cancer
L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans .

HY-19884B

Relamorelin TFA RM-131 TFA; BIM-28131 TFA	GHSR	Metabolic Disease
Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for GHS-1a receptor. Relamorelin TFA is centrally penetrant. Relamorelin TFA increases growth hormone levels and accelerates gastric emptying. Relamorelin TFA has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research .

HY-145364

Ghrelin receptor full agonist-2	GHSR	Metabolic Disease
Ghrelin receptor full agonist-2 (compound 12j) is a highly potent Ghrelin receptor full agonist.

HY-P1366A

*des-Gln14-Ghrelin* TFA**	GHSR	Metabolic Disease
des-Gln14-Ghrelin TFA is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca ²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM .

HY-113906

GSK1614343	GHSR	Metabolic Disease
GSK1614343 is the potent antagonist of growth hormone secretagogues type 1a (GHS1a) receptors. GSK1614343 inhibits the calcium response induced by ghrelin with a pIC₅₀ value of 7.90. GSK1614343 represents a useful tool to investigate the physiological relevance of the ghrelin system in rat models .

HY-P1432

K-(D-1-Nal)-FwLL-NH2	GHSR	Metabolic Disease
K-(D-1-Nal)-FwLL-NH2 is a high affinity, potent and inverse ghrelin receptor agonist (EC₅₀=3.4 nM, K_i=4.9 nM). K-(D-1-Nal)-FwLL-NH2 can be used for the research of obesity .

HY-19884

Relamorelin RM-131; BIM-28131	GHSR	Metabolic Disease
Relamorelin (RM-131), a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for GHS-1a receptor. Relamorelin is centrally penetrant. Relamorelin increases growth hormone levels and accelerates gastric emptying. Relamorelin has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research .

HY-19884A

Relamorelin acetate RM-131 acetate; BIM-28131 acetate	GHSR	Metabolic Disease
Relamorelin (RM-131) acetate, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for GHS-1a receptor. Relamorelin acetate is centrally penetrant. Relamorelin acetate increases growth hormone levels and accelerates gastric emptying. Relamorelin acetate has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research .

HY-14903

Ulimorelin TZP-101	GHSR Adrenergic Receptor	Metabolic Disease
Ulimorelin (TZP-101) is a ghrelin receptor (GRLN) agonist with an EC₅₀ of 29 nM and a K_i of 16 nM. Ulimorelin is a prokinetic agent and causes vasorelaxation through competitive antagonist action at α1-adrenoceptors. Ulimorelin stimulates intestinal motility and is used for malnutrition .

HY-Y0337R

L-Cysteine (Standard)	Endogenous Metabolite	Metabolic Disease Cancer
L-Cysteine (Standard) is the analytical standard of L-Cysteine. This product is intended for research and analytical applications. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans .

HY-111232

GSK894281	GHSR	Metabolic Disease
GSK894281 is an orally active and highly potent ghrelin receptor full agonist with a pEC₅₀ of <4.9 at the human motilin receptor. GSK894281 effectively enters the CNS. GSK894281 has the potential for constipation or to assist in emptying the colon prior to colonoscopy or colon surgery research .

HY-P1306

Obestatin(rat)	GHSR	Cardiovascular Disease Inflammation/Immunology
Obestatin(rat), encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) has anti-inflammatory, anti-myocardial infarction and antioxidant activities .

HY-P1306A

Obestatin(rat) TFA	GHSR	Cardiovascular Disease Inflammation/Immunology
Obestatin(rat) TFA, encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) TFA suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) TFA has anti-inflammatory, anti-myocardial infarction and antioxidant activities .

HY-P1139

Cortistatin-8 PCFWKTCK	GHSR	Metabolic Disease
Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals .

HY-Y0337A

L-Cysteine hydrochloride 4 Publications Verification	Endogenous Metabolite	Metabolic Disease Cancer
L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses *ghrelin* and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF) .

HY-Y0337AR

L-Cysteine hydrochloride (Standard)	Endogenous Metabolite	Metabolic Disease Cancer
L-Cysteine (hydrochloride) (Standard) is the analytical standard of L-Cysteine (hydrochloride). This product is intended for research and analytical applications. L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF) [4].

HY-P10673

KwFwLL-NH2	GHSR	Metabolic Disease
KwFwLL-NH2, a hexapeptide, is a ghrelin receptor ligand. KwFwLL-NH2 can act as a specific inverse agonist at the ghrelin receptor but with moderate potency (EC₅₀=45.6 nM) .

HY-115272

GSK894490A	GHSR	Neurological Disease
GSK894490A is a non-peptide ghrelin receptor agonist .

HY-14734B

Anamorelin Fumarate ONO-7643 Fumarate; RC1291 Fumarate	GHSR	Endocrinology Cancer
Anamorelin Fumarate is a novel ghrelin receptor agonist with EC₅₀ value of 0.74 nM in the FLIPR assay.

HY-13964A

YIL781 hydrochloride	GHSR	Metabolic Disease
YIL781 hydrochloride is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 hydrochloride produces a greater improvement in glucose homeostasis in rats. YIL781 hydrochloride inhibits the calcium response induced by ghrelin with pIC₅₀ values of 7.90 and 8.27, respectively .

HY-13964

YIL781	GHSR	Metabolic Disease
YIL781 is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 produces a greater improvement in glucose homeostasis in rats. YIL781 inhibits the calcium response induced by ghrelin with pIC₅₀ values of 7.90 and 8.27, respectively .

HY-P0232

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH Fmoc-Thr(Ac₃AcNH-α-Gal)-OH	Amino Acid Derivatives	Inflammation/Immunology Cancer
AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.

HY-P0231

AZP-531 2 Publications Verification	GHSR	Metabolic Disease Endocrinology
AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.

HY-14734

Anamorelin Maximum Cited Publications 8 Publications Verification RC-1291; ONO-7643	GHSR	Endocrinology Cancer
Anamorelin (RC-1291) is a potent ghrelin receptor agonist with EC₅₀ value of 0.74 nM in the FLIPR assay.

HY-14734A

Anamorelin hydrochloride Maximum Cited Publications 8 Publications Verification RC-1291 hydrochloride; ONO-7643 hydrochloride	GHSR	Endocrinology Cancer
Anamorelin (RC-1291) hydrochloride is a potent ghrelin receptor agonist with EC₅₀ value of 0.74 nM in the FLIPR assay.

HY-12584

PF-5190457 PF-05190457	GHSR	Metabolic Disease Endocrinology
PF-5190457 (PF-05190457) is a potent and selective ghrelin receptor inverse agonist with a pK_i of 8.36 .

HY-N12348

Emoghrelin	GHSR	Others
Emoghrelin, isolated from? Heshouwu Polygonum multiflorum, stimulates growth hormone secretion via activation of the ghrelin receptor .

HY-P1432A

K-(D-1-Nal)-FwLL-NH2 TFA	GHSR	Cancer
K-(D-1-Nal)-FwLL-NH2 TFA is a high affinity and potent ghrelin receptor inverse agonist (K_i values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). K-(D-1-Nal)-FwLL-NH2 blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.

HY-148869A

Hexanoyl-Coenzyme A triammonium 06:0 Coenzyme A	Biochemical Assay Reagents	Metabolic Disease
Hexanoyl-Coenzyme A triammonium (06:0 Coenzyme A) is a medium-chain fatty acyl CoA that is an acyl donor substrate for ghrelin O-acyltransferase (GOAT) .

HY-14734R

Anamorelin (Standard)	GHSR	Endocrinology Cancer
Anamorelin (Standard) is the analytical standard of Anamorelin. This product is intended for research and analytical applications. Anamorelin (RC-1291) is a potent ghrelin receptor agonist with EC₅₀ value of 0.74 nM in the FLIPR assay.

HY-157556

BPP-2	GHSR	Others
BPP-2 is a GHSR ligand with an F element. Using ¹⁸F isotope labeling BPP-2, a PET probe targeting GHSR can be obtained. The binding affinity K_i of ¹⁸F-BPP-2 for GHSR is 274 nM .

HY-129207

JMV 3002	GHSR	Endocrinology
Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. JMV3002 is a potent ghrelin receptor antagonist with an IC₅₀ value of 1.1 nM in vitro. 80 μg/kg, JMV3002 inhibits hexarelin-stimulated food intake by as much as 98% in rats. JMV3002 alone does not elicit growth hormone release nor does it inhibit hexarelin-stimulated growth hormone secretion when tested in infant rats at a dose of 160 μg/kg.

HY-W016715

L-Cysteine hydrochloride hydrate 4 Publications Verification	Endogenous Metabolite	Metabolic Disease Cancer
L-Cysteine hydrochloride hydrate is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride hydrate suppresses ghrelin and reduces appetite in rodents and humans .

HY-116625

PF-04628935	GHSR	Neurological Disease
PF-04628935 (compound 10n) is a potent ghrelin receptor inverse agonist, with an IC₅₀ of 4.6 nM. PF-04628935 exhibits oral bioavailability of 43% in rats and shows reasonable penetration into the brain. PF-04628935 can be used for stress and anxiety research .

HY-P1212

Cortistatin 14 (mouse, rat) CST-14 (mouse, rat)	Somatostatin Receptor	Neurological Disease
Cortistatin 14, mouse, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus .

HY-Y0337S5

L-Cysteine-d3	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
L-Cysteine-d₃ is the deuterium labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-Y0337S6

L-Cysteine-d2	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
L-Cysteine-d₂ is the deuterium labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-113906A

(αR,8aS)-GSK1614343	GHSR	Inflammation/Immunology
(αR,8aS)-GSK1614343 (compound 18a, d2) is a cyclized *ghrelin* antagonist with an pIC₅₀ value of 8.4. (αR,8aS)-GSK1614343 shows a competitive antagonism of hGHSR1a with a mean pK_b value of 8.06 .

HY-114610

13Z,16Z-Docosadienoic acid	Endogenous Metabolite Free Fatty Acid Receptor	Metabolic Disease
13Z,16Z-Docosadienoic acid, a ω-6 polyunsaturated fatty acid, possesses anti-borreliae effect. 13Z,16Z-Docosadienoic acid, as a long-chain fatty acid (LCFA), is a free fatty acid receptor 4 (FFAR4 or GPR120, a LCFA receptor) agonist .

HY-Y0337S1

L-Cysteine-15N	Endogenous Metabolite	Metabolic Disease
L-Cysteine- ¹⁵N is the ¹⁵N-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-Y0337S4

L-Cysteine-13C3	Endogenous Metabolite	Metabolic Disease
L-Cysteine- ¹³C₃ is the ¹³C-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-W016715R

L-Cysteine hydrochloride hydrate (Standard)	Endogenous Metabolite	Metabolic Disease
L-Cysteine (hydrochloride hydrate) (Standard) is the analytical standard of L-Cysteine (hydrochloride hydrate). This product is intended for research and analytical applications. L-Cysteine hydrochloride hydrate is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride hydrate suppresses ghrelin and reduces appetite in rodents and humans .

HY-Y0337S2

L-Cysteine-3-13C	Endogenous Metabolite	Metabolic Disease
L-Cysteine-3- ¹³C is the ¹³C-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-Y0337S3

L-Cysteine-1-13C	Endogenous Metabolite	Metabolic Disease
L-Cysteine-1- ¹³C is the ¹³C-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-Y0337S

L-Cysteine-13C3,15N	Endogenous Metabolite	Metabolic Disease
L-Cysteine- ¹³C₃, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-Y0337S7

L-Cysteine-d3,15N	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
L-Cysteine-d₃, ¹⁵N is the deuterium and ¹⁵N-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-103479

GOAT-IN-1	Acyltransferase	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of obesity, diabetes, hyperlipidemia, metabolic, non-alcoholic fatty liver, steatohepatitis, sarcopenia, appetite control, alcohol/narcotic dependence, Alzheimer’s disease, Parkinson’s disease, cerebrovascular dementia, cerebral apoplexy, cerebral infarction, cardic disease, some kind of tumors.

HY-137061

AZ-GHS-22	GHSR	Metabolic Disease
AZ-GHS-22 is a potent, non-CNS penetrant GHS-R1a inverse agonist (IC₅₀=0.77 nM) .

Cat. No.	Product Name	Target	Research Area

HY-P1366

des-Gln14-Ghrelin	GHSR	Metabolic Disease
des-Gln14-Ghrelin is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca ²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM .

HY-P4687

*(Ser(Ac)3)-Ghrelin* (mouse, rat)**	Peptides	Others
(Ser(Ac)3)-Ghrelin (mouse, rat) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-19884B

Relamorelin TFA RM-131 TFA; BIM-28131 TFA	GHSR	Metabolic Disease
Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for GHS-1a receptor. Relamorelin TFA is centrally penetrant. Relamorelin TFA increases growth hormone levels and accelerates gastric emptying. Relamorelin TFA has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research .

HY-P1306

Obestatin(rat)	GHSR	Cardiovascular Disease Inflammation/Immunology
Obestatin(rat), encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) has anti-inflammatory, anti-myocardial infarction and antioxidant activities .

HY-P1366A

*des-Gln14-Ghrelin* TFA**	GHSR	Metabolic Disease
des-Gln14-Ghrelin TFA is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca ²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM .

HY-P1432

K-(D-1-Nal)-FwLL-NH2	GHSR	Metabolic Disease
K-(D-1-Nal)-FwLL-NH2 is a high affinity, potent and inverse ghrelin receptor agonist (EC₅₀=3.4 nM, K_i=4.9 nM). K-(D-1-Nal)-FwLL-NH2 can be used for the research of obesity .

HY-19884

Relamorelin RM-131; BIM-28131	GHSR	Metabolic Disease
Relamorelin (RM-131), a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for GHS-1a receptor. Relamorelin is centrally penetrant. Relamorelin increases growth hormone levels and accelerates gastric emptying. Relamorelin has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research .

HY-19884A

Relamorelin acetate RM-131 acetate; BIM-28131 acetate	GHSR	Metabolic Disease
Relamorelin (RM-131) acetate, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for GHS-1a receptor. Relamorelin acetate is centrally penetrant. Relamorelin acetate increases growth hormone levels and accelerates gastric emptying. Relamorelin acetate has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research .

HY-P1306A

Obestatin(rat) TFA	GHSR	Cardiovascular Disease Inflammation/Immunology
Obestatin(rat) TFA, encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) TFA suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) TFA has anti-inflammatory, anti-myocardial infarction and antioxidant activities .

HY-P1139

Cortistatin-8 PCFWKTCK	GHSR	Metabolic Disease
Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals .

HY-P10673

KwFwLL-NH2	GHSR	Metabolic Disease
KwFwLL-NH2, a hexapeptide, is a ghrelin receptor ligand. KwFwLL-NH2 can act as a specific inverse agonist at the ghrelin receptor but with moderate potency (EC₅₀=45.6 nM) .

HY-P0232

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH Fmoc-Thr(Ac₃AcNH-α-Gal)-OH	Amino Acid Derivatives	Inflammation/Immunology Cancer
AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.

HY-P0231

AZP-531 2 Publications Verification	GHSR	Metabolic Disease Endocrinology
AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.

HY-P1432A

K-(D-1-Nal)-FwLL-NH2 TFA	GHSR	Cancer
K-(D-1-Nal)-FwLL-NH2 TFA is a high affinity and potent ghrelin receptor inverse agonist (K_i values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). K-(D-1-Nal)-FwLL-NH2 blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.

HY-P1421A

Obestatin(human) TFA	Peptides	Metabolic Disease
Obestatin(human) TFA is an endogenous peptide derived from the same prepropeptide as ghrelin. Obestatin(human) suppresses food intake and reduce body weight-gain in rats.

HY-P5129

ASB20123	Peptides	Others
ASB20123 is a CNP/ghrelin chimeric peptide. ASB20123 stimulate bone growth. ASB20123 can be used in research of growth disorders and dwarfism .

HY-P4904

RFRP-3 (rat)	Peptides	Neurological Disease
RFRP-3 (rat) is a neuropeptide. RFRP-3 (rat) inhibits gonadotropin secretion, causing a marked increase in ghrelin mRNA and plasma growth hormone levels .

HY-P1212

Cortistatin 14 (mouse, rat) CST-14 (mouse, rat)	Somatostatin Receptor	Neurological Disease
Cortistatin 14, mouse, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y0337

L-Cysteine 4 Publications Verification Cysteine	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans .

HY-Y0337A

L-Cysteine hydrochloride 4 Publications Verification	Structural Classification Classification of Application Fields Anti-aging Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses *ghrelin* and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF) .

HY-W016715

L-Cysteine hydrochloride hydrate 4 Publications Verification	Structural Classification Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-Cysteine hydrochloride hydrate is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride hydrate suppresses ghrelin and reduces appetite in rodents and humans .

HY-114610

13Z,16Z-Docosadienoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Free Fatty Acid Receptor
13Z,16Z-Docosadienoic acid, a ω-6 polyunsaturated fatty acid, possesses anti-borreliae effect. 13Z,16Z-Docosadienoic acid, as a long-chain fatty acid (LCFA), is a free fatty acid receptor 4 (FFAR4 or GPR120, a LCFA receptor) agonist .

HY-Y0337R

L-Cysteine (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Source classification Amino acids Endogenous metabolite	Endogenous Metabolite
L-Cysteine (Standard) is the analytical standard of L-Cysteine. This product is intended for research and analytical applications. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans .

HY-Y0337AR

L-Cysteine hydrochloride (Standard)	Structural Classification Source classification Amino acids Endogenous metabolite	Endogenous Metabolite
L-Cysteine (hydrochloride) (Standard) is the analytical standard of L-Cysteine (hydrochloride). This product is intended for research and analytical applications. L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF) [4].

HY-N12348

Emoghrelin	Quinones Structural Classification Anthraquinones Polygonaceae Source classification Fallopia multiflora (Thunb.) Harald. Plants	GHSR
Emoghrelin, isolated from? Heshouwu Polygonum multiflorum, stimulates growth hormone secretion via activation of the ghrelin receptor .

HY-W016715R

L-Cysteine hydrochloride hydrate (Standard)	Structural Classification Source classification Amino acids Endogenous metabolite	Endogenous Metabolite
L-Cysteine (hydrochloride hydrate) (Standard) is the analytical standard of L-Cysteine (hydrochloride hydrate). This product is intended for research and analytical applications. L-Cysteine hydrochloride hydrate is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride hydrate suppresses ghrelin and reduces appetite in rodents and humans .

Cat. No.	Product Name	Chemical Structure

HY-Y0337S5

L-Cysteine-d3
L-Cysteine-d₃ is the deuterium labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-Y0337S6

L-Cysteine-d2
L-Cysteine-d₂ is the deuterium labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-Y0337S1

L-Cysteine-15N
L-Cysteine- ¹⁵N is the ¹⁵N-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-Y0337S4

L-Cysteine-13C3
L-Cysteine- ¹³C₃ is the ¹³C-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-Y0337S2

L-Cysteine-3-13C
L-Cysteine-3- ¹³C is the ¹³C-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-Y0337S3

L-Cysteine-1-13C
L-Cysteine-1- ¹³C is the ¹³C-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-Y0337S

L-Cysteine-13C3,15N
L-Cysteine- ¹³C₃, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

HY-Y0337S7

L-Cysteine-d3,15N
L-Cysteine-d₃, ¹⁵N is the deuterium and ¹⁵N-labeled L-Cysteine. L-Cysteine is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine suppresses ghrelin and reduces appetite in rodents and humans[1].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81482

	Obestatin Antibody (YA1227) GHRL; MTLRP; UNQ524/PRO1066; Appetite-regulating hormone; Growth hormone secretagogue; Growth hormone-releasing peptide; Motilin-related peptide; Protein M46; ghrelin-27ghrelin-28 (ghrelin); Obestatin	IHC-P	Human
	Obestatin Antibody (YA1227) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1227), targeting Obestatin. Obestatin Antibody (YA1227) can be used for IHC-P experiment in human background.

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